ライフサイエンスコーパス: signal

1 ic features, suggesting a more generic alarm signal.

2 learning model, were regressed against BOLD signal.

3 hat are used to generate the acoustic speech signal.

4 of tilt-selective cells into a tilt position signal.

5 nd an enhancement of the ligand fluorescence signal.

6 information about the phase of the received signal.

7 cretory cargo by adding a vacuolar targeting signal.

8 ing the involvement of task-related feedback signals.

9 ubunit gene (gp60) requires several recoding signals.

10 s based on the strength of their replication signals.

11 (eQTL) and allele-specific expression (ASE) signals.

12 ssue both showed hydroquinone-resembling NMR signals.

13 ltimode patterns themselves and the detector signals.

14 regulate integrin activation and outside-in signaling.

15 inflammatory gene expression through reverse signaling.

16 ion is considered to be a key step in KAR/KL signaling.

17 ed during embryogenesis to mediate proper HH signaling.

18 atic lungs through complement C5a receptor 1 signaling.

19 sm as transcriptional targets of CRZ1/GnRHL1 signaling.

20 ected stimulatory role in GPCR-mediated eNOS signaling.

21 ce of beta-ADP-heptose/ ALPK1/TIFA/NF-kappaB signaling.

22 ion in the absence of D2R-mediated G protein signaling.

23 ic interactions to finely control nucleotide signaling.

24 impaired AMP-activated protein kinase (AMPK) signaling.

25 of colon cancer by attenuating RSK1 and MSK2 signaling.

26 lve phagocytosis, endocytosis, adhesion, and signaling.

27 entia, and the arrestins are common to their signaling.

28 thetic phenotype and downregulated Akt1/mTOR signaling.

29 roup with smaller hearts and proinflammatory signaling.

30 enting transforming growth factor (TGF) beta signaling.

31 iggered cell death through PTCH proapoptotic signaling.

32 sgenic mouse line that sustains cortical MET signaling.

33 ent diversity in Na(V) channel-mediated itch signalling.

34 ut environment in ICP to alter enterohepatic signalling.

35 rom in-phase to anti-phase behaviour occurs, signalling a reorganization of the climate-carbon cycle

36 The vmPFC signals a multiplicity of decision variables, the streng

37 um without adverse safety or quality of life signals, a larger trial, with modifications to improve p

38 Wnt/beta-catenin signaling achieves this in part by increasing the expres

39 neuronal biology by retrogradely propagating signals along axons to the targets of those axons.

40 n altered neuroendocrine control of hormonal signaling, altered neurotransmitter control of nervous s

41 both CNTs and AuNPs, represents a promising signal amplification strategy for achieving a sensitive

42 e electrochemical cell allows to amplify the signal and associated response slope by n times.

43 oduce a dual-constriction pore with improved signal and base-calling accuracy for homopolymer regions

44 tional and frequency content of the incident signal and imparts a frequency conversion between differ

45 suggested that the N-terminal myristoylation signal and the C-terminal FXXF motif in PKAc regulate it

46 These findings demonstrate that STAT1 signaling and CD8 T cells concomitantly act to mitigate

47 lls enhanced unfolded protein response (UPR) signaling and cell death upon ER stress induction.

48 l role of BCKAs in regulating muscle insulin signaling and function.

49 identified proinflammatory TNFalpha/NFkappaB signaling and hdac1 as mediators of stress susceptibilit

50 lices we found that D(1)R-induced cell death signaling and neuronal degeneration, are mitigated by an

51 Blocking NF-kappaB activation rescued FXR signaling and partially ameliorated liver injury and sin

52 potential intermediary between early calcium signaling and subsequent tissue regeneration.

53 , specific Ship1 inhibition enhanced calcium signaling and thereby abrogated an anergic response to B

54 onophosphate, a key second messenger in cell signaling and tissue homeostasis.

55 c IFITM3(Y20E) mutant induced oncogenic PI3K signalling and initiated the transformation of premalign

56 e mechanistic basis of this microbiota-brain signalling and its physiological relevance are largely u

57 a significant number of genes involved in N signalling and metabolism.

58 ur necrosis factor-alpha (TNF-alpha)-induced signalling and prevention of cell death.

