ライフサイエンスコーパス: short-lived

1 marrow, PCs in the gut have been considered short lived.

2 eveal that 20% of spines lack PSD-95 and are short lived.

3 unfolded protein response and are extremely short lived.

4 rated by influenza vaccination in adults are short-lived.

5 nd the induced immune response is narrow and short-lived.

6 mmunization in humans are often described as short-lived.

7 iveness of most cancer targeted therapies is short-lived.

8 ncer chest wall metastases but responses are short-lived.

9 (e.g. a specific ubiquitin ligase) is itself short-lived.

10 t relatively poor B-cell responses which are short-lived.

11 d titer increases were only about 2-fold and short-lived.

12 g among auditory cortex neurons was weak and short-lived.

13 cted that this species should be kinetically short-lived.

14 nefficient polarization in water, relatively short-lived (1)H-polarization, and relatively limited su

15 e terrestrial planets can be traced with the short-lived (146)Sm-(142)Nd system (~100-My half-life).

16 multiply charged iodine ions are issued from short-lived (~20 fs) transient states, whereas the singl

17 prohibitive to clinical translation, but the short-lived (51)Mn (t1/2: 46 min, beta(+): 97%) represen

18 As most asexual lineages are short-lived, abandoning sex is commonly regarded as an e

19 hat ubiquitin-like processing of Sde2 into a short-lived activated form may function as a checkpoint

20 pecific proteases Ubp5 and Ubp15 generates a short-lived activated Sde2-C fragment with an N-terminal

21 extrafollicular B cell differentiation into short-lived AFCs as a key mechanism of anti-DNA autoreac

22 d also hold for other high-affinity mAbs and short-lived alpha-emitters.

23 GC B cells are short lived and are prone to caspase-mediated apoptosis.

24 We describe novel short lived and cycling patterns of gene expression and

25 erval [CrI] 95.1-98.3) of the response being short lived and decaying within the first 6 months and t

26 IN, however, is short lived and is rapidly degraded by the host ubiquiti

27 tebrate species, is thought to be relatively short lived and is typically of hybrid origin.

28 n the glomerular capillaries, where they are short lived and make a modest contribution to glomerular

29 during the Pliocene but this propagation was short-lived and aborted close to the Pliocene-Pleistocen

30 Mycoplasma pneumoniae-specific ASCs are short-lived and associated with clinical disease, making

31 The storm effects were short-lived and bacterial communities quickly recovered

32 Such responses are typically short-lived and can be suppressed by proteins that act p

33 Mass extinction events are short-lived and characterized by catastrophic biosphere

34 These short-lived and episodic synoptic-scale events transport

35 Using the WorMotel, we find that short-lived and long-lived strains exhibit patterns of b

36 al studies indicate that these exceptionally short-lived and low-abundance species form Watson-Crick-

37 t antibody kinetics in wildlife hosts can be short-lived and produce patterns that are repeatable acr

38 Classically considered short-lived and purely defensive leukocytes, neutrophils

39 hus providing the opportunity to detect even short-lived and reactive transformation products.

40 peracids (CF(3)SO(3)H, FSO(3)H) gave rise to short-lived and reactive trifluoroalkyl carbocations of

41 The formation of short-lived and stable radicals was investigated using e

42 P]) interstitial macrophages of the lung are short-lived and succumb early to SIV infection.

43 their analysis is strongly hindered by their short-lived and terminally differentiated nature.

44 its protein coat, but this altered state is short-lived and thus poorly understood.

45 ll populations, which are counterintuitively short-lived and typically exposed to limited amounts of

46 of this type of lead glass from Saqunda was short-lived and was subsequently refined by introducing

47 netics may be suitable for labeling with the short-lived and widely clinically available radiometal (

48 mmunology where ligand-receptor bindings are short lived, and a few antigens are sufficient for cell

49 with 95.0% (85.7-98.1) of the response being short lived, and the long lived phase decaying with a ha

50 Side effects were short-lived, and clinical improvement was maintained for

51 ders diploid partial apomicts evolutionarily short-lived, and results in fixation of triploid apomict

52 s than after RV144, but these responses were short-lived, and their magnitude did not increase with s

