ライフサイエンスコーパス: shut

1 n and close while the nucleotide lid remains shut.

2 ion with a second photoreceptor protein Eyes Shut.

3 plex and SecA's polypeptide-binding clamp is shut.

4 that takes place while the channel is still shut.

5 C-linker, and twists the inner helical gate shut.

6 of alpha-kleisin from Smc3, thereby locking shut a "DNA exit gate." How Scc3 and Pds5, regulatory su

7 ) in PhuT H-bonds with a heme propionate, in ShuT a peptide loop partially takes up the space occupie

8 inning of the pandemic, as universities were shutting, a meme did the rounds on social media.

9 block is very fast and that the channel can shut almost as fast as normal when the blocker was bound

10 eliciting the change of conformation between shut and open states of the channel.

11 ure of the heme pocket is quite different in ShuT and PhuT.

12 at cadherin cell-cell junctions to keep them shut and to prevent myosin II-dependent contractility fr

13 , were required for the release of heme from ShuT and translocation to ShuS.

14 assium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of

15 tors whose ligand-binding clefts were locked shut by disulfide bridges engineered across lobes.

16 il increased the occupancy of the long-lived shut conformations, thereby reducing the open probabilit

17 they promptly inhibit neighbouring cells and shut down activity.

18 gonists and antiandrogens, cannot completely shut down AR signaling.

19 r ecosystem service of leguminous crops--was shut down at high nano-CeO(2) concentration.

20 Ethylene production is shut down at the level of 1-aminocyclopropane-1-carboxyl

21 ent-ionization (RESI) channel, are virtually shut down by mid-IR fields.

22 ar antigen and DNA, but the activity was not shut down by Pol delta in accord with rapid association/

23 ated in a system where cross-presentation is shut down by pretreatment with CpG.

24 pathogen, but then, the NKT cell response is shut down by two mechanisms; apoptotic contraction and m

25 ndfast sea ice produces enough resistance to shut down calving at the terminus.

26 rapy regimens, these xenograft breast tumors shut down classic estrogen signaling and activate altern

27 attenuates the TGFbeta signaling pathway to shut down clusterin expression, thereby stimulating angi

28 ed significant inhibition, and nitrification shut down completely with TBP addition.

29 isplatin activates ATR, CHK1 and WEE1, which shut down DNA replication and attenuate cisplatin induce

30 CME is shut down during early mitosis, but the mechanism of thi

31 Thus, L. pneumophila can shut down ER-mitochondria communication through cleavage

32 both on the non-recombining Y chromosome, to shut down expression of maladapted genes [3], and on the

33 t documents, but by 1967, it was effectively shut down following the refusal of journals to accept ar

34 methylation alone might not be sufficient to shut down gene expression.

35 Human adenoviruses (HAdVs) shut down host cellular cap-dependent mRNA translation w

36 ly, IL-10-producing neutrophils specifically shut down IL-17A production by Th17 CD4 cells, but not I

37 These Treg shut down IL10, gain potential to express IL17, and swit

38 echanism by which activated transcription is shut down in human cells.

39 at have opposite electronic polarizations to shut down intersystem crossing.

40 ings, national and international travel, and shut down large parts of the economy.

41 ovides a basis for eukaryotes to effectively shut down mature mRNA transport and thereby tailor prote

42 ling tubercle bacilli to restrict growth and shut down metabolism in a coordinated fashion.

43 translation in response to diverse stresses shut down most protein translation to conserve energy an

44 ith clinical preparedness, universities have shut down most scientific research activities.

45 in dendritic cells serving to simultaneously shut down multiple pathways of inflammation.

46 It forced most institutions to shut down nearly every aspect of their research and educ

47 of the tumor microenvironment including the shut down of angiogenesis and the induction of cellular

48 Stable shut down of miR-21, p47(phox) or STAT3 and overexpressi

49 tes that a fraction of tumour cells survives shut down of oncogenic signalling.

50 physiological changes occur that lead to the shut down of photosynthesis and a cessation of growth.

51 xicity syndrome includes the transcriptional shut down of PI3K expression.