59 f the specific roles of these proteins in SA signalling and their potential for engineering plant imm

60 convert mechanical stimuli into biochemical signals and physiological responses is still limited.

61 immobilization decreases mechanotransductive signaling, and completely inhibits HO.

62 Applying synthetic signaling approaches to plants offers the promise of mit

63 rtex (M1), residual subperceptual hand touch signals are simultaneously demultiplexed from ongoing ef

64 Collectively, our results revealed three signals associated with systemic sclerosis in Han Chines

65 eal the well-associated optical and electron signal at a high specificity, with an interspace of ~41

66 he acetylcholine receptor (AChR) and inhibit signaling at the neuromuscular junction.

67 erall, these studies provide evidence that a signaling axis involving key UPS components contributes

68 requires cannabinoid type 1 receptor (CB1R) signaling based on the fundamental role of the endocanna

69 rising bidirectional regulation of molecular signaling between sensory neurons and non-target motor n

70 ferents to the striatum can trigger dopamine signals, but their release properties are not well under

71 tingly, the feedback regulation of DBL-1/BMP signaling by collagens is likely to be contact independe

72 ng to blockade of RasGAP binding and optimal signaling by the two receptors.

73 During development, signaling by this superfamily regulates a variety of emb

74 The activation of 41BB costimulatory signals by agonistic Abs enhances the expansion and func

75 Disruption of BMP signaling can trigger cardiovascular diseases, such as a

76 ption, the Fzr-ubiquitinated H2B (H2Bub)-Myc signaling cascade also positively regulates the transcri

77 ography, we found that loss of this critical signaling cascade exaggerated the vasoconstrictor respon

78 at the endosomal pathway is required for the signaling cascade initiated by BDNF and its receptors at

79 utation results in dysregulation of the cAMP signaling cascade, leading to upregulation of phosphodie

80 tively disrupting a previously unappreciated signaling cascade.

81 embryos of unknown sex, whether BDNF-induced signaling cascades are altered when early and recycling

82 NF-kappaB-regulating signaling cascades, in concert with NF-kappaB-mediated t

83 essions, post-translation modifications, and signaling cascades.

84 Type I IFN signaling caused tight junction dysregulation in IECs, p

85 However, discrete TH-ir signals colocalized with EGFP(Vgat) neurons, which we va

86 More importantly, blockade of NFkappaB signaling completely reversed elevated pro-inflammatory

87 d sequence through autonomous formation of a signaling concatemer.

88 The receptor adopts two major signaling conformations, one of which couples almost exc

89 However, how LMP2A signaling contributes to tumorigenesis remains elusive.

90 ow assessment of critical microenvironmental signals controlling hybrid EMT phenotypes and indicate t

91 rgic transmission carrying reward-associated signals converges in the NAc and regulates various aspec

92 Thus, TH signaling coordinately regulates both spectral sensitivi

93 ed that NRARP, a negative regulator of Notch signaling, could have a suppressive role in T-ALL.

94 We provide evidence that, Frizzled/Vang signaling couples to the Fat/Dachsous PCP directional si

95 hereas Keap1-an endogenous inhibitor of Nrf2 signaling-dampens these protective responses.

96 TGFBR2 expression, while inhibiting TGF-beta signaling decreased tECM-mediated expression of integrin

97 species recognition systematically increases signal diversity during clade radiation remains debated.

98 ion that impacts cell death and inflammatory signaling downstream of various innate immunity receptor

99 Aberrant Wnt signaling drives a number of cancers through regulation

100 Our results indicate that Smad4-mediated signaling drives the functional maturation and connectiv

101 s known about the molecule(s) regulating FGF signaling during nephron development.

102 NIRS signals during the verbal fluency task (VFT) was acquire

103 roduced different patterns of RelA and c-Rel signaling dynamic features, such as variations in durati

104 de cells and tissues distort the fluorescent signal emitted from single-molecule probes, which rapidl

105 s and a Posterior Medial cortical network in signaling event boundaries.

106 The signaling events activate the transcription factors AP-1

107 polymerization and activation of downstream signaling events.

108 available for binding, rather than specific signalling events.

