ライフサイエンスコーパス: signaling

1 atic lungs through complement C5a receptor 1 signaling.

2 sm as transcriptional targets of CRZ1/GnRHL1 signaling.

3 ected stimulatory role in GPCR-mediated eNOS signaling.

4 ce of beta-ADP-heptose/ ALPK1/TIFA/NF-kappaB signaling.

5 ion in the absence of D2R-mediated G protein signaling.

6 ic interactions to finely control nucleotide signaling.

7 impaired AMP-activated protein kinase (AMPK) signaling.

8 of colon cancer by attenuating RSK1 and MSK2 signaling.

9 om C-dnO1 mice, associated with blunted Pyk2 signaling.

10 st differentiation through enhanced TNFalpha signaling.

11 ling as the nutrient-sensitive branch of BMP signaling.

12 resistant to cancer drugs and diminished ERK signaling.

13 enabling grip reanimation regulated by touch signaling.

14 not interfere with cardioprotective MIF/CD74 signaling.

15 ic characteristics associated with oncogenic signaling.

16 division, transcription regulation, and cell signaling.

17 tory factors and various downstream cellular signaling.

18 ribute to disease states through altered sEV signaling.

19 ns express VGLUT1, a marker of glutamatergic signaling.

20 a nodal cytosolic kinase involved in insulin signaling.

21 ion, as well as in systemic versus localized signaling.

22 8-PUUC induced both NF-kappaB and interferon signaling.

23 the receptor level as well as on downstream signaling.

24 orylates the TCR/CD3 complex to initiate TCR signaling.

25 lve phagocytosis, endocytosis, adhesion, and signaling.

26 entia, and the arrestins are common to their signaling.

27 thetic phenotype and downregulated Akt1/mTOR signaling.

28 roup with smaller hearts and proinflammatory signaling.

29 enting transforming growth factor (TGF) beta signaling.

30 iggered cell death through PTCH proapoptotic signaling.

31 sgenic mouse line that sustains cortical MET signaling.

32 regulate integrin activation and outside-in signaling.

33 inflammatory gene expression through reverse signaling.

34 ion is considered to be a key step in KAR/KL signaling.

35 ed during embryogenesis to mediate proper HH signaling.

36 and was equally suppressive compared to PD-1 signaling; (2) PD-L1(+) T cells restrained effector T ce

37 is region highlighted regulator of G-protein signaling 4 (Rgs4) within laser-capture micro-dissected

38 Wnt/beta-catenin signaling achieves this in part by increasing the expres

39 r responses through the modulation of Ca(2+) signaling, actin organization, vesicle trafficking and c

40 PD-L1 signaling also induced an anergic T-bet(-)IFN-gamma(-) p

41 protection from TAC-induced cellular Ca(2+) signaling alterations (increased SOCE, decreased [Ca(2+)

42 n altered neuroendocrine control of hormonal signaling, altered neurotransmitter control of nervous s

43 tion and proliferation require Hedgehog (HH) signaling and aberrant HH signaling causes birth defects

44 These findings demonstrate that STAT1 signaling and CD8 T cells concomitantly act to mitigate

45 lls enhanced unfolded protein response (UPR) signaling and cell death upon ER stress induction.

46 at nonspectral color perception is vital for signaling and foraging.

47 l role of BCKAs in regulating muscle insulin signaling and function.

48 identified proinflammatory TNFalpha/NFkappaB signaling and hdac1 as mediators of stress susceptibilit

49 ntially methylated regions in glucocorticoid signaling and inflammation-related genes were associated

50 ointly regulate host-derived danger molecule signaling and integrate specific global responses agains

51 lices we found that D(1)R-induced cell death signaling and neuronal degeneration, are mitigated by an

52 Blocking NF-kappaB activation rescued FXR signaling and partially ameliorated liver injury and sin

53 s of fibroblasts resulting in sustained MTOR signaling and poor lapatinib response.

54 he functions of histone acetylation in auxin signaling and root morphogenesis.

55 potential intermediary between early calcium signaling and subsequent tissue regeneration.

56 , specific Ship1 inhibition enhanced calcium signaling and thereby abrogated an anergic response to B

57 onophosphate, a key second messenger in cell signaling and tissue homeostasis.

58 tumors continue to depend on hyperactive AR signaling and will respond to potent second-line antiand

59 immobilization decreases mechanotransductive signaling, and completely inhibits HO.

