ライフサイエンスコーパス: short hairpin RNA

1 fects were abolished after TGR5 reduction by short hairpin RNA.

2 2, BCL-XL and DAD1) was downregulated by BTK short hairpin RNA.

3 been knocked down with lentivirus-transduced short hairpin RNA.

4 TGFBR2 were knocked-down in CRC cells using short hairpin RNA.

5 rexpressed in human PDAC tumor samples using short hairpin RNAs.

6 s by using in vivo gene delivery of specific short hairpin RNAs.

7 were knocked down in Hepa1-6 cells by using short hairpin RNAs.

8 containing RNA via microRNA 30 (miR30)-based short hairpin RNAs.

9 nhibited by three different mechanisms: InsR short hairpin RNA, a small InsR-blocking peptide, S961 a

10 no-associated virus (AAV) vector producing a short hairpin RNA (AAV.sh.p11).

11 GBM cells with lentiviral particles carrying short hairpin RNA against Ca(v)3.1 resulted in GBM cell

12 migration of the TNBC cell lines expressing short hairpin RNA against CDCP1.

13 Short hairpin RNA against EGFR and LY294002 were used to

14 g by an adeno-associated viral vector (AAV2) short hairpin RNA against GSK3beta.

15 n adeno-associated viral vector expressing a short hairpin RNA against Homer1 mRNA (AAV-shHomer1).

16 ng factors (Oct4, Klf4, Sox2, and c-Myc) and short hairpin RNA against p53 ("4-in-1 CoMiP").

17 nd in BE(2)-M17 cells stably transduced with short hairpin RNA against PINK1.

18 ophages nucleofected with plasmid containing short hairpin RNA against PKCalpha showed markedly reduc

19 of CeL PKCdelta and SOM in incubation using short-hairpin RNAs against PKCdelta or SOM that we devel

20 Stable knockdown of PDE10 by short hairpin RNA also inhibits colony formation and inc

21 sAC knockdown by tetracycline-inducible short hairpin RNA also prevented BSIA.

22 We circumvented these limitations with short hairpin RNA and CRISPR technology to assess Crk's

23 cific inhibition of HER2 using an inhibitor, short hairpin RNA and dominant-negative mutant HER2 abol

24 he expression of Munc13-2 in B6 mice using a short hairpin RNA and found this recapitulated the presy

25 long 3' untranslated region (L-3'-UTR) using short hairpin RNA and investigated changes in cell morph

26 Finally, we report that anti-Fsp27 short hairpin RNA and PPARalpha agonists synergize to am

27 transduced with lentivirally expressed N-Ras short hairpin RNA and pulsed with L. major-expressed MAP

28 as well as viral vector-mediated delivery of short hairpin RNAs and artificial microRNAs.

29 Recent work using short-hairpin RNA approaches in vitro suggest that the p

30 r complex, or expression of a c-Jun-specific short hairpin RNA attenuated pregnenolone sulfate-induce

31 of endogenous SRC-3 expression by lentivirus short hairpin RNA attenuated the migration and invasion

32 ong with bioluminescence, calcium FLIPR, and short hairpin RNA-based gene-silencing assays.

33 Crh-short hairpin RNA, but not control short hairpin RNA, gi

34 ilon using a selective chemical inhibitor or short hairpin RNA complements the effects of idelalisib,

35 AL1 in erythroid K562 cells using lentiviral short hairpin RNA, compromising its association in the b

36 chymal delivery of an adeno-associated virus-short hairpin RNA construct was sufficient to markedly a

37 and in the LAD2 MC line by using lentiviral short hairpin RNA constructs.

38 We also found that ACK1 depletion with short hairpin RNA decreased EGFR degradation when activa

39 Furthermore, animals treated with NOX2 short hairpin RNA did not develop sustained AF for up to

40 decreasing expression of HER3 or HER4 using short hairpin RNAs did not block the induction of G2/M a

41 Transducing 3D CPCs with Notch1-shRNA (short hairpin RNA) did not reduce retention, but signifi

42 se targets with small molecule inhibitors or short hairpin RNA diminished the proliferation of patien

43 Depletion of P85 by P85-specific short hairpin RNAs disrupts their interaction and dimini

44 ion of peripheral blood CLL cells with STAT3 short hairpin RNA downregulated Wnt5a mRNA and protein l

45 activities by specific inhibitors as well as short-hairpin RNA downregulation of beta1 integrin signi

46 The combination of two short hairpin RNAs (dual-shRNA) against different coding

47 ns were electroporated with SLC7A5 or Slc7a5 short hairpin RNA encoding plasmids.