109 xus (ChP) epithelium is a source of secreted signaling factors in cerebrospinal fluid (CSF) and a key

110 sed low levels of calreticulin (the "eat me" signal for macrophages) and high levels of CD47 (the "do

111 and high levels of CD47 (the "do not eat me" signal for macrophages) and PD-L1 (a T-cell inactivator)

112 leadership positions, slower but encouraging signals for "Asian" and "Hispanic" members, and less pro

113 can continuously monitor vital physiological signals for self-powered health diagnostics and therapeu

114 MALT1 mediates signaling from many immune receptors in mammals, but was

115 we determined the relative importance of MEN signaling from the SPB that is delivered into the daught

116 ) development is orchestrated by coordinated signals from adjacent epithelial and mesenchymal cells.

117 ethod by simultaneous readout of fluorescent signals from bacteria expressing fluorescent proteins an

118 Galphabetagamma) are the main transducers of signals from GPCRs, mediating the action of countless na

119 For selectivity, it successfully rejected signals from pH changes, histamine, and H(2)O(2).

120 Both hydrolytic and signaling functions require precise regulation of lysoso

121 which allows for the target recognition and signal generation regions to be designed independently.

122 ver, several recent studies suggest they may signal global motion.

123 (fMRI) studies have revealed that the global signal (GS) exhibits a nonuniform spatial distribution a

124 Although Wnt signaling has been intensively studied in colorectal can

125 w rotavirus (RV) subverts host innate immune signaling has greatly increased over the past decade.

126 No activators of cGAMP signaling have yet been identified, and the signaling pa

127 nd extracellular signal-regulated kinase 1/2 signaling; however, the clinical efficacy of inhibitors

128 ing pathway activation and ligand-responsive signaling hyperactivation by ACVR1-R206H.

129 -1BB (CD137, TNFRSF9) mediates costimulatory signals important for activation and persistence of cyto

130 couples to the Fat/Dachsous PCP directional signal in opposite directions depending on whether Pk(pk

131 We show that the increased cytokinin signaling in ARR1 gain-of-function transgenic lines is a

132 ted pathways for cell survival and apoptosis signaling in cancer remain to be elucidated.

133 at RSPOs 2 and 3 potentiate WNT/beta-catenin signaling in cells lacking leucine-rich repeat-containin

134 xpression as well as the role of NOTCH1-DLL4 signaling in collective bladder cancer invasion.

135 rate that the capacity for rapid Na(+)-based signaling in eukaryotes is not restricted to animals or

136 ositions within functional niches, cell-cell signaling in homeostatic health, the responses to injury

137 Aberrant NLRC5 signaling in macrophages can promote B-cell lymphomagene

138 findings suggest a pivotal role of caspase 3 signaling in mediating spine injury and the modulation o

139 Notably, selective abrogation of EGFR signaling in myeloid cells was sufficient to protect aga

140 dii and Neospora caninum activated GABAergic signaling in phagocytes.

141 Here, we study the roles of GABA and insulin signaling in starvation-dependent modulation of olfactor

142 Activation of EGFR signaling in the ALA neuron has previously been suggeste

143 , their role in controlling VEGF A and FGF 2 signaling in the CL of water buffalo is not known.

144 Therefore, agonist-induced signaling in this system involves two distinct receptor-

145 dings imply a simple phenotypic model of TCR signaling in which multiple T cell responses share a com

146 acrophage colony-stimulating factor (GM-CSF) signalling in astrocytes drives the expression of MAFG a

147 Given the importance of inappropriate NOTCH1 signalling in T-cell acute lymphoblastic leukaemia (T-AL

148 showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in

149 Our results demonstrate the value of EIS signals in battery management systems.

150 re highly informative and outperformed other signals in information content and decoding accuracy.

151 Further testing of 34 of these 36 signals in the CHARGE and SpiroMeta consortia showed tha

152 Estrogen receptor -alpha signaling increased IL-33 release and ILC2-mediated airw

153 In the presence of O(2) , Aer2 signaling increases the autophosphorylation of the histi

154 We report that (1) calcium signaling increases with the application of ultrasound;

155 n smoothened, the obligate transducer of Shh signaling, indicating that Inpp5e functions within the c

156 B cell antigen receptor (BCR) signals induce Syk activation followed by rapid phosphat

157 n of oncogenic c-Jun N-terminal kinase (JNK) signaling, induced by the latent membrane protein 1 (LMP

158 inases (GRKs) play a key role in terminating signals initiated by agonist-bound GPCRs.

