ライフサイエンスコーパス: signal transduction

1 her receptor endocytosis is required for Wnt signal transduction.

2 rcoded transcriptional reporter of G protein signal transduction.

3 desmin and vimentin directly participate in signal transduction.

4 e LAIR-1-induced inhibition of the human TCR signal transduction.

5 ncover a function for ribosome collisions in signal transduction.

6 P-1 interaction with CD63 and the subsequent signal transduction.

7 itide metabolism and inhibits MyD88-directed signal transduction.

8 ases, enabling robust ABA and osmotic stress signal transduction.

9 nt-negative affinity reagents that block Ras signal transduction.

10 tenna-like organelles essential for cellular signal transduction.

11 part, by impairing the MEK-ERK axis of MAPK signal transduction.

12 regulatory functions in gene expression and signal transduction.

13 mice are viable and fertile with normal Shh signal transduction.

14 icking, RNA processing and modification, and signal transduction.

15 xes, such as those observed in intracellular signal transduction.

16 s key nodes for interorganelle crosstalk and signal transduction.

17 er complexes and they orchestrate downstream signal transduction.

18 gnaling in the ASP are also dependent on Bnl signal transduction.

19 Bacteria masterfully co-opt and subvert host signal transduction.

20 components of mammalian visual and olfactory signal transduction.

21 hat endocytosis is not a requirement for Wnt signal transduction.

22 s long been used to reveal new mechanisms of signal transduction.

23 o be achieved in the cell to ensure accurate signal transduction.

24 novel mechanism in which NAD(+) affects TLR4 signal transduction.

25 osphatases, are central elements of cellular signal transduction.

26 d downstream intracellular calcium-dependent signal transduction.

27 ed that lysosomes are organizing centers for signal transduction.

28 uorum-sensing signaling and second messenger signal transduction.

29 r of complexity to our understanding of cAMP signal transduction.

30 e Wnt9a-Fzd9b-LRP signalosome and subsequent signal transduction.

31 amental organelle in cellular metabolism and signal transduction.

32 ary CRISPR-linked genes, often implicated in signal transduction.

33 uce signal transduction, led to induction of signal transduction.

34 eins seem not to be directly responsible for signal transduction.

35 r compartmentation of Ca(2+) and calcineurin signal transduction.

36 (homo- or heterodimerization) is central to signal transduction.

37 nvolved in protein folding, trafficking, and signal transduction.

38 are membrane proteins implicated in cellular signal transduction.

39 nes that require TYK2 and Janus kinase 1 for signal transduction.

40 wraps around axons to facilitate electrical signal transduction.

41 l membrane proteins responsible for cellular signal transductions.

42 D-PLNPs, resulting from MI-triggered R-PersL signal transductions.

43 s of non-canonical AUX/IAA proteins in auxin signaling transduction.

44 Ub ligases, for perception and initiation of signaling transduction.

45 with a requirement for G-proteins to mediate signal transduction, a situation similar, but not identi

46 NPM1c mislocalizes FLT3-TKD and changes its signal transduction ability.

47 results in the context of an intramolecular signal transduction accounting for many previous observa

48 ll remodeling, targeted protein degradation, signal transduction, adhesion, and small secreted protei

49 es play essential roles in regulating neural signal transduction along neural circuits in CNS.

50 recently been reported to enable long-range signal transduction also in asymmetric dimers containing

51 Signal transduction analyses reveal that both human and

52 ukin (IL)-6/IL-6 receptor-alpha (IL-6Ralpha)/signal transduction and activation of the transcription

53 An AuNP-antibody conjugate serves as a signal transduction and amplification agent by promoting

54 omain dimerization is essential for internal signal transduction and autophosphorylation in this prot

55 stable predictions to guide further study of signal transduction and cell behavior that affect mesenc

56 Protein kinases are essential for signal transduction and control of most cellular process

57 and links trypanosome environmental sensing, signal transduction and developmental gene expression in

58 e implications of RAF kinase dimerization in signal transduction and for drug development, both from

59 diverse cell-autonomous processes, including signal transduction and gene expression patterns, arisin

60 gement, cell movement, microtubule dynamics, signal transduction and gene expression.

