ライフサイエンスコーパス: sibling

1 additional twins were scanned without their siblings).

2 t least one home-reared and one adopted-away sibling.

3 affected by AgP and an unaffected parent and sibling.

4 d sex, and when compared to their unaffected sibling.

5 th schizophrenia and at least one unaffected sibling.

6 r and a within-sibpair comparison among term siblings.

7 els of cooperation (or competition) in their siblings.

8 th the clinical presentation of the affected siblings.

9 ed and unmeasured familial factors shared by siblings.

10 d generations or affected only a few of many siblings.

11 otect cells from intoxication by neighboring siblings.

12 ases variance among families of full or half-siblings.

13 onnectivity in patients and their unaffected siblings.

14 gnant women (index children) and their older siblings.

15 ll observed and unobserved factors shared by siblings.

16 ncreased compared with controls, spouses, or siblings.

17 CT phenotypes were highly comparable between siblings.

18 comparisons with their respective wild-type siblings.

19 ng consistent feeding routines in subsequent siblings.

20 h Consortium (BSRC), encompassing 288 infant siblings.

21 ients who received a transplant from matched siblings.

22 r functional impact than those in unaffected siblings.

23 for cousins whose parents were paternal half-siblings.

24 ce among mothers and older sibling age among siblings.

25 ompared with their nonmigrant rural-dwelling siblings.

26 stinguishable from heterozygous or wild-type siblings.

27 ssociation of these two entities, more so in siblings.

28 considerations of the patient, parents, and siblings.

29 , unlike the de novo mutations in unaffected siblings.

30 a higher prevalence of frailty compared with siblings.

31 r in ASD probands versus in their unaffected siblings.

32 orbidity and familial factors shared between siblings.

33 1.4-2.0) for cousins whose parents were full siblings; 1.1 (95% CI = 0.7-1.8) for cousins whose paren

34 gs; 2.1 (95% CI = 1.5-3.0) for maternal half-siblings; 1.3 (95% CI = 0.9-2.1) for paternal half-sibli

35 gs; 1.3 (95% CI = 0.9-2.1) for paternal half-siblings; 1.7 (95% CI = 1.4-2.0) for cousins whose paren

36 ted individuals relative to their unaffected siblings (17% versus 4%, p < 0.001).

37 Twenty-two unaffected siblings, 18 FEP patients, and 15 healthy unrelated cont

38 significantly greater in male than in female siblings (+19%; CI(95%) : +13% to +27%; p < .01).

39 reports on 288 children, which included 127 siblings, 19 cousins, and 142 singletons; 150 (52%) had

40 typed (173,661 SNPs) along with 2 unaffected siblings, 2 unaffected parents, and 15 unrelated control

41 gotic twins; 4.7 (95% CI = 3.9-5.6) for full siblings; 2.1 (95% CI = 1.5-3.0) for maternal half-sibli

42 ng a total 8034 first-degree relatives (3776 siblings, 4258 parents or offspring) of 2122 unrelated v

43 0.3) also reported poorer Organization than siblings (49.9 +/- 0.4; P < .001).

44 ms in Task Efficiency (T-scores mean +/- SD: siblings, 50.0 +/- 0.4; CNS, 61.4 +/- 0.4; non-CNS, 53.3

45 +/- 0.3; non-CNS 53.4 +/- 0.2), and Memory (siblings, 50.8 +/- 0.4; CNS, 58.9 +/- 0.4; non-CNS, 53.5

46 non-CNS, 53.3 +/- 0.3), Emotion Regulation (siblings, 51.4 +/- 0.4; CNS, 54.5 +/- 0.3; non-CNS 53.4

47 donor groups between epochs 2 and 3 (matched sibling: 54.0% [95% CI 53.1-54.8] to 54.6% [53.6-55.6];

48 g survivors was 3 times higher compared with siblings (6.4%; 95% CI, 4.1% to 8.7%; v 2.2%; 95% CI, 1.

49 lial hypercholesterolemia (86%) and 77 of 95 siblings (81%) were seen in follow-up; among the 214 pat

50 enerational families, each with, at least, 2 siblings (a total of 249 mother-child transmissions).