52 he Drosophila model of aggression, the acute shut down of the entire serotonergic system yields flies

53 ly due to the across-the-board, non-specific shut down of transcription in a condition of growth arre

54 at later times postinfection, likely due to shut down of transgene expression, and indicating that t

55 s are driven toward the MS, and the field is shut down once the ions reach the vicinity of the MS inl

56 s X-linked genes in males [7], while mammals shut down one of the X chromosomes in females [8].

57 re activated intracellularly (PrfA 'ON') but shut down outside the host (PrfA 'OFF').

58 overy tool to find molecular mechanisms that shut down pain.

59 elay, while pyrylium-like ether terminations shut down proton exchange.

60 For example, it can be used to shut down radical pathways and to give access to aryl ca

61 Point mutations that disrupt the Y-Y dyad shut down radical transport.

62 w the replication of the virus to be quickly shut down should adverse effects be detected.

63 Wake-active wake-promoting neurons in turn shut down sleep-active neurons, thus forming a bipartite

64 Surprisingly, Aire could be shut down soon thereafter and remain off for long period

65 Many will shut down sooner.

66 expressed on activated T cells and serves to shut down T-cell activation, culminating in T-cell death

67 embly during DNA replication and the need to shut down the activating system under replication-stress

68 e V Acr proteins use enzymatic activities to shut down the Cas12a endonuclease, providing a multi-tur

69 While AG is known to shut down the expression of the stem cell maintenance ge

70 Here we show that SA can directly shut down the expression of the vir regulon.

71 This process may completely shut down the gated injection.

72 d with impurities and other methods that can shut down the hydrogenation reactions are highlighted in

73 The objective of HSCT is to immediately shut down the immune response and allow the transplanted

74 sor or valve during infection to temporarily shut down the lymph node to further antigenic challenge.

75 the N-RPS19 interaction is a novel target to shut down the N-mediated translation strategy and hence

76 ssion and glycolysis, and IFN-gamma addition shut down the oxidative metabolism in SYL-infected mphis

77 ker studies demonstrated the ability of 3 to shut down the PI3K/Akt pathway and induce apoptosis in c

78 ed task-related signals, but also completely shut down the spontaneous activity within the IO, which

79 ntegrated stress response is able to rapidly shut down the synthesis of proteins in eukaryotic cells.

80 ly directed cell migration, but they fail to shut down their protrusive behavior and undergo the norm

81 rine bone marrow-derived M2 macrophages also shut down their TIMP-1 expression and produced proMMP-9

82 g infection, HSV-1 has evolved mechanisms to shut down these responses to evade the proinflammatory c

83 hotochemical azide activation pathway can be shut down through coordination of the terminal azide lig

84 caused by an indirect mechanism: these cells shut down transcription in response to DNA damage, effec

85 Stressed cells shut down translation, release mRNA molecules from polys

86 tant Ndel1 lacking key phosphorylation sites shut down transport completely, as did a dominant-negati

87 How caspase activity is restrained and shut down under such nonapoptotic conditions remains unk

88 ntially cytotoxic proteins that specifically shut down various processes in the bacterial host, inclu

89 aureus colonization by producing a signal to shut down virulence.

90 This exchange process is completely shut down when [Cp2TiCH2CH(CD3)(SiMe3)](+) is used, sugg

91 D-19), some types of public spaces have been shut down while others remain open.

92 e conditions until the decarbonation factory shut down with the collision of Greater India with Asia

93 ectopic expression patterns and hence were "shut down" by the model.

94 stituent (R=tBu), this catalytic reaction is shut down, but the complex becomes active for aqueous el

95 metabolism of alternative carbon sources is shut down, due to catabolite repression.

96 Under these conditions, where motility is shut down, microarray experiments showed an increased RN

97 Once star formation has been shut down, perhaps during the quasar phase of rapid accr

98 d that during mitosis, when transcription is shut down, Runx2 selectively occupies target gene promot

99 that the Compound I (peroxidase) pathway is shut down, so that instead the reaction intermediate div

100 when the plant was operating to when it was shut down, the plant was found to contribute a large per

101 ellular stress, cap-dependent translation is shut down.

102 from chromatin rapidly once transcription is shut down.

103 , for the first time, that RTS-based control shuts down a dangerous short-circuit event 3 times earli

104 during embryonic development, but it usually shuts down after birth.