53 NO(*)-derived reactive species are typically short-lived, and their preferential fates depend on kine

54 Short-lived animals inhabiting such environments often s

55 ture of patterns expected for long-lived and short-lived animals, and between income and capital bree

56 In both ageing dimensions, we found that short lived-animals aged faster than long-lived animals.

57 We now demonstrate that the presence of a short-lived anionic flavin semiquinone (ASQ) is not suff

58 dependently of germinal center formation via short-lived antibody-forming cells (AFCs) localized to e

59 rovide new insight into the poorly known and short-lived Arctic forest community of the Early Eocene

60 We have found indication of short-lived ASCs in the local lymphoid tissue, further e

61 The frequent, but short-lived, associations of bison with different spatia

62 Here, we used short-lived auxin signaling proteins and model N-end rul

63 DNA breaks generated by topoisomerases are short-lived because of the religation activity of these

64 sion outside the injection site resulting in short lived benefits while causing systemic toxicity.

65 This short-lived burst in kinase activity links development w

66 of beta-band activity, which is dominated by short-lived, burst-like events.

67 reely diffuse in solution, while 3 generates short-lived caged radicals that rapidly form product C-O

68 s with stroma cells as indicated by sporadic short-lived calcium spikes.

69 m of the NM-R and compared it to that of the short-lived, cancer-prone mouse.

70 raising cAMP, stimulated the degradation of short-lived cell proteins, but unlike cAMP, also markedl

71 horylation, and the selective degradation of short-lived cell proteins.

72 LRG1(+)CD127(low) population is dominated by short-lived cells and shows that KLRG1 downregulation is

73 Because monocytes are short-lived cells, HCMV must subvert the natural short l

74 ocyte survival, where monocytes are normally short-lived cells.

75 nt subtypes of afferent fibres and to detect short-lived changes in synaptic plasticity as measured b

76 We found that short-lived channel closures during channel openings rep

77 ms that might account for this link involves short-lived chemical reaction intermediates known as rad

78 Rather, a short-lived CheR binding interaction appears to promote

79 Understanding the role of short-lived climate forcers such as black carbon (BC) at

80 /- 25.4 (for RCP4.5) mug m(-3) following the short-lived climate pollutant (SLCP) mitigation emission

81 , the super pollutant (SP) lever to mitigate short-lived climate pollutants, and the carbon extractio

82 -time constant (taucf ), which describes the short-lived closures that interrupt open bursts, was gre

83 rs of ANCL CSPalpha mutants were shown to be short-lived compared with wild-type CSPalpha, suggesting

84 A relatively short-lived component (0.3-1.7 mus) accounts for only 3-

85 d that anchor-matrix bonds that are weak and short-lived confer superior trapping potency, contrary t

86 and biophysical tools, we characterize three short-lived conformational states over the ns-ms timesca

87 er half-lives in indolent cases, and weaker, short-lived contacts mediating the aggressive ones.

88 one marrow LLPCs compared with their splenic short-lived counterparts (SLPCs).

89 uel simply effects the formation of a single short-lived covalent bond.

90 nsulin like growth factor (IGF) receptor and short lived daf-16/FOXO transcription factor mutants.

91 ong-lived stem cells and frequently-dividing short-lived daughter transit cells.

92 Short-lived dcap-1 mutants exhibit a neurosecretion-depe

93 S4 undergoes alpha-helical conformation to a short-lived different secondary structure transiently be

94 Chemotherapy and targeted therapies offer short-lived disease control.

95 are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor

96 Most were short-lived, dynamic, exploratory, and originated near s

97 Short-lived ectotherms that exhibit plasticity in their

98 pecific CTL response by enhancing expansion, short-lived effector and effector/memory differentiation

99 t this balance is tipped where T cells favor short-lived effector but not memory or T(FH) responses.

100 Short-lived effector CD8 T cells are constitutively repl

101 CXCR3 promotes memory T cells, CCR4 supports short-lived effector cell generation.

102 CD8 T cell survival in vitro and survival of short-lived effector cells in vivo in response to Lister

103 ector cells (MPECs), which are distinct from short-lived effector cells that provide acute protection

104 igh expression of T-bet, a characteristic of short-lived effector cells, GW-treated cells demonstrate

105 the early viral spread, whereas cDC1 induced short-lived effector CTL that eventually cleared the vir

106 bisulfite sequencing of primary human naive, short-lived effector memory (TEM), and longer-lived cent

107 the gene encoding FOXO1, T cells revert to a short-lived effector phenotype, exhibit reduced viabilit

108 killer (NK) cells have long been considered short-lived effectors of innate immunity.

