ライフサイエンスコーパス: shorten

1 not stem solely from kinetochore microtubule shortening.

2 ockwise, counter-clockwise), elongation, and shortening.

3 ted quiescence, which explains the life span shortening.

4 n of acquired, granulocyte-specific telomere shortening.

5 short QT syndrome), and E-4031 reverted APD shortening.

6 females) showed the slowest rate of telomere shortening.

7 emature senescence independently of telomere shortening.

8 in mouse hearts and a decrease in fractional shortening.

9 bility and levels through an effect on 3'UTR shortening.

10 omplete TPP1 KO cell lines, undergo telomere shortening.

11 premature transcription termination and mRNA shortening.

12 urprisingly modest action potential duration shortening.

13 iphosphate (ATP) is needed to fuel sarcomere shortening.

14 APA leading to 3' UTR shortening (3' US) is a common feature of most cancer ce

15 myocytes, ARDKO displayed reduced fractional shortening (~33%) and slower relaxation (~20%).

16 o constrain lumenal/extracellular domains or shortening a cytoplasmic loop abolishes transport activi

17 We have demonstrated that shortened action potential duration, slow conduction and

18 l, cyprodinil, and dimethomorph and observed shortened AGD in male pups after gestational exposure.

19 o-phenylphenol) were predicted to produce a shortened AGD in male pups, whereas two (lambda-cyhaloth

20 hyla, and is frequently associated with gene shortening akin to pseudogenization.

21 Poly(A) tail shortening, also termed deadenylation, is the rate-limit

22 ytes exhibit simultaneous pole-to-chromosome shortening (anaphase A) and pole-to-pole elongation (ana

23 des bind the tips of elongated nanofibers to shorten and narrow their length distributions.

24 function for exosc5 in zebrafish results in shortened and curved tails/bodies, reduced eye/head size

25 e exploratory routes at first, but gradually shortened and defined them as they matured, and they ret

26 The IBD Disk was developed, a shortened and self-administered tool, adapted from the I

27 ting pathways as the laser pulse duration is shortened and the laser intensity is increased.

28 al aging in wild-type mice leads to telomere shortening and a reduced proliferative potential of alve

29 nish Siah2-activity leading to primary cilia shortening and attenuation of the mitogenic response.

30 by whole-cell patch-clamp, and cardiomyocyte shortening and Ca(2+) transients with an Ionoptix system

31 ustrate how genetic mutations drive telomere shortening and dysfunction in these patients.

32 sed by preserved left ventricular fractional shortening and ejection fraction) even if increased card

33 s performed relatively less bending and more shortening and elongation as compared with other arm reg

34 s gene expression in the slow mutant: 3' UTR shortening and gene derepression by premature transcript

35 cardiac expression of only Tbx3, PR interval shortening and increased QRS duration.

36 systemic treatment with MVs prevented colon shortening and loss of crypt architecture.

37 gnificant reduction in both maximum fascicle shortening and maximum fascicle rotation on the paretic

38 We found PR interval shortening and prolonged QRS duration, as well as atriov

39 suggest a novel hydraulic mechanism of TBR: shortening and rotation of suprahyoid muscles compresses

40 he ciliary base; second, the ciliary axoneme shortens and motors slow down; and third, motors leave t

41 erially linked sarcomeres in muscle make the shortening (and the shortening speed) macroscopic, while

42 ing drug-induced inotropic effect (sarcomere shortening) and generating multi-parameter data to profi

43 s deformed, cell tentacles are significantly shortened, and cell migration is promoted.

44 m gestational exposures and manifesting as a shortened anogenital distance (AGD) in male rats.

45 ation that a blood culture is negative could shorten antibiotic courses.

46 ation of negative blood culture result would shorten antibiotic treatment.

47 Conversely, pretreatment with GS-967 shortened APD (mimicking short QT syndrome), and E-4031

48 ; however, isoproterenol (ISO) significantly shortened APD(80) in DBH-Sap but not control hearts, res

49 on enters the exponential phase reciprocally shortened as more hemin was bound to the insoluble matri

50 s lessened and mitotic microtubule length is shortened, as demonstrated by immunofluorescence stainin

51 d transcriptionally, conductive to sarcomere shortening assays.

