ライフサイエンスコーパス: signal transduction pathway

1 bly through a hitherto unknown communication signal transduction pathway.

2 the immunoreceptor tyrosine-based activation signal transduction pathway.

3 tion of the cJun NH(2)-terminal kinase (JNK) signal transduction pathway.

4 ed to inflammation or activation of the STAT signal transduction pathway.

5 rganelles harboring components of the visual signal transduction pathway.

6 ion, suggesting early activation of the STAT signal transduction pathway.

7 nt of the Toll-like receptor 4 (TLR4) immune signal transduction pathway.

8 a role in cell proliferation through the Shh signal transduction pathway.

9 ated kinase/mitogen-activated protein kinase signal transduction pathway.

10 /extracellular signal-regulated kinase (ERK) signal transduction pathway.

11 nd IL-1 receptor-like 1 (IL1RL1), act in one signal transduction pathway.

12 w that it is an indispensable part of the OS signal transduction pathway.

13 erized by constitutive activation of the Ras signal transduction pathway.

14 used these genes to investigate the c-di-GMP signal transduction pathway.

15 including those involved in the phytochrome signal transduction pathway.

16 rocesses as a mediator of cross-talk between signal transduction pathways.

17 on is a key regulator of protein function in signal transduction pathways.

18 ted proteins into complexes, organelles, and signal transduction pathways.

19 from external stimuli to regulate downstream signal transduction pathways.

20 duced cell transformation and the associated signal transduction pathways.

21 lotting were used to determine activation of signal transduction pathways.

22 for sensory physiology and modulate various signal transduction pathways.

23 Cells communicate with their environment via signal transduction pathways.

24 bosome biogenesis, and phosphorylation-based signal transduction pathways.

25 lular messenger that plays a central role in signal transduction pathways.

26 y support mechanical integrity and influence signal transduction pathways.

27 s are evolutionarily conserved regulators of signal transduction pathways.

28 the measured responses of a few proteins or signal transduction pathways.

29 receptor conformations activating different signal transduction pathways.

30 in degradation, subcellular localization and signal transduction pathways.

31 ral nervous system functions through diverse signal transduction pathways.

32 r stromule frequency in reaction to internal signal transduction pathways.

33 ase-3 (Gsk-3) is a key regulator of multiple signal transduction pathways.

34 aches to cancer treatment focus on targeting signal transduction pathways.

35 is, and cellular regulation of immune system signal transduction pathways.

36 one of the critical steps for many cellular signal transduction pathways.

37 cellular outputs and responses by modulating signal transduction pathways.

38 ncert exert reversible control over numerous signal transduction pathways.

39 cytokinesis 8 (DOCK8), which are involved in signal transduction pathways.

40 process, and is often activated by multiple signal transduction pathways.

41 aracterized by their involvement in critical signal transduction pathways.

42 ARPs are not simply downstream executors of signal transduction pathways.

43 /ligand interactions that stimulate numerous signal transduction pathways.

44 esolution that is necessary in understanding signal transduction pathways.

45 marize how SUMOylation regulates a number of signal transduction pathways.

46 required to selectively modulate downstream signal transduction pathways.

47 ght allow activation of yet to be identified signal transduction pathways.

48 lation of cytokine receptors or TLR-mediated signal transduction pathways.

49 peutically important phosphatases feature in signal transduction pathways.

50 sions, and function as scaffolds for various signal transduction pathways.

51 s and downstream signaling effectors in many signal transduction pathways.

52 cesses and pathways, including signaling and signal transduction pathways.

53 o T cell activation reveal key insights into signal transduction pathways.

54 transcriptional regulation and activation of signal transduction pathways.

55 ally reversible, PTMs serve as regulators of signal transduction pathways.

56 many proteins involved in a wide variety of signal transduction pathways.

57 ite specificity for directing protein kinase signal transduction pathways.

58 ity and trafficking, and the organization of signal transduction pathways.

59 d that Epr3 is integrated into the symbiosis signal transduction pathways.

60 arcinoma cells and for the study of involved signal transduction pathways.

