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1 l (RBC) surface receptors, many of which are sialylated.
2 retained the ability to bind fH when LOS was sialylated.
3 f polylactosamine alpha chains that could be sialylated.
4 s lipooligosaccharides (LOS) that are highly sialylated.
5 ave been reported to be complex and multiply sialylated.
6 clinical biomarkers but should also embrace sialylated Abeta standards to reveal specific sialylatio
7 anation for these findings is that levels of sialylated airway ligands for Siglec-F might be diminish
9 rmines that it binds to one or more alpha2,3-sialylated and alpha1,3-fucosylated glycan receptors tha
10 d glycine residues to interact with alpha2,3-sialylated and alpha1,3-fucosylated glycan receptors, in
12 udies, we obtained insights into the role of sialylated and fucosylated glycans in zebrafish hematopo
13 ological staining revealed that IAV binds to sialylated and non-sialylated glycans and binding is not
15 ity to detect labile glycans such as heavily sialylated and polysialic acid N-glycans, which are diff
16 ine specificity of Siglec-8 toward different sialylated and sulfated carbohydrate ligands and determi
22 s related to its glycosylation consisting of sialylated and unsialylated Tn-antigens and core 1 and c
23 ed, showing a range of 26 neutral, sulfated, sialylated, and both sulfated and sialylated core 1 (Gal
24 ence of various fucosylated, phosphorylated, sialylated, and multiply sulfated moieties as modificati
25 ctive species of Panx3, likely glycosylated, sialylated, and phosphorylated, was highly expressed in
26 structural variants, including high mannose, sialylated, and terminal galactosylated species were stu
29 onstrating that immune complexes composed of sialylated antihemagglutinin antibodies and seasonal ina
31 ents were enriched in SAA, LBP, ApoC-III, di-sialylated ApoC-III (ApoC-III2) and desialylated A2HSG.
32 an also be engaged by two potentially lethal sialylated bacterial pathogens of newborns and infants,
33 of 20 different saccharide compositions with sialylated bi-, tri-, and tetra-antennary structures.
36 een the TGN and the plasma membrane, was not sialylated by a sialyltransferase at the TGN and that th
37 e may explain the increased pathogenicity of sialylated C. jejuni and may be key to the initiation of
44 n of increased surface expression of several sialylated cell adhesion molecules, including the known
45 rties in vivo Sialidase treatment of heavily sialylated CHO-sKlotho increased its co-receptor activit
47 catalysis and the rituximab glycoform with a sialylated complex-type biantennary glycan terminated wi
48 P1 of HPyV6 and HPyV7 does not interact with sialylated compounds in solution or on cultured human ce
50 an studies revealed a pathological excess of sialylated conjugates as well as dermatan and heparan su
51 sulfated, sialylated, and both sulfated and sialylated core 1 (Galbeta1-3GalNAcalpha1-) and core 2 (
56 ts of eukaryotic plasma membranes, and their sialylated derivatives, gangliosides, are the major clas
62 G subclass and Fc glycans, with abundance of sialylated Fc glycans (sFc) predicting quality of vaccin
63 eering of the IVIG's Fc glycans into a fully sialylated Fc glycoform, which may possess significantly
65 unctional P1 promoter, was unable to produce sialylated Fc in the systemic circulation, despite the p
66 parison of the structures of asialylated Fc, sialylated Fc, and F241A Fc, a mutant that displays incr
67 inflammatory status, pretreatment levels of sialylated FetA in the blood are indicative of the likel
68 y reveals that high levels of O-glycosylated sialylated FetA isoforms are found in patients exhibitin
70 odies made by p individuals recognize x2 and sialylated forms of x2, whereas x2 is lacking on P-defic
72 ma, during which a 55% increase of alpha-2,6-sialylated fucosylated N-glycans was revealed, demonstra
73 in which preferentially recognizes alpha-2,6 sialylated galactosides showed strong binding reactivity
74 on from Lewis(x)-type structures in mESCs to sialylated Galbeta1,3GalNAc-type glycans on differentiat
75 ialic acid precursor analogs to modulate the sialylated ganglioside-dependent interaction of MLV part
76 alylated PrP(C) contained greater amounts of sialylated gangliosides and cholesterol than membrane ra
79 that each pathotype makes use of a different sialylated glycan ligand, with binding sites on opposite
80 ies on sialic acid recognition using a novel sialylated glycan microarray containing modified sialic
82 Crystal structures of EV-D68 in complex with sialylated glycan receptor analogues show that they bind
84 on surfaces, obstructing a groove that binds sialylated glycan receptors in many other polyomaviruses
87 itative binding affinity of HA to alpha2-->6 sialylated glycans (human receptors) is one of the impor
88 evealed that IAV binds to sialylated and non-sialylated glycans and binding is not concordant with re
90 in SK1 SRR adhesin affects interactions with sialylated glycans and glycoproteins, we determined high
92 The reovirus attachment protein sigma1 binds sialylated glycans and proteinaceous receptors to mediat
94 Single-cell binding studies indicate that sialylated glycans are likely not required for initial a
95 demonstrate that different distributions of sialylated glycans are related to the metastatic propert
97 tissues and highlight a functional role for sialylated glycans as reovirus coreceptors in the CNS.