109 ment the gammadeltaT-17 response in favor of short-lived effectors with limited plasticity, particula

110 n intrinsic propensity to differentiate into short-lived effectors.

111 ereas KLRG1(+)CD127(low) cells are viewed as short-lived effectors.

112 lted in only a mild and transient rash and a short-lived elevation of the body temperature.

113 ed CPL luminescence to be distinguished from short-lived emission of other fluorescent species.

114 ed capture and carrier CaCO(3) beads and the short-lived emission of the dye-stained bacteria with ti

115 ng the half-life of these vital but normally short-lived enzymes.

116 response to stress signaling is supported by short-lived epigenetic changes.

117 we analyzed the degradation pathways of two short-lived ER membrane model proteins in mammalian cell

118 lular pertussis (aP) vaccines is partial and short-lived, especially in teenagers, calling for novel

119 However, the elevated level of attention is short-lived, even though the initial announcements are f

120 also indicates that these sensors can track short-lived events of pollution, especially in conjuncti

121 phorous triamide intermediates are typically short lived, evolving with elimination of the N-borylami

122 the abundance and lifetime of low-populated short-lived excited states by up to 10-fold.

123 , which greatly suppresses the reactivity of short-lived excited states, provides a means for directl

124 asts and plasma cells (PCs) by enhancing the short-lived extrafollicular response and reducing the po

125 ect SM-FDC virion transfer also depends upon short-lived FDC network abutment, likely triggered by SC

126 ch longer periplasmic vestibule and it has a short-lived flexible pseudopilus.

127 e reporter system, we genetically inserted a short-lived fluorescence reporter downstream of the endo

128 Nonetheless, imaging short-lived forces transmitted by low-abundance receptor

129 ropagules (for example, animals), others are short-lived, form by aggregation, and propagate only onc

130 Here we observe such a transition in a short-lived gas of exciton-polaritons, bosonic light-mat

131 re stable or decreasing due to reductions in short-lived gases or net radiative forcing.

132 The establishment of exercise protocols for short-lived genetic models will be critical for decipher

133 analyses of short-lived Mdh2 as a target of short-lived Gid4, we illustrate the advantages of PRT ov

134 We show that short-lived greenhouse gases contribute to sea-level ris

135 lived groups that propagate continuously and short-lived groups that propagate only once, with the la

136 We show that the large short-lived Hg spike, and nadirs in delta(202)Hg and del

137 that mu-ORs interact with each other to form short-lived homodimers on the plasma membrane.

138 The short-lived hydrophobic gas nitric oxide (NO) is a broad

139 mited to the early Eocene, especially during short-lived hyperthermals.

140 In either case, a very short-lived (i.e., between 75 and 95 fs) echo is observe

141 ge-dominated tropical reefs will be rare, or short-lived, if they occur at all into the future in the

142 y and functionally related B-cell subsets of short-lived IgE(+) plasmablasts and IgG(+) memory B cell

143 se cells rapidly switch isotype, expand into short-lived IgE(+) plasmablasts, and serve as a potentia

144 is attributed in part to the suboptimal and short-lived immunity elicited by acellular pertussis vac

145 infections, including minimal pathology and short-lived immunity.

146 recurs frequently and establishes a weak and short-lived immunity.

147 In contrast, responses to TKI treatment are short lived in advanced phases of the disease or in BCR-

148 These chemical species are short-lived in biological settings, and detecting them i

149 d, suggesting that elevational generalism is short-lived in geological time?

150 Snail1 is short-lived in normal epithelial cells as a consequence

151 mparable in magnitude to today's extreme but short-lived increases in water level due to storms.