48 fects were further confirmed using p22(phox) short-hairpin RNA-engineered HeLa cells and Nox2(-/-) co

49 beta1-mediated cytostasis evident in control short hairpin RNA-expressing HK-2 cells.

50 AF, we performed targeted injection of NOX2 short hairpin RNA (followed by electroporation to facili

51 sistant BACH1 mutant in cells that express a short hairpin RNA for BACH1 rescues the BACH1 phenotype

52 xpression of small noncoding RNAs, including short hairpin RNAs for RNAi experiments and guide RNAs f

53 Here, we curated a library of short hairpin RNAs for targeted silencing of all known e

54 Crh-short hairpin RNA, but not control short hairpin RNA, given into the central nucleus of the

55 Control short hairpin RNA had no effect on these TGF-beta1-induc

56 in-D1 and c-Myc, while silencing EphA2 using short hairpin RNA had the opposite effect.

57 Gene therapy with a virus encoding Salv short hairpin RNA improves heart function when delivered

58 Silencing TCTP by short hairpin RNA in breast carcinoma MCF-7 cells leads

59 ER2 using either IGF-1R antibodies or IGF-1R short hairpin RNA in combination with trastuzumab result

60 Reduction of KLF13 with short hairpin RNA in differentiating HPV-positive cells

61 deno-associated virus carrying HPIP-specific short hairpin RNA in vivo attenuates OA histological sig

62 TGB1 were overexpressed or knocked down with short hairpin RNAs in AsPC-1 and MIA PaCa-2 pancreatic c

63 Knockdown of Tip60 with short hairpin RNAs in cells that maintain HPV episomes b

64 ing of TREX1, SAMHD1, RNASEH2A, and ADAR1 by short hairpin RNAs in human neural stem cell-derived ast

65 encing of both PYCR1 and PYCR2 by expressing short hairpin RNAs induced defects in cell proliferation

66 cell motility, while depletion of STIM1 with short hairpin RNA inhibited CRC cell migration.

67 ngiogenesis in Matrigel plugs, while p56/Lck short hairpin RNA inhibited the antiangiogenic effect of

68 In contrast, short hairpin RNA inhibition of AGS3 enhanced CXCL8-indu

69 Further, reconstitution with short hairpin RNA-insensitive SLC25A23 cDNA restores mit

70 nt of ATF2 or expression of an ATF2-specific short hairpin RNA interfered with TRPM3-mediated stimula

71 rest, and that reducing DHX33 levels through short hairpin RNA interference has the same effect.

72 infusion of a lentivirus vector to express a short-hairpin RNA into the mHb or IPn to knock-down Chrn

73 Adenovirus-short hairpin RNA knockdown (KD) of Syt-7 in human islet

74 characterizations such as drug-sensitivity, short hairpin RNA knockdown and CRISPR-Cas9 knockout dat

75 manipulations through small interfering RNA/short hairpin RNA knockdown and ectopic expression, west

76 Furthermore, using a short hairpin RNA knockdown approach, we observed that t

77 duced pluripotent stem cell (iPSC) and MeCP2 short hairpin RNA knockdown approaches to identify novel

78 null HSPC phenotype, as both in vitro Dnmt3a short hairpin RNA knockdown assays and a genetic haploin

79 increased LNCaP proliferation, whereas PSGR short hairpin RNA knockdown inhibited proliferation and

80 Skin of CTSH-deficient mice and CTSH short hairpin RNA knockdown keratinocytes showed reduced

81 whereas specific pharmacologic inhibition or short hairpin RNA knockdown of Akt1 in alveolar macropha

82 Short hairpin RNA knockdown of Chrna7 in the DG enhanced

83 Short hairpin RNA knockdown of CLC/Gal-10 in human cord

84 Concurrent, but not individual, short hairpin RNA knockdown of FLOT1/2 and AP2A1/2 reduc

85 s) and pharmacologic (imatinib) and genetic (short hairpin RNA knockdown of IL4RA and ABL1) approache