52 ~30% decrease in cAMP content and fractional shortening associated with a mild cardiac hypertrophy th

53 found that one factor, Clp1, promotes 3'UTR shortening associated with higher transcript stability a

54 When shortening at a constant speed of 7 +/- 1 muscle lengths

55 his proof-of-concept study, percentage of T1 shortening at early enhanced T1 mapping showed high accu

56 s production, oxidative damage, and telomere shortening, at the individual and intergenerational leve

57 agnostic performance than late percentage T1 shortening (AUC, 0.97 vs 0.90, respectively; P = .03) an

58 eased cytoplasmic localization of TDP-43 and shortened axons.

59 rom this study, we successfully engineered a shortened benzylisoquinoline alkaloid pathway to produce

60 at this phenomenon is caused not by telomere shortening, but by cyclic GMP-AMP synthase (cGAS) recogn

61 ductions in ejection fraction and fractional shortening, but no evidence of heart failure.

62 the Raman spectrum and fluorescence lifetime shortened by 0.4 ns compared to uncalcified regions.

63 rsisted, the interval between injections was shortened by 2 weeks, to a minimum of 4 weeks.

64 ulated by the RIFTA, the total dwell time is shortened by a factor of two and the RMS in a 5 x 50 mm

65 the Omega Fe-C5' bond of tau ~ 5-6 s, likely shortened by enzymatic activation as is the case with th

66 syndrome type 2 myocytes revealed that GS967 shortened Ca(2+) transient duration via accelerating Na(

67 in microRNA (miRNA/miR)-146a succumb to life-shortening chronic inflammation.

68 The p.Arg293His CRY1 variant caused a shortened circadian period in a Cry1 (-/-) Cry2 (-/-) do

69 portion of patients had clearly prolonged or shortened CLTs.

70 of Wnts, caused misrotated sensory cells and shortened cochlea - both hallmarks of PCP defects.

71 e required for the standard FXM, potentially shortening cold ischemia time and providing clinicians w

72 fiber work done while the muscle fibers were shortening compared to rearfoot striking.

73 monary arterial hypertension (PAH) is a life-shortening condition.

74 lectively, our results suggest that telomere shortening could represent a mechanism that moderates th

75 Optimal early T1 shortening cut-off value and its diagnostic performance

76 ts as part of an individualized strategy for shortened DAPT duration following percutaneous coronary

77 alogram (EEG) total power, but significantly shortens delay to isoelectric EEG, which precedes respir

78 with multiple CH mutations; and (3) telomere shortening determined in granulocytes suggested ~20 year

79 ecting hole/electron conduction and severely shortening device lifetime.

80 However, shortening digestion time for the on-line approach of an

81 10 which disseminated feasible strategies to shorten door-to-needle times for thrombolytic therapy.

82 infection, supporting further evaluation of shortened-duration pan-genotypic therapy in this setting

83 ants grew faster but the fast-growing period shortened during the mid-growing season.

84 Progressive telomere shortening during lifespan is associated with restrictio

85 We propose that, upon telomere shortening, early apoptosis leads to cell depletion and

86 GBCA following the expected significant T(1) shortening effect, compromising the ability of MRF T(1)

87 A low endocardial fraction shortening (eFS) was present in 17% (9 of 52) of severe

88 Modelling of these findings reveals that a shortened EIP would result in a significant increase in

89 ersistent cohesion that occurs with telomere shortening ensures a measured approach to replicative se

90 ace ectoderm cells undergo proximal junction shortening, establishing a transitory semi-rosette-like

91 in order to improve outcomes and potentially shorten existing therapy will require identification of

92 While shortening expansion compromised cell yield, this method

93 ScPk shortened fermentation time by 24 h.

94 ese presynaptic dopaminergic neurons exhibit shortened flight bouts and a disinterest in seeking food

95 e To evaluate the value of early enhanced T1 shortening for the diagnosis of acute myocarditis.

96 icting in vivo anti-androgenicity (i.e., AGD shortening) for chemicals with in vitro activity and for

97 Ejection fraction (EF) and shortening fraction (SF) were recorded after each course

98 lization of the ECG abnormalities (their QTc shortened from 492+/-37 to 423+/-25 ms [P<0.001]; their

99 , in case the mRNA has been exonucleolyticly shortened from the 3' end by the exosome complex.