105 zation of azobenzene switching, while Cu(II) shuts down azobenzene isomerization.

106 ctivated during mitochondrial inhibition and shuts down biosynthetic processes to help conserve cellu

107 ular ischemia model in mice that selectively shuts down blood supply to the ipsilateral hippocampal f

108 f the enzyme and induces a loop closure that shuts down catalysis at the active site.

109 tion of a long-chain phospholipid completely shuts down electron transfer.

110 OP1 provides a regulatory feedback loop that shuts down excessive inflammatory responses and thereby

111 an erythrocyte, the developing erythroblast shuts down expression of most of its genes but preserves

112 S. Typhi of TviA, a regulatory protein that shuts down flagellin (FliC) expression when bacteria tra

113 This process shuts down general protein synthesis to conserve amino a

114 iation of a "switched" Th1 population, which shuts down IFN-gamma secretion and upregulates IL-10 and

115 findings will help explain how L. heterotoma shuts down its hosts' immunity and shed light on the mol

116 tions become unfavorable in early autumn, it shuts down its reproductive axis, increases its body wei

117 Galphas promotes maturation of endosomes and shuts down mitogenic MAPK-ERK1/2 signals from endosomes.

118 of the IDH mutation on intrinsic apoptosis, shuts down oxidative phosphorylation and reduces ATP lev

119 Thus, upon abrupt glucose depletion, yeast shuts down pathways consuming large amounts of energy, i

120 Moreover, viomycin shuts down proofreading-based error correction.

121 d stress response pathways in bacteria, RelE shuts down protein synthesis by cleaving mRNA within the

122 Increasing steric bulk around the Mn shuts down rapid homolytic H(2) evolution rendering the

123 motes NRP internalization, which effectively shuts down receptor-mediated signaling by a second ligan

124 Knock-down of either pathway shuts down SA biosynthesis and abrogates pathogen resist

125 NeuAc), added to the media of cultured cells shuts down sialylation by a mechanism involving its intr

126 d isomerization to the open merocyanine form shuts down the FRET process by efficient quenching of th

127 The use of base shuts down the isomerization pathway and allows for the

128 m the environmental occurrence of P3N, which shuts down the Krebs cycle by inactivating succinate deh

129 R (PKR), a versatile antiviral host factor, shuts down the translation machinery upon activation in

130 tiation of human dendritic cells effectively shuts down their immunogenic pathways and implicates tra

131 in eukaryotic mRNA decay that simultaneously shuts down translation initiation and activates mRNA deg

132 e autoregulation (RPAR) loop is critical for shutting down ATP-consuming active potassium uptake to c

133 romoting adipogenesis and lipogenesis and by shutting down catabolic processes such as lipolysis and

134 mediated cleavage of complement C3b, thereby shutting down complement activation.

135 The likely contaminant responsible for shutting down cross-presentation is peptidoglycan (PGN).

136 aining NuRD complex plays a critical role in shutting down expression of specific synaptogenesis-rela

137 ic (D/DMga4) is completely inactive in vivo, shutting down expression of the Mga regulon.

138 of the mutant phenotypes can be recovered by shutting down FAF1 expression through the administration

139 Our study also reveals a novel mechanism of shutting down gp96 post-translationally in regulating it

140 sport networks of small safe conduits and/or shutting down hydraulic function by dropping leaves duri

141 orylation at S344 of MtCCaMK is adequate for shutting down its activity, and is epistatic over previo

142 on through depleting client oncoproteins and shutting down multiple oncogenic pathways.

143 ion (EHT) is a dynamic process involving the shutting down of endothelial gene expression and switchi

144 ation genes, but rather is important for the shutting down of the pluripotency network in differentia

145 and rapidly moved to restore Pak1 levels by shutting down Pak1 shRNA expression through a methylatio

146 duced starvation response can be reverted by shutting down polyP synthesis genetically or pharmacolog

147 ere, we demonstrate that RFS-1/RIP-1 acts by shutting down RAD-51 dissociation from ssDNA.

148 rylation, VEGF, or VEGFR2 are ineffective in shutting down signaling to ERK1/2.

149 e homolog as a repair template is regulated, shutting down simultaneously for both CO and noncrossove

150 rations, favoring fast nutrient utilization, shutting down stress responses, and boosting growth.