51 2 SD), the predictors identify the affected sibling about 70-90% of the time across a variety of dis

52 associated with increased adiposity of urban siblings, accounting for 4% and 6.5% of adiposity differ

53 A higher number of siblings [adjusted odds ratio (aOR): 1.39; 95% CI: 1.11,

54 Four PWD full-siblings affected with EOPRA diagnosed at 2-3 years of a

55 was identified in 51% of patients and 50% of siblings, against 15% of controls (P < 0.05).

56 and rural residence among mothers and older sibling age among siblings.

57 nificant when compared with their unaffected siblings (aHR, 1.74; 95% CI, 1.53-1.97).

58 According to the parents, these siblings also displayed reduced muscle tone, and one of

59 According to the parents, these siblings also displayed reduced muscle tone, and one of

60 Co-sibling analyses suggested that they were substantially

61 esponse to win outcomes, either in the GD or sibling analysis compared with their control group.

62 18,041 matched controls; we also conducted a sibling analysis using 2773 patients with IgAN with 6210

63 hite matter integrity compared to unaffected sibling and matched general population controls (P = 2.2

64 , particularly for patients with HLA-matched sibling and unrelated donors.

65 ysis using 2773 patients with IgAN with 6210 siblings and a spousal analysis that included 2234 pairs

66 P had reduced GABA plasma levels compared to siblings and controls (p < 0.05 for both).

67 non-sibling subjects to those obtained among siblings and find that typically most of the predictive

68 cell-derived cardiomyocytes of the affected siblings and investigated the patient-specific cardiomyo

69 odevelopmental disorders and 1911 unaffected siblings and observed an 8.33-fold enrichment of patient

70 ls regularly breed with relatives, including siblings and parents.

71 , suicide) were compared between mothers and siblings and their controls.

72 and permutation testing, taking into account siblings and twins, identified using genetic data.

73 e was evidence of putative in-home (enrolled siblings) and outpatient clinic transmission.

74 nic risk score (PRS) identifies the affected sibling, and also compute Relative Risk Reduction as a f

75 m 540 schizophrenia patients, 247 unaffected siblings, and 844 control subjects.

76 tion level, professional training, number of siblings, and birth order) was applied to estimate the a

77 cortical measures, case subjects, unaffected siblings, and control subjects in the NeuroIMAGE study (

78 s, full siblings, maternal and paternal half siblings, and cousins.

79 ardiomyopathy was corrected in both affected siblings, and in the 6-years-old, the retinal degenerati

80 for cousins whose parents were maternal half-siblings; and 1.9 (95% CI = 1.2-2.9) for cousins whose p

81 cids in early psychosis and their unaffected siblings are rare.

82 sential for accurate forward selection among siblings as markers that track pedigree are of little us

83 ily-based association tests (FBATs) that use siblings as well as parents especially suited for the an

84 matched on gender, birth year, and number of siblings at birth 1:10 with children born to nontranspla

85 For patients without a matched sibling available for transplantation, our data do not f

86 This complicates both sibling-based prognosis and genotype-phenotype correlati

87 ed the odds of preterm birth were higher for siblings born following an IPI of <6 months (adjusted in

88 ociated with difference in adiposity between siblings, but no clear association was observed for inta

89 ioning of cell organelles, or differences in sibling cell size or shape.

90 C do not efficiently partition, resulting in sibling cells without CC or LC.

91 e precisely localized at new growth poles in sibling cells.

92 Hispanic ethnicity and an infected sibling close contact are associated with increased SARS

93 These associations were not observed in the sibling cohort.

94 The mother and sibling cohorts were matched to corresponding population

95 significantly larger values in patients and siblings compared with controls (P < 0.05).

96 we used alternative comparison groups (e.g., sibling comparison OR = 1.22, 95% CI 0.60-2.48, p = 0.58

97 Sibling comparison studies, which use a woman as her own

98 e associated with odds of ASD in the matched sibling comparison.

99 oduction; 1245 children were included in the sibling comparison.

100 Sibling-comparison analyses can best assess individual f

101 Second, we used a sibling-comparison approach that has not been used befor

102 mained for uncontrolled asthma in Grade 9 in sibling comparisons (Grade 9: beta = -7.7 points; 95% CI

103 The remaining associations in sibling comparisons between uncontrolled asthma in Grade

104 when controlling for familial factors using sibling comparisons suggests that the differences were d

105 We used sibling comparisons to account for unmeasured familial f

106 Register-based cohort study with sibling comparisons.

107 ers, but the associations were attenuated in sibling comparisons.