61 factors act indirectly via receptor-mediated signal transduction pathways.

62 thyroid carcinoma and describe the involved signal transduction pathways.

63 pressor genes, and dysregulation of multiple signal-transduction pathways.

64 opmental decision-making in association with signal-transduction pathways.

65 e a role in regulating protein stability and signaling transduction pathways.

66 regulate membrane trafficking and to control signaling transductions pathways.

67 a can function as an integrated two-receptor signal transduction pathway, a finding with implications

68 Developmental signal transduction pathways act diversely, with context

69 Many signal transduction pathways activate RhoA-for instance,

70 Signal transduction pathways activated by chemoattractan

71 MK2 is also one of the major players in the signal transduction pathways activated in response to DN

72 enic responses depending upon the balance of signal transduction pathways activated, targeting specif

73 and molecular composition, the intracellular signal transduction pathways, active during specific pha

74 sion, activation of TAK-1 by the TLR-4/MyD88 signal transduction pathway and MLCK by NF-kappaB p65/p5

75 w-abundance signaling molecules that control signal transduction pathways and are necessary for cellu

76 Integrating changes in signal transduction pathways and cellular metabolism is

77 anslational modification controlling several signal transduction pathways and displaying an acute eff

78 tein FHL2 is a crucial modulator of multiple signal transduction pathways and functions as a scaffold

79 n many chicken genes and pathways, including signal transduction pathways and immune system processes

80 oteins are known to participate in canonical signal transduction pathways and in the regulation of ac

81 ting actin cytoskeletal dynamics, regulating signal transduction pathways and inhibiting host secreto

82 Ras GTPase mediates several cellular signal transduction pathways and is found mutated in a l

83 albumin concentrations, which disrupt normal signal transduction pathways and lead to an overactivati

84 G-protein-coupled receptors regulate signal transduction pathways and play diverse and pivota

85 Uncovering the missing elements of signal transduction pathways and psbA gene expression co

86 ulated kinase 1/2, and ribosomal S6 kinase 1 signal transduction pathways and subsequent increase in

87 t the role of the ERM proteins in regulating signal transduction pathways and suggests that modulatio

88 n to uncover the links between the classical signal transduction pathways and the physical mechanisms

89 nderstood with our evolved knowledge of many signal transduction pathways and the way they converge a

90 rk architecture to integrate the activity of signal transduction pathways and transcriptional regulat

91 comprised different, functionally unrelated signal transduction pathways and were expressed in diffe

92 We address both biochemical signal-transduction pathways and engineering principles

93 3/phosphoinositide 3-kinase/protein kinase B signal transduction pathway, and that can be overcome by

94 and cell cycle control, microRNA silencing, signal transduction pathways, and hormone-driven disease

95 bolism are tightly controlled by enzymes and signal transduction pathways, and their dysregulation le

96 veal a cross-talk among the external milieu, signal transduction pathways, and transcription factors

97 Systems biology approaches to defining how signal transduction pathways are integrated at the level

98 Host cell signal transduction pathways are often targets of bacter

99 , the main downstream effectors of the Hippo signal transduction pathway, are emerging as pivotal det

100 oaches to induce cardioprotection, and their signal transduction pathways, are discussed.

101 rticipates in the canonical Wnt/beta-catenin signal transduction pathway as well as modulating cytosk

102 Increasing knowledge about signal transduction pathways as drivers of cancer growth

103 ment, generating a holistic view of cellular signal transduction pathways as exemplified by analysis

104 this study are the first to define the LytSR signal transduction pathway, as well as determine the me

105 ays influenced by all targets were primarily signal transduction pathways associated with CF, includi

106 is the ligand-specific activation of certain signal transduction pathways at a receptor that can sign

107 oral manner and therefore fills a gap in the signal transduction pathway between pathogen recognition

108 ling, via FGF receptor 4 (Fgfr4), mediates a signal-transduction pathway between Wnt16 and Dlc, but n

109 ches to tune the activation of intracellular signal transduction pathways both predictably and select

110 ein methylation is an important modulator of signal transduction pathways, but methyltransferases the

111 nal cues are controlled by a small number of signal-transduction pathways, but how the specificity of

112 Our data suggest a complete signal transduction pathway by which cAMP increases NCC

113 P450 expressed only in males, as well as the signal transduction pathway by which episodic GH solely

114 These data uncover a previously unknown signal transduction pathway by which the SE facilitates

115 receptors, and some family members modulate signal transduction pathways by acting as co-receptors.

