ライフサイエンスコーパス: short-term plasticity

1 de insight as to the mechanisms underpinning short term plasticity.

2 ve synaptic ribosomes and at synapses during short term plasticity.

3 e into functional circuits and show enhanced short-term plasticity.

4 pletion of synaptic vesicles determined this short-term plasticity.

5 TD without a change in basal transmission or short-term plasticity.

6 naptic conductance waveform and postsynaptic short-term plasticity.

7 e to maintain a fixed EPSC-IPSC ratio during short-term plasticity.

8 c facilitation, and protracted maturation in short-term plasticity.

9 gs at CA3/CA1 synapses revealed a deficit in short-term plasticity.

10 hout altering basal synaptic transmission or short-term plasticity.

11 presynaptic terminal, whose properties shape short-term plasticity.

12 ograde way, resulting in altered presynaptic short-term plasticity.

13 r contributing significantly to this form of short-term plasticity.

14 in more detail and identifies its impact on short-term plasticity.

15 (iii) cbl-b null mice show an enhancement in short-term plasticity.

16 r collateral axons have target-cell specific short-term plasticity.

17 T1 at distinct synaptic sites with different short-term plasticity.

18 for determining basal synaptic strength and short-term plasticity.

19 (Delta47)) differ in release probability and short-term plasticity.

20 n mean amplitude, failure rate, kinetics and short-term plasticity.

21 are unreliable, highly variable and exhibit short-term plasticity.

22 ion of EPSP slope, a measure of pre-synaptic short-term plasticity.

23 us trains, varying 2-fold or more because of short-term plasticity.

24 ate basic aspects of transmitter release and short-term plasticity.

25 or using a synaptic mechanism, such as with short-term plasticity.

26 from MCs exhibited clear cell type-specific short-term plasticity.

27 read with more recording sites demonstrating short-term plasticity.

28 trol of excitatory synaptic transmission and short-term plasticity.

29 asing or decreasing responses, suggestive of short-term plasticity.

30 ion, as well as for modeling the dynamics of short-term plasticity.

31 differentially poised for exocytosis shapes short-term plasticity.

32 recruitment determines basal SV priming and short-term plasticity.

33 cycle, modulating synaptic transmission and short-term plasticity.

34 scharged them after induction of presynaptic short-term plasticity.

35 ng-term synaptic plasticity without altering short-term plasticity.

36 ential-evoked release probability and alters short-term plasticity.

37 c, continuously changing because of synaptic short-term plasticity.

38 hips between initial release probability and short-term plasticity.

39 nsmitter release, synaptic transmission, and short-term plasticity.

40 p to 200 Hz, the EPSC kinetics together with short-term plasticity allow for faithful transmission wi

41 utamatergic motor neuron synapses shows that short-term plasticity also varies greatly between synaps

42 lly contributes to both the excitability and short-term plasticity alterations that we observed.

43 n and suggest that, in addition to effecting short-term plasticity, AMPA receptors regulate genes inv

44 calmodulin binding (CaMb) domain involved in short-term plasticity and a C(2)A domain that forms an i

45 Contrasting patterns of short-term plasticity and a size criterion identified tw

46 Furthermore, short-term plasticity and calcium sensitivity of neurotr

47 tion to identify the quantal determinants of short-term plasticity and combine these with a short-ter

48 In the current paper it is proposed that short-term plasticity and dynamic changes in the balance

49 pe calcium currents through Ca(v)1 fine-tune short-term plasticity and facilitate SV recycling.

50 of tau suppression was, in turn, confined to short-term plasticity and memory.

51 Whereas both inhibitory short-term plasticity and miniature IPSC frequency and a

52 nnels by CaS proteins is required for normal short-term plasticity and normal encoding of information

53 within the same terminals, we found that the short-term plasticity and pharmacological modulation of

54 RIM-BP2 lowered release probability altering short-term plasticity and reduced evoked EPSCs.

55 A systematic analysis of short-term plasticity and synapse-to-synapse variability

56 tsynaptic inactivation of presenilins alters short-term plasticity and synaptic facilitation.