100 Color-coded maps of the percentage of T1 shortening from precontrast to early postcontrast were g

101 In this model, in vivo fractional shortening (FS) remained constant despite HW:BW ratio in

102 g compensated hypertrophy in vivo fractional shortening (FS) remains constant until heart failure (HF

103 s (ROS), mitochondrial dysfunction, telomere shortening, genomic instability, epigenetic changes, pro

104 itch ACLY in esophageal adenocarcinoma cells shortened glycerophospholipid chains, linking de novo li

105 iated with a number of mechanisms leading to shortened graft survival.

106 The shortened group 3 regimen induced comparable peak immune

107 nkeys to test the protective efficacy of the shortened group 3 regimen.

108 Early T1 shortening had better diagnostic performance than late p

109 tient intravenous antibiotic completion) and shortened hospital length of stay by 23.5 days.

110 tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies

111 ializations of extant cetaceans, including a shortened humerus, narrow peduncle, and loss of radial t

112 ctivity caused a ~50% decrease in fractional shortening, hypertrophy, dilatation, and premature death

113 aque monkeys, we tested the extrinsic muscle shortening hypothesis, which posits that shortening of t

114 Treatment duration was shortened in 11 of the 29 patients (38%).

115 al period for ocular dominance plasticity is shortened in NF1 mice due to its early closure but unalt

116 Telomere shortening in human cells leads to a DNA damage response

117 We modelled telomere shortening in human hippocampal progenitor cells in vitr

118 ary contractions, the StartReact response (a shortening in reaction time evoked by a startling stimul

119 ow the mean), there was a significant 5-year shortening in telomere length, whereas no significant re

120 l to imitate the functionality of commercial shortening in the baking industry.

121 completely blocked and reversed maladaptive shortening in the length of axon initial segments (AIS)

122 Force and shortening in the muscle sarcomere are due to myosin mot

123 ed of incompressible fluid, intrinsic muscle shortening increases tongue length and displaces the ton

124 stopping') at a rate of ~13 km/year, thereby shortening individual migration distance on an average b

125 tional procedure, change in drop regimen, or shortened interval follow-up) at the POD1 visit after un

126 recently extended interval, and 3 (7%) had a shortened interval.

127 ere are no concerning pancreas lesions, with shortened intervals and/or the performance of EUS in 6-1

128 Msi1-overexpressing mice had shortened intestines, diminished intestinal epithelial c

129 ures imply global transfer of impact-related shortening into transversal strain.

130 Telomere shortening is a hallmark of aging.

131 Telomere shortening is a presumed tumor suppressor pathway that i

132 a road block to cell proliferation, telomere shortening is currently viewed as a tumor suppressor mec

133 Strikingly, the transcript shortening is unrelated to cell proliferation, a feature

134 d, reducing its chromatin association, and a shortened isoform of Mst2 histone acetyltransferase is e

135 creasing [GABA] through GABA uptake blockade shortens it.

136 ss data and more surrogate measures, and has shortened its review times.

137 s towards vancomycin by 75%, and resulted in shortened lag-phase and increased colony formation at su

138 t may also benefit from less variability and shortened latencies at subsequent synapses.

139 windows of reduced response variability and shortened latency.

140 We show that 3'UTR shortening leads to transcripts with higher mRNA stabili

141 Despite having high comorbidity rates and shortened life expectancy, patients with ESKD may harbor

142 abolished by chronic high-Pi diet which also shortened life span in the BK/BK;kl/kl mice.

143 , i.e., tumor insensitivity to chemotherapy, shortens life expectancy of cancer patients.

144 eficiency in adult mice causes liver damage, shortens life span to 3 mo due to neurodegeneration, and

145 y, we find that accumulation of LDs does not shorten lifespan, but does protect aged cells against st

146 eport that miR-155 in T cells contributes to shortened lifespan of miR-146a(-/-) mice.

147 obesity is associated with comorbidities, a shortened lifespan, and a poorer quality of life, but ep

148 us and induced tumorigenesis, while they had shortened lifespan, but did not show progeria-like pheno

149 often result in lower limb amputations and a shortened lifespan.

150 ymptoms, including cognitive impairment, and shortened lifespan.

151 ty in adults, while neuronal DCP1 deficiency shortens lifespan and affects wing morphogenesis, cell n

152 ial ALDH2 and cytoplasmic ADH5, have greatly shortened lifespans and develop leukemia.