116 diated, in part, through redox-sensitive AKT signal transduction pathways by up-regulating the expres

117 However, the signal transduction pathways by which extracellular sign

118 A common approach is to insulate signal-transduction pathways by minimizing molecular-lev

119 In budding yeast, one such signal transduction pathway called the mitotic exit netw

120 Changes in these signal transduction pathways can lead to differential ge

121 biotic stresses are often very specific, but signal transduction pathways can partially or completely

122 lles and membrane-trafficking intermediates, signal transduction pathways, cell cycle regulators, the

123 tion of mtDNA may emerge from studies of how signal transduction pathways command mitochondrial funct

124 l lines with disruptions of cAMP and/or AprA signal transduction pathway components, and delineated t

125 isic acid (ABA) that acts through a receptor-signal transduction pathway comprising a PYRABACTIN RESI

126 of which is controlled through a proteolytic signal transduction pathway comprising a sensor protein

127 Serotonin acts through a signal transduction pathway conserved between C. elegans

128 re we characterise a multi-step phosphorelay signal transduction pathway consisting of TcsA, TcrA, Fs

129 tors of the phosphoinositide 3-kinase (PI3K) signal transduction pathway contribute to the hypothalam

130 GTPase signal transduction pathways control cellular decision m

131 In normal cells, signal transduction pathways control core cellular funct

132 Multiple wound-related signal transduction pathways control the deposition of E

133 ble kinase 3 (SIK3) as the central node in a signal transduction pathway controlling glial K(+) and w

134 tical cellular stress response; however, the signal transduction pathways controlling autophagy induc

135 Ras is at the hub of signal transduction pathways controlling cell proliferat

136 ed, indicating that targeting a specific D2R signal transduction pathway could allow for more precise

137 ession profiles of genes enriched in several signal transduction pathways critical for coronary heart

138 links to and regulates synaptic adhesion and signal transduction pathways critical for normal cogniti

139 However, the signal transduction pathways culminating in the biologic

140 r regulation of several processes, including signal transduction pathways, development, and disease.

141 s, cytoskeletal protein networks and complex signal transduction pathways driven by localized protein

142 ignaling pathway is considered to be a major signal transduction pathway during embryonic development

143 dissect in vivo the requirement of different signal transduction pathways emanating from KIT for tumo

144 extracellular factors and the intracellular signal transduction pathways engaged in this process rem

145 Activation of the EphR-Ephrin signal transduction pathway enhances S863 phosphorylatio

146 lso function as modulators of a multitude of signal transduction pathways evoked by environmental sti

147 has been proposed to play a central role in signal transduction pathways evoked by the drought and s

148 on the PhoB and TctD mediated two-component signal transduction pathways exemplify how P. aeruginosa

149 ects through direct interactions with ILK, a signal transduction pathway firmly linked to cell motili

150 The signal transduction pathways for the cross talk between

151 NPM-ALK co-opts several intracellular signal transduction pathways, foremost being the STAT3 p

152 Notch signaling is a ubiquitous signal transduction pathway found in most if not all met

153 thesis with sphingolipid metabolism and link signal transduction pathways from the plasma membrane to

154 The evolutionary conserved Wnt signal transduction pathway has long been known for its

155 Although central elements in the cytokinin signal transduction pathway have been identified, mechan

156 Light signal transduction pathways have been extensively studi

157 entified crucial pathways, including several signal transduction pathways, hormone response, oxidativ

158 lem of signaling regulation, a two-component signal transduction pathway in bacterial homeostasis, an