57 for the first time how the interplay between short-term plasticity and temporal summation mediates th

58 Nxph1 plays an instructive role in synaptic short-term plasticity and the configuration with GABA re

59 naptic and ectopic sites in the magnitude of short-term plasticity and the proportions of Ca2+ channe

60 nc13-2-mediate opposite forms of presynaptic short-term plasticity and thus differentially affect neu

61 er of releasable vesicles reliably reproduce short-term plasticity and variance of synaptic responses

62 Rapid cold hardening (short-term plasticity) and developmental acclimation (lo

63 able to residual calcium (Ca(res))-dependent short-term plasticities, and the actions of neuromodulat

64 readily releasable pool of vesicles, alters short-term plasticity, and changes the properties of evo

65 e showed normal basal synaptic transmission, short-term plasticity, and decremental long-term potenti

66 ase probability, Ca2+ dependence of release, short-term plasticity, and fusion pore kinetics.

67 ces in some but not all forms of presynaptic short-term plasticity, and heterogeneity in the short te

68 Thus, basal synaptic strength, short-term plasticity, and homeostasis are determined in

69 dendritic spine maintenance, corticostriatal short-term plasticity, and learning in adult male and fe

70 synapses with appropriate receptor kinetics, short-term plasticity, and long-term dendritic spike-tim

71 r release properties, including probability, short-term plasticity, and vesicle pools.

72 ngstanding debate about a widespread form of short-term plasticity, and will enable future studies th

73 2/3) synapse in rodent somatosensory cortex, short-term plasticity appears to contradict the depletio

74 Here we show that, although a variety of short-term plasticities are normal, LTP at mossy fibre s

75 Several forms of short-term plasticity are caused largely by changes in t

76 in presynaptic release probability (Pr ) and short-term plasticity are intriguing features of cortica

77 est that alterations in presynaptic forms of short-term plasticity are linked to alterations in prepu

78 ngs suggest that basal synaptic strength and short-term plasticity are regulated at the level of rele

79 investigated whether specific mechanisms of short-term plasticity are regulated in a target-dependen

80 cs of different current components and their short-term plasticity are tuned to establish sound inten

81 Our results identify altered short-term plasticity as a neural substrate underlying t

82 surable change in basal synaptic strength or short-term plasticity as analyzed in cultured cortical n

83 evoked release, they differentially affected short-term plasticity as assessed by the paired-pulse ra

84 ncludes a dynamic functional connection with short-term plasticity as well as effects due to the rece

85 nstrating the dominant role of timing in the short-term plasticity as well as the immediate response

86 pocampus are distinctive for their prominent short-term plasticity, as studied in slices.

87 We show how the differential recruitment of short-term plasticity at breathing versus sniffing frequ

88 ed a method of quantitatively characterizing short-term plasticity at cortical synapses that permits

89 t ultrastructural abnormalities and impaired short-term plasticity at dentate gyrus-CA3 excitatory sy

90 functional properties as well as presynaptic short-term plasticity at mossy fiber synapses are unalte

91 ere a progressive derailment of both LTD and short-term plasticity at perirhinal synapses.

92 d a novel mechanism for target cell-specific short-term plasticity at Schaffer collateral synapses in

93 iring in dentate gyrus PV cells, and altered short-term plasticity at synapses on granule cells, as w

94 This property presumably reflects the ample short-term plasticity at the corticogeniculate synapse.

95 targeting and are accompanied by changes in short-term plasticity at the mossy fiber/CA3 circuit.

96 Here, we studied short-term plasticity at the reciprocal synapse between

97 els can account for the Ca(2+) dependence of short-term plasticity at these synapses.