61 ting theoretical and experimental studies on signal transduction and gene regulation.

62 s its role as a peptidase, APN also mediates signal transduction and is involved in the activation of

63 ed receptors (GPCRs) plays a central role in signal transduction and is uniquely positioned to sense

64 ve view of the molecular events of the IL-17 signal transduction and its regulation.

65 he recognized importance of PPIn species for signal transduction and membrane homeostasis, there is s

66 o clathrin-coated structures is essential to signal transduction and nutrient uptake.

67 ogy, ranging from genetics and biophysics to signal transduction and physiology.

68 starch and sucrose metabolism, plant hormone signal transduction and plant-pathogen interaction pathw

69 The lysosome also serves as a hub for signal transduction and regulates longevity via affectin

70 brane proteins that are either essential for signal transduction and solute transport or function as

71 S has significant interactions with CusR for signal transduction and that CusS's affinity toward CusR

72 Cilia are essential for Shh signal transduction and the ciliary phosphatidylinositol

73 BCCs with implications for zinc finger-based signal transduction and therapeutics.

74 it is unclear how GPR52 and G(s) couple for signal transduction and whether a native ligand or other

75 ch as transcriptional regulation, apoptosis, signal transduction, and cell migration.

76 ns to cell division, DNA replication/repair, signal transduction, and glutathione metabolism.

77 deepen our mechanistic understanding of Wnt signal transduction, and have implications for harnessin

78 lluminating the regulatory mechanisms of ABA signal transduction, and the physiological importance of

79 s ion transport, oxidative stress tolerance, signal transduction, and transcriptional regulation.

80 f cytokine-dependent cellular proliferation, signal transduction, and transcriptome analysis.

81 cellular functions, including cell motility, signal transduction, and virus replication.

82 ions can contribute to the complexity of RTK signal transduction, and we highlight the utility of qua

83 innate immune response and the regulation of signal transduction, apoptosis, cell proliferation, and

84 Some targets of Hh signal transduction are common to the disc, ASP and myob

85 igger cilia formation, extension and ciliary signal transduction are still not fully understood.

86 he proteins that bind the molecule to effect signal transduction are unknown.

87 ands, the turnover of Wnt receptors, and the signaling transduction are tightly regulated and fine-tu

88 f TL1A-stimulated fibroblasts identified Rho signal transduction as a major pathway activated by TL1A

89 normal ciliogenesis but severely altered Hh-signal transduction as a result of either altered PC tra

90 anslation, protein phosphorylation, cellular signal transduction, as well as mechanical roles.

91 sight into key components necessary for KRAS signal transduction at the PM, we used synthetic membran

92 virus entry in which receptor engagement and signal transduction bring the coreceptor to viral partic

93 as not due to stochasticity of intracellular signal transduction but rather to preexisting establishe

94 To specifically study signal transduction by CARs, we developed a cell-free, l

95 dings reveal how long-lasting attenuation of signal transduction by degradation events regulates cell

96 Although signal transduction by immunoreceptors such as the T cel

97 uced folding transition commonly observed in signal transduction by intrinsically disordered proteins

98 raction with CusR likely ensure an efficient signal transduction by providing proper conformation and

99 oupled receptors, but they may also modulate signal transduction by several other mechanisms.

100 ases the expression of genes involved in the signal transduction by the p53 class mediator, which is

101 ses the environmental cue that initiates the signal transduction cascade leading to changes in cellul

102 A signal transduction cascade regulates this process, a co

103 e key developmental regulators that engage a signal transduction cascade through receptor tyrosine ki

104 Exit Network (MEN), a budding yeast Ras-like signal transduction cascade, translates nuclear position

105 ape-complementary coreceptor and initiates a signal transduction cascade, which leads to a variety of

106 all FGF activities depend on this canonical signal transduction cascade.

