ライフサイエンスコーパス: shedding

1 ular domain (ectodomain), a process known as shedding.

2 the respiratory system, and prolonged virus shedding.

3 in one macaque, we observed prolonged rectal shedding.

4 t about oseltamivir's ability to alter viral shedding.

5 n eukaryotic virome abundance and poliovirus shedding.

6 proteases such as ADAM17, a process known as shedding.

7 quired for colonization and, in turn, robust shedding.

8 the complex regulation of ADAM-dependent TNF shedding.

9 blocking receptor attachment and inducing S1 shedding.

10 hibitory/excitatory imbalance linked to RAGE shedding.

11 course, patient-specific factors, and viral shedding.

12 rapid removal of MAC through endocytosis or shedding.

13 about the mechanisms that govern ectodomain shedding.

14 sensitive and specific manner only upon TNF shedding.

15 ct of vaccination or prior exposure on stool shedding.

16 echanisms: cone scale flexion and cone scale shedding.

17 induction of oxidative stress and glycocalyx shedding.

18 at undergoes autocleavage for activation and shedding.

19 6) were inversely associated with poliovirus shedding.

20 women with less frequent subclinical HSV DNA shedding.

21 active EGFR family ligands in the via ligand shedding.

22 s but without concurrent LID/DeltaM2-2/1030s shedding.

23 eclined among participants with no/low viral shedding.

24 eclined among participants with no/low viral shedding (-0.04 +/- 0.02, P = 0.047, interaction P < 0.0

25 ldren aged 1-5 years had prolonged viral RNA shedding (+/-1-2 days) compared with older children and

26 s of TENGs using unfixed charges in domains, shedding a new light on high-performance mechanical ener

27 nection between HSV-1 release and syndecan-1 shedding, a phenomenon that is regulated by HPSE and exe

28 esulted in soluble PC7 and loss of its hTfR1 shedding activity.

29 were highly refractory to induction of cell shedding after intraperitoneal administration of liposac

30 High and persistent rotavirus shedding among vaccinated children with breakthrough dis

31 Quantifying rotavirus shedding among vaccinated individuals will aid understan

32 gh 59 months in the immunogenicity and viral shedding analyses.

33 ne elicited a significant reduction in virus shedding and a decrease in both the severity and frequen

34 ociated with a significant decrease in virus shedding and a reduction in both the severity and freque

35 Viral shedding and clinical disease were evaluated daily.

36 amic equilibrium-salivary flow and adhesion, shedding and colonization-and by interactions among and

37 HA stalk antibody levels and influenza viral shedding and disease duration using accelerated failure

38 ns evidenced by significantly reduced oocyst shedding and disruption of the intestinal blood barrier.

39 gher total viral burden with prolonged virus shedding and had an increased risk of acquiring resistan

40 gher total viral burden with prolonged virus shedding and had an increased risk of acquiring resistan

41 creased entry correlates with less S1-domain shedding and higher S-protein incorporation into the vir

42 Viral RNA shedding and IFN-stimulated gene expression were measure

43 se, mechanistic readout of respiratory virus shedding and local immune responses.

44 earchers better understand the regulation of shedding and may aid in the development of drugs targeti

45 d diarrhea; however, there was reduced viral shedding and mortality in the icPEDV-EnUmt-infected anim

46 Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274,

47 We found that, as seen with poliovirus, CVB3 shedding and pathogenesis were reduced in antibiotic-tre

48 streptomycin, was sufficient to reduce CVB3 shedding and pathogenesis while having no effect on poli

49 genesis while having no effect on poliovirus shedding and pathogenesis.

50 ress and inflammatory responses, tumour-cell shedding and pro-angiogenic and/or growth factors, might

51 require consideration when correlating virus shedding and protection.

52 muscarinic agonist carbachol promotes PrP(C) shedding and reduces the binding of AbetaO to the cell s

53 cycle the endometrium undergoes remodeling, shedding and regeneration, all of which are driven by su

54 >=80 were associated with further shortened shedding and significantly shortened symptom duration (i

55 Baboons had prolonged viral RNA shedding and substantially more lung inflammation compar

56 howed the most complete suppression of virus shedding and the greatest improvement in pathology.