152 LiF-MS peptide ligands carry a short-lived, indiscriminately reactive cleavable crossli

153 igen-presenting cells results in: 1) initial short-lived interactions (0 to 6 h), between CD8(+) T ce

154 the presence and translocation mechanisms of short-lived intermediate bound states that are likely to

155 Additionally, a new short-lived intermediate species with a CO peak at 1896

156 lic attack of a water molecule, leading to a short-lived intermediate that tautomerizes to form H(2)P

157 A very short-lived intermediate was observed to start the G4 fo

158 u(A) formation occurs rapidly and involves a short-lived intermediate with a lambda(max) of 360 nm.

159 rstanding on the structure and properties of short-lived intermediates but also with the aim to creat

160 saturated silicon clusters (siliconoids) are short-lived intermediates during the transition from mol

161 New syntheses with very short-lived intermediates have been enabled by sub-milli

162 (2AA), are reactive metabolites produced as short-lived intermediates in a number of enzymatic proce

163 S(4)](3+) charge state have been proposed as short-lived intermediates in a number of enzymatic react

164 tructural information about the proposed and short-lived intermediates.

165 In contrast, application of short-lived intraventricular pressure surges neither tri

166 On labeling with the short-lived isotopes (18)F and (68)Ga, excellent molecul

167 Mn(2+) upconversion emission and relatively short-lived lanthanide upconversion emission in a partic

168 al high mean LAI, with the reverse found for short-lived leaves and higher maximum photosynthetic cap

169 ely populated ( approximately 0.02-0.4%) and short-lived (lifetimes approximately 0.2-2.5 ms) Hoogste

170 Short-lived lipid radicals were measured ex situ in ethy

171 To monitor short-lived lipid-radicals, N-tert-butyl-alpha-phenylnit

172 used in Xenopus laevis embryos to visualize short-lived, local breaches in epithelial barrier functi

173 that RNAs exist in dynamic equilibrium with short-lived low-abundance 'excited states' that form by

174 RNA to preferentially bind and stabilize the short-lived low-abundance ES relative to the long-lived

175 cannot be maintained, resulting in multiple short-lived (<6 day) ice flow perturbations.

176 Monocytes are circulating short-lived macrophage precursors that are recruited on

177 wers, which are heterotrophic and relatively short-lived, may not be constrained by the same physiolo

178 Through analyses of short-lived Mdh2 as a target of short-lived Gid4, we ill

179 d rule pathway, whose substrates include the short-lived Mdh2 malate dehydrogenase.

180 Thus, infrequent and short-lived mechanical events are tagged.

181 Neutrophils are critical and short-lived mediators of innate immunity that require co

182 Short-lived memory was mediated by trehalose synthase an

183 -metathesis by-products-and the formation of short-lived methylidene complexes.

184 the hydrogen abstraction pathway, yields the short-lived methylthiomethylperoxy radical (MSP; CH(3)SC

185 ge, which is substantial during the aging of short-lived mice, is stabilized at low levels during the

186 While some short-lived migrants are known or believed to repeat the

187 s, thereby specifying the half-lives of most short-lived miRNAs.

188 ric dissolved organic matter ((3)CDOM*) is a short-lived mixture of excited-state species that plays

189 ialization include reliance on findings from short-lived model organisms, poor biological understandi

190 Finally, we discuss how knowledge from short-lived model species can be translated to economica

191 while such patterns are widely recognized in short-lived model systems, how they apply to long-lived

192 electron microscopy (cryo-EM) grids to study short-lived molecular states.

193 ation of Akt to drive the differentiation of short-lived monocytes into long-lived macrophages, which

194 As a result, short-lived mRNAs were imaged throughout their complete

195 ast, Undaria was likely to be competing with short-lived native annuals on rocky reef due to large ni

196 r promiscuous reactivity, low abundance, and short-lived nature limit our ability to study them in re

197 ntermediates remained elusive owing to their short-lived nature.