159 l fold-change calculations directly using MS signal intensities can be misleading.

160 e fraction (AVF) was estimated from relative signal intensity (aortic blood signal intensity was used

161 Differences in signal intensity ratios did not correlate significantly

162 ate that, due to the nonlinear ESI response, signal intensity ratios of a metabolic feature calculate

163 from relative signal intensity (aortic blood signal intensity was used as a reference).

164 To further analyse in vivo signalling interplay, a CCK-1 antagonist (lorglumide) wa

165 This error signal is accompanied by alpha coherence between the two

166 Additionally, a food signal is required to turn on TRA-1 expression in the in

167 Therefore, TrkB signaling is a key regulator of a previously uncharacter

168 Here, we determined whether mTORC1 signaling is also a target for decanoic acid, a key comp

169 hromatin functions associated with ubiquitin signaling is emerging.

170 the commensal fungus Candida albicans IL-17R signaling is essential to prevent OPC in mice and humans

171 Dysregulation of TrkB signaling is implicated in neurodegenerative disorders a

172 ration of these functions, and failure of RA signaling is perhaps associated with normal cognitive de

173 thematical model demonstrating growth factor signaling is sufficient to guarantee this robustness and

174 nical and nontranscription-mediated receptor signalling is more common than hitherto appreciated.

175 anscriptomic analysis we show that intact SA-signalling is required for potato defences against the n

176 Effective application of signaling kinetics to developing new therapeutics requir

177 paxillin and focal adhesion kinase from the signaling layer of focal adhesions, whereas vinculin rem

178 The mutant quenches light-induced rhodopsin signaling like wild type, demonstrating that in vivo mon

179 ted in terms of specificity (methoxy/acetate signal), linearity (range 0.05-5.00 mg per assay), sensi

180 from each scan pattern were compensated for signal loss and averaged.

181 n mechanism, and targeting cancer methionine signalling may provide an immunotherapeutic approach.

182 However, the function of GPR139 and its signaling mechanisms are poorly understood.

183 nd guidance is to understand how cytoplasmic signaling modulates the cytoskeleton to produce directed

184 We propose that the EPFL2 signaling module evolved to control the initiation and r

185 We identified cell signaling molecular targets by meta-analysis of microarr

186 Carbon monoxide (CO) is a cell-signaling molecule (gasotransmitter) produced endogenous

187 s are consistent with NAE 18:3 being a lipid signaling molecule in plants with a requirement for G-pr

188 rigolactones are an important class of plant signalling molecule with both external rhizospheric and

189 cilitating rapid exchange of metabolites and signal molecules, plant cells use the extracellular matr

190 , these data provide novel insights into the signalling molecules and mechanisms regulating trophobla

191 In this report, we suggest that the auxin signaling must be controlled harmoniously by two counter

192 M-1 is required for the longevity of insulin signaling mutants, but surprisingly, loss of PQM-1 incre

193 udies, the composition and regulation of the signalling network underlying the cytosolic calcium fluc

194 ulatory mechanisms driving complex mammalian signaling networks.

195 d into the nucleus with nuclear localization signal (NLS)-bearing paralogues in the NMCP1-clade was d

196 As a result, these bionic PDs offer a signal/noise ratio of ~10(6) , a large bandwidth of 543

197 into either the MHb or IPN restored a "stop" signal on nicotine self-administration.

198 d fluorescent probe 6qcNIR, which produces a signal only in the protease-rich tumor microenvironment,

199 , but was not previously implicated in IL-17 signaling or nervous system function.

200 ellular (eg, transcription, translation, and signaling), organ (eg, contractility and metabolism), an

201 creening revealed that inhibition of MEK/ERK signaling overcame the HIF1a-mediated block in oligodend

202 reveal additional new compound families and signaling paradigms.

203 ting that TrkA is an important player in the signaling pathway activated by eotaxin-1 during eosinoph

204 , is dispensable for both ligand-independent signaling pathway activation and ligand-responsive signa

205 ose the mammalian target of rapamycin (mTOR) signaling pathway as a candidate mechanism.

