ライフサイエンスコーパス: shortening

1 at-based carriers (coconut oil and vegetable shortening).

2 not stem solely from kinetochore microtubule shortening.

3 females) showed the slowest rate of telomere shortening.

4 emature senescence independently of telomere shortening.

5 in mouse hearts and a decrease in fractional shortening.

6 bility and levels through an effect on 3'UTR shortening.

7 omplete TPP1 KO cell lines, undergo telomere shortening.

8 was sufficient to cause pronounced life span shortening.

9 premature transcription termination and mRNA shortening.

10 en subsequently experiencing PTB or cervical shortening.

11 re repair complex cause accelerated telomere shortening.

12 seen on trans-vaginal ultrasound as cervical shortening.

13 ional telomeres, without detectable telomere shortening.

14 addition, the tel2 mutation caused telomere shortening.

15 ve oxygen species (ROS) accelerates telomere shortening.

16 ease in rescue frequency and the slowdown in shortening.

17 urprisingly modest action potential duration shortening.

18 ional adaptation to cancer ensues through TL shortening.

19 cancer cells leads to generational telomere shortening.

20 s that predict preterm birth and/or cervical shortening.

21 nced, resulting in action potential duration shortening.

22 iphosphate (ATP) is needed to fuel sarcomere shortening.

23 ockwise, counter-clockwise), elongation, and shortening.

24 ted quiescence, which explains the life span shortening.

25 n of acquired, granulocyte-specific telomere shortening.

26 short QT syndrome), and E-4031 reverted APD shortening.

27 ookies as a fully replacement for commercial shortenings.

28 umoxytol-labeled MASIs showed significant T2 shortening (22.2 msec +/- 3.2 vs 27.9 msec +/- 1.8; P <

29 proved left ventricular function (fractional shortening, 28.4% versus 18.8%; P=0.0114), reduced left

30 APA leading to 3' UTR shortening (3' US) is a common feature of most cancer ce

31 myocytes, ARDKO displayed reduced fractional shortening (~33%) and slower relaxation (~20%).

32 /- 4.1 ms at t = 15 s, P < 0.05) followed by shortening (46.5 +/- 9.1 ms at t = 60 s, P = NS vs. t =

33 o constrain lumenal/extracellular domains or shortening a cytoplasmic loop abolishes transport activi

34 n contrast to this prediction, we found that shortening a heterochromatic domain in Saccharomyces had

35 hyla, and is frequently associated with gene shortening akin to pseudogenization.

36 Poly(A) tail shortening, also termed deadenylation, is the rate-limit

37 ytes exhibit simultaneous pole-to-chromosome shortening (anaphase A) and pole-to-pole elongation (ana

38 al aging in wild-type mice leads to telomere shortening and a reduced proliferative potential of alve

39 nish Siah2-activity leading to primary cilia shortening and attenuation of the mitogenic response.

40 by whole-cell patch-clamp, and cardiomyocyte shortening and Ca(2+) transients with an Ionoptix system

41 tion of a subset of genes, which cause cilia shortening and centriole overduplication.

42 combination in G2, concomitant with telomere shortening and damage.

43 ustrate how genetic mutations drive telomere shortening and dysfunction in these patients.

44 sed by preserved left ventricular fractional shortening and ejection fraction) even if increased card

45 s performed relatively less bending and more shortening and elongation as compared with other arm reg

46 hair cells dysfunction, which manifests with shortening and fusion of inner hair cells stereocilia an

47 s gene expression in the slow mutant: 3' UTR shortening and gene derepression by premature transcript

48 cardiac expression of only Tbx3, PR interval shortening and increased QRS duration.

49 systemic treatment with MVs prevented colon shortening and loss of crypt architecture.

50 harmacological inhibition of NKAalpha led to shortening and loss of rod OSs.

51 causes NKAalpha downregulation, also causes shortening and loss of rod outer segments (OSs); the sym

52 Compromised NKAalpha function leads to shortening and loss of the photoreceptor outer segments

53 gnificant reduction in both maximum fascicle shortening and maximum fascicle rotation on the paretic

54 dilated cardiomyopathy, decreased fractional shortening and metabolic dysfunction involving reduced m

55 We found PR interval shortening and prolonged QRS duration, as well as atriov

56 ignant cells results in progressive telomere shortening and reduction in cell proliferation.