108 ived by medically assisted reproduction with siblings conceived naturally and, thus, controlled for a

109 =0.005), and more likely to have an infected sibling contact (p=0.001) than uninfected children.

110 c control group, and four using a discordant-sibling control group.

111 een both phenotypes and when compared with a sibling control in EMV size and release based on Nanosig

112 In sibling-controlled analyses, every kilogram per meter sq

113 Among term infants, we conducted sibling-controlled analyses.

114 When using sibling controls, the estimates for SDP were clearly att

115 Mother and sibling demographic factors associated with increased ri

116 xamines the robustness of the findings using sibling design.

117 ustment for family-level confounding using a sibling design.

118 Discordant-sibling designs effectively addressed surveillance bias

119 , neither psychiatric control nor discordant-sibling designs supported an association between prenata

120 of the predictive power persists in between-sibling designs.

121 A pair of siblings diagnosed as LCA who presented with RAH with no

122 HR) group includes children with one or more siblings diagnosed with ASDs; whereas the 'low risk' (LR

123 les from 20 PCa families, with three or more siblings diagnosed with metastatic PCa, we identified mu

124 ch family consisted of at least two affected siblings diagnosed with schizophrenia and at least one u

125 Two of his older male siblings died around 2-3 years of age due to pneumonia.

126 For quantitative traits we examine between-sibling differences in trait values as a function of pre

127 Here, we present a family with two siblings displaying an autosomal recessive form of NS wi

128 ddition and gene editing strategies, matched sibling donor haematopoietic stem cell transplantation (

129 Whether matched sibling donor hematopoietic stem cell transplantation (M

130 ts age 13 years or older with an HLA-matched sibling donor or age 12 years or younger with an HLA-mat

131 If an HLA-matched sibling donor or HLA-matched family donor is available,

132 age 12 years or younger with an HLA-matched sibling donor were at the lowest risk with a 3-year EFS

133 splantation at age 53 with a haplo-identical sibling donor.

134 If HLA-matched sibling donor/HLA-matched family donor HSCT or HSC-GT ar

135 , and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemothe

136 HLA-C, and HLA-DRB1), including HLA-matched sibling donors, haploidentical related donors, matched u

137 l between recipients of transplants from non-sibling donors: haploidentical related donors (1.43, 0.8

138 xtent of parental care can determine whether siblings evolve to compete or to cooperate.

139 Both mothers and siblings experience elevated and prolonged need for ment

140 tatus as higher than their same-aged and sex sibling, experienced better well-being in early and late

141 54 K SNP panel was used to genotype 10 full-sibling families each consisting of ~ 110 offspring chal

142 115 older adults with a parental or multiple-sibling family history of sporadic AD (PREVENT-AD [PRe-s

143 Bone sialoprotein (BSP) is a member of the SIBLING family with essential roles in skeletogenesis.

144 ition, overexpressing wild-type LonP1 in the siblings' fibroblasts down-regulated phosphoE1alpha.

145 nk and replicated our findings using 222,368 siblings from 23andMe.

146 We investigated two siblings from the Faroe Islands born with multiple malfo

147 can affect estimates using data from 61,008 siblings from the Nord-Trondelag Health Study and UK Bio

148 redictors using tens of thousands of genetic siblings from the UK Biobank (UKB), for whom we have SNP

149 FAF phenotypes are highly comparable between siblings, functional outcomes differ substantially.

150 drivers are genetic parasites that destroy 'sibling' gametes lacking the driver allele.

151 nds were linked to their biological parents, siblings, grandparents, uncles/aunts, and cousins.