151 ressing the formation of H3+ and effectively shutting down that mode of cooling.

152 t contribute to decreasing DC activation and shutting down the production of pathogenic IL-23.

153 for achieving an effective HTP, is twofold: shutting down the radically induced chain-growth additio

154 These results suggest that shutting down the residual activity of the limbic-arousa

155 ect of syndecan-mediated signaling either by shutting down this signaling pathway or by activating a

156 onally thought as a consequence of the brain shutting down to external inputs, it is now acknowledged

157 phenotype than Lis1 RNAi alone, essentially shutting down transport.

158 ming of the cold-induced FLC transcriptional shut-down and upregulation of FLC antisense transcripts,

159 eceptor promotes M2-polarization in order to shut-down deleterious immune responses and limit bystand

160 lcyclopropane and ethephon revealed that the shut-down mechanism in ethylene biosynthesis is developm

161 even under the harsh conditions of start-up, shut-down, and/or hydrogen starvation.

162 the active ES, correlated with transcription shut-down.

163 e, open probability (P(OPEN)), and mean open/shut duration.

164 desensitized state in which the ion channel shuts even though the neurotransmitter molecules remain

165 rst crystal structures of two such proteins, ShuT from Shigella dysenteriae and PhuT from Pseudomonas

166 increased even more sharply when the animal shut his eyes and disengaged completely from the task (5

167 Mutations in eyes shut homolog (EYS), a secreted extracellular matrix prot

168 re readings taken after the Macondo well was shut in for the well integrity test.

169 After the well was successfully capped and shut in on July 15, 2010, a variety of monitoring activi

170 that the Macondo Well was not leaking after shut in, and therefore, it could remain safely shut unti

171 ociated with the flow rate of the well, well shut in, killing the well, and determination of the loca

172 grity Team evaluated the geologic hazards of shutting in the Macondo Well at the seafloor and determi

173 irically from pressures measured during well shut-in and from pressures and flow rates measured the p

174 t plume depths for over six weeks after well shut-in and were likely caused by common marine heterotr

175 A hypothetical injection shut-in in April 2017 causes the earthquake probability

176 To investigate reactions during the shut-in period of hydraulic fracturing, experiments were

177 possibility that, under the anticipated high shut-in pressures, oil could leak out of the well casing

178 allation of the capping stack and subsequent shut-in.

179 and closing, the location and nature of the shut ion channel gate, the transitions between the close

180 ision based on the processed information and shuts itself down.

181 ATP/ADP binding to Kir6.2 shuts K(ATP).

182 mic binding proteins, demonstrates that PhuT/ShuT more closely resembles BtuF, which reflects the clo

183 totic fusion pores that can flicker open and shut multiple times.

184 When V. philippinarum were wired shut, octopuses switched techniques.

185 to active, phosphorylated GPCRs and thereby shut off 'classical' signalling to G proteins, trigger i

186 uption to enhance NMJ stability, and is then shut off allowing NMJ disassembly during persistent cyto

187 econd, signalling activities display a rapid shut off and a slower adaptation during which responsive

188 ation and rapidly declining when the origins shut off and neighboring promoters turn on.

189 activated cells, host DNA synthesis is then shut off and replaced with virus DNA synthesis.

190 eraction and subvert the immune response are shut off at intermediate levels of CodY activity, while

191 While normal B cells promptly shut off BCL6 when they exit the GC, many GC-derived B-c

192 l of GRK1 accelerated the dim flash response shut off but had no effect on the saturated response shu

193 shed the acceleration of saturated responses shut off during light adaptation.

194 LF delayed the time taken for these genes to shut off during recovery from heat shock.

195 adults with COPD and all persistent strains shut off expression during persistence.

196 Failure to shut off histone expression disrupts centromeric chromat

197 d 3C(pro), to process their polyproteins and shut off host cell activities detrimental to virus repli

198 We also show that the viruses fail to shut off host cell polypeptide production.

199 rods and the acceleration of their response shut off in background light.

200 ve cytokines, although IL-17A production was shut off in the course of the infection.

201 levels of OTUD1 inhibit cancer stemness and shut off metastasis.