206 Investigation of whether a certain signaling pathway can confer bistability involves a subs

207 content release, we sought to elucidate the signaling pathway downstream of PAR4 activation that lea

208 e show that PIFs positively regulate the ABA signaling pathway during the seedling stage specifically

209 by an increased activation of the NF-kappaB signaling pathway in bone marrow and BM-MSC of DeltaNC16

210 results uncover a role for the beta-catenin signaling pathway in fine tuning the granulocytic produc

211 an hepatocyte growth factor receptor (c-MET) signaling pathway is dysregulated in several malignancie

212 on were connected by a novel synapto-nuclear signaling pathway that surprisingly invoked mechanisms a

213 The Wnt signaling pathway triggers human BTSC proliferation in v

214 c mutations in factors governing the hypoxia signaling pathway, resulting in metabolic dysregulation,

215 dition to known components of the interferon signaling pathway, we found that replication termination

216 n about the evolutionary roots of this major signaling pathway, will shed light on the origins of reg

217 nic events associated with the hedgehog (hh) signaling pathway.

218 ine motifs and is present in a wide range of signaling pathways across different evolutionary taxa.

219 t PG specifically inhibits NF-kappaB and Akt signaling pathways and promotes accelerated cell death i

220 oblasts and early activation of pro-fibrotic signaling pathways before adverse ventricular remodeling

221 signaling have yet been identified, and the signaling pathways for cGAMP have been inferred to displ

222 Signaling pathways in cells were analyzed by immunoblots

223 mechanisms integrating light and temperature signaling pathways in plants remain poorly understood.

224 Differences in cell-signaling pathways in the uterine tissues of G12D and G1

225 astid-to-nucleus communication by retrograde signaling pathways is essential for fine-tuning of respo

226 As such, discovering signaling pathways that modulate albuminuria is desirabl

227 pathways, transcriptional networks, hormone signaling pathways, and plant developmental processes.

228 t also explain the operation of other immune signaling pathways.

229 ed cell death process is mediated by several signalling pathways (referred to as intrinsic and extrin

230 uromodulatory activity, define mechanisms of signalling pathways from the gut microbiota to the brain

231 ells do not depend on type I IFN or on IL-22 signaling, pathways responsible for protection against a

232 Fibroblast growth factor (FGF) signaling plays pivotal roles in generating and maintain

233 yses to evaluate sphingolipid metabolism and signaling post-MI.

234 ecoy-resistant' IL-18 (DR-18) that maintains signalling potential but is impervious to inhibition by

235 ic approaches directed towards specific TLR2 signaling processes might be developed for treatment of

236 ucidated design principles for ratio-sensing signal processing that can be used in other biological s

237 77 appeared to be particularly important for signal propagation from the allosteric site to the activ

238 evaluation of the phosphorylation status of signaling proteins across different B cell subpopulation

239 tion of USP7 interactions with innate immune signaling proteins TRAF3 and TRAF6, and that vIRF-2 targ

240 ning inhibitory control (i.e. increased Stop-signal reaction time; p = 0.031 and p = 0.053 respective

241 ation of MAPK kinase (MEK) and extracellular signal-regulated kinase 1/2 signaling; however, the clin

242 NPY, and we therefore hypothesized that NPY signaling regulates activity in the IC.

243 l2rg deficiency with the expression of human signal regulatory protein alpha, a negative regulator of

244 unodeficient Rat Rag-/- Gamma chain-/- human signal regulatory protein alpha-positive (RRGS) rats com

245 Additionally, TCR signal strength is able to regulate CD8(+) T cell effect

246 d ubiquitin complex that attenuates Hedgehog signaling strength and genetically interact to regulate

247 aken together, our data indicated that IL-25 signaling subverts the induction of protective immunity

248 elength velocities are useful for retrieving signals such as uplift along elevated viaducts of Metro

249 The time course of these signals suggest that this misaligned contribution likely

250 nd, remained unaltered upon manipulating Wnt signalling, suggesting Wnt-related genes to be downstrea

251 However, the extrinsic signals supervising these phenotypic transitions remain

252 Galanin signalling suppresses insulin secretion in animal models

253 ally design a DNA-based artificial molecular signaling system that uses the confined microenvironment

254 These data suggest a model whereby guidance signaling systematically shapes the intrinsic, stochasti

255 igh-pass filter to distort and attenuate the signal that reaches the recording amplifier.

