ライフサイエンスコーパス: short-chain dehydrogenase

1 nd has structural features characteristic of short chain dehydrogenases.

2 sification as belonging to a novel family of short-chain dehydrogenases.

3 SDR9C7, with short-chain dehydrogenase and/or reductase activity, is

4 lso illustrate the multifunctional nature of short-chain dehydrogenases and provide a potential mecha

5 etinal generated in transfected cells by the short-chain dehydrogenases CRAD1, CRAD3, or RDH1, to rec

6 and characterize an evolutionarily conserved short chain dehydrogenase, DHS-16, as a novel 3-hydroxys

7 g WWOX transcripts lack part, or all, of the short chain dehydrogenase domain and the putative mitoch

8 nhibitors of this and related enzymes of the short chain dehydrogenase enzyme class.

9 oss 20 diverse substrates by this remarkable short-chain dehydrogenase enzyme.

10 aratose synthase, a likely new member of the short-chain dehydrogenase family, represents the first d

11 late season, and upregulate transcripts for short-chain dehydrogenase, molybdopterin oxidoreductase,

12 A bpss2242 gene, encoding a putative short-chain dehydrogenase/oxidoreductase (SDR) in Burkho

13 entified and characterized two P trichocarpa short-chain dehydrogenases, PtPAR1 and PtPAR2, which wer

14 pecificity observed for other members of the short chain dehydrogenase reductase family of enzymes of

15 This study on GFS, a unique member of the short chain dehydrogenase reductase family, coupled with

16 Like FabI and FabL, FabV is a member of the short chain dehydrogenase reductase superfamily, althoug

17 termed SDR57C, belongs to the heterogeneous short-chain dehydrogenase reductase (SDR) superfamily.

18 , and the epoxyalcohol dehydrogenase SDR9C7 (short-chain dehydrogenase-reductase family 7 member 9).

19 re NAD(+)-dependent enzymes belonging to the short chain dehydrogenase/reductase (SDR) family of enzy

20 trate binding loops for other members of the short chain dehydrogenase/reductase (SDR) family, which

21 eaction confirm PTR1's membership within the short chain dehydrogenase/reductase (SDR) family.

22 ses (PKSs) based on homology modeling to the short chain dehydrogenase/reductase (SDR) superfamily of

23 critical Ser-Tyr-Lys catalytic triad of the short chain dehydrogenase/reductase (SDR) superfamily.

24 hloroplast endoribonuclease belonging to the short chain dehydrogenase/reductase (SDR) superfamily.

25 UDP-glycosyltransferase (UGT), as well as a short chain dehydrogenase/reductase and a cytochrome P45

26 the identification of missense mutations in short chain dehydrogenase/reductase family 9C, member 7

27 17beta-HSD6 is a member of the short chain dehydrogenase/reductase family and shares 65

28 the identification of a novel member of the short chain dehydrogenase/reductase family, photorecepto

29 is highly homologous to other members of the short chain dehydrogenase/reductase family.

30 uctural themes found in other members of the short chain dehydrogenase/reductase family.

31 multiple retinol dehydrogenases (Rdh) of the short chain dehydrogenase/reductase gene family and reti

32 Reduction of the C9 carbonyl by a short chain dehydrogenase/reductase initiates isochroman

33 Tsc10p is a member of the short chain dehydrogenase/reductase protein family.

34 om the redox reactions normally catalyzed by short chain dehydrogenase/reductase superfamily enzymes.

35 The enzyme is a member of the short chain dehydrogenase/reductase superfamily in which

36 RDH1 represents a new member of the short chain dehydrogenase/reductase superfamily that dif

37 Here, we report that a novel member of the short chain dehydrogenase/reductase superfamily, frog sd

38 rt characterization of a novel member of the short chain dehydrogenase/reductase superfamily.

39 es which are well established members of the short chain dehydrogenase/reductase superfamily.

40 catalytic properties of a new member of the short chain dehydrogenase/reductase superfamily.