202 ld is predicted to decrease with time and to shut off naturally when the Moon recedes far enough from

203 it can compensate for radiative cooling and shut off precipitation.

204 tion; however, the mechanisms of PAR1 signal shut off still remain unclear.

205 The liver, skin, and tail fibroblasts shut off tadpole genes and activate frog genes in the sa

206 To enter into mitosis, cells must shut off the cell cycle inhibitor Wee1.

207 lizes kinetochore-microtubule attachments to shut off the spindle checkpoint, suggesting that cells r

208 tly induced upon viral infection and rapidly shut off thereafter.

209 olved mechanisms to rapidly and specifically shut off these beneficial inflammatory activities before

210 lation of a strong cytotoxic drug completely shut off this unwanted immune response.

211 n the intestine, and environmental stressors shut off TRA-1 expression in the entire non-gonadal soma

212 impaired the cell's ability to appropriately shut off transcription of the induced ARG1 gene, indicat

213 cellular compartments where it is unable to shut off translation and repress viral replication.

214 ed these processes but subsequently acted to shut off viral gene expression and replication after the

215 age of a temperature-sensitive polymerase to shut off viral transcription, and we demonstrate that SI

216 expression had been induced and subsequently shut off were able to persist in vivo and reinitiate leu

217 ermits NO signalling, and this signalling is shut off when Hb alpha is reduced to the Fe(2+) state by

218 receptors bind ethylene, their signaling is shut off, activating responses.

219 During mitosis, transcription is shut off, chromatin condenses, and most transcription fa

220 entual promoter eviction and transcriptional shut off.

221 but had no effect on the saturated response shut off.

222 ng infection, when host protein synthesis is shut off.

223 al mRNAs culminating in host transcriptional shut off.

224 in no longer is required and the gene can be shut off.

225 ranscription after active P-TEFb function is shut off.

226 ntraction coupling, and ideally this release shuts off completely between heartbeats.

227 s of a hormone-coupled molecular switch that shuts off earlier developmental programs to allow for la

228 Influenza A virus (IAV) infection shuts off host cell gene expression at transcriptional a

229 protein of encephalomyocarditis virus (EMCV) shuts off host cell nucleocytoplasmic trafficking (NCT)

230 )-linked polyubiquitination of MAVS and thus shuts off innate antiviral immune response.

231 mediated conformational switch of HK853 that shuts off its phosphatase activity under acidic conditio

232 This defect shuts off miR-198 expression in favor of sustained FSTL1

233 transport of Li ions, while the Li-based SEI shuts off Na-ion transport.

234 EPEC barely elicits cytokine production and shuts off nuclear translocation of NF-kappaB p65.

235 g Glc addition in the light, C. zofingiensis shuts off photosynthesis within days and accumulates lar

236 cking general-base capability in this pocket shuts off rescue.

237 AML1-ETO quickly shuts off scl expression, and restoration of scl express

238 pathway deregulates mitochondrial dynamics, shuts off subcellular organelle movements, and prevents

239 The cold upper atmosphere shuts off the anticipated enhanced-Jeans, hydrodynamic-l

240 d a cell autonomous program that temporarily shuts off the insulin gene.

241 the AAA ATPases in the 19 S regulatory cap, shuts off the proteasome through the inhibition of ATPas

242 locking the activity of its phosphatase that shuts off those signals.

243 al trafficking to the cortical cytoskeleton, shuts off tumor cell migration and invasion, and inhibit

244 or pharmacological targeting of this pathway shuts off tumor cell motility and invasion, kills Myc-ex

245 ontrol loop model that is proposed to aid in shutting off ABA signal transduction, to counteract leak

246 Vesicle motion is in turn impeded by shutting off axonal actin polymerization, mediated by ni

247 In addition to its role in shutting off cap-dependent host mRNA translation, L(pro)

248 ter anomaly was carried to the Labrador Sea, shutting off deep convection.

249 n of type I IFNs and IFN-stimulated genes by shutting off host cell macromolecular synthesis, which i

250 tical to control the differentiation program shutting off the c-Myc gene in large pre-B cells.