153 care innovation has encouraged hospitals to shorten LOS under financial pressures with uncertain imp

154 appaB-Ras accelerates tumour development and shortens median survival.

155 le sub-clinical phenotype involving markedly shortened metacarpophalangeal bones with intrafamilial v

156 The current study explored whether telomere shortening might have an influence on cognitive function

157 lifespan, and shields the organism from life-shortening mitochondrial stress in the face of continuou

158 Actin filaments elongate and shorten much faster at their barbed end than their point

159 Rationale: Cystic fibrosis (CF) is a life-shortening, multisystem hereditary disease caused by abn

160 ls undergo alterations that include telomere shortening, nuclear area enlargement, and genomic and mi

161 independently with clinically significant QT shortening of 2.80 milliseconds (95% CI: -3.17 to -2.42)

162 Early T1 shortening of 70% or greater identified acute myocarditi

163 evoked I(SK) in VMs from Shams, resulting in shortening of action potentials in VMs and ex vivo optic

164 Shortening of BGRDs is linked to derepression of transcr

165 alator into a chain capper, allowing dynamic shortening of chain length in the supramolecular aggrega

166 bonucleoprotein complex that counteracts the shortening of chromosome ends due to incomplete replicat

167 toluminescence weakening and reveal that the shortening of interparticle distance decreases photolumi

168 This shortening of latency and increased reproducibility may

169 on (postaxial polydactyly, narrow chest, and shortening of long bones), and enteric nervous system (a

170 lated cells and cancer cells have widespread shortening of mRNA 3'-untranslated regions (3'UTRs) and

171 the ventral cell center through the dynamic shortening of myosin IIA-associated actin stress fibers

172 rapid eye movement) sleep, demonstrated as a shortening of REM latency, an increase of REM density, a

173 nts with TERT-low/non-ALT tumors, continuous shortening of telomeres and decreasing viability occurre

174 process underlying aging is the progressive shortening of telomeres, the structures that protect the

175 thod whereby tumor cells escape the critical shortening of telomeres.

176 cardiomyocyte repolarization and physiologic shortening of the cardiac action potential.

177 ed expression of cell cycle proteins, and/or shortening of the G0/G1 cell cycle phase leading to cell

178 cle shortening hypothesis, which posits that shortening of the hyoglossus and styloglossus muscles pu

179 from XS to the DB anions XS(-), the unusual shortening of the internuclear Si...N distance is always

180 mptoms including small stature with proximal shortening of the limbs, contractures, facial dysmorphis

181 hysiological expression of the mutant causes shortening of the outer segments and photoreceptor death

182 urial glia using RNAi results in significant shortening of the ventral nerve cord, compression of the

183 tomy was performed in goldfish that severely shortened OKAN, but pOKR was acquired comparable to norm

184 stant generative period in wild plants and a shortened one in agricultural crops.

185 The planned 8-week treatment period could be shortened or extended if needed according to the timing

186 Shortened or prolonged PWD is associated with atrial fib

187 apacity, and thereby replication rates, thus shortening or lengthening S-phase, respectively.

188 ITGAV expression was correlated with a shortened overall-survival in the patients' group that u

189 etry and immunocytochemistry methods, and it shortens overall assay times (to 20 min) and lowers samp

190 educed susceptibility and duration of AF and shortened P-wave duration in Akita mice.

191 at W110(PD-L2) acts as an "elbow" that helps shorten PD-L2 engagement with PD-1 and therefore lower a

192 cleavage to all basic residues and produces shortened peptides that could improve the spatial resolu

193 fected tesidolumab PK and PD, resulting in a shortened period of full complement activity inhibition.

194 Rather, telomere shortening prevents the up-regulation and activation of

195 cilia assembly, increased cilia disassembly, shortened primary cilia, a retrograde IFT defect for IFT

196 oderm derivation is not impacted by telomere shortening, progressive telomere dysfunction impaired he

197 n our current study, we report that telomere shortening promotes cancer in a noncell autonomous manne

198 cs, TERRA is highly expressed, and telomeres shorten rapidly.