86 Short hairpin RNA knockdown of NEDD4 elevated HER3 level

87 C3-deficient macrophages and fibroblasts and short hairpin RNA knockdown of NLRC3 in THP1 cells.

88 Finally, we demonstrate that short hairpin RNA knockdown of nudC in tadpole rod photo

89 Short hairpin RNA knockdown of RNase L allowed us to dis

90 D34(+) cells from DBA patients and following short hairpin RNA knockdown of RPS19, RPL5, and RPL11 ex

91 Lentiviral short hairpin RNA knockdown of scavenger receptor class

92 Lentiviral short hairpin RNA knockdown of vimentin led to a signifi

93 FABP4 inhibition using FABP4 short hairpin RNA knockdown or a small molecule inhibito

94 te cell cultures RAPTOR upregulation or AKT1 short hairpin RNA knockdown reduced expression of the pr

95 Using chemical inhibition, short hairpin RNA knockdown, and gain of function approa

96 th occurring during HIV-1 infection, we used short hairpin RNA knockdown, CRISPR deletion, or Abs spe

97 Short-hairpin RNA knockdown of Mybpc3 mRNA in wild-type

98 Using short-hairpin RNA knockdown/rescue, we find that palmito

99 me activity assays, confocal microscopy, and short hairpin RNA knockout of CLC/Gal-10 expression in h

100 Depletion of FOXO1 with short hairpin RNA led to almost complete resistance to c

101 We infected cardiomyocytes using a short hairpin RNA lentivirus library in which the mouse

102 unctional screening in MM cell lines using a short hairpin RNA library against cancer driver genes.

103 Through screening a short hairpin RNA library, we found that RARgamma was es

104 screen of a human interferon-stimulated gene short-hairpin RNA library, we identified a viral restric

105 A short hairpin RNA (M7.8L) was selected from a pool for s

106 Knockdown of Atg7 in AML cells using short hairpin RNA markedly increased apoptosis and DNA d

107 mutation in Npas2 and adeno-associated virus-short hairpin RNA mediated knockdown of Npas2 and Clock

108 shRNA (short hairpin RNA)-mediated knockdown of talin1 expressi

109 stasis, combined with an inducible system of short hairpin RNA-mediated Akt isoform knockdown in huma

110 Short hairpin RNA-mediated depletion of C3G in epithelia

111 Along these lines, short hairpin RNA-mediated depletion of NRP1, but not th

112 tion in an in vivo irradiation model, as did short hairpin RNA-mediated depletion of PKCdelta in vitr

113 Initial studies revealed that short hairpin RNA-mediated depletion of the HIF1beta in

114 ed in colonoids derived from DRA-KO mice and short hairpin RNA-mediated DRA knockdown in Caco-2 cells

115 ransient inactivation of the gp78 complex by short hairpin RNA-mediated gene silencing causes signifi

116 Using an array of methods, including short hairpin RNA-mediated gene silencing, RNA and ChIP

117 Short hairpin RNA-mediated inhibition of PTX2 levels in

118 In HB2 mouse brown preadipocytes, short hairpin RNA-mediated knockdown (KD) of LSD2 impair

119 However, short hairpin RNA-mediated knockdown (KD) of Usp9x in my

120 CL cell lines, CC-122-induced degradation or short hairpin RNA-mediated knockdown of Aiolos and Ikaro

121 Short hairpin RNA-mediated knockdown of Bnip3 in culture

122 which was abrogated by Ca(2+) chelators and short hairpin RNA-mediated knockdown of CnAbeta mRNA.

123 -mediated knockout and doxycycline-inducible short hairpin RNA-mediated knockdown of EXT1, a critical

124 gh) ALL cell lines, which was antagonized by short hairpin RNA-mediated knockdown of Mer.