57 PCR for the detection of Salmonella enterica shedding and to compare that ability to culture-based te

58 Protection from virus shedding and viremia during challenge infection in combi

59 ssociated with significantly shortened viral shedding, and among adults they were also associated wit

60 try, and thereby protect from disease, viral shedding, and cell-associated viremia.

61 mals had low viremia titers, showed no virus shedding, and developed a strong virus-specific antibody

62 ikely significantly reduce HSV reactivation, shedding, and lesions.

63 The RSV serum antibodies, vaccine shedding, and reactogenicity were assessed.

64 vaccines, the presence and extent of faecal shedding, and the neurovirulence of shed virus.

65 istent infection with low levels of periodic shedding as a likely route for virus maintenance and spi

66 sing an oral route of inoculation, and fecal shedding as a marker for GI colonization, we showed that

67 a genetically encoded reporter to study TNF shedding at the single-cell level.

68 However, there was no difference in nasal shedding between vaccinated and control SARS-CoV-2-infec

69 emonstrating susceptibility and evidence for shedding but no disease.

70 and viral RNA data that inform exposure and shedding, but extensive variation in assays, study group

71 domain of substrates make them resistant to shedding by the metalloprotease ADAM17.

72 brane protein involved in protein ectodomain shedding, cell adhesion and signalling.

73 Turtles from Hawaii actively shedding ChHV5 were more seropositive than nonshedders.

74 ologous and allogenic islet transplantation, shedding close light on our own latest experience in the

75 ng capacity and are more resistant to fibril shedding compared to alphaS fibrils alone.

76 creased dispersion of AFCL and likely vortex shedding contributes to rotor formation, compensating fo

77 Our results suggest that bacteria shedding corisin are involved in acute exacerbation of I

78 Subclinical CMV and EBV shedding could contribute to the dynamics of the HIV DNA

79 pport the theory that persistent CMV and EBV shedding could contribute to the dynamics of the HIV DNA

80 ital or rectal secretions, termed discordant shedding (DS).

81 confidence interval [CI], 34-85%) shortened shedding duration (mean, 1.0 vs 3.2 days).

82 ciated with a 32% (95% CI, 13-47%) shortened shedding duration (mean, 3.9 vs 6.0 days).

83 in the accurate determination of live viral shedding during convalescence to inform decisions to end

84 Exploring viral genital shedding during LDRs is crucial to ensure their safety.

85 We analyzed shedding episodes during chronic HSV-2 infection; viral

86 Given that short shedding events were often linked to gastrointestinal di

87 they do not allow the live visualization of shedding events.

88 subset frequencies coincided with peak virus shedding, followed by marked activation of T and NK cell

89 ay be useful in differentiating asymptomatic shedding from active infection.

90 ted air and surface samples to examine viral shedding from isolated individuals.

91 and acute interstitial pneumonia, with RESTV shedding from oronasal mucosal membranes.

92 atory tract infection in 12 (67%), and viral shedding from the nasopharynx was prolonged for 7 days o

93 mal compartment (exosomes) or as a result of shedding from the plasma membrane (microvesicles, oncoso

94 Virus shedding from the upper respiratory tract was not reduce

95 term infection raises the possibility of IAV shedding from tonsils, which may have an impact on host-

96 of metalloprotease-induced IL-15Ralpha-IL-15 shedding from trans-presenting cells, whereas S6 phospho

97 itochondria (from 6 h) along with glycocalyx shedding (from 6 h), which were blocked by probenecid.

98 pisodes (17%) had instances of seminal viral shedding >=400 copies/mL despite viral suppression in th

99 ulfate, and HA are the main components whose shedding has been claimed to represent the endothelial g

100 loprotease (MMP)-14-mediated Tie2 ectodomain shedding has recently been recognized as a possible mech

101 ts in our laboratory were from vaccine virus shedding in 71/152 (46.7%) infants with a request for ro

102 cient specificity and sensitivity to monitor shedding in badgers via latrine sampling, delivering a p

103 d values from nasopharyngeal swabs and viral shedding in blood, urine, and stool.

104 y evaluations included adverse events, viral shedding in body fluids, and vector antibody responses.