199 Earlier vitrectomy may shorten recovery times for MG.

200 ntly attenuated the DSS-induced colon length shortening, rectal bleeding, bodyweight loss, and diseas

201 The two shortened regimens elicited comparable antibody titres a

202 Such shortened regimens would be valuable to increase vaccine

203 tantial forces during microtubule growth and shortening requires a high activation energy barrier in

204 pendent increases and decreases in sarcomere shortening, respectively.

205 ower gear ratios, fibers rotated less during shortening resulting in smaller pinnation angles, a conf

206 ined the morphological effects of expressing shortened RH-RhoGEF DH/PH constructs of p115RhoGEF/ARHGE

207 Maximum fascicle shortening/rotation was significantly decreased in paret

208 text improved overall performance, similarly shortening RTs and enhancing N2pc amplitudes for all tar

209 ong the pronephric kidney, consistent with a shortened S1 segment.

210 The mutants showed shortened sarcomeres with no thick filaments and M-lines

211 of TT during diastolic stretch and systolic shortening serves to mix TT luminal content and assists

212 Mutants that shorten SFs cause disoriented BBs.

213 ody levels >=80 were associated with further shortened shedding and significantly shortened symptom d

214 a 69% (95% confidence interval [CI], 34-85%) shortened shedding duration (mean, 1.0 vs 3.2 days).

215 were associated with a 32% (95% CI, 13-47%) shortened shedding duration (mean, 3.9 vs 6.0 days).

216 Early T1 shortening showed high diagnostic performance (area unde

217 ime of the most abundant isomer, 1,2-IHN, is shortened significantly by a water-mediated process (lea

218 ially increased neurotransmitter release and shortened sleep duration, and these effects are nonaddit

219 meres in muscle make the shortening (and the shortening speed) macroscopic, while the intrinsic insta

220 ctahedral chains in anatase TiO(2) , thereby shortening staggered octahedron chains to form an amorph

221 acules, [2] axillary/inguinal freckling, [3] shortened stature, [4] tibial bone curvature, and [5] ne

222 show that mean serial intervals of COVID-19 shortened substantially from 7.8 to 2.6 days within a mo

223 Low SMI is associated with shortened survival in advanced cancer patients treated w

224 iltration in the tumor microenvironment, and shortened survival time in mice.

225 odel accelerated prostate carcinogenesis and shortened survival.

226 e tumors associated with distant metastasis, shortening survival.

227 further shortened shedding and significantly shortened symptom duration (influenza-like illness, 82%;

228 among adults they were also associated with shortened symptom duration.

229 e reactions can be more frequent, along with shortened symptoms onset time.

230 efforts to optimize antimicrobial dosing and shorten TB treatments(2).

231 ecapitulates TDP43 pathology by upregulating shortened TDP43 (sTDP43) splice isoforms.

232 While insufficient loading of TRF2 at shortened telomeres contributes to the DNA damage respon

233 Shortened telomeres recruit insufficient TRF1 and as a c

234 They exhibited shortened telomeres similar to nonregressing CLL, indica

235 e co-evolution of resistance mechanisms that shorten the clinical lifetime of any given class of anti

236 for which improved approaches are needed to shorten the course of treatment and to combat the emerge

237 mide chase assay revealed that EMD tended to shorten the half-life of c-Myc by approximately half.

238 To shorten the preparation time of the NMR sample, the foll

239 rtificial intelligence systems, is likely to shorten the reading time making SBCE even more effective

240 intering method by Joule heating effectively shorten the sintering time from several hours to <25 s,

241 The capability to significantly shorten the synthetic period of a broad spectrum of open

242 osing FDA approved drugs could significantly shorten the time and reduce the cost compared to de novo

243 l season and reduced evapotranspiration will shorten the water resources scarcity period for most mon

244 eep vein thrombosis, and pressure sores; and shortened the duration of mechanical ventilation, length

245 tic ablation of smooth muscle TRPC3 channels shortened the duration of SE by eliminating a secondary

246 Wyoming, United States, we show that drought shortened the duration of spring green-up by approximate

247 Birds gradually shortened the duration of the non-breeding period by adv

248 ination suppression events moved the PAB and shortened the pseudoautosomal region in haplorrhines.

