ライフサイエンスコーパス: short consensus repeat

1 tide polymorphisms in the signal peptide and short consensus repeat 1 of Sle1c Crry were identified.

2 nalyses revealed that FH constructs spanning short consensus repeats 1 to 7 and 16 to 20 bind to FhbA

3 ric N-terminal region of mouse factor H (fH; short consensus repeats 1-5) linked to the same CR2 frag

4 a recombinant negative inhibitor containing short consensus repeats 19 and 20 (rfH19-20), which impa

5 t on the carboxyl-terminal domain containing short consensus repeats 19 and 20.

6 We found that replacement of human short consensus repeat 2 (SCR2) with murine SCR2 ablated

7 ing to DAF; these residues interact with DAF short consensus repeat 2 (SCR2), which is known to be es

8 shown to be critical for HHV-6 fusion (i.e. short consensus repeats 2 and 3).

9 Residues within short consensus repeat 20 of factor H that are relevant

10 t consensus repeats of FHR1 and the terminal short consensus repeat 20 of FH.

11 Binding of Dr(+) E. coli to the short consensus repeat 3 domain of DAF expressed by Chin

12 Deletion of short consensus repeat 3 domain or replacement of Ser(16

13 known Dr adhesins has been localized to the short consensus repeat-3 (SCR-3) domain of decay acceler

14 recombinant fragments, we observed that both short consensus repeats 5-7 and 19-20 regions are respon

15 ng site for all three fHbp variants on fH to short consensus repeat 6 (SCR 6).

16 that the PspC binding site is located in the short consensus repeat 6-10 region of FH.

17 binds to the region of Factor H encompassing short consensus repeats 6 to 8, impairing the ability of

18 The Fba binding site was localized to short consensus repeat 7 (SCR 7), a domain common to FHL

19 Gpd2 binds factor Hand and FHL-1, mainly via short consensus repeat 7; and binds plasminogen, via lys

20 Factor H contacts Lpd via short consensus repeats 7 and 18-20.

21 interacted with the complement regulator FH short consensus repeats 7 and 18-20.

22 SpBf is a mosaic protein, composed of five short consensus repeats, a von Willebrand Factor domain,

23 tional protein domain of DAF (the N-terminal short consensus repeat) between C(H)1 and the functional

24 erating factor, we are able to conclude that short consensus repeat domain 3 contributes approximatel

25 signal sequence and the first extracellular short consensus repeat domain of the mature protein.

26 ontain the amino acids present in the second short consensus repeat domain of the smallpox protein wo

27 of decay-accelerating factor comprises four short consensus repeat domains (domains 1-4) and a mucin

28 ition, we show that IFN-alpha interacts with short consensus repeat domains 1 and 2 in a region that

29 V12 bound to a fragment of DAF consisting of short consensus repeat domains 3 and 4 from cryo-negativ

30 Factor H binds to Lig proteins via short consensus repeat domains 5 and 20.

31 in consists of four domains with homology to short consensus repeat domains followed by a stalk.

32 inst the lectin, epidermal growth factor, or short consensus repeat domains lacked this activity.

33 We found the two N-terminal short consensus repeat domains of CFHR5 contact properdi

34 een the lectin, epidermal growth factor, and short consensus repeat domains of the selectins also mod

35 The short-consensus-repeat fold (SCR) within the first extra

36 8 RCA protein, containing the four conserved short consensus repeats, inhibited murine C3 deposition

37 r H, a secretory glycoprotein composed of 20 short consensus repeat modules, is an inhibitor of the c

38 its homologous FIMs as well as two adjoining short consensus repeat modules.

39 amework-specific disulfide bonds in factor H short consensus repeat modules.

40 e entire hydrophobic face interacts with the short-consensus-repeat motif, covering a large intermole

41 single-nucleotide polymorphism in the first short consensus repeat of Sle1c Crry introduced a novel

42 lting fusion protein contains the first four short consensus repeats of FHR1 and the terminal short c

43 prodrugs, comprising, respectively, the four short consensus repeats of human decay accelerating fact

44 linked to IgG4 Fc and the three NH2-terminal short consensus repeats of human decay accelerating fact

45 onsists of 390 amino acids and contains four short consensus repeats of internal homology characteris

46 This polymorphism occurs in short consensus repeat (SCR) 7 of FH and results in decr

47 This gene encodes a unique short consensus repeat (SCR) domain protein.

48 irs (kb) encode a 155-kDa protein containing short consensus repeat (SCR) domains 1-20 and a 45-kDa p

49 Human factor H is composed of 20 short consensus repeat (SCR) domains containing approxim

50 of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.

51 It contains four short consensus repeat (SCR) domains.

52 fH consists of 20 short consensus repeat (SCR) domains.

53 ns, the protein is composed of 20 homologous short consensus repeat (SCR) domains.

54 chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR

55 isoform (MCPi) containing the four invariant short consensus repeat (SCR) regions and a unique C-term

56 Analysis of the short consensus repeat (SCR) regions that comprise most

57 The protein is a member of the short consensus repeat (SCR) superfamily containing four

58 The fold is identified as a short consensus repeat (SCR), a common protein interacti

59 protein discovered based on its homology to short consensus repeat (SCR)-containing proteins of the

60 phic structures of human free C3d, free CR2 (short consensus repeat (SCR)1-2), and the C3d-CR2(SCR1-2

61 composed of a linear array of 20 homologous short consensus repeats (SCR) domains with many function

62 All members contain tandemly arranged short consensus repeats (SCR) typical of the regulators

63 prised contiguous fH domains (fH contains 20 short consensus repeat [SCR] domains) fused to murine Fc

64 ules containing the NH2-terminal alpha-chain short consensus repeat (SCR1) bound to both Por1A and Po

65 stal-derived structure of the two N-terminal short consensus repeat (SCR1-2) domains of CR2 in comple

66 erized the interaction between the first two short consensus repeats (SCR1-2) of complement receptor

67 The N-terminal two short consensus repeats (SCR1-SCR2) of the receptor inte

68 nd CspZ, which bind to the sixth and seventh short consensus repeats (SCR6-7) of FH and the OspE fami

69 y to factor H recombinant fragments spanning short consensus repeats (SCRs) 1 to 7 (H7 construct) and

70 Phylogenetic trees inferred from individual short consensus repeats (SCRs) and divergence among repe

71 inly of four domains that are similar to the short consensus repeats (SCRs) present in complement reg

72 esulted in the duplication of the N-terminal short consensus repeats (SCRs) that are conserved in FHR

73 roximately 70 amino acid long regions termed short consensus repeats (SCRs) that share homology with

74 ansmembrane protein including fifteen tandem short consensus repeats (SCRs), resembling complement C3

75 mbrane receptor, with 15 or 16 extracellular short consensus repeats (SCRs), that promotes B lymphocy

76 embrane protein, with 15 or 16 extracellular short consensus repeats (SCRs), that promotes B lymphocy

77 CFH is a modular protein with 20 homologous short consensus repeats (SCRs).

78 plement activation (RCA) that contain tandem short consensus repeats (SCRs).

79 ntegral membrane glycoprotein composed of 30 short consensus repeats (SCRs).

80 Here we tested the effect of various short consensus repeats (SCRs, "sushi" domains) of human

81 2-glycoprotein 1 (beta2GP1), a member of the short consensus repeat superfamily, binds phosphatidylse

82 Another EST matches to several short consensus repeats that are characteristic of a var