107 pathogenic fungi, given their involvement in signal transduction cascades.

108 ith important implications for intracellular signal transduction, cell migration, and differentiation

109 of electrophysiological studies of synaptic signal transduction, conventional models of neurotransmi

110 eceptor pairs based on ligand binding and/or signal transduction could advance hormone-based physiolo

111 regulates diverse cellular processes such as signal transduction, cytoskeletal organization and cell

112 ncluding cell growth and cell cycle control, signal transduction, DNA repair, transcription, and many

113 While the signal transduction downstream of EGFR has been extensiv

114 rker of mitogen-activated protein kinase-ERK signal transduction downstream of FGF receptor activatio

115 phosphatase SHP2, a critical mediator of RAS signal transduction downstream of multiple RTK, represen

116 mber of the JAK kinase family that regulates signal transduction downstream of receptors for the IL-2

117 Evidence is emerging that signal transduction elements are activated in a-nucleate

118 This response is dependent on early and late signal transduction events that involve important signal

119 rane-localized receptors of legumes activate signal transduction following perception of rhizobial si

120 -phase chemistry and offers a novel route to signal transduction for the sensing of energetic materia

121 However, the regulation of the signal transduction from the IL-17 receptor (IL-17R) rem

122 ain redox homeostasis signaling and modulate signal transduction, gene expression and cellular functi

123 le of endogenous N-RasG12D palmitoylation in signal transduction, hematopoietic differentiation, and

124 mplicity of operation, unique versatility of signal transduction (i.e. average or discrete signals),

125 n-binding protein FLNA (filamin A) regulates signal transduction important for cell locomotion, but t

126 he globin domain's dimerization interface in signal transduction in AfGcHK.

127 strongly implicated as master regulators of signal transduction in cancer, where raft compartmentali

128 all 4 aptamer RCAs significantly induced the signal transduction in chicken HD11 macrophage cell line

129 on of cell cycle progression, DNA repair and signal transduction in different cancers.SEMA is a first

130 We compared signal transduction in expanded T cells to that in T cel

131 nses to gentle touch and sound by amplifying signal transduction in low-threshold mechanoreceptors (S

132 esponses and are essential for Hedgehog (Hh) signal transduction in mammals.

133 e physiological functions of CD36 in insulin signal transduction in mice fed a low-fat diet.

134 ocytosis with quantitative assessment of Wnt signal transduction in mouse embryonic stem cells (mESCs

135 EPS improved insulin signal transduction in myotubes from lean but not severe

136 dyes (VSDs) are important tools for probing signal transduction in neurons and other excitable cells

137 at are involved in developmental control and signal transduction in plants.

138 GFbeta) and bone morphogenetic protein (BMP) signal transduction in postnatal mice, with BMP signalin

139 We also analyzed signal transduction in T cells expressing BCR or B cells

140 receptors that mediate rapid electrochemical signal transduction in the animal nervous system through

141 ral studies have elucidated the mechanism of signal transduction in the cGAS pathway at the atomic re

142 and PERK, do not contribute to inhibition of signal transduction in the insulin signaling pathway.

143 not, and decreased mechano- and chemosensory signal transduction in uninjured bystander neurons.

144 entrations, and activate Ca(2+) , ABA and JA signaling transductions in plants.

145 a subcellular compartment that orchestrates signal transduction independent from the cell body.

146 Here, IL-22 SyCyRs phenocopied native IL-22 signal transduction, indicated by induction of cytokine-

147 Kv7.4 and Kv7.5 channels are known signal transduction intermediates and drug targets for r

148 asma membrane-associated abscisic acid (ABA) signal transduction is an integral part of ABA signaling

149 n the endodermally derived epithelium, while signal transduction is confined to the mesenchymal compa

150 Specificity in signal transduction is determined by the ability of cell

151 ar mechanism by which proteoglycans regulate signal transduction is largely unknown.

152 In mammalian cells, much of signal transduction is mediated by weak protein-protein

153 How TARK1 participates in immune signal transduction is not well understood.

154 rokinetic-based streaming current method for signal transduction is proposed.