152 From 30 screened F(3) sibling groups, where each was derived from an individua

153 One sibling had late onset hearing loss and both siblings ha

154 Siblings had lower GLU, Glx and PRO (p < 0.05 for all) b

155 sibling had late onset hearing loss and both siblings had symmetric high myopia, normal stature, and

156 SNVs) or single-base insertions/deletions, 3 siblings harbored a heterozygous single-base insertion,

157 thin these families, an ASD-related CNV in a sibling has a positive predictive value (PPV) for ASD or

158 ntroduction of donors other than HLA-matched siblings has been a pivotal change in stem cell transpla

159 Thirteen siblings have copy number variants (CNVs) involving ASD-

160 Siblings have typically experienced similar environments

161 atio=1.24, 95% CI=0.93, 1.66) and discordant-sibling (hazard ratio=0.97, 95% CI=0.68, 1.37; odds rati

162 autism diagnoses, other childhood vaccines, sibling history of autism, and autism risk factors to ch

163 or sex, parental age at birth, and, for half siblings, history of major depression in the nonshared p

164 vuncular (AV) pairs, and 75.5%-98.5% of half-siblings (HS) pairs compared to PADRE's rates of 38.5%-7

165 y of donors, in the absence of HLA-identical siblings, HSCT with TCRalphabeta+/CD19+ graft depletion

166 g mouse pedigrees and compare to three multi-sibling human pedigrees.

167 and leptin receptor concentrations from 3068 siblings in 1133 sibships from the Framingham Heart Stud

168 related individuals with predictions between siblings in a within-family design is a powerful approac

169 er, the youngest of four children, had older siblings in education, and she focused on early childhoo

170 en 2014 and 2016, 11,337 survivors and 2,146 siblings in the Childhood Cancer Survivor Study complete

171 equations to account for correlation between siblings in the Early Determinants of Mammographic Densi

172 spectrum disorder (ASD) and their unaffected siblings in the Simons Simplex Collection.

173 se 5 (EXO5) gene was present in all affected siblings in three PCa families.

174 low risk for autism from the British Autism Sibling Infant Study (BASIS).

175 55-65% of the time the higher PRS sibling is the case.

176 disease risk or complex trait values between siblings is a strong test of genomic prediction in human

177 hippocampal morphology in patients and their siblings is suggestive of a genetic imaging phenotype, i

178 allergy in parents, type of delivery, having siblings, keeping pets, age at weaning, and having had >

179 nd bouts from hundreds of mutant and control sibling larvae.

180 retrospective, cohort study comparing HLA-ID sibling LDKTx (n=175) to HLA non-ID LDKTx (n=175; matche

181 cate that sequencing as few as three to four sibling lines generally results in fewer than five candi

182 Compared with siblings, LMB survivors were at increased risk for adver

183 multiple gestation, the presence of affected sibling, low level of Hemoglobin at birth, respiratory d

184 children is 85 000 (4900-546 000), for their siblings (<20 years) is 75 000 (4400-483 000), for their

185 partners and the child's healthy sibling or siblings, managing self-care, and coping with feelings o

186 -related OCD), we identified all twins, full siblings, maternal and paternal half siblings, and cousi

187 Unaffected siblings may be a possible risk group for metabolic abno

188 line mutation rates and spectra in six multi-sibling mouse pedigrees and compare to three multi-sibli

189 t differ from 2 comparison groups: cisgender siblings (n = 189) and cisgender controls (n = 316).

190 ychosis (FEP) patients (n = 166), unaffected siblings (n = 76), and community-based controls (n = 166

191 tion controls (n = 66,820) and to unaffected siblings (n =13,943).

192 productive systems disease in three affected siblings of a consanguineous family.

193 without clinically diagnosed drug addiction, siblings of addicted individuals, and control volunteers

194 sex, and residence were identified, as were siblings of all study participants.

195 opulation-based controls, and 203 unaffected siblings of ASD cases in this case-control study nested

196 Biological siblings of cases with GD (n = 17, unrelated to the curr

197 rate population-based cohorts of mothers and siblings of children diagnosed with cancer between 1998

198 We identified 4,773 mothers and 7,897 siblings of children diagnosed with cancer during the st

199 GFD, 57 healthy children, and 19 unaffected siblings of children with CD) in Glasgow, Scotland.

200 Siblings of GD showed some overlapping effects; namely,

201 eneral estimate of ASD transmission risk for siblings of individuals affected by ASD, the first ever

202 or fatal (grade 3-5) health conditions than siblings of the same age (HR 4.2 [95% CI 3.7-4.8] for ea

203 11.1] and 8.0 [4.6-14.0]) when compared with siblings of the same age, although all these risks were

204 ildhood cancer survivors, by comparison with siblings of the same age, which were most notable more t

205 and bone cancer) by comparing both groups to siblings of the same age.