256 was Traf3, a negative regulator of NF-kappaB signaling that has never previously been linked to densi

257 napse generated large negative extracellular signals that nonsynaptically inhibited neighboring PCs.

258 ceptors (RLR) are cytosolic RNA sensors that signal through the MAVS adaptor to activate IFN response

259 PI3K lipid kinases signal through the PI3K/Akt pathway, regulating cell gro

260 depends on the integration of extracellular signaling through multiple receptors, including the T-ce

261 ants critical for agonist binding and biased signaling through PAR4.

262 A literature survey indicated signaling time course data usually conform to one of fou

263 del, in this paper we develop methods to add signal to real RNA-seq datasets.

264 c factor that uses canonical dSmad2-mediated signaling to regulate wing size.

265 ified differences in adjustments of acoustic signals to anthropogenic noise among species.

266 olved in transducing phosphoantigen-mediated signals to human Vgamma9Vdelta2 T cells.

267 cell types may be coordinated to communicate signals to NSCs.

268 The signal-to-noise (S/N) for analytes improved up to 19-fol

269 of the sensor, we significantly improved the signal-to-noise ratio of UlaG detection.

270 MAB can be more sensitive and have a better signal-to-noise ratio, a bioluminescence-based assay was

271 -beta1) because of interleukin-4 (IL-4)- and signal transducer and activator of transciription-6 (STA

272 A significant decrease in phosphorylation of signal transducer and activator of transcription 5, a do

273 They serve as peroxide scavengers, sensors, signal transducers, and chaperones, depending on conditi

274 feature of the vertebrate Hh pathway is that signal transduction requires the primary cilium (PC) whe

275 ubiquitin chains is a key regulatory step in signal transduction that impacts cell death and inflamma

276 mechanisms and consequences of TLR-mediated signal transduction with a focus on themes identified in

277 with a requirement for G-proteins to mediate signal transduction, a situation similar, but not identi

278 l membrane proteins responsible for cellular signal transductions.

279 ghout the nervous system, mediating critical signal transmission and integration, as well as emergent

280 BCR signaling triggers a cascade of intracellular mediators

281 ay provide insights into understanding miRNA signaling underlying cancer cell metabolism and developm

282 s, that this interaction modulates antiviral signaling via disruption of USP7 interactions with innat

283 s suggest that FL3 inhibits Wnt/beta-catenin signaling via PHB1-dependent activation of Axin1.

284 rd to the ability of this molecule to induce signaling via rhesus macaque CD200R, as well as the pote

285 We uncovered a role for Xinbeta in signaling via the Hippo-YAP pathway by recruiting NF2 to

286 gical levels and their central role in redox signalling via different post-translational modification

287 Interleukin 22 (IL-22) signals via both IL-22 receptor alpha1 (IL-22Ralpha1) an

288 ion (PCR) detection corresponded well to ZsG signal, virus was only isolated from some lung, brain, l

289 these species, but insufficient phylogenetic signal was available.

290 le vial, from which Threshold Time of sensor signal was determined and then TVC values (CFU/cm(2)) we

291 togen-activated protein kinases and NFkappaB signaling was unaffected by global or HDAC3/6-selective

292 transcription 5, a downstream molecule of PL signaling, was observed in islets from Adipoq (-/-) dams

293 Because caspase-8 mediates CD95 signaling, we applied genetic approaches to dissect the

294 In general, the secondary ion signals were significantly enhanced by up to 3 orders of

295 me reversion and normalized T(H)17 cell/IL23 signaling, whereas dupilumab led to a stronger increase

296 hrough mechanical activation of p38-YAP-TEAD signaling, which likely contribute to myofibroblast hete

297 nd showed evidence of higher TCR-transmitted signals, which are also characteristics of recent thymic

298 s, we examined associations of brain insulin signaling with diabetes, AD, and level of cognition.

299 ood intake, understanding the role of opioid signaling within the OFC is fundamental for a mechanisti

300 the microdomain as well as enhanced phospho-signalling within, leading to a submicron gradient of ac