98 IL-6 secretion were enriched in ApoC-III, di-sialylated glycans at multiple A1AT glycosylation sites
99 The IgG1 Fc fragments containing complex sialylated glycans attached to the N-terminal Asn(221) s
100 ot only result in accurate identification of sialylated glycans but also improve the characterization
101 ows for linkage specific characterization of sialylated glycans directly from the precursor mass but
106 me, fluorescence and radionuclide imaging of sialylated glycans in a murine tumor model in vivo.
107 s revealed the importance of sialylation and sialylated glycans in breast cancer brain metastasis.
108 ring 3F-NeuAc to mice dramatically decreases sialylated glycans in cells of all tissues tested, inclu
113 serine-rich repeat (SRR) adhesins recognize sialylated glycans on human salivary, platelet, and plas
117 s in ionization efficiency among neutral and sialylated glycans prevent direct quantitative compariso
118 in the expression of truncated core 1-based sialylated glycans rather than the core 2-based glycans
122 binding to sialyl Lewis x (sLe(x)) and other sialylated glycans that decorate P selectin glycoprotein
123 tiates viral entry by engaging host receptor sialylated glycans via its receptor-binding site (RBS).
124 and alkaline BGE systems, the mobilities of sialylated glycans were shifted relative to nonsialylate
125 for simultaneous profiling both neutral and sialylated glycans without derivatization or labeling.
126 high-mannose glycans, fucolsylated glycans, sialylated glycans, and hybrid structures were studied.
127 process, including initial binding of IAV to sialylated glycans, fusion between the viral envelope an
128 2)v showed a predominant binding to alpha2-6-sialylated glycans, similar to human-adapted influenza A
129 which bound almost exclusively to alpha-2,6 sialylated glycans, the seal H3 bound preferentially to
138 -adapted pathogen that encounters terminally sialylated glycoconjugates and free sialic acid (Sia) in
140 genic tetrazine, allowing for the imaging of sialylated glycoconjugates within live zebrafish embryos
142 sease mouse model, and find that an alpha2-3 sialylated glycoform designed to eliminate uptake by the
143 nflammation, depends on a specific alpha-2,6-sialylated glycoform of IgG Fc to induce Interleukin 4 (
145 in the presence of m-NBA the charge state of sialylated glycopeptides increased and the chromatograph
146 can quantitatively and qualitatively enrich sialylated glycopeptides more than the commercially avai
149 moniae hemadsorption (HA) and binding to the sialylated glycoprotein laminin by 95% failed to inhibit
150 n-destructed mutants, transgenic plants that sialylate glycoproteins in alpha2,6- or alpha2,3-linkage
151 processes; however, it is laborious to study sialylated glycoproteins due to the labile nature of sia
152 However, OpeRATOR is not fully active toward sialylated glycoproteins, and it has been suggested that
158 ionally modified with N-linked glycans and a sialylated glycosylphosphatidylinositol (GPI) anchor.