41 and characterized a sterol/retinol-oxidizing short chain dehydrogenase/reductase that prefers NAD+ an

42 yl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate

43 aldo-keto reductase and previously annotated short chain dehydrogenase/reductase, respectively, in Cl

44 he retinoid substrate specificity of a novel short-chain dehydrogenase/reductase (SDR) encoded by Ral

45 of either the alcohol dehydrogenase (ADH) or short-chain dehydrogenase/reductase (SDR) enzyme familie

46 SQD1 is a member of the short-chain dehydrogenase/reductase (SDR) family of enzy

47 and IV demonstrates that they belong to the short-chain dehydrogenase/reductase (SDR) family of enzy

48 CDP nucleotide utilizing dehydratase of the short-chain dehydrogenase/reductase (SDR) family to be d

49 genes that encode proteins belonging to the short-chain dehydrogenase/reductase (SDR) family, wbmF,

50 carboxylase domain with other members of the short-chain dehydrogenase/reductase (SDR) family, we pro

51 NmrA shows an unexpected similarity to the short-chain dehydrogenase/reductase (SDR) family, with t

52 ture confirms that the enzyme belongs to the short-chain dehydrogenase/reductase (SDR) family.

53 ry DNA (cDNA) encoding a novel member of the short-chain dehydrogenase/reductase (SDR) gene family th

54 , expressed and identified as members of the short-chain dehydrogenase/reductase (SDR) gene family.

55 ols, involves a bioactivation by HSD17B11, a short-chain dehydrogenase/reductase (SDR) known to oxidi

56 Subsequent conversion by the short-chain dehydrogenase/reductase (SDR) MdpC into the

57 recognized as substrate by human microsomal short-chain dehydrogenase/reductase (SDR) RoDH-4 with th

58 Although the short-chain dehydrogenase/reductase (SDR) superfamily co

59 that vestitone reductase is a member of the short-chain dehydrogenase/reductase (SDR) superfamily de

60 sent evidence that the structurally distinct short-chain dehydrogenase/reductase (SDR) superfamily ma

61 In humans, four different members of the short-chain dehydrogenase/reductase (SDR) superfamily of

62 uctase 9 (DHRS9, also known as SDR9C4 of the short-chain dehydrogenase/reductase (SDR) superfamily) e

63 gene is predicted to encode a member of the short-chain dehydrogenase/reductase (SDR) superfamily, b

64 e enzymes are closely related members of the short-chain dehydrogenase/reductase (SDR) superfamily.

65 structure in one such class of proteins, the short-chain dehydrogenase/reductase (SDR) superfamily.

66 mediates, which are then dehydrogenated by a short-chain dehydrogenase/reductase (SDR) to the corresp

67 nd with NAD(+) and UDP reveals a homodimeric short-chain dehydrogenase/reductase (SDR), belonging to

68 We report a mouse short-chain dehydrogenase/reductase (SDR), retinol dehyd

69 io-oxidation of the carbinol by the HSD17B11 short-chain dehydrogenase/reductase (SDR), the resulting

70 T2 (ABA2) which encodes a unique Arabidopsis short-chain dehydrogenase/reductase (SDR1) that function

71 novel gene that we have designated prostate short-chain dehydrogenase/reductase 1 (PSDR1), that exhi

72 mily that we have designated murine prostate short-chain dehydrogenase/reductase 1 (Psdr1).

73 at has been designated variously as prostate short-chain dehydrogenase/reductase 1, retinal reductase

74 We have previously identified a short-chain dehydrogenase/reductase 3 (dhrs3), which sho

75 r from Nostoc linckia NIES-25 that encodes a short-chain dehydrogenase/reductase and a nonheme iron(I

76 Following this step, the annotated short-chain dehydrogenase/reductase and aldehyde dehydro

77 his expression pattern and the presence of a short-chain dehydrogenase/reductase domain and specific

78 ains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain.