98 le release processes summate to give rise to short-term plasticity at this synapse: (1) a basal, high

99 ere, we report that these receptors regulate short-term plasticity at two loci in the corticothalamic

100 reduced paired-pulse facilitation, a form of short term plasticity attributed to presynaptic mechanis

101 an enhanced synaptic strength and changes in short-term plasticity because of an increased glutamate

102 The model predicts that the differences in short-term plasticity between synapses onto CA1 pyramida

103 ein receptor (SNARE) proteins play a role in short-term plasticity, Botulinum toxins A, E, and F, wer

104 a stimulus train and does not contribute to short-term plasticity, but induces a steady-state, async

105 Cortical synapses exhibit several forms of short-term plasticity, but the contribution of this plas

106 excitatory synaptic transmission and effect short-term plasticity, but they do not directly regulate

107 gest that NCS-1 acts as a calcium sensor for short-term plasticity by facilitating neurotransmitter o

108 Hyperpolarization may effect a form of short-term plasticity by promoting recovery from sodium

109 lease of 0, 1 or multiple vesicles), P(RRV), short-term plasticity, calcium transients and the requis

110 hat interactions between multiple sources of short-term plasticity can account for the complex kineti

111 However, short-term plasticity causes synapses to act as temporal

112 Inhibitory short-term plasticity changes detected through paired-pu

113 supply to variable demand and thus influence short-term plasticity characteristics and synaptic funct

114 display unique time- and frequency-dependent short-term plasticity characteristics in response to spi

115 synaptic kainate receptors contribute to the short-term plasticity characteristics of mossy fiber syn

116 for how excitatory-inhibitory co-tuning and short-term plasticity collaborate in recurrent networks

117 ned this hypothesis by investigating whether short-term plasticity contributes to the temporal filter

118 The observed short-term plasticity could enable mitral cells to overc

119 However, the effects of short-term plasticity (depression and facilitation) are

120 locker CNQX, and displayed multiple forms of short-term plasticity (depression in approximately 70% t

121 Short-term plasticity differentially alters responses fr

122 Short-term plasticity differs at each connection.

123 Here we compared the short-term plasticity displayed by a neocortical and a h

124 cilitation, suggesting that any differential short-term plasticity does not reflect differences in th

125 At most synapses in the brain, short-term plasticity dynamically modulates synaptic str

126 Short-term plasticity endows synapses with nonlinear tra

127 itation and temporal summation, two forms of short-term plasticity essential for working memory.

128 Synaptic depression is a form of short-term plasticity exhibited by many synapses.

129 -to-release quanta, and distinct from faster short-term plasticity (f-STP).

130 All forms of short-term plasticity failed to significantly affect ong

131 Together, they determine short-term plasticity features that are superficially si

132 may thus be useful tools for characterizing short-term plasticity from multi-electrode spike recordi

133 proaches for estimating synaptic weights and short-term plasticity from pre- and postsynaptic spike o

134 ransporter as a master regulator of dopamine short-term plasticity, governing the balance between rel

135 on rapid timescales, but no suitable form of short-term plasticity has been identified that is both a

136 Although it is presynaptic, short-term plasticity has been shown at some synapses to

137 Thus short-term plasticity has real, important functional con

138 Target cell-specific differences in short-term plasticity have been attributed to difference

139 e smaller global Ca(2+) increases to produce short-term plasticity have remained elusive.

140 Some synapses show two forms of short-term plasticity, homosynaptic facilitation, and a

141 of both normal channel protein turnover and short-term plasticity, how is the balance of membrane co

142 riven by one instruction for learning causes short-term plasticity in a Purkinje cell's mossy fiber/p

143 of presynaptic terminals that can influence short-term plasticity in a stimulus-dependent manner.

144 in weaker synapses that are less capable of short-term plasticity in aged individuals, and therefore

145 Previous studies of short-term plasticity in central nervous systems synapse

146 le session of unilateral arm cycling induces short-term plasticity in corticospinal projections to th

147 abbits is divided into two opposing forms of short-term plasticity in different cell classes.

148 the maturation of synaptic transmission and short-term plasticity in endbulb synapses.

149 riments that elucidate how facilitation, and short-term plasticity in general, contributes to circuit

150 osensitivity, the discovery of long-term and short-term plasticity in hypoxic ventilatory regulation,

151 described "augmenting responses," a form of short-term plasticity in some thalamocortical pathways t

152 wo interconnected neurons exhibited enhanced short-term plasticity in terms of paired pulse ratio (PP

153 on itself exhibited a trend toward enhanced short-term plasticity in terms of PPR and Pr.