125 Short hairpin RNA-mediated knockdown of NRP1 reduced the

126 Additionally, short hairpin RNA-mediated knockdown of PP1alpha results

127 Furthermore, a short hairpin RNA-mediated knockdown of SIRT3 in human m

128 Although short hairpin RNA-mediated knockdown of the STAT5A and S

129 Alternatively, short hairpin RNA-mediated knockdown of TRPV3, like the

130 ell proliferation in vitro and in vivo while short hairpin RNA-mediated knockdown or pharmacologic in

131 Furthermore, short hairpin RNA-mediated knockdown or pharmacologic in

132 erythroid cells, UNC0638 and EHMT1 or EHMT2 short hairpin RNA-mediated knockdown significantly incre

133 Here we use short hairpin RNA-mediated knockdown to survey the funct

134 Using HCC cell lines, we found that short hairpin RNA-mediated macroH2A1 knockdown induces a

135 ulated kinase kinase (MEK)/ERK inhibitors or short hairpin RNA-mediated MSK1 depletion enhanced cell

136 the single cell level in MEPs and found that short hairpin RNA-mediated MYB knockdown promoted commit

137 Short hairpin RNA-mediated S100A4 silencing in 231BR-EGF

138 By interrogating data from a large-scale short hairpin RNA-mediated screen across 390 cancer cell

139 Short hairpin RNA-mediated silencing identified TBX5 as

140 that reducing nuclear lamin B1 expression by short hairpin RNA-mediated silencing in cancer cell line

141 a ligand and inhibitor or through lentiviral short hairpin RNA-mediated TGFBR2-specific knockdown.

142 Short hairpin RNA-mediated Vps35 knockdown revealed that

143 Rosa-rtTa mice (controls) and Rosa-rtTa;TRE-short hairpin RNA mice, which have reversible knockdown

144 of ischemia with NRF2 knockdown by means of short hairpin RNA or an NRF2 inhibitor was tested.

145 TLR2 short hairpin RNA or anti-TLR2 or anti-lipophosphoglycan

146 b with Cdk5 inhibition (genetic knockdown by short hairpin RNA or CRISPR/Cas9 and pharmacologic inhib

147 re evaluated in various cell-based models by short hairpin RNA or inhibition by cabozantinib, the mul

148 s, depletion of G9a by small interfering RNA/short hairpin RNA or inhibition of G9a by specific pharm

149 combination of STAT3- and C/EBPbeta-specific short hairpin RNA or miR-142-3p confirmed the importance

150 Treatment of WT1mut AML cells with short hairpin RNA or pharmacologic PRC2/enhancer of zest

151 hoA or rhotekin from airway SM tissues using short hairpin RNA or small interfering RNA prevented NM

152 ASPH knockdown or knockout was achieved by short hairpin RNAs or the CRISPR/Cas9 system, respective

153 proteins were reduced in Caco-2 cells using short-hairpin RNAs or proteins were inhibited pharmacolo

154 lines (NE3 and NE083), and other cells with short hairpin RNAs, or by genome engineering.

155 demonstrated that N-WASP down-regulation by short hairpin RNA prevented TGF-beta1-mediated disruptio

156 emical inhibitors or knockdown of COX2 using short hairpin RNA reduced MDV titers, suggesting that CO

157 MSI-1 levels, whereas silencing of NOTCH3 by short hairpin RNA reduced MSI-1 levels in both colorecta

158 Knockdown of microRNA-3151 (miR-3151) with short hairpin RNAs reduces cell proliferation and increa

159 Silencing of C5aR2 using lentiviral short hairpin RNA rendered the cells unresponsive to C5a

160 r-enhancer, or BET protein BRD4 depletion by short hairpin RNA, repressed RUNX1, inhibited cell growt

161 ed TH activity whereas knockdown of Hsc70 by short hairpin RNA resulted in decreased TH activity and

162 ckdown of VTA CTR via adeno-associated virus short hairpin RNA resulted in hyperphagia and exacerbate

163 In a short hairpin RNA screen for genes that affect AKT phosp

164 eed, we developed a high content image-based short hairpin RNA screen monitoring levels of the autoph

165 Using a targeted short hairpin RNA screen of BCL-2 family members, we ide

166 ponse of B-ALL to GCs with a next-generation short hairpin RNA screen to identify GC-regulated "effec

167 In this study, we performed a genome-scale short hairpin RNA screen to identify mediators of predni

168 , we use a high-content confocal image-based short hairpin RNA screen to identify tumour suppressors

169 pe and then validated these through a pooled short hairpin RNA screen.