79 Members of the alcohol dehydrogenase and short-chain dehydrogenase/reductase enzyme families cata

80 ide-diphosphosugar modifying subclass of the short-chain dehydrogenase/reductase enzyme family, havin

81 SalM is a short-chain dehydrogenase/reductase enzyme from the mari

82 ecycling enzymes and identifies a library of short-chain dehydrogenase/reductase enzyme prospects tha

83 ve protein exhibit homology to the family of short-chain dehydrogenase/reductase enzymes and thus ide

84 Although short-chain dehydrogenase/reductase enzymes are widely r

85 cromonospora belonging to the superfamily of short-chain dehydrogenase/reductase enzymes, EvdS6.

86 two murine epidermal retinol dehydrogenases, short-chain dehydrogenase/reductase family 16C member 5

87 R domains are members of the short-chain dehydrogenase/reductase family and function

88 ts reveals that IBR1 encodes a member of the short-chain dehydrogenase/reductase family and that IBR1

89 nases (R-HPCDH and S-HPCDH) belonging to the short-chain dehydrogenase/reductase family catalyze the

90 de reductase was identified by searching the short-chain dehydrogenase/reductase family for proteins

91 dehydrogenase 5, and dehydrogenase/reductase short-chain dehydrogenase/reductase family member 9, whi

92 nt example of the recruitment of a canonical short-chain dehydrogenase/reductase family member as an

93 if, found in NRPS R domains but not in other short-chain dehydrogenase/reductase family members, play

94 nded N terminus was also observed in several short-chain dehydrogenase/reductase family members.

95 This protein, a member of the short-chain dehydrogenase/reductase family of enzymes, h

96 , whose predicted product is a member of the short-chain dehydrogenase/reductase family of enzymes, w

97 oupled to a region with high homology to the short-chain dehydrogenase/reductase family of enzymes.

98 ng information, and predict inclusion in the short-chain dehydrogenase/reductase family of enzymes.

99 other tropane alkaloids, no proteins of the short-chain dehydrogenase/reductase family were found th

100 zation of a previously unknown member of the short-chain dehydrogenase/reductase family, CRAD3 (cis-r

101 on by retinol dehydrogenases, members of the short-chain dehydrogenase/reductase family.

102 n is known to be catalyzed by enzymes of the short-chain dehydrogenase/reductase family.

103 NAD(+)-dependent epimerase belonging to the short-chain dehydrogenase/reductase family.

104 us of WAX2 is most similar to members of the short-chain dehydrogenase/reductase family.

105 ecific gene Jingwei (jgw) is a newly evolved short-chain dehydrogenase/reductase in Drosophila.

106 2 represents the fifth isozyme in a group of short-chain dehydrogenase/reductase isozymes (retinol de

107 folM encodes an unusual short-chain dehydrogenase/reductase known to have dihydr

108 d that dhrs3a, which encodes a member of the short-chain dehydrogenase/reductase protein family, is b

109 for identifying candidate substrates for 27 short-chain dehydrogenase/reductase proteins of known ca

110 UDP-galactose 4-epimerase are members of the short-chain dehydrogenase/reductase SDR family.

111 ol/carveol dehydrogenases are members of the short-chain dehydrogenase/reductase superfamily and are

112 dehydrogenase, retSDR1, that belongs to the short-chain dehydrogenase/reductase superfamily and loca

113 rates that tyvelose epimerase belongs to the short-chain dehydrogenase/reductase superfamily of enzym

114 rogenase 12 (RDH12) is a novel member of the short-chain dehydrogenase/reductase superfamily of prote

115 CF244 and HCF173 are members of the atypical short-chain dehydrogenase/reductase superfamily, a modif

116 HCF173 belongs to the short-chain dehydrogenase/reductase superfamily, associa

117 Thus, unlike other members of the short-chain dehydrogenase/reductase superfamily, FabG un

118 al characterization of a novel member of the short-chain dehydrogenase/reductase superfamily, retinal

119 with the 5,6-dehydratases, belong to the NS-short-chain dehydrogenase/reductase superfamily.

120 id biosynthesis, which instead belong to the short-chain dehydrogenase/reductase superfamily.