154 and altered basal synaptic transmission and short-term plasticity in the CA1 region of the hippocamp

155 Here we looked for the signature of short-term plasticity in the fine-timescale spiking rela

156 therefore play a critical role in regulating short-term plasticity in the olfactory system.

157 Here, we report evidence for short-term plasticity in the ventral division of the pul

158 putative monosynaptic interactions reflected short-term plasticity in their dynamic and predictable m

159 ) regulate glutamate release probability and short-term plasticity in various areas of the brain.

160 MKII promoter led to deficits in presynaptic short-term plasticity including paired-pulse facilitatio

161 rst discharge >14 Hz and showed considerable short-term plasticity, including paired-pulse depression

162 s miniature synaptic currents and eliminates short-term plasticity induced by nicotine.

163 t an unknown mechanism mediates this form of short-term plasticity induced by the VTA-to-NAc projecti

164 nt species and is considered to be a form of short-term plasticity inherent to the processing of sens

165 eedback pathway, the different components of short-term plasticity interacted to increase EPSC amplit

166 y projection neurons (SPNs), corticostriatal short-term plasticity, intrinsic physiological propertie

167 Synaptic short-term plasticity is a key regulator of neuronal com

168 Short-term plasticity is a pervasive feature of synapses

169 ar and tufted neurons, and that this form of short-term plasticity is attributable to a reduction of

170 Although short-term plasticity is believed to play a fundamental

171 ven the polarity, of that activity-dependent short-term plasticity is changed.

172 tion of synaptic vesicle fusion kinetics and short-term plasticity is critical for rapid encoding and

173 Short-term plasticity is frequency-dependent and compose

174 , indicating that the uniquely robust mf-CA3 short-term plasticity is KAR independent.

175 short-term changes in the state of synapses, short-term plasticity is often thought of as a mechanist

176 transmit a range of frequencies in spite of short-term plasticity is poorly understood.

177 Rather, short-term plasticity is strongly determined by mechanis

178 owever, paired-pulse facilitation, a form of short-term plasticity, is significantly decreased in BDN

179 the normal maturation of synaptic inhibitory short-term plasticity (iSTP) in the auditory cortex, and

180 entiation (PTP) is a widely observed form of short-term plasticity lasting for tens of seconds after

181 al synaptic functions such as phototriggered short-term plasticity, long-term potentiation, and neura

182 Short-term plasticity may contribute, therefore, to temp

183 Moreover, multiple forms of short-term plasticity may converge on a mechanism of rev

184 ibition (DSI) is an endocannabinoid-mediated short-term plasticity mechanism that couples postsynapti

185 Here, we report that sensitization, a short-term plasticity mechanism, solves this difficult c

186 euron subtypes and experimentally identified short-term plasticity mechanisms can implement response

187 In summary, our work suggests a role of short-term plasticity mechanisms in generating nonlinear

188 Such short-term plasticity might also contribute to spatio-te

189 ort-term plasticity and combine these with a short-term plasticity model and cumulative excitatory po

190 Analyses with constrained short-term plasticity models revealed faster SV priming

191 The molecular mechanisms of short-term plasticity observed during synaptic transmiss

192 rt-term plasticity, and heterogeneity in the short term plasticity of synapses onto interneurones.

193 The observed differential short-term plasticity of afferent inputs further offers

194 ed-pulse and tetanic depression, whereas the short-term plasticity of asynchronous release has not be

195 the properties and underlying mechanisms of short-term plasticity of asynchronous release.

196 We investigated the short-term plasticity of both the mitral-to-granule exci

197 These results suggest that short-term plasticity of cortical synapses could shape t

198 obability and axonal activity in determining short-term plasticity of dopamine release, using fast-sc

199 The strength, kinetics, and short-term plasticity of each input differed as did the

200 hus demonstrating spiking activity-dependent short-term plasticity of electrical synapses.

201 atory and inhibitory neuron and incorporated short-term plasticity of EPSPs and IPSPs and slow IPSPs.