251 accelerating turnover of Mre11 at DNA ends, shutting off the DNA damage checkpoint and allowing cell

252 ding, NADP(+) bends and interacts with D317, shutting off the entrance to create a protected micro-en

253 e and high quality printing while completely shutting off the nonilluminated counterparts.

254 cell division and the processes involved in shutting off YneA activity.

255 to neuronal cell death, indicating that the shut-off aerobic glycolysis is essential for neuronal su

256 of chromosomal intertwines, transcriptional shut-off and complete segregation of chromosomes.

257 roarray analysis revealed host transcription shut-off and identified three temporal classes of phage

258 hosphate-responsive element-binding protein) shut-off and nuclear accumulation of class IIa histone d

259 ng the interaction between protein synthesis shut-off and virus control in chickens.

260 n accumulation can be cleared after promoter shut-off by a combination of autophagy and vacuolar prot

261 ha-P dephosphorylation, assessed by a kinase shut-off experiment, progressed normally in Sephin1-trea

262 emonstrate that RNase L drives translational shut-off in response to dsRNA by promoting widespread tu

263 To prevent toxic accumulation, rapid shut-off mechanisms are required.

264 ation factor (eIF)-2 complex, resulting in a shut-off of general translation, induction of apoptosis,

265 deficient states, resulting in translational shut-off of global hepatic protein synthesis, including

266 Coliphage N4 infection leads to shut-off of host DNA replication without inhibition of h

267 pressed by serine withdrawal, which leads to shut-off of SRG1 synthesis.

268 ing that inhibition of NMD induces premature shut-off of TCR-beta rearrangement.

269 eting function, sigma(X) mediates the timely shut-off of the pneumococcal competence cycle, preservin

270 eformed replicase, thereby resulting in slow shut-off of viral RNA synthesis.

271 nct residues as the activator as well as the shut-off signal of Wnt/beta-catenin signaling and (ii) s

272 Of 177 selected conditional shut-off strains tested, the virulence of 102 was blocke

273 We propose a so-called shut-off strategy that aims at inhibiting key inflammato

274 nts via interaction with RecA and competence shut-off via interaction with ComE, avoiding physiologic

275 thogen and a paradigm for virus-induced host shut-off.

276 prA interaction with ComE altered competence shut-off.

277 l a specific stimulus commands a coordinated shut-off.

278 We found that after 1 or 3 weeks of shutting-off hAPP expression, the glomerular circuit was

279 cooperate with host immunity in an effort to shut out pathogens.

280 the glycine receptor-and find that the open-shut reaction is similar for both full and partial agoni

281 Site-directed mutagenesis of ShuT residues proposed to be required for stabilization

282 erall yield from dimedone using an "open and shut" (ring-opening and ring-closing) strategy.

283 d antigenicity analyses show we successfully shut S in the closed state without otherwise altering it

284 fect acoustic insulation provided by a fully shut single-glazed window in ideal conditions.

285 echanisms with three binding sites and extra shut states could describe the observations.

286 that contain more than the minimum number of shut states, either as desensitized distal states (Jones

287 ngs show only whether the channel is open or shut: states of equal conductance are aggregated, so tra

288 ption of this short-helix crippled PDLIM2 in shutting Tax to the nuclear matrix for ubiquitination-me

289 A new study indicates that repressors can 'shut the door' to newly initiating polymerases, allowing

290 ormal range of extracellular pH, pH 7.4-7.3, shut the pore by a conformational transition referred as

291 Shutting the window is usually the last resort in mitiga

292 rtunities for ligand interaction and then to shut them down as ligands become isolated on distinct sc

293 vigilante groups, and hackers, who sometimes shut them down with cybernetic attacks.

294 ifenprodil selectively affected the area of shut time constants, but not the time constants themselv

295 UBP684 produced a dramatic reduction in long shut times and a robust increase in mean open time.

296 ly longer (~160-800-fold, respectively), and shut times are shorter (~8-fold) when activated by 4BP-T

297 f heme from the periplasmic binding protein, ShuT, to the cytoplasmic binding protein, ShuS, are coup

298 ut in, and therefore, it could remain safely shut until reservoir pressures were suppressed (killed)

299 Nucleocytoplasmic shutting was determined by heterokaryon analyses.

300 A comparison of PhuT/ShuT with the vitamin B(12)-binding protein BtuF and the