57 suggest a novel hydraulic mechanism of TBR: shortening and rotation of suprahyoid muscles compresses

58 cardiomyocyte contractility by reducing peak shortening and shortening/relengthening velocity, prolon

59 ts support the notion that critical telomere shortening and the consequent onset of telomeric DNA dam

60 ng of the Indian continental lithosphere and shortening and thickening of the Northern Tibetan lithos

61 ed in high-risk women who developed cervical shortening and who delivered prematurely and were predic

62 opriate telomeric structures drives telomere shortening and, in turn, genomic instability.

63 romising alternative to hydrogenated oils in shortenings and spreads formulations.

64 erially linked sarcomeres in muscle make the shortening (and the shortening speed) macroscopic, while

65 ing drug-induced inotropic effect (sarcomere shortening) and generating multi-parameter data to profi

66 ession is to induce oncogenes through 3'-UTR shortening, and to inactivate tumor suppressor genes via

67 variable degrees of tracheal stenosis and/or shortening, and/or pulmonary arterial sling anomaly.Obje

68 25 and 10 Ma, a rate consistent with crustal shortening as the dominant driver of surface uplift.

69 d transcriptionally, conductive to sarcomere shortening assays.

70 ~30% decrease in cAMP content and fractional shortening associated with a mild cardiac hypertrophy th

71 found that one factor, Clp1, promotes 3'UTR shortening associated with higher transcript stability a

72 ed at term, 14 preterm and 21 early cervical shortening at <20 weeks gestation.

73 When shortening at a constant speed of 7 +/- 1 muscle lengths

74 his proof-of-concept study, percentage of T1 shortening at early enhanced T1 mapping showed high accu

75 s production, oxidative damage, and telomere shortening, at the individual and intergenerational leve

76 y to predict PTB (AUC = 0.8725) and cervical shortening (AUC = 0.8514).

77 agnostic performance than late percentage T1 shortening (AUC, 0.97 vs 0.90, respectively; P = .03) an

78 t of sarcomeres, the basic contractile unit, shortening because of hydrolysis of adenosine triphospha

79 otein tau regulates the critical growing and shortening behaviors of MTs, and its normal activity is

80 at this phenomenon is caused not by telomere shortening, but by cyclic GMP-AMP synthase (cGAS) recogn

81 ductions in ejection fraction and fractional shortening, but no evidence of heart failure.

82 To determine whether telomere shortening can be a single parameter to predict species

83 meter, left ventricular mass, and fractional shortening), carotid-femoral pulse wave velocity, and ce

84 f the hallmarks of aging, including telomere shortening, cellular senescence, activation of PI3 kinas

85 re significantly effective at mitigating and shortening cholera outbreaks in Haiti.

86 in microRNA (miRNA/miR)-146a succumb to life-shortening chronic inflammation.

87 e required for the standard FXM, potentially shortening cold ischemia time and providing clinicians w

88 fiber work done while the muscle fibers were shortening compared to rearfoot striking.

89 the loss of RTEL1 results in rapid telomere shortening, concurrent loss of both RAD51 genes has no e

90 monary arterial hypertension (PAH) is a life-shortening condition.

91 lectively, our results suggest that telomere shortening could represent a mechanism that moderates th

92 Optimal early T1 shortening cut-off value and its diagnostic performance

93 with multiple CH mutations; and (3) telomere shortening determined in granulocytes suggested ~20 year

94 ecting hole/electron conduction and severely shortening device lifetime.

95 However, shortening digestion time for the on-line approach of an

96 e in response to stresses including telomere shortening, DNA damage, or oncogenic signaling.

97 son-to-person variation in age-dependent LTL shortening during adulthood to offset the wide interindi

98 Progressive telomere shortening during lifespan is associated with restrictio

99 We propose that, upon telomere shortening, early apoptosis leads to cell depletion and

100 GBCA following the expected significant T(1) shortening effect, compromising the ability of MRF T(1)

101 DCE) imaging, known for its significant T(1) shortening effect.

102 ionship between period and phase, and period shortening effects of lithium.