202 Short-term plasticity of EPSPs with increasing frequency

203 We show that, in vivo, short-term plasticity of excitatory inputs to CA3 pyrami

204 (KO) of Rab3B does not alter the strength or short-term plasticity of excitatory or inhibitory synaps

205 GABAB receptors, modulate the amplitude and short-term plasticity of excitatory synapses, a result n

206 stimulation, we isolated and quantified the short-term plasticity of GABAergic lateral IPSCs (L-IPSC

207 Therefore, this short-term plasticity of GABAergic synaptic inputs is li

208 pyramidal cells and interneurones including short-term plasticity of inhibitory and excitatory synap

209 Short-term plasticity of L-IPSCs may thus influence the

210 amplitude, kinetics, voltage dependence and short-term plasticity of mossy fibre-mediated EPSCs.

211 Short-term plasticity of On- and Off-EPSPs, and its pote

212 rtex (V1) show pronounced adaptation-induced short-term plasticity of orientation tuning primarily at

213 he synchronization, temporal patterning, and short-term plasticity of spiking in projection neurons,

214 Surprisingly, the time course and short-term plasticity of synaptic signaling were nearly

215 Thus, short-term plasticity of the intracortical circuit can m

216 thermore, domain specific differences in the short-term plasticity of the postsynaptic response indic

217 ores the contributions to different forms of short-term plasticity of the readily releasable vesicle

218 , demonstrating that they are concerned with short-term plasticity of the synapse.

219 th differences in intrinsic excitability and short-term plasticity of their inputs.

220 Induction of LTP or LTD altered the short-term plasticity of transmission onto both pyramida

221 rticularly in the Ca(2+)-sensitivity and the short-term plasticity of vesicular release, whereas STX1

222 synthesis is required for long-term, but not short-term, plasticity of GABA release from type 1 canna

223 ptual framework for analyzing the effects of short-term plasticity on the I/E balance in disease mode

224 ges in the size of evoked synaptic currents, short-term plasticity, or apparent calcium dependence of

225 ad no effect on basal synaptic transmission, short-term plasticity, or LTP induced by several trains

226 distribution revealed strong constraints on short-term plasticity; particularly facilitation was dif

227 These processes most likely set the short-term plasticity pattern and reliability of the MOC

228 tracellular Ca(2+) requirement for a form of short-term plasticity, post-tetanic potentiation (PTP) a

229 A leading mechanism for a prevalent form of short-term plasticity, post-tetanic potentiation (PTP),

230 NMDAR) activation can trigger both long- and short-term plasticity, promote cell survival, and initia

231 ate of inhibitory inputs combined with their short-term plasticity properties, regardless of the actu

232 n transmission was accompanied by changes in short-term plasticity properties, which switched from fa

233 Subsequently, short-term plasticity quenches the run-away dynamics int

234 the reciprocal impact of different forms of short-term plasticity (reactivations) on a persistent fo

235 ic facilitation (SF) is a ubiquitous form of short-term plasticity, regulating synaptic dynamics on f

236 dependent manner, but the mechanisms of such short-term plasticity remain unknown.

237 nprimary auditory cortices, attention-driven short-term plasticity retunes neurons to segregate relev

238 red facilitation (PPF), which quantifies the short-term plasticity, reveal time constants (tau(1) = 2

239 In short-term plasticity, RIM1 accelerates the priming of s

240 ggest new mechanisms by which inhibition and short term plasticity shape neural responses.

241 significant role in three important forms of short-term plasticity: short-term depression, facilitati

242 adapting neurons connected by synapses with short-term plasticity, showing that the observed linear

243 ation that interacts with activity-dependent short-term plasticity so that the magnitude, and sometim

244 Short Term Plasticity (STP) has been shown to exist exte

245 ose-dependently (0.5-2 mg/kg, i.p.) impaired short-term plasticity (STP) and long-term potentiation (

246 ment is tightly controlled by the profile of short-term plasticity (STP) at granule cell (GC)-MLI syn

247 Presynaptic short-term plasticity (STP) dynamically modulates synapt

248 Studies of short-term plasticity (STP) in the hippocampus, performe

249 examine how long-term potentiation (LTP) and short-term plasticity (STP) interact in two different ce