198 to estimate overall engagement of areas into short-lived networks related to the StretchEP, and Globa

199 To date, investigations report short-lived neuromodulatory effects, but to deliver on i

200 ation and propagation of aggregates, whereby short-lived oligomeric intermediates cause neurotoxicity

201 re pauses of 1-1000 s duration, of which the short-lived ones (1-10 s) are the temporal signature of

202 .g., leaves) than in ontogenetically similar short-lived ones (e.g., petals), and that mutation rate

203 t it is equivocal whether the improvement is short-lived or long-lasting, and additionally what accou

204 how that intermediate N-azidoamines are very short-lived or their formation is bypassed by direct gen

205 he presence of a noncognate substrate but is short-lived owing to lack of optimal complementarity bet

206 ys in ~4 ps via a 2-step process involving a short-lived P(+)B(B) (-) intermediate, analogous to init

207 d during malaria, a disease characterized by short-lived, parasite-specific Ab responses.

208 This coupled excitable system leads to short-lived patches of activated Ras and associated F-ac

209 high levels of Th17 and CD8(+) T cells while short-lived patients with high burden of SCNAs have high

210 During short-lived perturbations, such as inflammation, the gut

211 The short-lived PET radionuclide (68)Ga, available on a regu

212 Lys-SDE2Ct constitutes a short-lived physiological substrate of the Arg/N-end rul

213 The extrafollicular pathway gives rise to short-lived plasma cells (PCs) that can rapidly secrete

214 ere, we report that the rapid development of short-lived plasmablasts during experimental malaria une

215 g-lived greenhouse gas carbon dioxide and of short-lived pollutants, including sulfur dioxide, that c

216 Short-lived populations from the outer margin of the spe

217 phenomena arise from a confluence of rapid, short-lived positive signals driven by the protein tyros

218 boxylic acids and amide derivatives with the short-lived positron emitter carbon-11 (t1/2 = 20.4 min)

219 on of synthetic biomolecules often result in short-lived presentations, or require genetic manipulati

220 lso local probe reactions, in which unstable short-lived products have been synthesized and analyzed.

221 oil associated with the decay of (222)Rn and short-lived progeny.

222 ent study, we have discovered that PDK4 is a short lived protein (t(1/2) approximately 1 h) and is sp

223 p53 is a short-lived protein with low basal levels under normal h

224 ed proteins to become stabilized relative to short-lived proteins, leading to alterations in the abun

225 agents promoted the selective degradation of short-lived proteins, which are misfolded and regulatory

226 egrons were the first degradation signals in short-lived proteins.

227 Here we report that abundances of short-lived r-process isotopes in the early Solar System

228 Although short-lived r-process isotopes-with half-lives shorter t

229 ous features, limitation in mass transfer of short-lived radical species is an inherent drawback of t

230 Under UV light irradiation, short-lived radicals (i.e., HO(*), NO(2)(*), and CO(3)(*

231 instantly generates a high concentration of short-lived radicals that can quickly neutralize and dec

232 Our findings will enable further studies of short-lived radioactive molecules for fundamental physic

233 present an experimental approach to studying short-lived radioactive molecules, which allows us to me

234 aterial has merely been studied by analyzing short-lived radioisotopes.

235 cy, and speed of microfluidics to synthesize short-lived radiolabeled compounds.

236 nontarget tissues, and facilitate the use of short-lived radionuclides that would otherwise be incomp

237 e capability to produce, extract, and detect short-lived reaction products under the demanding experi

238 usive species that are mostly encountered as short-lived reactive reaction intermediates.

239 The short-lived reactive species in CAP may activate cells i

240 h output with increased volatility and deep, short-lived recessions; and alternation of high- and low

241 hat selectively eliminates dysfunctional and short-lived regulatory proteins in eukaryotes.

242 ltifaceted enzymes limit the accumulation of short-lived, regulatory proteins within mitochondria, mo

243 eport on LSD in 1950, psychedelics enjoyed a short-lived relationship with psychology and psychiatry.

244 infection with particular viruses conferred short-lived relative cross-protection against FRI.

245 We investigated the presence of short-lived relative cross-protection conferred by speci

246 irth and subsequent growth) and mortality of short-lived, relatively shade-intolerant tree species.

247 IgE(+) plasma cells are extremely scarce and short-lived, respectively.

248 lived response) and immunoglobulin G3 (IgG3; short-lived response indicating more recent infection) f

249 the lack of abortive RNA in initiation from short-lived ribosomal promoter OCs are well described by

250 ers are inhibited by GreB/DksA because their short-lived RNAP complexes do not allow sufficient time

251 The short-lived ROS and H(2)O(2) generated from each fractio

252 In this study, we aim to quantify short-lived ROS and H(2)O(2) laser printer emissions, as

253 generated 2.68 times more total ROS (sum of short-lived ROS and H(2)O(2)) than the vapor fraction.