103 A low endocardial fraction shortening (eFS) was present in 17% (9 of 52) of severe

104 hs), as evidenced by decreases in fractional shortening, ejection fraction, and cardiac output.

105 ersistent cohesion that occurs with telomere shortening ensures a measured approach to replicative se

106 te closure in long bones, precipitating limb shortening, epiphyseal distortion, and widespread chondr

107 ace ectoderm cells undergo proximal junction shortening, establishing a transitory semi-rosette-like

108 While shortening expansion compromised cell yield, this method

109 e To evaluate the value of early enhanced T1 shortening for the diagnosis of acute myocarditis.

110 icting in vivo anti-androgenicity (i.e., AGD shortening) for chemicals with in vitro activity and for

111 Ejection fraction (EF) and shortening fraction (SF) were recorded after each course

112 tolic function (ejection fraction [EF], 60%; shortening fraction [SF], 32%), and conventional chemoth

113 Apnea-induced effective refractory period shortening from 110.20+/-31.3 ms to 90.6+/-29.1 ms ( P<0

114 Color-coded maps of the percentage of T1 shortening from precontrast to early postcontrast were g

115 ted that Cfz led to a significant fractional shortening (FS) depression in protocols 2 and 3, a borde

116 In this model, in vivo fractional shortening (FS) remained constant despite HW:BW ratio in

117 g compensated hypertrophy in vivo fractional shortening (FS) remains constant until heart failure (HF

118 s (ROS), mitochondrial dysfunction, telomere shortening, genomic instability, epigenetic changes, pro

119 Early T1 shortening had better diagnostic performance than late p

120 Telomere shortening has been associated with multiple age-related

121 scence, a process driven in part by telomere shortening, has been implicated in age-related tissue dy

122 c fibrosis (CF) remains the most common life-shortening hereditary disease in white populations, with

123 d subsidies could counteract this process by shortening hibernation.

124 ctivity caused a ~50% decrease in fractional shortening, hypertrophy, dilatation, and premature death

125 aque monkeys, we tested the extrinsic muscle shortening hypothesis, which posits that shortening of t

126 Telomere shortening in human cells leads to a DNA damage response

127 We modelled telomere shortening in human hippocampal progenitor cells in vitr

128 actions (MVCs), and the StartReact response (shortening in reaction time evoked by a startling stimul

129 ary contractions, the StartReact response (a shortening in reaction time evoked by a startling stimul

130 nd MVC values and positively correlated with shortening in reaction time.

131 cell division may be contributed to telomere shortening in SE.

132 de counterpart of 5-MeCITP leads to telomere shortening in telomerase-positive cancer cells, while re

133 ow the mean), there was a significant 5-year shortening in telomere length, whereas no significant re

134 l to imitate the functionality of commercial shortening in the baking industry.

135 completely blocked and reversed maladaptive shortening in the length of axon initial segments (AIS)

136 Force and shortening in the muscle sarcomere are due to myosin mot

137 n with conventional heating but it allowed a shortening in the retention times of several TGs in abou

138 first trimester can predict PTB and cervical shortening in women at risk of preterm delivery.

139 ed of incompressible fluid, intrinsic muscle shortening increases tongue length and displaces the ton

140 modulate gut microbiota and cause intestinal shortening, indicating a disruption of gut homeostasis.

141 stopping') at a rate of ~13 km/year, thereby shortening individual migration distance on an average b

142 In contrast, AP shortening induced by activators of two K(+) channels (M

143 Telomere shortening induces cellular senescence in proliferative

144 ures imply global transfer of impact-related shortening into transversal strain.

145 Telomere shortening is a hallmark of aging.

146 Therefore, we suggest that AP shortening is a potential intervention to avert developm

147 Telomere shortening is a presumed tumor suppressor pathway that i

148 Telomere shortening is associated with early mortality and chroni

149 This diffusion-based shortening is countered by viscous drag, leading to an u

150 a road block to cell proliferation, telomere shortening is currently viewed as a tumor suppressor mec

151 g due to musculus syringealis ventralis (VS) shortening is intrinsically constraint at maximally 12%

152 (APA)-mediated 3'-untranslated region (UTR) shortening is known to increase protein expression due t

153 Strikingly, the transcript shortening is unrelated to cell proliferation, a feature

154 However, shortening it by as little as two residues or making sub

155 We show that 3'UTR shortening leads to transcripts with higher mRNA stabili

156 care by reducing unnecessary antibiotic use, shortening length of hospital stay, improving influenza

157 ians were blinded to results unless cervical shortening less than 15 mm was identified.