105 y, and emergence of drug resistance on viral shedding in children infected with influenza A or B viru

106 needed to understand the high rates of virus shedding in children without AGE symptoms.

107 We demonstrate SNAPS can detect shedding in chimeras of diverse cell surface receptors,

108 d MMP-7 as important sheddases of syndecan-1 shedding in corneal epithelial cells, which are natural

109 eduction in merozoite replication and oocyst shedding in E. tenella in vitro and in vivo.

110 tal rats, CDC-9 P45 showed reduced rotavirus shedding in fecal specimens and did not induce diarrhea

111 actors other than anti-HA antibody may limit shedding in healthy volunteers.

112 Subclinical HSV shedding in HIV/HSV-coinfected women during ART may sust

113 oMT; however, they did not change glycocalyx shedding in HUVECs.

114 This study aims to better evaluate HIV shedding in men with urethritis receiving ART, and impli

115 gy and viral load in the lungs but not viral shedding in nasal swabs.

116 that only a few of these may result in viral shedding in pigs upon infection, providing opportunities

117 viruses were shown to infect and cause virus shedding in pigs.

118 ymerase chain reaction in blood and by viral shedding in saliva, in 878 people aged 3 to 89 years of

119 le the transmission of KSHV occurs via viral shedding in saliva.

120 functions of the endothelial glycocalyx, its shedding in several pathologic conditions such as sepsis

121 e infection and spread systemically prior to shedding in stool.

122 of infecting the gastrointestinal tract and shedding in the environment for potential human-to-human

123 on density within the GI tract and levels of shedding in the feces differed among the clinical isolat

124 no evidence of increased HIV-RNA and/or -DNA shedding in the genital fluids of people who maintained

125 reatment significantly delayed live organism shedding in the rectal swabs.

126 Viral shedding in the semen can increase the risk of ZIKV tran

127 Oseltamivir decreased viral shedding in this low-risk population.

128 Most importantly, NTZ reduces viral shedding in vivo, exhibiting its potential as a future c

129 ule was associated with higher levels of GAS shedding, independent of the strain background.

130 prior vaccination reduced the likelihood of shedding influenza B but not (H1N1)pdm09.

131 ented biomarkers for the responder subgroup, shedding insights into therapeutic mechanisms.

132 r for advanced glycation end-products (RAGE) shedding into soluble and nuclear forms, and subsequentl

133 h adult-onset kidney disease and podocalyxin shedding into the urine is a common biomarker of a varie

134 Duration of viral shedding is a determinant of infectivity and transmissib

135 Intestinal epithelial cell (IEC) shedding is a fundamental response to intestinal damage,

136 Our group and others have shown that CMV shedding is associated with a larger HIV reservoir.

137 Viral shedding is highest before symptom onset, suggesting hig

138 The basis for host control of virus shedding is not well understood, although adaptive immun

139 tification by enabling simulation of protein shedding kinetics based on tumor tissue-specific charact

140 eraction of the allergen with airway mucosa, shedding light into its potential role in the immunologi

141 hort study) and 130 tracked with weight loss shedding light into the pathophysiology of obesity.

142 the missing mediator of the phosphate flush, shedding light on a 45-year-old mystery.

143 enza virus by balancing HA and NA functions, shedding light on an alternative approach for optimizing

144 rresponding 2,3-dioxygenated products, while shedding light on an unequivocally occurring, putative f

145 ming protein obstacles to replication forks, shedding light on cellular responses to anti-cancer ther

146 work solids such as zeolites is critical for shedding light on collective vibrations of medium-range

147 underrepresented Hispanic/Latino community, shedding light on disease etiology.

148 ors for crystalline lattice self-assemblies--shedding light on engineering intermolecular interaction

149 d within-host life cycle of the pathogen are shedding light on how humoral immunity to Salmonella ope

150 turn, stimulated studies in other bacteria, shedding light on how protein function and cell morpholo

151 YM155 reduces EGFR expression in TNBC cells, shedding light on its potential mechanism of synergism w

152 ional attacks is presented, with the goal of shedding light on local dynamics and vulnerability of ne

153 with CaMKII at proximal dendritic segments, shedding light on our understanding of the functional di

154 ctive is provided on the most recent studies shedding light on pathogenesis, including the central ro

155 has become a classic example of coevolution, shedding light on predator-prey dynamics, the molecular

156 sugar accumulation and softening of acerola, shedding light on promising key regulatory genes.