159 r microenvironment, activating the NF-kappaB signal transduction pathway in MDSCs and regulating thei

160 Our data describe a novel signal transduction pathway in neurons whereby ApoE acti

161 arious BMP receptors and members of the SMAD signal transduction pathway in nociceptive sensitization

162 e Arabidopsis thaliana forward nuclear auxin signal transduction pathway in Saccharomyces cerevisiae

163 n the bacterial phosphotransferase system, a signal transduction pathway in which phosphoryl transfer

164 enes were involved in multiple signaling and signal transduction pathways in a wide variety of cellul

165 Protein kinases regulate the majority of signal transduction pathways in cells and have become im

166 The crosstalk between these signal transduction pathways in coordinating environment

167 Epigenetic enzymes modulate signal transduction pathways in different biological con

168 xpression of IFN-kappa and its modulation by signal transduction pathways in human keratinocytes.

169 mprehensive, validated, and annotated map of signal transduction pathways in inflammatory Mvarphis ba

170 ifunctional signal transducer that regulates signal transduction pathways in leukocytes, including ma

171 Calcium is a second messenger in signal transduction pathways in plants, and it has been

172 Crk and CrkL are capable of initiating major signal transduction pathways in response to extracellula

173 plex disease, the molecular underpinnings of signal transduction pathways in the cell, and drug disco

174 w for a screening-type analysis of potential signal transduction pathways in the cells.

175 Crosstalk may happen among receptor-mediated signal transduction pathways in the same host during sim

176 d that AprA uses a subset of chemoattraction signal transduction pathways including Ras, protein kina

177 icroglial cells may over time engage various signal transduction pathways, inflammasome activation, w

178 igated the extent to which modulation of the signal transduction pathways influence TNFalpha producti

179 Emerging work points to Nrf2-Keap1 signal transduction pathway inhibitors, including Bach1

180 imeric G proteins play a pivotal role in the signal-transduction pathways initiated by G-protein-coup

181 lists confirms the pan-cancer importance of signal transduction pathways, innate and adaptive immune

182 However, broad inhibition of such a central signal transduction pathway involved in essential cellul

183 However, the downstream signal transduction pathways involved are poorly charact

184 However, little is known about the signal transduction pathways involved in mechanical stim

185 However, signal transduction pathways involved remain largely uni

186 we concisely highlight the main biochemical signal-transduction pathways involved in the biocompatib

187 Traditional study of signal transduction pathways involves mapping cellular s

188 These data define a novel signal transduction pathway involving c-src that is acti

189 trations is reported that operates through a signal transduction pathway involving multivalent intera

190 vascular remodeling is mediated by specific signal transduction pathways involving NFAT or C/EBPbeta

191 FLS is controlled by multiple interconnected signal transduction pathways involving reversible phosph

192 activation is not mediated by the canonical signal transduction pathway, involving ApoER2/VLDLR and

193 Moreover, we reveal that the chemotactic signal transduction pathway is conserved in Shewanella,

194 BR signal transduction pathway is well elucidated in Arabid

195 Fluctuation in signal transduction pathways is frequently observed duri

196 ferentially signal through a small number of signal transduction pathways is not well resolved.

197 ent analysis reveals that the 'plant hormone signal transduction' pathway is enhanced during pollen-p

198 emerging evidence demonstrates that the PI3K signaling transduction pathway is linked to the patholog

199 highly homologous yet distinct components of signal transduction pathways known to regulate cell surv

200 Additionally, rewired kinase signal transduction pathways likely contribute to the su

201 Signal transduction pathways mediated by p38 mitogen-act

202 Understanding the mechanism of the signal transduction pathways mediated by these proteins

203 First, we examined whether Pfs47 affected signal transduction pathways mediating mosquito immune r

204 To address the signal transduction pathways mis-regulated in renal inju

205 lls are endowed with a PLCbeta2/IP3 R3/TRPC6 signal transduction pathway modulating release of neurop

206 The pooled prevalence indices of signal transduction pathway mutations in gastric cancer,

207 actions between HIV-1 proteins and key human signal transduction pathways necessary for activation of

208 evealed as the upstream components of growth signal transduction pathway of psoriatic pathogenesis.