158 The current study explored whether telomere shortening might have an influence on cognitive function

159 lifespan, and shields the organism from life-shortening mitochondrial stress in the face of continuou

160 ults in proximal polyadenylation site usage, shortening mRNA 3' untranslated regions (UTRs).

161 Rationale: Cystic fibrosis (CF) is a life-shortening, multisystem hereditary disease caused by abn

162 ociated with spontaneous PTB and/or cervical shortening (n = 16 term no short, n = 13 preterm, n = 24

163 ls undergo alterations that include telomere shortening, nuclear area enlargement, and genomic and mi

164 independently with clinically significant QT shortening of 2.80 milliseconds (95% CI: -3.17 to -2.42)

165 e, APA site-switching genes displayed global shortening of 3' untranslated regions with increased exp

166 Early T1 shortening of 70% or greater identified acute myocarditi

167 evoked I(SK) in VMs from Shams, resulting in shortening of action potentials in VMs and ex vivo optic

168 Developmental shortening of APs ensures I(Ca) as a tail current and fa

169 Shortening of BGRDs is linked to derepression of transcr

170 Ensuing shortening of bridges and accompanying juxtaposition of

171 Experimental shortening of cell-cycle duration via cyclin E overexpre

172 alator into a chain capper, allowing dynamic shortening of chain length in the supramolecular aggrega

173 bonucleoprotein complex that counteracts the shortening of chromosome ends due to incomplete replicat

174 viscoplasticity originates from progressive shortening of epidermal microfilaments that are induced

175 toluminescence weakening and reveal that the shortening of interparticle distance decreases photolumi

176 This shortening of latency and increased reproducibility may

177 The possible factors associated with the shortening of lead time between ocean warm water volume

178 on (postaxial polydactyly, narrow chest, and shortening of long bones), and enteric nervous system (a

179 lated cells and cancer cells have widespread shortening of mRNA 3'-untranslated regions (3'UTRs) and

180 the ventral cell center through the dynamic shortening of myosin IIA-associated actin stress fibers

181 on 5 of Grin1 alone partially attenuates the shortening of NMDAR-mediated excitatory postsynaptic cur

182 rapid eye movement) sleep, demonstrated as a shortening of REM latency, an increase of REM density, a

183 through contractile mechanisms that involve shortening of sarcomeres along myofibrils.

184 nian behavior and Lorentz contraction, i.e., shortening of solitons' characteristic length.

185 nts with TERT-low/non-ALT tumors, continuous shortening of telomeres and decreasing viability occurre

186 ons, during which time there was progressive shortening of telomeres, and obtained primary skin fibro

187 process underlying aging is the progressive shortening of telomeres, the structures that protect the

188 thod whereby tumor cells escape the critical shortening of telomeres.

189 anges were sufficient to induce this change: shortening of the beta3-alphaC loop and mutation of the

190 ng, the PAS domain contracts, resulting in a shortening of the C-terminal beta-strand.

191 cardiomyocyte repolarization and physiologic shortening of the cardiac action potential.

192 -molecule assays, we show that elongation or shortening of the coiled-coil stalk that connects the mo

193 of increase of their dipole moment with the shortening of the dative Si <- N contact.

194 bioaccessibility test features a significant shortening of the extraction time against the batch meth

195 ed expression of cell cycle proteins, and/or shortening of the G0/G1 cell cycle phase leading to cell

196 cle shortening hypothesis, which posits that shortening of the hyoglossus and styloglossus muscles pu

197 from XS to the DB anions XS(-), the unusual shortening of the internuclear Si...N distance is always

198 mptoms including small stature with proximal shortening of the limbs, contractures, facial dysmorphis

199 The systematic shortening of the noncovalent element of a C8-linked pyr

200 , especially the tip of the nose, indicating shortening of the nose and upturning of the nose tip.