159 e generated their degalactosylated or highly sialylated glycovariants and compared their pathogenic e
160 n FcgammaR-independent mechanism by which Fc-sialylated glycovariants might limit proinflammatory IgG
163 ctional importance of Arg-1203 by incubating sialylated gonococci with normal human serum, in the pre
166 are consistent with the hypothesis that the sialylated GPI anchor attached to PrP(C) acts as a synap
167 tition studies showed that pretreatment with sialylated GPIs prevented the targeting of PrP(C) to syn
168 Convergent access to this key alpha(2,6)-sialylated hexasaccharide was also achieved through a [3
171 atic activity to be confined to specific non-sialylated HMOs and synergistic with a number of convent
172 in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those
173 ), and relative abundance of fucosylated and sialylated HMOs with language at 18 mo (P < 0.001 and P
174 s of HMOs (total HMOs, fucosylated HMOs, and sialylated HMOs), 51 individual HMOs, and 6 bioactive pr
177 allowed the generation of SM6 decorated with sialylated human-type oligosaccharides, comparable to pl
178 heir capacity to produce inhibitory IgG4 and sialylated IgG able to mediate anti-inflammatory mechani
179 Transfer of low amounts of antigen-specific sialylated IgG Abs was sufficient to inhibit B cell acti
181 ry from murine studies, which states that Fc-sialylated IgG alters the balance between activating and
185 nvolving basophils and the binding of highly sialylated IgG Fc to DC-SIGN-expressing myeloid cells.
186 on of IVIg, but unexpectedly, recombinant Fc-sialylated IgG or sialic acid-enriched IVIg were equally
187 Protective antibodies, including IgG4, Fc sialylated IgG, and IgA, have the capacity to modulate t
188 through the generation of immunosuppressive sialylated IgGs and may provide insight on the role of T
189 tory mechanism mediated by anti-inflammatory sialylated IgGs that are formed on TD tolerance inductio
190 se expression and secreted immunosuppressive sialylated IgGs that were sufficient to block antigen-sp
191 that TI immune responses induced suppressive sialylated IgGs, in contrast to TD proinflammatory Th1 a
193 ibits unique regioselectivity and is able to sialylate internal galactose residues in poly-LacNAc ext
194 d to the discrimination of alpha2,3/alpha2,6-sialylated isomers, unambiguous identification of sialog
195 able process for generating a well-qualified sialylated IVIg drug candidate with maximum Fc sialylati
198 form of Lewis A (suLe(A)) trisaccharide and sialylated Lewis A and that fluoresceinated versions of
200 immune encephalomyelitis, Sn interacted with sialylated ligands expressed selectively on CD4(+)Foxp3(
202 eltafHbp DeltaNspA Deltalst mutant unable to sialylate lipooligosaccharide or bind human fH via the k
206 tran show that the endosomal accumulation of sialylated molecules can be largely attributed to impair
207 nfluenza infection increases sialic acid and sialylated mucin availability and enhances desialylation
209 ion of virions bound to vesicles coated with sialylated mucin mimics was possible, the kinetics of fu
211 unoglobulin G (IgG) and the search for serum sialylated N-glycan biomarker candidates of hepatocellul
215 ering approach led to secreted A1AT carrying sialylated N-glycan structures largely resembling its se
216 attributed to a decrease in neutral and mono-sialylated N-glycans and an increase in di-sialylated N-
217 Asn-145 and Asn-160 contain lower levels of sialylated N-glycans and higher levels of high-mannose N
218 that cell surface-associated VEGFR2 displays sialylated N-glycans at Asn-247 and, in contrast, that t
220 isomer-specific, quantitative comparison of sialylated N-glycans between bovine and rabbit immunoglo
221 l viruses tested interacted with one or more sialylated N-glycans but not O-glycans or glycolipid-der
222 and guinea pig erythrocytes contain complex sialylated N-glycans but that they differ with respect t
223 inhibitory activities, showing a key role of sialylated N-glycans in inducing the IgM-mediated immune
224 combination of enzymes and lectins to modify sialylated N-glycans in real time in the capillary so th