209 The signal transduction pathway of the DNA damage response (

210 nd assessed systemic insulin sensitivity and signal transduction pathways of glucose utilization at t

211 mponents, and compounds able to modulate the signal transduction pathways of the cannabinoid type-2 r

212 However, the underlying intracellular signalling transduction pathways of alpha-syn-mediated m

213 lates iTreg cell outcomes through 2 distinct signal transduction pathways: one Smad3 dependent and th

214 somatic events converging on the same gene, signal transduction pathway, or protein complex in diffe

215 suppressed following stimulation by multiple signal transduction pathways, our findings also suggest

216 view Ca2+/CaM as a limiting resource in the signal transduction pathway owing to its low abundance r

217 a transcription factor of the abscisic acid signal transduction pathway, plays a major role during s

218 The signal transduction pathways present during the early ph

219 stalk mechanisms on the dynamics of parallel signal transduction pathways; reciprocal side-effects be

220 structure, constitutive activity, isoforms, signal transduction pathways, regional differences in ex

221 e understanding of the protein complexes and signal transduction pathways regulated by RGS proteins i

222 Signal-transduction pathways regulated by extracellular

223 mic reticulum stress and modulating multiple signal transduction pathways regulating cancer cell grow

224 To screen for signal transduction pathways regulating mRNA export comp

225 ar mechanisms that negatively regulate these signal transduction pathways remain poorly understood.

226 us STIM1-Orai1 clusters but whether distinct signal transduction pathways require different cluster n

227 In this study, we investigated the signal transduction pathways responsible for APOBEC3B up

228 Little is known about the signal transduction pathway(s) controlling PhyR phosphor

229 Investigating the YopH-targeted signal transduction pathway(s) in neutrophils during inf

230 This highlights the existence of signal transduction pathway(s) that limit plant developm

231 rs of sub-zero acclimation, although the CBF signal transduction pathway seems to be less important d

232 Transcripts involved in signal transduction pathways, stress and antioxidant res

233 nscription 3 (STAT3), while preserving other signal transduction pathways such as Akt and extracellul

234 apies with cytotoxic drugs and inhibitors of signal transduction pathways such as mTOR-Is.

235 or internalization and activation of several signal transduction pathways, such as phosphoinositide 3

236 Eukaryotic chemoattraction signal transduction pathways, such as those used by Dict

237 We also found signal transduction pathways tend to show extensive dyna

238 gonadotropes, we investigated the potential signal transduction pathway that conveys the inhibitory

239 evelopmental Cell, Ho and Treisman uncover a signal transduction pathway that coordinates muscle grow

240 the MAP kinase signaling cascade, a central signal transduction pathway that governs a broad spectru

241 minin acts both like a component of the FGF4 signal transduction pathway that governs trophoblast pro

242 core-signaling unit within a multicomponent signal transduction pathway that includes a diverse set

243 The major pathway is the canonical ethylene signal transduction pathway that incorporates CONSTITUTI

244 so trigger assembly of T6SS organelles via a signal transduction pathway that involves protein phosph

245 tch signaling is an evolutionarily conserved signal transduction pathway that is essential for metazo

246 ctivity of the alpha7 nAChR is mediated by a signal transduction pathway that is independent of ion c

247 ieA is part of an operon encoding the VieSAB signal transduction pathway that is nearly silent in V.

248 omeostatic synaptic plasticity; however, the signal transduction pathway that links reduced Ca(2+)-le

249 st that H2O2 signaling is under control of a signal transduction pathway that links the respiratory c

250 /4/5/8 operate downstream of cytokinins in a signal transduction pathway that negatively regulates pl

251 have tested this hypothesis by perturbing a signal transduction pathway that plays a major role in c

252 ing a nitric oxide/S-nitrosylation-dependent signal transduction pathway that regulates the growth co

253 servations suggest that metformin inhibits a signal transduction pathway that results in an inflammat

254 ed by the unfolded protein response (UPR), a signal transduction pathway that senses the fidelity of

255 e in T6SS activity was dependent on the same signal transduction pathway that was previously shown to

256 eting agent that invokes the blockage of two signal transduction pathways that are central to the dev

257 fully capable of activating several cellular signal transduction pathways that are ICP27 dependent.

