ライフサイエンスコーパス: sialomucin

1 and podocalyxin comprise the CD34 family of sialomucins.

2 es a sulfated oligosaccharide carried by the sialomucins.

3 m selective metastasis of cells that produce sialomucins.

4 decrease in cell surface 9-O-acetylation of sialomucins.

5 des, O-linked chains carried on cell surface sialomucins.

6 gs to the CD34-family of highly glycosylated sialomucins.

7 The C2-O-sLe(X) motif occurs primarily on sialomucins and has been directly shown to contribute to

8 Thus, 9-O-acetylation on these sialomucins appears to be primarily regulated by the rat

9 Densely glycosylated sialomucins are the primary carriers of these glycans, i

10 mmune checkpoint receptor, selectively binds sialomucins as biological ligands, whereas the related r

11 rodimeric glycoprotein complex composed of a sialomucin ascites sialoglycoprotein (ASGP)-1 and a tran

12 ed expression of cell surface 9-O-acetylated sialomucins (but not the 9-O-acetylated ganglioside).

13 digestion with a glycoprotease that digests sialomucins, but no adhesion to cells that express selec

14 clonal antibody MECA-79 reacts with the PNAd sialomucins by recognizing an N-acetylglucosamine (GlcNA

15 These ligands consist of a complex of sialomucins, candidates for which are glycosylation- dep

16 Finally, we identify the sialomucin CD164, as a reliable marker for the earliest

17 The sialomucin CD34 is expressed on human and mouse hematopo

18 One such stem cell-associated antigen is the sialomucin CD34, a highly O-glycosylated cell surface gl

19 and demonstrated increased expression of the sialomucins CD34 and ENCM, which were also observed at t

20 reported that MAb L11, against the leukocyte sialomucin CD43, blocks T-lymphocyte binding to lymph no

21 Muc4/Sialomucin complex (SMC) acts as an intramembrane ligand

22 Overexpression of the membrane mucin MUC4/Sialomucin complex (SMC) has been observed during malign

23 Muc4/sialomucin complex (SMC) is a heterodimeric glycoprotein

24 Sialomucin complex (SMC) is a large heterodimeric glycop

25 Sialomucin complex (SMC) is a large, heterodimeric glyco

26 Muc4/sialomucin complex (SMC) is a multifunctional glycoprote

27 mucin is considered as the homologue of rat sialomucin complex (SMC, rat Muc4) due to its similar st

28 Sialomucin complex (SMC, rat Muc4) is a heterodimeric gl

29 Sialomucin complex (SMC, rat Muc4) is a heterodimeric gl

30 Sialomucin complex (SMC, Rat Muc4) is a heterodimeric gl

31 Sialomucin complex (SMC, rat Muc4) is a membrane mucin i

32 munofluorescence staining was used to detect sialomucin complex in frozen sections and impression cyt

33 rmal growth factor, induce the expression of sialomucin complex in mammary epithelial cells.

34 These combined results indicate that sialomucin complex is a unique secreted product in the m

35 Because sialomucin complex is also present in the ocular tear fi

36 Sialomucin complex joins MUC1 as another membrane mucin

37 ent epitope on the mucin subunit (ASGP-1) of sialomucin complex occurs in a differentiation-dependent

38 n blot analysis assays were used to identify sialomucin complex RNA in ocular surface epithelia.

39 for carbohydrate and peptide epitopes on the sialomucin complex subunits.

40 Sialomucin complex transcripts were also detected in the

41 Sialomucin complex was immunoprecipitated from tear flui

42 Sialomucin complex was originally identified in rat mamm

43 Northern blot analyses were used to identify sialomucin complex/Muc4 (SMC/Muc4) mRNA in rat lacrimal

44 d peripheral node addressin (PNAd), a set of sialomucins displayed on high endothelial venules (HEVs)

45 nsin-180 contains 17 leucine-rich repeats, a sialomucin domain, an apparent transmembrane domain, and

46 re with the other family members including a sialomucin domain, but also possesses an extremely acidi

47 The sialomucin endolyn is a transmembrane protein with a uni

48 The sialomucin endolyn is implicated in adhesion, migration,

49 In this report, we show that CD43, a sialomucin expressed constitutively on T cells, can also

50 selectin glycoprotein ligand 1 (PSGL-1) is a sialomucin expressed on leukocytes that mediates neutrop

51 in ligand-1 (PSGL-1), a heavily glycosylated sialomucin expressed on most leukocytes, has dual functi

52 cantly increased levels of mRNA for CD164, a sialomucin found on human CD34+ hematopoietic stem cells

53 We show that purified neutrophil PSGL-1, a sialomucin glycoprotein that serves as a ligand for both

54 The L11 antigen is CD43, a sialomucin implicated in vitro in regulation of lymphocy

55 Antibodies to CD49f and PODXL, a sialomucin in the CD34 family, were the most robust for

56 heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inf

57 to cells that express selectins that bind to sialomucin ligands could be detected.

58 teractions mediated by L-selectin binding to sialomucin ligands in high endothelial venules (HEVs).

59 ectin expressed on lymphocytes with sulfated sialomucin ligands such as CD34 and GlyCAM-1 on high end

60 We hypothesized that podoplanin, a sialomucin-like glycoprotein, increases the risk of VTE

61 mediated by binding of L-selectin to unknown sialomucin-like glycoproteins.

62 Both GD3.5 Ag and WC1 appeared to be sialomucin-like molecules that share similar O-sialoglyc

63 , indicating that it belongs to the class of sialomucin-like proteins.

64 ion into lymphoid tissues through binding to sialomucin-like receptors on the surface of high endothe

65 ll incompletely defined, they share a common sialomucin-like structure which is thought to present cl

66 P-selectin glycoprotein ligand-1 (PSGL-1), a sialomucin on human leukocytes, mediates rolling of leuk

67 nitor cells (HSPCs) express platelet-binding sialomucin P-selectin (CD162) and integrin Mac-1 (CD11b-

68 y and confirmed recently that podocalyxin, a sialomucin, plays a major role in maintaining the urinar

69 Endoglycan, a sialomucin, plays a role in axon guidance in the central

70 The glycocalyx component and sialomucin podocalyxin (PODXL) is required for normal ti

71 m that results in expression of glycosylated sialomucin proteins and the vesicle tethering and fusion

72 ning of neutrophils was diminished following sialomucin removal by O-glycoprotease, and its reactivit

73 differentiation of cultured myoblasts, (ii) sialomucins represent a class of potential effectors of

74 calyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and seque

75 an endopeptidase that selectively degrades O-sialomucins such as PSGL-1, abolished P-selectin but not

76 ) in total acidic mucins and in the ratio of sialomucin:sulfomucin (P = 0.0001).

77 D164 encodes a widely expressed cell surface sialomucin that has been implicated in regulation of cel

78 odocalyxin is an anti-adhesive transmembrane sialomucin that has been implicated in the development o

79 lyxin-like protein (PCLP) is a transmembrane sialomucin that is similar in structure to the well-char

80 CD164 is a cell surface sialomucin that is targeted to endosomes and lysosomes v

81 L-selectin on lymphocytes and PNAd, a set of sialomucins that are constitutively displayed on high en

82 se-dependent expression of this CD34-related sialomucin was discovered in Kit(+)CD71(high) proerythro

83 D34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues inc

84 Furthermore, we show that GD3.5 and WC1 are sialomucins, which provides important clues to their fun

85 hepatic endothelial cells, and inhibition of sialomucin with antisense to the MUC2 gene inhibited adh