170 By interrogating our functional short-hairpin RNA screen dataset across 398 cancer cell

171 Here, we use a targeted short-hairpin RNA screen in a B-cell lymphoma line to id

172 Results from an short-hairpin RNA screen indicated that MAP3K19 is essen

173 We performed a large-scale short-hairpin RNA screen, targeting 363 epigenetic regul

174 Using a short hairpin RNA screening, we have identified FBXL5 as

175 etic dependencies, we conducted genome-scale short hairpin RNA screens in 17 AML cell lines and analy

176 enome CRISPR knockout, and reductase-focused short hairpin RNA screens to interrogate modifiers of ev

177 RNA [shNT]) and FLG knockdown (FLG knockdown short hairpin RNA [shFLG]) LSEs were identified by means

178 ns from paired control (nontargeting control short hairpin RNA [shNT]) and FLG knockdown (FLG knockdo

179 ocytes with knocked down either SCT or SR by short hairpin RNAs show reduced EV secretion during LPS

180 as expressed from an adenoviral vector and 2 short hairpin RNAs (shRdRp2.4) directed against CVB3 wer

181 fficiently delivered synergistic DNA CpG and short hairpin RNA (shRNA) adjuvants, as well as tumor-sp

182 Short hairpin RNA (shRNA) against either TopBP1 or Brd4

183 se down-regulation of DDX20 expression using short hairpin RNA (shRNA) amplified ATF3- and NF-kappaB-

184 PLCbeta1 activities were inhibited by STIM1 short hairpin RNA (shRNA) and absent in TRPC1(-/-) cells

185 e-wide genetic screens in the CNS using both short hairpin RNA (shRNA) and CRISPR libraries.

186 However, short hairpin RNA (shRNA) and CRISPR-mediated targeting

187 We compared the ability of short hairpin RNA (shRNA) and CRISPR/Cas9 screens to ide

188 erference experiments using lentivirus-based short hairpin RNA (shRNA) delivery.

189 We show that short hairpin RNA (shRNA) depletion of TET2 results in a

190 In Neuro-2a cells, ZIP12 deficiency by short hairpin RNA (shRNA) depletion or CRISPR/Cas9 genom

191 , AG1024 and picropodophyllin (PPP), or with short hairpin RNA (shRNA) directed against IGF1R selecti

192 These interventions, or short hairpin RNA (shRNA) directly targeting SQSTM1/p62,

193 Cells were transfected with DBR1 short hairpin RNA (shRNA) followed 48 h later by infecti

194 alidated using small interfering RNA (siRNA)/short hairpin RNA (shRNA) gene knockdown and clustered r

195 rotein 1 (LAMP-1)-positive vesicles based on short hairpin RNA (shRNA) gene silencing and the colocal

196 NS axon regrowth, while PTEN repression with short hairpin RNA (shRNA) improves regeneration but to a

197 here, we report that depletion of EYA1 using short hairpin RNA (shRNA) in breast cancer cells destabi

198 Here using in utero electroporation of NDE1 short hairpin RNA (shRNA) in embryonic rat brains, we ob

199 ited by TRPC1 and STIM1 antibodies and STIM1 short hairpin RNA (shRNA) in wild-type VSMCs, and was ab

200 wn of human LIM domain kinase 1 (LIMK1) with short hairpin RNA (shRNA) inhibits HIV infection, no spe

201 0 but not that of ADAM17, as demonstrated by short hairpin RNA (shRNA) knockdown of furin, and promot

202 r the soluble IFN decoy receptor B18R nor by short hairpin RNA (shRNA) knockdown of mitochondrial ant

203 Furthermore, short hairpin RNA (shRNA) knockdown of Yap1 expression i

204 (MDA-MB-435S and SK-MEL-28) cell lines using short hairpin RNA (shRNA) lentiviral vectors.

205 ted viral vector containing either the SGLT1 short hairpin RNA (shRNA) or a scrambled RNA sequence.

206 genes were either silenced using lentiviral short hairpin RNA (shRNA) or functionally ablated using

207 n depleted of GADD45gamma by transfection of short hairpin RNA (shRNA) or in which the gene had been

208 iral vector expressing mutant Krt75-specific short hairpin RNA (shRNA) persistently suppressed this p

209 Adult mice transduced with Trpm4-targeted short hairpin RNA (shRNA) progressively decreased the ti

210 of YAP binding to MT or silencing of YAP via short hairpin RNA (shRNA) reduced MT transformation, sug