254 3% by mass, produced 69x and 202x times more short-lived ROS and H(2)O(2), respectively, on a mass ba

255 sh PM(0.1) generated 282x and 32x times more short-lived ROS and H(2)O(2), respectively, than aged an

256 eodymium-142 ((142)Nd), the decay product of short-lived samarium-146 ((146)Sm).

257 cy of breeding Adelie penguins, a relatively short-lived seabird species, in order to gain a broader

258 ward communities dominated by bloom-forming, short-lived seaweeds.

259 Campylobacteriosis typically manifests as a short-lived, self-limiting gastrointestinal infection in

260 wing clinical malaria episodes, children had short-lived, sequence-independent increases in average w

261 It is usually episodic and short-lived, so when a patient presents to their clinici

262 However, this is a short-lived solution unless reducing conditions are main

263 Together, these observations indicate short-lived, specialized reinforcement in the spindle ce

264 25 nm is critical to avoid the limitation of short-lived species diffusion and achieve kinetics that

265 lack of effective tools to characterize this short-lived species in between two condensed matter laye

266 The identification of short-lived species, likely active species, is often hin

267 size and a lower population growth rate than short-lived species.

268 nic radicals are usually highly reactive and short-lived species.

269 lation period T, enhances the sensitivity to short-lived species.

270 unique geochemical signature within the ODZ-short-lived spikes of ammonium that are found in measure

271 Species with short-lived spores reproducing where there is strong tur

272 s approach for four biological systems where short-lived states are of high interest.

273 tail, even in cases where excursions involve short-lived states.

274 time scales of reversibility of TSLR due to short-lived substances provides insights into physical p

275 ) undergoes single electron transfer to form short-lived superoxide, which then recombines to form a

276 d MDC peaked early (Tmax=15-45 min) and were short lived (t1/2=60-90 min), while HHMC and HMMC peaked

277 scription and local chromatin signatures are short-lived, the IFNgamma-primed state stably propagates

278 mal anomalies culminate in the generation of short-lived tissue-invasive effector T cells.

279 er possibility, that the connections are too short-lived to be captured by microscopy during a normal

280 quantification of myocardial blood flow with short-lived tracers, such as (82)Rb-chloride, requires a

281 The p53 tumour suppressor protein is a short-lived transcription factor that can inhibit the gr

282 vations of XFEL-induced electronic decay via short-lived transient electronic states in the diiodomet

283 these different time scales: contrary to the short-lived transient states which relax by molecular Au

284 Once activated, SCs typically give rise to short-lived transit-amplifying cells (TACs), which then

285 We conclude that, despite being short-lived, transplanted ASCs can accelerate wound-heal

286 of quality control that regulate turnover of short-lived, unfolded, and misfolded proteins.

287 n documented as well, but these are commonly short-lived (up to a few hours).

288 Long-lived normal FOB cells became short lived upon ectopic Xbp1s expression.

289 a unique insight into the interplay between short-lived valley excitons and spin-dependent interlaye

290 , and their regulation by food intake in the short-lived vertebrate model Nothobranchius furzeri.

291 lifish (Nothobranchius furzeri), a naturally short-lived vertebrate, we show that the gut microbiota

292 On its own, this moderate, short-lived warming was unlikely to cause widespread dam

293 e-like responses are typically thought of as short-lived, we found that changes persisted for months

294 eutrophils are terminally differentiated and short-lived with a high turnover rate.

295 However, these reducing moieties are short-lived (with a half-life of 1.9 h) and easily oxidi

296 rders in which benefits from shunting may be short-lived, with a consequently unfavorable risk-benefi

297 The response duration was rather short-lived, with a median progression-free survival of

298 lowing the ingestion of 6 g BCAA and BCKA is short-lived, with higher myofibrillar protein synthesis

299 l in inducing remissions, these are normally short-lived, with median response durations of <1 year.

300 A stepwise mechanism involving short-lived zwitterion intermediates is established.