155 ilize periodic hole arrays in gold films for signal transduction is reported.

156 Pre-T-cell receptor (TCR) signal transduction is required for developing thymocyte

157 Although dysfunctional signaling transduction is attributed to airway inflammat

158 zyme playing critical roles in intracellular signal transduction, is essential for epidermal barrier

159 hich previously was considered not to induce signal transduction, led to induction of signal transduc

160 as recently shown that the SE functions as a signal transduction ligand that activates a cell surface

161 sor domain, unraveling features critical for signal transduction, ligand binding, and voltage sensing

162 cytoplasmic calcium, a novel finding for OR signal transduction, likely because of cell lineage.

163 r their receptors and/or receptor-associated signal transduction machinery such as Janus kinases.

164 s, particularly Hsp90, central regulators of signal-transduction machinery, with important impacts on

165 findings provide critical insights into the signal transduction mechanism of the histidine kinase Af

166 FET conductivity and thereby constituted the signal transduction mechanism of the modified transistor

167 efence, has received much attention, but the signal transduction mechanisms are poorly defined.

168 Yet, signal transduction mechanisms for salty taste have rema

169 A detailed understanding of the signal transduction mechanisms in heme-containing sensor

170 axis has been obtained and inactivation and signal transduction mechanisms indicate that RAF dimeriz

171 We examined the signal transduction mechanisms of serelaxin when applied

172 ure provides a blueprint for deciphering the signal transduction mechanisms of synaptic AMPARs.

173 h which to decipher the mechanistic modes of signal transduction mediated by GABA(B) dimers, and have

174 A signal transduction model based on nonlinear direct cell

175 or of G protein signaling (RGS) proteins are signal transduction modulators, expressed widely in vari

176 ization of specific receptors and associated signal transduction modules in the cilium.

177 changes at the cell surface, and downstream signal transduction modules.

178 entral to many biological processes, such as signal transduction, molecule translocation, and ion tra

179 ts suggest a refined picture of the platelet signal transduction network associated with CLEC-2.

180 In order to analyze how a signal transduction network converts cellular inputs int

181 ultaneous measurement of multiple nodes of a signal transduction network within single cells.

182 mplex osmotic-stress and abscisic acid (ABA) signal transduction network.

183 which genes that confer ASD risk operate in signal transduction networks critical for both cortical

184 lecule inhibitors targeting either oncogenic signal transduction or epigenetic regulation can alter s

185 critical roles in apoptosis, cell adhesion, signal transduction, or metabolite homeostasis.

186 -STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for r

187 ibed roles in regulating glycolytic flux and signal transduction, particularly gene transcription.

188 sion, activation of TAK-1 by the TLR-4/MyD88 signal transduction pathway and MLCK by NF-kappaB p65/p5

189 Our data suggest a complete signal transduction pathway by which cAMP increases NCC

190 These data uncover a previously unknown signal transduction pathway by which the SE facilitates

191 isic acid (ABA) that acts through a receptor-signal transduction pathway comprising a PYRABACTIN RESI

192 Serotonin acts through a signal transduction pathway conserved between C. elegans

193 The pooled prevalence indices of signal transduction pathway mutations in gastric cancer,

194 evelopmental Cell, Ho and Treisman uncover a signal transduction pathway that coordinates muscle grow

195 so trigger assembly of T6SS organelles via a signal transduction pathway that involves protein phosph

196 have tested this hypothesis by perturbing a signal transduction pathway that plays a major role in c

197 ing a nitric oxide/S-nitrosylation-dependent signal transduction pathway that regulates the growth co

198 ed by the unfolded protein response (UPR), a signal transduction pathway that senses the fidelity of

199 e in T6SS activity was dependent on the same signal transduction pathway that was previously shown to

200 , the main downstream effectors of the Hippo signal transduction pathway, are emerging as pivotal det

201 nt of the Toll-like receptor 4 (TLR4) immune signal transduction pathway.