211 A comprehensive genome-wide short hairpin RNA (shRNA) screen identified >350 genes m

212 Through a short hairpin RNA (shRNA) screening, we identified singl

213 Knockdown of endogenous NFAT3 expression by short hairpin RNA (shRNA) significantly inhibited tumor

214 Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the g

215 Using a short hairpin RNA (shRNA) system, we show that loss of B

216 th inducible promoters and cognate-inducible short hairpin RNA (shRNA) targeted against the reporter

217 BCH-BB694 lentiviral vector, which encodes a short hairpin RNA (shRNA) targeting BCL11A mRNA embedded

218 ansduction of a lentiviral vector encoding a short hairpin RNA (shRNA) targeting Grb2 decreased the e

219 deno-associated virus-mediated delivery of a short hairpin RNA (shRNA) targeting the endogenous rat S

220 o circumvent potential compensation, we used short hairpin RNA (shRNA) to acutely knock down Sgce in

221 an RNA CD30 aptamer was utilized to deliver short hairpin RNA (shRNA) to CD30(+) T cells to target r

222 eno-associated virus (AAV) vector expressing short hairpin RNA (shRNA) to knock down the translation

223 re we utilize a mouse model of inducible p53 short hairpin RNA (shRNA) to show that temporarily block

224 Knockdown of Hrs by short hairpin RNA (shRNA) transduction resulted in signi

225 down in stromal fibroblasts using lentiviral short hairpin RNA (shRNA) transduction.

226 crophages that had been depleted of Rab1B by short hairpin RNA (shRNA) treatment, indicating that T2S

227 Specific inhibitors and short hairpin RNA (shRNA) were employed to demonstrate r

228 ably express the K-Ras oncogene and obscurin short hairpin RNA (shRNA), but not scramble control shRN

229 nflammasome-induced pathway was inhibited by short hairpin RNA (shRNA), HBoV1-induced cell death drop

230 Using an unbiased genome-scale screen with short hairpin RNA (shRNA), we identified the receptor TR

231 Acute short hairpin RNA (shRNA)-mediated depletion of c-MYC re

232 Lentiviral short hairpin RNA (shRNA)-mediated depletion of Ror2 in

233 that the acute and selective Fgf14-targeted short hairpin RNA (shRNA)-mediated in vivo "knock-down"

234 Short hairpin RNA (shRNA)-mediated knockdown of LC3 prev

235 We demonstrate that short hairpin RNA (shRNA)-mediated knockdown of Megf10,

236 Furthermore, short hairpin RNA (shRNA)-mediated knockdown of the p75N

237 ation of KLF4 were significantly reversed by short hairpin RNA (shRNA)-mediated selective depletion o

238 -) or Foxp3-mRFP/cd69(-/-) reporter mice and short hairpin RNA (shRNA)-mediated silencing and miR-155

239 Using short hairpin RNA (shRNA)-mediated suppression of NRP1,

240 hat are prone to Gravin depletion and Gravin short hairpin RNA (shRNA)-treated cells, an increase in

241 Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain

242 In parallel, 362 short-hairpin RNA (shRNA) constructs against 276 unique

243 We also constructed a short-hairpin RNA (shRNA) for silencing fatty-acid-bindi

244 Knockdown of endogenous MEF2D with a short-hairpin RNA (shRNA) increases sensitivity to etopo

245 Using a barcoded lentivirus-based pooled short-hairpin RNA (shRNA) library combined with next gen

246 Indeed, short-hairpin RNA (shRNA)-mediated knockdown of p62 impa

247 compared to other RNAi-based methods such as short-hairpin RNAs (shRNA).

248 nsduction system to deliver microRNA-adapted short hairpin RNAs (shRNAmirs) into the parasite to sile

249 Using short hairpin RNAs (shRNAs) against VASH1, VASH2, and SV

250 Systematic knockdown of all six genes using short hairpin RNAs (shRNAs) and follow-up functional stu

251 MTOR dependency was confirmed by distinct short hairpin RNAs (shRNAs) and high sensitivity of the

252 Short hairpin RNAs (shRNAs) are effective in generating

253 plex, including CUL4B, DDB1 or DCAF11, using short hairpin RNAs (shRNAs) attenuated the ubiquitinatio

254 Recent studies have shown that short hairpin RNAs (shRNAs) can induce gene-specific kno

255 ae (baker's yeast) was engineered to produce short hairpin RNAs (shRNAs) corresponding to the Aedes a

256 A screen using pooled short hairpin RNAs (shRNAs) identified the ATP-buffering

257 oblast-specific lentiviral delivery of FOSL1 short hairpin RNAs (shRNAs) provided in vivo validation

258 ens using short interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs), as well as for Drosophila s

259 classifier to predict potent microRNA-based short hairpin RNAs (shRNAs).