121 It is composed of putative short-chain dehydrogenase/reductase Ycf39, encoded by th

122 whereas microsomal retinol dehydrogenase (a short-chain dehydrogenase/reductase) catalyzes the reduc

123 We determined the orientation of the SDR (short-chain dehydrogenase/reductase) rat RoDH1 (retinol

124 r of the subclass 'intermediate' of the SDR (short-chain dehydrogenase/reductase) superfamily with th

125 rex phenotype is caused by a mutation in the short-chain dehydrogenase/reductase, RDH10.

126 e report cloning a cDNA that encodes a novel short-chain dehydrogenase/reductase, SDR-O, conserved in

127 Human and mouse liver express SDR-O (short-chain dehydrogenase/reductase-orphan) mRNA intense

128 the NCBI data bank that encodes a peroxisome short-chain dehydrogenase/reductase.

129 Although they belong to the superfamily of short chain dehydrogenase-reductases, the epimerase-acti

130 Two short chain dehydrogenase/reductases mediate naphthol re

131 rogenase (ABAD) is a member of the family of short chain dehydrogenase/reductases whose distinctive p

132 ultifunctional catalytic nature, as do other short chain dehydrogenase/reductases.

133 lar carbonyl reductase (PTCR) belongs to the short chain dehydrogenases/reductases (SDR) superfamily

134 Interestingly, mycobacterial short chain dehydrogenases/reductases (SDRs) within fami

135 be significant in the sequentially analogous short chain dehydrogenases/reductases, where a serine is

136 Short-chain dehydrogenase/reductases catalyse the metabo

137 ode proteins that belong to a superfamily of short-chain dehydrogenases/reductases (SDR16C5 and SDR16

138 Short-chain dehydrogenases/reductases (SDRs) are one of

139 Three genes coding for the NAD(+)-dependent short-chain dehydrogenases/reductases (SDRs) NV10127, NV

140 ntified and functionally characterized three short-chain dehydrogenases/reductases (SDRs) NV10127, NV

141 We report two short-chain dehydrogenases/reductases (SDRs), identified

142 ave significant sequence homology with other short-chain dehydrogenases/reductases (SDRs).

143 d insight into the multifunctional nature of short-chain dehydrogenases/reductases and into the enzym

144 protein has sequence similarity to bacterial short-chain dehydrogenases/reductases and might represen

145 e superfamily and are related to other plant short-chain dehydrogenases/reductases involved in second

146 Human short-chain dehydrogenases/reductases with dual retinol/

147 and demonstrate that Rdh1, Crad1, and other short-chain dehydrogenases/reductases, which share simil

148 cture is similar to that of NAD(H)-dependent short-chain dehydrogenases/reductases, with a conserved

149 ily with remarkable substrate diversity, the short-chain dehydrogenases/reductases.

150 mbrane protein that belongs to the family of short-chain dehydrogenases/reductases.

151 acid similarity with other retinoid/steroid short-chain dehydrogenases/reductases: CRAD1, CRAD2, and

152 The short-chain dehydrogenase-related protein Ayr1 forms an

153 Thus, the new short chain dehydrogenase represents a novel type of mic

154 tyrate dehydrogenase (BDH2), a member of the short-chain dehydrogenase (SDR) family of reductases, ca

155 245-amino acid protein presents the typical short-chain dehydrogenase (SDR) Rossmann-fold motif for

156 The enzyme, which is a member of the short chain dehydrogenase superfamily, uses NAD+ as a co

157 ructure reveals that 3HNR is a member of the short-chain dehydrogenase superfamily of enzymes.

158 RDH1 is the most efficient known mouse short-chain dehydrogenase that catalyzes dehydrogenation

159 e a mouse cDNA that encodes a 316-amino acid short-chain dehydrogenase that prefers NAD+ as its cofac

160 t a mouse cDNA that encodes a 317-amino acid short-chain dehydrogenase which recognizes as substrates

161 codes retinol dehydrogenase type 1 (RDH1), a short-chain dehydrogenase, which recognizes as substrate

162 oid/androgen dehydrogenase type 1 (CRAD1), a short-chain dehydrogenase, which recognizes as substrate

163 tion: a zinc-dependent alkyltransferase, two short-chain dehydrogenases with specificities for the ch