202 tion of the cJun NH(2)-terminal kinase (JNK) signal transduction pathway.

203 Many signal transduction pathways activate RhoA-for instance,

204 Integrating changes in signal transduction pathways and cellular metabolism is

205 oteins are known to participate in canonical signal transduction pathways and in the regulation of ac

206 Uncovering the missing elements of signal transduction pathways and psbA gene expression co

207 n to uncover the links between the classical signal transduction pathways and the physical mechanisms

208 GTPase signal transduction pathways control cellular decision m

209 In normal cells, signal transduction pathways control core cellular funct

210 extracellular factors and the intracellular signal transduction pathways engaged in this process rem

211 xpression of IFN-kappa and its modulation by signal transduction pathways in human keratinocytes.

212 ifunctional signal transducer that regulates signal transduction pathways in leukocytes, including ma

213 plex disease, the molecular underpinnings of signal transduction pathways in the cell, and drug disco

214 igated the extent to which modulation of the signal transduction pathways influence TNFalpha producti

215 However, the downstream signal transduction pathways involved are poorly charact

216 Fluctuation in signal transduction pathways is frequently observed duri

217 Signal transduction pathways mediated by p38 mitogen-act

218 mponents, and compounds able to modulate the signal transduction pathways of the cannabinoid type-2 r

219 e understanding of the protein complexes and signal transduction pathways regulated by RGS proteins i

220 apies with cytotoxic drugs and inhibitors of signal transduction pathways such as mTOR-Is.

221 Identifying the important signal transduction pathways that control monocyte chemo

222 nce and cellular stress to the intracellular signal transduction pathways that drive the liver fastin

223 verexpressed in many cancers and involved in signal transduction pathways that promote cancer cell pr

224 ogy (Rho) GTPases regulate cell polarity and signal transduction pathways to control morphogenetic re

225 the discovery and characterization of novel signal transduction pathways to exploring the molecular

226 oaches to induce cardioprotection, and their signal transduction pathways, are discussed.

227 icroglial cells may over time engage various signal transduction pathways, inflammasome activation, w

228 Eukaryotic chemoattraction signal transduction pathways, such as those used by Dict

229 nt are likely to function in development and signal transduction pathways, while those that are mutat

230 mutations abrogated established FGF-induced signal transduction pathways, yet FGF functions such as

231 aracterized by their involvement in critical signal transduction pathways.

232 marize how SUMOylation regulates a number of signal transduction pathways.

233 sions, and function as scaffolds for various signal transduction pathways.

234 s and downstream signaling effectors in many signal transduction pathways.

235 ally reversible, PTMs serve as regulators of signal transduction pathways.

236 on is a key regulator of protein function in signal transduction pathways.

237 from external stimuli to regulate downstream signal transduction pathways.

238 y support mechanical integrity and influence signal transduction pathways.

239 lates iTreg cell outcomes through 2 distinct signal transduction pathways: one Smad3 dependent and th

240 We address both biochemical signal-transduction pathways and engineering principles

241 we concisely highlight the main biochemical signal-transduction pathways involved in the biocompatib

242 regulate membrane trafficking and to control signaling transductions pathways.

243 These genes were mainly associated with signal transduction, photosynthesis, regulation and resp

244 esses such as transcription and translation, signal transduction, post-translational modification cas

245 The molecular mechanisms of Ca(2+)/CaM signal transduction processes and their functional signi

246 anding of the spatiotemporal coordination of signal transduction processes in Arabidopsis.

247 Deciphering signal transduction processes is crucial for understandi

248 t tools that provide control over biological signal transduction processes.

249 ion, and play essential roles in an array of signal transduction processes.