206 airs (urban migrant and their rural-dwelling sibling) of the same sex (31% female) were analysed.

207 f her different pregnancies (i.e., comparing sibling offspring), have gained popularity as a strategy

208 oreover, transfection of healthy non-carrier sibling OPCs confirmed a pathogenic effect on cell survi

209 nships with partners and the child's healthy sibling or siblings, managing self-care, and coping with

210 ment of GVHD in the setting of HLA-identical sibling or unrelated donor transplantation in adult pati

211 shared familial factors among paternal half-siblings (OR 1.20, 95% CI 0.80-1.81), full-cousins (OR 1

212 aching about 40% for children with 2 or more siblings (OR = 0.62; P-value = .048).

213 , 95% CI 0.96-1.14, p = 0.27), and unexposed siblings (OR = 0.99, 95% CI 0.85-1.14, p = 0.92).

214 in a first-degree relative: mother, father, sibling, or children.

215 disease (mother: OR, 5.7; 95% CI, 1.4-22.3, siblings: OR, 5.1; 95% CI, 1.1-23.9, children: OR, 6.0;

216 risk was observed with increasing number of siblings (P-value = .023), the protective effect reachin

217 during verbal encoding in patients and their siblings [P < 0.05, familywise error (FWE)-corrected].

218 is the best-known tumor suppressor, but its sibling p63 is a master regulator of epidermis developme

219 Studying a sibling pair that is compound heterozygous for mutations

220 describing a severely hypotonic child and a sibling pair with a progressive encephalopathic syndrome

221 h establishment of chronic infection in a CF sibling pair.

222 direct patient-to-patient transmission in a sibling pair.

223 Sibling-pair analysis found support for causal and grade

224 c similarity of the birds' songs, with adult sibling pairs (same songs) sharing similar waveforms and

225 nts (median age 43 years) comprised of 1,232 sibling pairs (urban migrant and their rural-dwelling si

226 Here, we describe two sibling pairs and three unrelated males who presented in

227 n how studies of related individuals such as sibling pairs or parent-offspring trios can be used to o

228 phenotypes in 56,396 twin pairs and 724,513 sibling pairs out of 44,859,462 individuals that live in

229 Within full sibling pairs, the sibling with less-related mates produ

230 r group comparison and paired t-test for FEP-Sibling pairs.

231 fferences, and compare to performance in non-sibling pairs.

232 e coalitions had higher likelihood of having sibling partners, while pairs were primarily unrelated.

233 fish tested was 2.1 x 10(-5) and the PI for siblings (PIsib) was 6.4 x 10(-3), as calculated by the

234 substrate distortions observed for Family X siblings Pols beta or lambda.

235 heterologous relapses whose 50% are from by sibling/recombinant clones.

236 nts in GWAS but reestimating effect sizes in siblings reduces but does not eliminate stratification.

237 ts were more likely of Indian ethnicity, had siblings, reported childcare attendance, early wheezing

238 inally phenotyped ASD families from the Baby Siblings Research Consortium (BSRC), encompassing 288 in

239 4% and 6.5% of adiposity difference between siblings, respectively.

240 Sibling rivalry is commonplace within animal families, y

241 e fully compensated for the fitness costs of sibling rivalry.

242 he predictor correctly identifies the taller sibling roughly 80 percent of the time when the (male) h

243 s (mothers: rate ratio [RR], 1.4; P < .0001; siblings: RR, 1.1; P < .0001).

244 Offspring of mothers with a sibling(s) diagnosed with ASD had higher rates of ASD th

245 ons predict redundancies between lower level sibling SCPs within each type of high level SCP.

246 gnosis at baseline, 16 [6-30] years) and 720 siblings self-reported PA and neurocognitive problems.

247 ity study (1959-2008; n = 700 women with 116 sibling sets; mean age = 44.1 years).

248 mobility is rooted in family advantages that siblings share over and above genetic transmission.

249 Interestingly, fibroblasts of both siblings showed glucose-repressed oxygen consumption com

250 oups (F = 6.01 and 0.004), with patients and siblings showing lower insulin sensitivity, compared to

251 zophrenia (SCZ), as well as their unaffected siblings (SIB), show functional connectivity (FC) altera

252 tic effects (IGEs) that occur when different sibling social environments induce the expression of mor

253 cies complexes and may aid identification of sibling species with a complex.