260 either RAGE overexpression or knockdown with short hairpin RNAs (shRNAs).

261 or when p53 expression was knocked down with short hairpin RNAs (shRNAs).

262 using tetraspanin antibodies and tetraspanin short hairpin RNAs (shRNAs).

263 e gene expression consequences of expressing short hairpin RNAs (shRNAs).

264 Conversely, Aurora B knock down by short-hairpin RNAs (shRNAs) suppresses AKT/GSK3beta/Snai

265 d in wild-type mice receiving AAV8-scrambled short hairpin RNA (shSCR).

266 n of S100A8 and S100A9 in cancer cells using short hairpin RNA significantly diminished migration and

267 g endosomal membranes, and NHE5 knockdown by short hairpin RNA significantly elevates pH of TfR-posit

268 Using short hairpin RNA-silenced human MC line LAD2 and stably

269 Short hairpin RNA silencing of kindlin-2, but not c-Src,

270 engineered to carry short interfering RNA or short hairpin RNA specific to oncogenic Kras(G12D), a co

271 K) inhibitors dichloroacetate and AZD7545 or short hairpin RNA-specific depletion of PDK1, enhanced t

272 cally inhibited its liver expression using a short hairpin RNA strategy in mice.

273 Using a short hairpin RNA strategy, we demonstrate here that the

274 d SPOP mutants or upon knockdown of SPOP via short-hairpin-RNA, suggesting that SPOP inactivation dir

275 el, subcutaneous injection of SK5 cells with short hairpin RNA-targeted downregulation of mGlu1 recep

276 ably transduced PC12 cells with an inducible short hairpin RNA targeting clathrin heavy chain, result

277 Adenovirus expressing short hairpin RNA targeting fibroblast growth factor 21

278 ma3e using adeno-associated virus 2 carrying short hairpin RNA targeting Sema3e promoted disoriented

279 nses to IL-17 using a tetracycline inducible short hairpin RNA targeting TRAF3IP2.

280 Importantly, short hairpin RNA targeting USF2 in pathogenic Th17 cell

281 dings, we administered lentivirus-expressing short hairpin RNAs targeting either ERalpha or ERbeta in

282 f an adeno-associated virus (AAV) expressing short hairpin RNAs targeting GHSR (or a control AAV) for

283 of the Methods, the pLKO.1 plasmids encoding short hairpin RNAs targeting human Rnd1 were incorrectly

284 ion of galectin-3 in human melanocytes using short hairpin RNA technology resulted in the reduction o

285 -associated virus (AAV-GLP-1R) that utilizes short hairpin RNA to chronically knock down GLP-1 recept

286 ere transfected with histidine decarboxylase short hairpin RNA to decrease histamine secretion and su

287 By using short hairpin RNA to deplete proteins involved in specif

288 e downstream effects could be reversed using short hairpin RNA to KISS1 or PGC1alpha, these data appe

289 graft were pretreated with HDAC inhibitor or short hairpin RNA to knock down expression of HDAC4 and

290 eotactically injected viral vectors encoding short hairpin RNA to knock down expression of the essent

291 We used knockout mice and short hairpin RNA to knock down guanine nucleotide bindi

292 each candidate protein in HepG2 cells using short hairpin RNAs to determine their effect on LDL upta

293 xpression of GPA, GPB, or GPC via lentiviral short hairpin RNA transduction of erythroid progenitor c

294 tatus of these cells compared with nontarget short hairpin RNA-treated cells.

295 nonsustained AF increased by >5-fold in NOX2 short hairpin RNA-treated dogs.

296 translational validity of the Bdnf L-3'-UTR short hairpin RNA-treated mice was confirmed by signific

297 Furthermore, short hairpin RNA vectors and small molecule inhibitors

298 d, validated, and used a novel Cre-inducible short-hairpin RNA virus for MSN-subtype-specific knockdo

299 To investigate LSP1 function in HCC, short hairpin RNA was utilized to stably knock down LSP1

300 were individually silenced using lentiviral short hairpin RNAs, which lead to a decrease (>/=80%) of