201 hysiological expression of the mutant causes shortening of the outer segments and photoreceptor death

202 Shortening of the poly(A) tail, termed deadenylation, re

203 f age, echocardiographic parameters revealed shortening of the pulmonary artery acceleration time ass

204 An unusual shortening of the rhenium-Cp bond distances in 1.L relat

205 Conclusion: With a shortening of the time between surgery and adjuvant RITh

206 urial glia using RNAi results in significant shortening of the ventral nerve cord, compression of the

207 Kinesin-4-mediated shortening of these overlaps at the onset of cytokinesis

208 Although prolongation and then shortening of visual evoked potential (VEP) latencies in

209 The fascicle rotation per fascicle shortening on the paretic side was also significantly sm

210 ent in youths comes from studies of telomere shortening or advanced pubertal development following ci

211 apacity, and thereby replication rates, thus shortening or lengthening S-phase, respectively.

212 shape detailing for example the activation, shortening or passive re-lengthening have been linked to

213 at the tips of dendrite branches, leading to shortening or removal of dendrites.

214 Shortening or scrambling the IDRs in both subunits ablat

215 ted the correlation between diseases and the shortening (or lengthening) of 3' UTRs.

216 the membrane rescues the ventral nerve cord shortening, peripheral glial compression, and locomotor

217 of muscle responses to both lengthening and shortening perturbations.

218 L elongation was dominant in NSE, whereas TL shortening prevailed in SE.

219 Rather, telomere shortening prevents the up-regulation and activation of

220 oderm derivation is not impacted by telomere shortening, progressive telomere dysfunction impaired he

221 n our current study, we report that telomere shortening promotes cancer in a noncell autonomous manne

222 We found that the telomere shortening rate, but not the initial telomere length alo

223 This study aimed to examine LTL shortening rates and tracking in children and their pare

224 ntly attenuated the DSS-induced colon length shortening, rectal bleeding, bodyweight loss, and diseas

225 uli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (

226 on and direct microbial kill-based treatment shortening regimens for drug-susceptible and drug-resist

227 consistent dose across time, while vegetable shortening released oxazepam rapidly at the start of the

228 ontractility by reducing peak shortening and shortening/relengthening velocity, prolonging time to re

229 tantial forces during microtubule growth and shortening requires a high activation energy barrier in

230 at both cytokinin and ethylene-dependent RAM shortening requires ethylene binding to ETR1 and the HK

231 pendent increases and decreases in sarcomere shortening, respectively.

232 n states that enables microtubule growth and shortening, respectively?

233 ower gear ratios, fibers rotated less during shortening resulting in smaller pinnation angles, a conf

234 Maximum fascicle shortening/rotation was significantly decreased in paret

235 text improved overall performance, similarly shortening RTs and enhancing N2pc amplitudes for all tar

236 of TT during diastolic stretch and systolic shortening serves to mix TT luminal content and assists

237 Early T1 shortening showed high diagnostic performance (area unde

238 gar; by decreasing physical activity; and by shortening sleep.

239 By shortening solid-state diffusion times, the nanoscale si

240 meres in muscle make the shortening (and the shortening speed) macroscopic, while the intrinsic insta

241 ctahedral chains in anatase TiO(2) , thereby shortening staggered octahedron chains to form an amorph

242 In summary, AP shortening suppressed or completely eliminated both CaT

243 e tumors associated with distant metastasis, shortening survival.

244 those receiving steroid medication had less shortening than those not using steroids.

245 unction mitigating the decline of fractional shortening that is normally seen.

246 onse to cessation of anterograde IFT: a slow shortening that is steady over time and a rapid deciliat

247 e need for dilute MB injections, and thereby shortening the acquisition time of ULM imaging and showi

248 gation-purification procedure, significantly shortening the bacterial culture time.