250 rchaeal genome, MiST 3.0 provides a complete signal transduction profile, thus facilitating theoretic

251 stered with the gene encoding the regulatory signal transduction protein PII, suggesting a functional

252 the pro-B-cell stage (via activation of the signal-transduction protein STAT5)(2-4) or pre-B-cell re

253 Heterotrimeric G proteins are signal transduction proteins involved in regulating nume

254 GTF2I targets were enriched for signal transduction proteins, including regulators of ph

255 aling three classes of dispersal components: signal transduction proteins, matrix-degradation enzymes

256 d by many of the enzymes involved, including signal transduction proteins, O(2) homeostasis systems,

257 tractant-dependent ErkB targeted core set of signal transduction proteins, which collectively suggest

258 sses of ligand binding, receptor activation, signal transduction, regulation by accessory proteins, a

259 In bacteria, signal transduction relies on two-component systems (TCS

260 ne signaling antagonizes abscisic acid (ABA) signal transduction require further investigation.

261 feature of the vertebrate Hh pathway is that signal transduction requires the primary cilium (PC) whe

262 Hh signal transduction requires the primary cilium for seve

263 presence of IL-7, this augmented downstream signal transduction, resulting in increased STAT5 transc

264 ional modifications (PTMs) are key events in signal transduction since they affect protein function b

265 As a central player in TGF-beta signal transduction, SMAD4 (also known as DPC4) is frequ

266 Sonic hedgehog (Shh) signal transduction specifies ventral cell fates in the

267 B. cinerea, combining the two most important signal transduction subproteomes.

268 and discovered that the BumSR two-component signal transduction system (TCS) directs a response to b

269 owledge, the BumSR TCS is the only bacterial signal transduction system identified so far that mediat

270 ficile employs phase variation of the CmrRST signal transduction system to generate phenotypic hetero

271 This occurs via a hitherto unrecognized signal transduction system whereby cytoplasmic sentinel

272 sphate starvation-responsive Pst/SenX3-RegX3 signal transduction system.

273 Bacteria and archaea employ dedicated signal transduction systems that modulate gene expressio

274 central to phosphotransfer in two-component signal transduction systems, regulating phosphorylation

275 a comprehensive classification of microbial signal transduction systems.

276 nisms are often controlled via two-component signal transduction systems.

277 nges via several broad categories of sensory signal transduction systems.

278 ubiquitin chains is a key regulatory step in signal transduction that impacts cell death and inflamma

279 tent modulator of G-protein-coupled receptor signal transduction that is expressed throughout the pai

280 osttranscriptional control, endocytosis, and signal transduction that is important for ESC proliferat

281 vide insight into the function of ITK in TCR signal transduction that ultimately regulates IRF4 expre

282 teins in the pathway established that during signal transduction they dynamically localize in primary

283 GTPases regulate cell growth and division by signal transduction through the ERK cascade and mutation

284 increases the specificity and efficiency of signal transduction through the ERK pathway.

285 Signal transduction through the RAF-MEK-ERK pathway, the

286 ver wire was introduced into electrochemical signal transduction to improve the sensitivity of electr

287 the overall homodimeric assembly and allows signal transduction to the covalently linked physiologic

288 docking interface, laying the foundation for signal transduction to the regulatory switch helix.

289 The IL-17A signal transduction triggers two broad, TRAF6- and TRAF5

290 ated to transpiration, root development, and signal transduction underlie these putative CT loci.

291 aimed to investigate CLEC-2-induced platelet signal transduction using computational modeling in comb

292 istic of membrane biology and is crucial for signal transduction, vesicle transport, and cell divisio

293 -expressed RRV vCD200 is capable of inducing signal transduction via RM CD200R, while the secreted fo

294 ng of CD3, which likely impact initiation of signal transduction via TCR.

295 f internalized VEGFR2, prolonging downstream signal transductions via PLCgamma, Erk, and Akt, and pro

296 a wide range of biological events including signal transduction, viral infection and membrane curvat

297 Signal transduction was strictly polarized to the serosa

298 nase 2 (LIMK2), an essential molecule in p21 signal transduction, was significantly upregulated and r

299 mechanisms and consequences of TLR-mediated signal transduction with a focus on themes identified in

300 These findings reveal a potential route of signal transduction within the CRISPR-Cas9 HNH nuclease,