254 cation) than intrinsic factors (namely, the (sibling) species of the mosquito caught) (respective Aka

255 relative (defined as a grandparent, parent, sibling, spouse, or child) for each COVID-19 death.

256 g Americans will lose a grandparent, parent, sibling, spouse, or child.

257 ies containing index persons, their parents, siblings, spouses, and children, comprising 314,819 indi

258 t 47% of symptomatic dual infections contain sibling strains likely to have been co-transmitted from

259 ompare validation results obtained using non-sibling subjects to those obtained among siblings and fi

260 Findings were similar in the sibling subset.

261 nsanguinity and similarly affected, deceased siblings, suggesting autosomal recessive inheritance.

262 Mortality among women was obtained from sibling survival data.

263 kidney transplants (LDKTx) from HLA matched siblings (termed HLA-identical (HLA-ID)) to HLA non-ID t

264 own about nutrient sensing in their cellular siblings, the absorptive enterocytes(1).

265 th microscopic colitis with their unaffected siblings, the aHRs of CD and UC were 5.4 (95% CI 3.2-9.2

266 Survivors were less likely than siblings to report consistent PA (28.1% v 33.6%) and mor

267 had suitable donors identified (two matched sibling, two matched unrelated, two haploidentical, and

268 System requires a mission to their Ice Giant siblings, Uranus and Neptune.

269 Compared with the rural siblings, urban migrants had 18% greater adiposity, 12%

270 dried blood spots from cases, controls, and siblings using a bead-based multiplex assay.

271 ly or paternally related-e.g., paternal half-siblings-using the locations of autosomal IBD segments s

272 ould be transferred via introgression to the sibling vector species Anopheles arabiensis.

273 patients whose allograft came from a matched sibling versus an unrelated donor.

274 The younger sibling was preemptively transplanted shortly after birt

275 ke, physical activity, and adiposity between siblings was examined using multivariable linear regress

276 pted compared with home-reared full and half siblings was reduced by 23% (95% CI=7-36) and by 19% (95

277 re calculated for offspring whose parents or siblings were diagnosed with GCA, TA or any other AID.

278 106 control siblings were enrolled.

279 37.6 +/- 9.4 years; 48% male, 86% white) and siblings were included (n = 2,097; mean age, 42.9 +/- 9.

280 of India, together with their rural-dwelling siblings, were surveyed.

281 izygotic twinning, the simultaneous birth of siblings when multiple ova are released, is an evolution

282 s with juvenile myoclonic epilepsy and their siblings, which are associated with reorganization of fu

283 The additional two patients ascertained are siblings who had an early frameshift mutation in EXOSC5

284 Two North American siblings who presented with a mild clinical phenotype of

285 PRS score (< 84 percentile, < + 1 SD) and 1 sibling with high PRS score (top few percentiles, i.e. >

286 Within full sibling pairs, the sibling with less-related mates produced an average of 3

287 Example results: Given 1 sibling with normal-range PRS score (< 84 percentile, <

288 as compared with offspring with a father or sibling with T1D.

289 We report a second family with 2 siblings with a homozygous frameshift mutation in MKL1.

290 defect in IL-2Rbeta, occurring in two infant siblings with a homozygous IL2RB mutation in the WSXWS m

291 In 2014, Sadat et al. reported two siblings with a rare genetic defect in ER alpha-glucosid

292 We report 2 siblings with a syndromic form of JRRP associated with m

293 htly more than was observed for fathers with siblings with ASD (relative risk, 2.08; 95% confidence i

294 Here, through exome sequencing of 2 siblings with autosomal-recessive thrombocytopenia, we i

295 Exomes of 2 siblings with IMD identified a novel heterozygous missen

296 LCA in siblings with multiple RAHs is an extremely rare associa

297 Exome sequencing of siblings with severe neurodevelopmental defects and clin

298 Phenotypic discordance between siblings with STGD1 carrying the same ABCA4 variants is

299 elevated TCD velocities, and had at least 1 sibling without SCA from the same 2 parents.

300 valent among individuals with ASD than their siblings without ASD, particularly in exons and near spl