250 This short-term plasticity (STP) is a key determinant of neur

251 SCs were smaller and frequency dependence of short-term plasticity (STP) less pronounced in bats.

252 y of the postsynaptic interneuron, while the short-term plasticity (STP) of inhibitory-to-excitatory

253 m the gating of specific pathways as well as short-term plasticity (STP) of the synapses, plays a dom

254 Short-term plasticity (STP) represents a key neuronal me

255 h the brain's synaptic plasticity, including short-term plasticity (STP), and long-term potentiation

256 napses display variable strength and diverse short-term plasticity (STP), even for a given type of co

257 ptic processes give rise to several forms of short-term plasticity (STP), which is believed to contro

258 this synapse reflects its functional role in short-term plasticity (STP).

259 the decrease in synaptic conductance through short-term plasticity (STP).

260 napses show large variations in strength and short-term plasticity (STP).

261 in high-frequency synaptic transmission and short-term plasticity (synaptic depression and potentiat

262 Key words : depression; facilitation; short-term plasticity; synaptotagmin 7.

263 measures to predict stable and varying (e.g. short-term plasticity) TBS response locations.

264 were modeled by incorporating mechanisms of short-term plasticity that are known to be driven by res

265 Here, we examine the mechanisms of short-term plasticity that can influence transmission at

266 nd the ready releasable pool-key elements of short-term plasticity that define the ability of synapse

267 Retinal sensitization is a form of short-term plasticity that elevates local sensitivity fo

268 urs in aging, negatively regulated a form of short-term plasticity that enhances synaptic throughput.

269 Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmissio

270 o medial olivocochlear (MOC) neurons exhibit short-term plasticity that is sensitive to calcium and t

271 Post-tetanic potentiation (PTP) is a form of short-term plasticity that lasts for tens of seconds fol

272 inner plexiform layer of the retina undergo short-term plasticity that may mediate different forms o

273 d here may represent a basic form of in vivo short-term plasticity that modifies neuronal function.

274 Facilitation is an important form of short-term plasticity that occurs in most synapses.

275 from incorporating nonlinear terms, such as short term plasticity, that provide theoretical advances

276 rachidonoylglycerol (2-AG)-dependent form of short-term plasticity, that is, depolarization-induced s

277 determines synaptic release probability and short-term plasticity, the facilitation or depression of

278 xhibit normal fast synaptic transmission and short term plasticity, they are severely impaired in in-

279 r control and an altered endocytosis affects short-term plasticity through quantal size changes.

280 n/secretion coupling, vesicle recycling, and short-term plasticity throughout the CNS.

281 Short-term plasticity thus favors the inhibition of Purk

282 The theory allows competing hypotheses of short-term plasticity to be tested and identifies the re

283 ase probability and consequential changes in short-term plasticity towards facilitation.

284 that glutamate release efficacy, but not its short-term plasticity, varies with time-dependent fluctu

285 modulate vagal brainstem circuits undergoes short-term plasticity via alterations in cAMP levels sub

286 Furthermore, short-term plasticity was disrupted in AC8-/- mice but n

287 In contrast, this form of short-term plasticity was not further enhanced in RIM1al

288 Short-term plasticity was unchanged at CF-PC synapses, s

289 possible mechanisms for these differences in short-term plasticity, we developed a mechanistic mathem

290 lus protocols that invoke different forms of short-term plasticity, we find differences in some but n

291 he experimental basis for a general model of short-term plasticity, we studied three synapses in rat

292 presynaptic proteins, and impaired synaptic short term plasticity were observed in hippocampal neuro

293 nal cortex were compared, and differences in short-term plasticity were identified.

294 These changes in short-term plasticity were mirrored by corresponding alt

295 by sustained high-frequency stimulation, and short-term plasticity were normal in Doc2b KO mice.

296 Moreover, reduced channel number affects short-term plasticity, which is rescued by increasing th

297 nother cell type tend to show characteristic short-term plasticity, which varies from facilitating to

298 This effect is accompanied by a change in short-term plasticity with decreased facilitation, decre

299 These results demonstrate the presence of short-term plasticity within spinal inhibitory circuits.

300 Short-term plasticity would allow rapid re-weighting tha