157 egional studies to a more local perspective, shedding light on socioeconomic processes, inheritance r

158 e promoters of pro-inflammatory necroptosis, shedding light on the biological complexity of the regul

159 For shedding light on the contribution of microbes to health

160 he hub genes involved in KIRC tumorigenesis, shedding light on the development of prognostic markers.

161 h ATP-dependent and -independent activities, shedding light on the etiology of CHD7-related congenita

162 reveals the importance of its immune system, shedding light on the evolutionary pathways that allowed

163 etain the aromatic ring of parent aromatics, shedding light on the fact that monocyclic aromatics can

164 ation in randomly packed granular materials, shedding light on the fundamental mechanisms controlling

165 uct (i.e., pyrophosphate) into the solution, shedding light on the general mechanistic and kinetic as

166 Advances in human genetics are shedding light on the genetic architecture of neurodevel

167 ion between urban areas and between species, shedding light on the importance to perform extensive in

168 s to brain images from 18,707 individuals is shedding light on the influence of aging on the brain.

169 haracterization of nucleotide modifications, shedding light on the interpretation of various biologic

170 These findings, while shedding light on the intricacies underlying ETP lineage

171 DAMPs and their function in thermal injury, shedding light on the mechanism of sterile inflammation

172 AT3 on the promoters of the repressed genes, shedding light on the mechanisms involved in STAT3-media

173 Overall, besides shedding light on the multiple functions played by OsPIP

174 al auditory processing in the 2 hemispheres, shedding light on the neural dynamics that potentially s

175 e amphipathic helices on this transition and shedding light on the proton-transport mechanism.

176 multiple host pathways for inducing the IPR, shedding light on the regulation of this novel transcrip

177 Emerging data is shedding light on the resistance mechanisms associated w

178 c models of protein folding mechanisms while shedding light on the role of non-native intermediates w

179 al function varies by retinal niche, thereby shedding light on the significance of microglia heteroge

180 Here we review recent studies shedding light on these issues.

181 these processes was largely nonoverlapping, shedding light on two complementary but distinct mechani

182 anding of drug biodistribution and, in turn, shedding light on ways to improve bioavailability.

183 (133)Cs, and (207)Pb nuclei) and locally and shedding light onto the connectivity, geometry, topology

184 Viral shedding measured from nasal and throat swabs, bronchoal

185 t also pose potential risks by harboring and shedding microbes into the drinking water distribution s

186 Overall, we show that protecting Tie2 shedding might offer a new therapeutic opportunity for t

187 spp. genes related to gamete fusion, oocyst shedding, mitosis and spermiogenesis.

188 ments move in opposite directions while also shedding myosins.

189 expand our perspectives on these processes, shedding new light on complex ecological phenomena such

190 th balances structure-function requirements, shedding new light on general principles of self-organis

191 esolution light and electron microscopy, are shedding new light on genome architecture and function.

192 Besides shedding new light on substrate preference of the chroma

193 canonical sites in the mitochondrial genome, shedding new light on the importance of complete RNA deg

194 and propagation of different diseases, thus shedding new light on the importance of protein clearanc

195 dulated by Torsins in the perinuclear space, shedding new light on the LAP1-Torsin interplay.

196 n prolidase activity and neuronal maturation shedding new light on the molecular basis of functional

197 how that genetic depletion of SUB2 abolishes shedding of a range of parasite proteins, identifying pr

198 No shedding of Bordetella pertussis was detected in systema

199 undergo a process termed "uncoating," i.e., shedding of CA molecules from the conical lattice.

200 e in extracellular matrix (ECM) turnover and shedding of cell-surface molecules.

201 epredation in feedlots contributing to fecal shedding of ciprofloxacin-resistant E. coli, but a singl

202 ively associated with increased cattle fecal shedding of ciprofloxacin-resistant E. coli.