249 THSG-revolutionized DPSCs significantly shortened the regenerative period of periodontal defects

250 ctDNA genotyping significantly shortened the screening duration (11 versus 33 days, P <

251 a personal glucose meter (blood glucometer), shortened the time of required sample incubation from 3

252 5.9%, intervention; RR 0.75 [0.32;1.77]) nor shortened the time to complete resolution of symptoms (1

253 e need for dilute MB injections, and thereby shortening the acquisition time of ULM imaging and showi

254 By simplifying the workflow and shortening the development cycle of NAATs, our platform

255 low-dose aspirin can be markedly improved by shortening the dosing interval to 12 hours, with no impr

256 r progression of stromal inflammation and in shortening the duration of herpes simplex stromal kerati

257 Further efforts will focus on shortening the extraction time, as 80 min is relatively

258 ent surges, and laboratories should consider shortening the incubation period from 5 days to 4 days,

259 Shortening the juvenile stage in citrus and inducing ear

260 ores otherwise inactive promoter activity by shortening the length of promoter non-optimal -35/-10 sp

261 Shortening the mini-linker did not affect the SNAP25-zDH

262 aracteristics might affect the potential for shortening the minimum duration of dual antiplatelet the

263 In addition to drastically shortening the reaction times, the use of microwaves res

264 yst and the computational environment, which shortens the analysis time and allows the analyst to exp

265 somal trafficking regulator gene (LYST) that shortens the corresponding protein by 603 amino acids an

266 cond non-infectious blood meal significantly shortens the EIP of ZIKV-infected Aedes aegypti by enhan

267 light-induced SMALL RNA DEGRADING NUCLEASE 1 shortens the half-life of several miRNAs in de-etiolated

268 lored, shows that the injection of electrons shortens the lifetime of the intermediate state O(640) f

269 on scattering in HKUST-1, which particularly shortens the lifetimes of low-frequency phonon modes.

270 ty accelerates the excitatory refinement and shortens the period of activity-dependent calcium signal

271 hB4 inhibition increases bone metastasis and shortens the time window to hind-limb locomotion deficit

272 urishing, one solution often suggested is to shorten their supply chains toward a regional rather tha

273 he light absorption of wood tar aerosols and shortens their absorption lifetime under daytime conditi

274 irect pathway projection neurons (dSPNs) but shorten them in striosomal dSPNs.

275 ing pregnancy, elicits widespread transcript shortening through APA in 3'UTRs and in introns.

276 s the side chains of certain ascarosides for shortening through beta-oxidation.

277 uvenile to the male phase and then gradually shortening throughout the transitional stages until its

278 NAC did not shorten time to ALT&100 U/L in participants with AT-DILI

279 These findings support efforts to shorten time to thrombolytic therapy.

280 TGLI1 activation is associated with a shortened time to develop BCBM and enriched in HER2-enri

281 olized physical rehabilitation significantly shortens time spent on mechanical ventilation and in ICU

282 w-nanomolar affinity, which subsequently was shortened to 19 residues with almost uncompromised affin

283 erials development and qualification must be shortened to realize future nuclear energy concepts.

284 sponses to negative stressful stimuli (here, shortened to stress response).

285 he immune response, reduce tissue damage and shorten treatment duration.

286 Clinicians and providers may consider shortening treatment intervals.

287 indications that increased growth rates may shorten trees' lifespan and thus recent increases in for

288 are required to test the suitability of the shortened vaccine regimens in humans.

289 Here, we report 14-nt 3' end-shortened variants of let-7a, miR-27a, and specific miR-

290 tance, but this benefit was offset by faster shortening velocity and poorer economy in late stance.

291 then calculated as the ratio of muscle belly shortening velocity to fascicle shortening velocity, and

292 tal relationships between force, length, and shortening velocity, and capture the extreme contractile

293 muscle belly shortening velocity to fascicle shortening velocity, and variable fascicle gearing was q

294 aminidase were associated with significantly shortened viral shedding, and among adults they were als

295 Median early T1 shortening was 75% (IQR, 72%-78%) in participants with A

296 lines in LV ejection fraction and fractional shortening were observed eight weeks post infection.

297 oreover, if each axon and dendrite strive to shorten while preserving connectivity, aggregate wiring

298 lining snow depths, rising air temperatures, shortening winters), spatially explicit assessments of s

299 genome instability, we propose that telomere shortening with age causes systemic chronic inflammation

300 Leukocyte telomere length (TL) shortens with age and is associated with coronary artery