226 n heterogeneity was identified of the highly sialylated N-glycans of rHuEPO by extensive acetylation,
230 ry appeared to be affected by the absence of sialylated N-glycans, dynamin-dependent entry was not af
231 uded the detection of a new class of heavily sialylated N-glycans, including polysialylated N-glycans
237 r knowledge, we show for the first time that sialylated N-linked glycans induce the internalization o
240 linear (maltooligosaccharides) and branched (sialylated, neutral and core fucosylated biantennary IgG
243 Using bovine fetuin (because it contains the sialylated O-glycans most commonly found on biopharmaceu
245 ritic cartilage and has reduced affinity for sialylated O-glycans, a glycophenotype associated with i
246 k facilitate the OpeRATOR digestion of fully sialylated O-glycopeptides that are mass tagged to ident
248 etylesterase acting on glycosidically linked sialylate-O-acetylesterase substrates, particularly at n
251 alpha1-acid glycoprotein (AGP) as well as of sialylated oligosaccharide reference standards and found
252 ires the engagement of two types of glycans, sialylated oligosaccharides and sulfated glycosaminoglyc
253 a library of differentially fucosylated and sialylated oligosaccharides starting from a single chemi
254 nce standards and found that for more highly sialylated oligosaccharides the loss is greater than the
257 ferences in interactions with strains of the sialylated pathogen, group B Streptococcus, and with sia
258 strate that Sn plays a key role in capturing sialylated pathogens and promoting rapid proinflammatory
259 al Tfp specifically recognize a triantennary sialylated poly-N-acetyllactosamine-containing N-glycan
260 gG3 mAb are poorly galactosylated and hardly sialylated, possibly contributing to the pathogenic pote
262 ae HA-negative mutant II-3 failed to bind to sialylated receptors but adhered to sulfatide in a tempe
263 uenza viruses to effectively bind human-like sialylated receptors is a major impediment to their effi
264 their capacity to bind nearly all canonical sialylated receptors other than a selection of biantenna
266 t unfavorable to bind any negatively charged sialylated receptors, consistent with the recombinant H1
269 ed homogeneous glycoforms, including a fully sialylated (S2G2F) glycoform that may gain anti-inflamma
270 atic, scalable process to produce a tetra-Fc-sialylated (s4-IVIg) IVIg drug candidate and its qualifi
274 orylated glycans, even as the recognition of sialylated structures is decreased through antigenic dri
275 enables the controlled in vivo synthesis of sialylated structures with different interlinkages and d
277 is strategy was not as effective with labile sialylated structures; instead, it was observed that the
278 tion mutant that lost the ability to grow on sialylated substrates, we showed that-in gnotobiotic mic
279 223 showed a decrease of high mannose versus sialylated sugars on N-glycoproteins such as the metallo
281 rapid identification of various fucosylated, sialylated, sulfated glycotopes and definitive determina
283 both the sialyl Lewis-X (sLe(X)) and the di-sialylated T-antigen (NeuAcalpha2,3Galbeta1,3(NeuAcalpha
284 counts for the accommodation of the alpha2,6-sialylated terminus of a biantennary N-glycan by viscumi
286 nnary structures, as well as the increase in sialylated tetraantennary and FA3G3S[3,3,3]3 structures.
288 ets can also supply the sialic acid donor to sialylate the synthetic acceptor, Gal(beta1,4)GlcNAcalph
289 have demonstrated that Neisseria gonorrhoeae sialylates the terminal N-acetyllactosamine present on i
290 an enzyme up-regulated in numerous cancers, sialylates TNFR1 and thereby protects tumor cells from T
291 lated tetra-antennary N-glycans and one mono-sialylated tri-antennary N-glycan of rHuEPO are reported
292 eover, we observed a progressive increase of sialylated triantennary and tetraantennary structures tw
296 d terminal Galp residues that become readily sialylated upon addition of parasite trans-sialidases.
298 et endothelial cell adhesion molecule-1, was sialylated via alpha2,6-linkages, as shown by Sambucus n
299 t strains when lipooligosaccharide (LOS) was sialylated, whereas PorB molecules of lptA null mutants