203 ive cholestyramine therapy reduced the fecal shedding of daptomycin-resistant E. faecium by up to 80-

204 han Coronin 1C-reexpressing cells due to the shedding of extracellular vesicles (EVs) containing MT1-

205 teases, heparanase, and hyaluronidase to the shedding of glycocalyx.

206 Shedding of gp120, known to severely complicate structur

207 al-regulated kinases (ERK1/2) pathway by the shedding of growth factors which triggers the formation

208 ZIKV NS1 induced shedding of HA and HS and altered expression of CD44 and

209 dentify that platelet-inflammasome-dependent shedding of IL-1beta and caspase-1-carrying platelet EVs

210 Shedding of infectious SARS-CoV-2 was observed up to 70

211 RS-CoV-2-positive individuals as a proxy for shedding of infectious virus.

212 from COVID-19 does not necessarily indicate shedding of infective virions.

213 rane repair by regulating ESCRT III-mediated shedding of injured plasma membrane.

214 "positive" test results and reproduction and shedding of intact virus.

215 uding enhancement of NADPH oxidase activity, shedding of l-selectin, or mobilization of CD11b.

216 s in TIMP-3 mRNA levels, but correlated with shedding of LRP1.

217 Shedding of mcr-1 E. coli by small gull flocks followed

218 Shedding of microbial extracellular vesicles constitutes

219 In contrast, shedding of non-expiratory micron-scale particulates fro

220 maged, and its degradation is accompanied by shedding of one or more glycocalyx components into the b

221 embly of the actin cytoskeleton, followed by shedding of plasma membrane microvesicles, disassembly a

222 schemic cerebral circulation indicated local shedding of platelet CD84.

223 oglobulin G titers were associated with less shedding of S. Typhi (P < .0001).

224 Shedding of S. Typhi was more common than S. Paratyphi.

225 In this study, we demonstrate that the shedding of syndecan-1 by MMP-3 and MMP-7 supports viral

226 It was reported that exercise promotes the shedding of the extracellular domain of Fndc5, generatin

227 Degradation and shedding of the glycocalyx by enzymes, such as hyaluroni

228 mechanisms, including but not limited to: 1) shedding of the HER2 extracellular domain, 2) steric hin

229 An early event is the shedding of the outermost fibrous corona layer of the ki

230 CV30 also induces shedding of the S1 subunit, indicating an additional mec

231 TSPN6 also inhibits the shedding of the SDC4 ectodomain, mimicking the effects o

232 cretase complex is preceded and regulated by shedding of the substrate's ectodomain by alpha- or beta

233 role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in hepatic stellate cells, which reduc

234 betaFurKO cells show impaired cleavage or shedding of vacuolar-type ATPase (V-ATPase) subunits Ac4

235 The shedding of viral RNA from sputum outlasted the end of s

236 nital HSV-2 infection that recapitulates the shedding of virus experienced by humans.

237 (FGT) are critical for suppression of viral shedding or effective preexposure prophylaxis.

238 ng post arrays to induce microfluidic vortex shedding, or muVS, for cell membrane poration that permi

239 ere we sought to determine pathological cell shedding outcomes throughout the postnatal developmental

240 illness often includes a phase of organismal shedding over a period of days to months.

241 s of C. difficile abundance, where increased shedding over short periods of 1-2 d interrupted week-lo

242 nd also exhibited higher rates of poliovirus shedding (p = 0.020).

243 colonized with mcr-1 positive E. coli, their shedding patterns, transmission among conspecifics, and

244 dicating more efficient virus replication in shedding-positive children than the 2016-2017 strain, al

245 6-2017 than 2017-2018 (P = .005), but within shedding-positive participants, the (H1N1)pdm09 titer in

246 trated by the detection of spontaneous HSV-2 shedding post-acute inoculation (10(2) to 10(3) DNA copi

247 N showed reduced clinical severity and viral shedding postchallenge on par with protection observed w

248 smFRET demonstrated that both shedding-preventing modifications shifted the conformati

249 ur results revealed that ADAM17 was also the shedding protease responsible for the transactivation of

250 The median per person oral HSV shedding rate was 9% of days that a swab was obtained (m

251 for 28 days to establish subclinical HSV DNA shedding rates and detection of HIV RNA by real-time PCR

252 e model enables evaluating the difference in shedding rates between extra- and non-extracellular prot

253 Viral shedding rates were correlated for those with the same b

254 We found HSV genital shedding rates were positively correlated with HIV DNA c

255 racteristics likely contribute to oral HSV-1 shedding rates.