258 r signaling, which may begin to identify the signal transduction pathways that are important in the p

259 om cytotoxin-induced death by stimulation of signal transduction pathways that are linked to prion pr

260 vival are poorly understood, but may include signal transduction pathways that are modulated by chang

261 Identifying the important signal transduction pathways that control monocyte chemo

262 the augmented IHVR, is regulated by multiple signal transduction pathways that could be potential the

263 nce and cellular stress to the intracellular signal transduction pathways that drive the liver fastin

264 r recovery from pneumonia, and modulation of signal transduction pathways that have been linked to pr

265 VEGF-A stimulates signal transduction pathways that modulate endothelial o

266 verexpressed in many cancers and involved in signal transduction pathways that promote cancer cell pr

267 er, after decades of basic research into the signal transduction pathways that promote cancer cell su

268 Restraint of intracellular signal transduction pathways that promote release of mas

269 tor phosphorylation, which in turn activates signal transduction pathways that regulate cell-collagen

270 Relatively little is known regarding key signal transduction pathways that serve as cytosolic bri

271 ional modification (PTM) is a key feature of signal-transduction pathways that allows the modulation

272 ment of cancer is to understand the cellular signaling transduction pathways that cause cancer at the

273 h contribute to TAV by initiating outside-in signaling transduction pathways that elicit monocyte rec

274 ct as an extension of the established immune signal transduction pathways, thereby adding an extra la

275 However, the signal transduction pathways through which mGluR5s regul

276 rse family of photoreceptors and discuss the signal transduction pathways through which these photore

277 , GDMT nucleation is controlled by a glucose signal-transduction pathway through cAMP and its effecto

278 of the CWI mitogen-activated protein kinase signal transduction pathway to target the relocalization

279 ogy (Rho) GTPases regulate cell polarity and signal transduction pathways to control morphogenetic re

280 led receptors (GPCRs) utilize (at least) two signal transduction pathways to elicit cellular response

281 ossibility is that information is encoded in signal transduction pathways to ensure stimulus- and cel

282 the discovery and characterization of novel signal transduction pathways to exploring the molecular

283 lusters, ranging from epigenetic control and signal transduction pathways to global and specific tran

284 ng CPEB4, thereby integrating phase-specific signal transduction pathways to regulate cell cycle prog

285 rahepatocytic beta1 integrins, which trigger signal transduction pathways toward choleresis.

286 variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of

287 diated by toll-like receptor 4 (TLR-4)/MyD88 signal-transduction pathway up-regulation of MLCK expres

288 nal permeability was mediated by TLR-4/MyD88 signal-transduction pathway up-regulation of MLCK.

289 membrane protein-1 (LMP1) activates numerous signal transduction pathways using its C-terminal activa

290 Protein kinases are key players in signal transduction pathways where they are crafted into

291 Targeting signal transduction pathways which promote therapy resis

292 exploited the Nuclear Factor-kappa B (NF-kB) signal transduction pathway, which is induced by several

293 hat often lead to dysregulation of oncogenic signal transduction pathways, which in turn alters downs

294 ors of NFkappaB and MAPKs were used to study signal transduction pathways while TLR4 and MyD88 were s

295 nt are likely to function in development and signal transduction pathways, while those that are mutat

296 RNPK), a protein known to integrate multiple signal transduction pathways with gene expression, as a

297 to drought stress depend on highly regulated signal transduction pathways with multiple interactions.

298 rategy for treating the disease by modifying signal transduction pathways with small-molecule drugs.

299 gnals on the exterior of a cell and activate signal transduction pathways within the cell.

300 mutations abrogated established FGF-induced signal transduction pathways, yet FGF functions such as