249 I(Ks) channel (Kv7.1/KCNE1) is effective in shortening the cardiac action potential in human-induced

250 ificantly facilitated neural excitability by shortening the decay time of 5-HT(3)R currents, lowering

251 HT(3)R subunits, 5-HT(3B) is responsible for shortening the decay time of 5-HT(3)R-mediated currents.

252 By simplifying the workflow and shortening the development cycle of NAATs, our platform

253 low-dose aspirin can be markedly improved by shortening the dosing interval to 12 hours, with no impr

254 r progression of stromal inflammation and in shortening the duration of herpes simplex stromal kerati

255 ly granulocyte colony-stimulating factor) in shortening the duration of neutropenia, as well as with

256 gated planes when at a low dihedral angle by shortening the end-to-end distance of adjacent pai plane

257 Further efforts will focus on shortening the extraction time, as 80 min is relatively

258 Such a mechanism may occur simultaneously, shortening the HPR delay and complicating interpretation

259 ent surges, and laboratories should consider shortening the incubation period from 5 days to 4 days,

260 Shortening the juvenile stage in citrus and inducing ear

261 ing the KASH domains of ANC-1 and UNC-83, or shortening the KASH domain of ANC-1, both result in a nu

262 ores otherwise inactive promoter activity by shortening the length of promoter non-optimal -35/-10 sp

263 Shortening the mini-linker did not affect the SNAP25-zDH

264 aracteristics might affect the potential for shortening the minimum duration of dual antiplatelet the

265 The effects of shortening the noncovalent element of the molecule on tr

266 Although shortening the noncovalent interactive element of 13 had

267 idly decreasing the monomeric population and shortening the oligomeric phase.

268 rthropods during the early Cambrian, thereby shortening the phylogenetic fuse.

269 In addition to drastically shortening the reaction times, the use of microwaves res

270 disorders that result in premature telomere shortening, the concept that inhibiting telomerase might

271 faster, and adopted a 'checking strategy' by shortening their fixation durations at the obstacle.

272 Shortening this interval would increase the rate at whic

273 ing pregnancy, elicits widespread transcript shortening through APA in 3'UTRs and in introns.

274 s the side chains of certain ascarosides for shortening through beta-oxidation.

275 uvenile to the male phase and then gradually shortening throughout the transitional stages until its

276 Variance of the time from peak sarcomere shortening to 50% re-lengthening (RT(50) ) was assessed

277 Telomere shortening to a critical length can trigger aging and sh

278 ellipsoid and parallel to the cortex before shortening to a near-spherical shape with flattened pole

279 nhibition prevents action potential duration shortening to maintain values observed among sinus rhyth

280 y; conversely, the rabbit heart requires APD shortening to produce optimal inotropic responses.

281 fold faster recombination kinetics (lifetime shortening to ~10 ps).

282 y be capable of delivering further treatment shortening, to days rather than weeks, if combined with

283 rast, our results suggest that substantially shortening treatment courses with stereotactic body radi

284 Clinicians and providers may consider shortening treatment intervals.

285 ing transition from isometric contraction to shortening under low load.

286 e APA, we define the mRNAs subject to 3'-UTR shortening upon Nudt21 depletion in GBM cells and observ

287 tance, but this benefit was offset by faster shortening velocity and poorer economy in late stance.

288 then calculated as the ratio of muscle belly shortening velocity to fascicle shortening velocity, and

289 tal relationships between force, length, and shortening velocity, and capture the extreme contractile

290 muscle belly shortening velocity to fascicle shortening velocity, and variable fascicle gearing was q

291 cle fiber contraction, including duty ratio, shortening velocity, ATP economy, and load dependence of

292 riated muscle fiber types, including maximum shortening velocity.

293 ric force/cross-sectional area) and unloaded shortening velocity; (iii) myosin/actin ratio and myosin

294 Median early T1 shortening was 75% (IQR, 72%-78%) in participants with A

295 The children's rate of LTL shortening was twice that of their parents (40.7 +/- 2.5

296 lines in LV ejection fraction and fractional shortening were observed eight weeks post infection.

297 Telomere shortening, which is a biomarker of biological aging and

298 lining snow depths, rising air temperatures, shortening winters), spatially explicit assessments of s

299 genome instability, we propose that telomere shortening with age causes systemic chronic inflammation

300 ciated with left ventricular (LV) fractional shortening (z-score for difference = 1.07; p = 0.02) and