256 ebo [n = 11]) and were monitored for vaccine shedding, reactogenicity, RSV-antibody responses and RSV

257 -tubulin as a result of MSU exposure and ECD-shedding reduced MSU phagocytosis in murine and human ma

258 CD44 ECD-shedding reduced the conversion of procaspase-1 to activ

259 conditions that stabilize membrane-bound and shedding-resistant virus Env trimers in state 1, potenti

260 chanisms and pathways known to regulate cell shedding responses.

261 ion for the primary analysis had day 3 viral shedding results.

262 Our findings suggest a higher shedding risk in less symptomatic patients, an important

263 ed to reduce transmission by controlling HSV shedding should include specific enhancement of HSV-spec

264 ime were analyzed in relation to CMV and EBV shedding status.

265 Vaccine poliovirus shedding stopped at a median of 23 days (IQR 15-36) afte

266 We conducted LAIV virus shedding studies to assess the effect of this change.

267 Hundreds of shedding substrates have been identified, but little is

268 ortance of CD4(+) T cells in controlling HSV shedding, suggesting that therapeutic vaccines designed

269 h a prolonged period of oral and nasal viral shedding that is not accompanied by clinical signs, and

270 ruses have evolved from enveloped viruses by shedding the membrane, indicating that this trait may be

271 rtance of CD4(+) T cells in control of HSV-2 shedding, this subset of immune cells was depleted from

272 There was less detection of shedding though the incidence of symptoms was similar to

273 longed mean death times (MDT), and the virus-shedding titers were significantly lower than those of t

274 Persistent shedding to day 7 was independently associated with both

275 IAV infections with possible impact on virus shedding to the population.

276 d 1-1 diad repeats in the polymer main chain shedding unique light on the relative contributions of c

277 ted with strain-specific prevention of viral shedding upon LAIV receipt.

278 e role of CD4(+) T cells in control of virus shedding using a guinea pig model of genital HSV-2 infec

279 ining the area under the curve for viral RNA shedding using logistic regression and Kaplan-Meier anal

280 d with late-recovered patients (>=14 days of shedding) using gene fragment phage display libraries an

281 Horizontal exposures to persons shedding virus in bodily secretions (young children, sex

282 The median duration of fecal shedding was 28 days (95% CI, 19-28).

283 IEC shedding was a UPR-dependent protective response to Glaf

284 ed at days 0, 7, 28, and 56, and stool viral shedding was assessed up to 28 days post-vaccination.

285 Frequent subclinical HSV DNA shedding was associated with increased HIV DNA tissue co

286 RV1 fecal shedding was detected in 41 of 60 vaccinated infants (68

287 piratory syndrome coronavirus 2 (SARS-CoV-2) shedding was observed from the upper respiratory tract o

288 fection by H3N2 virus, the duration of virus shedding was shortened, and clinical disease was markedl

289 women but seems to be more limited, as virus shedding was undetectable more than 40 days after the la

290 Pharyngeal virus shedding was very high during the first week of symptoms

291 The median copy numbers for peak shedding were 1.99 x 107 (interquartile range, 3.39 x 10

292 Presence and quantity of shedding were compared between strains and seasons with

293 disease, but intermittent viremia and virus shedding were detected up to day 60 postinfection (p.i.)

294 Safety, colonization, and shedding were monitored over 17 days in an inpatient fac

295 ipients who recovered early (<14 days of RSV shedding) were compared with late-recovered patients (>=

296 s restored LPS-induced small intestinal cell shedding, whereas adult fecal microbiota transplant alon

297 nduction of oxidative stress with glycocalyx shedding, which could be one of the mechanisms of UA-ind

298 s skin colonization results in environmental shedding, which underlies hospital transmissions, and pr

299 B specimens in a woman with frequent HSV DNA shedding, with mixing of minor variants between her tiss

300 ynx and gastrointestinal [GI]) colonization, shedding within feces, and transmission of K. pneumoniae