60 ed with genes involved in auxin response and signaling; and in anatomical structure development and m

61 Applying synthetic signaling approaches to plants offers the promise of mit

62 ization in eukaryotes and genes that tune PI signaling are implicated in human disease mechanisms.

63 ty to nutritive environment and point to Sax signaling as the nutrient-sensitive branch of BMP signal

64 stone acetylation in the modulation of auxin signaling as well as in the regulation of root morphogen

65 tivation of downstream MAPK/ERK and PI3K/Akt signaling as well as the neurite outgrowth of PC12 cells

66 he acetylcholine receptor (AChR) and inhibit signaling at the neuromuscular junction.

67 erall, these studies provide evidence that a signaling axis involving key UPS components contributes

68 requires cannabinoid type 1 receptor (CB1R) signaling based on the fundamental role of the endocanna

69 nal transduction in postnatal mice, with BMP signaling being restricted to basal VSNs and at the marg

70 rising bidirectional regulation of molecular signaling between sensory neurons and non-target motor n

71 Many GPCR AAs modulate receptor signaling, but molecular details of their modulatory act

72 he sequence-specific ability to increase E2F signaling by binding E2F negative regulator Retinoblasto

73 tingly, the feedback regulation of DBL-1/BMP signaling by collagens is likely to be contact independe

74 tein SOCS1 is known to downregulate cytokine signaling by inhibiting the JAK-STAT pathway.

75 ng to blockade of RasGAP binding and optimal signaling by the two receptors.

76 During development, signaling by this superfamily regulates a variety of emb

77 Disruption of BMP signaling can trigger cardiovascular diseases, such as a

78 ption, the Fzr-ubiquitinated H2B (H2Bub)-Myc signaling cascade also positively regulates the transcri

79 ography, we found that loss of this critical signaling cascade exaggerated the vasoconstrictor respon

80 at the endosomal pathway is required for the signaling cascade initiated by BDNF and its receptors at

81 and promotes activation of an SRC-dependent signaling cascade that controls YAP nuclear shuttling.

82 utation results in dysregulation of the cAMP signaling cascade, leading to upregulation of phosphodie

83 ress hormone abscisic acid (ABA) initiates a signaling cascade, which leads to increased H(2)O(2) and

84 tively disrupting a previously unappreciated signaling cascade.

85 the ultimate effector protein of this stress signaling cascade.

86 rmacologically tractable Prion Protein (PrP) signaling cascade.

87 embryos of unknown sex, whether BDNF-induced signaling cascades are altered when early and recycling

88 NF-kappaB-regulating signaling cascades, in concert with NF-kappaB-mediated t

89 essions, post-translation modifications, and signaling cascades.

90 Type I IFN signaling caused tight junction dysregulation in IECs, p

91 uire Hedgehog (HH) signaling and aberrant HH signaling causes birth defects or cancers.

92 thology; (ii) Renal function; (iii) Cellular signaling changes; (iv) Oxidative stress and inflammator

93 regression was associated with increased BCR signaling, CLL proliferation, and clonal evolution.

94 s was associated with aberrant innate immune signaling, complement dysregulation, Th2 skewing, and in

95 More importantly, blockade of NFkappaB signaling completely reversed elevated pro-inflammatory

96 mation of membrane-anchored TNFR1-containing signaling complex (complex I), RIPK1 ubiquitination, and

97 hat is poised to orchestrate assembly of key signaling components upon reception of an extracellular

98 d sequence through autonomous formation of a signaling concatemer.

99 The receptor adopts two major signaling conformations, one of which couples almost exc

100 However, how LMP2A signaling contributes to tumorigenesis remains elusive.

101 Thus, TH signaling coordinately regulates both spectral sensitivi

102 ed that NRARP, a negative regulator of Notch signaling, could have a suppressive role in T-ALL.

103 We provide evidence that, Frizzled/Vang signaling couples to the Fat/Dachsous PCP directional si

104 hereas Keap1-an endogenous inhibitor of Nrf2 signaling-dampens these protective responses.

105 TGFBR2 expression, while inhibiting TGF-beta signaling decreased tECM-mediated expression of integrin

106 Loss of androgen receptor (AR) signaling dependence occurs in approximately 15%-20% of

107 The activity of DNGR-1 maps to its signaling domain, which activates SYK and NADPH oxidase

108 d binding domain but lacks the intracellular signaling domain.

109 ion that impacts cell death and inflammatory signaling downstream of various innate immunity receptor

110 Aberrant Wnt signaling drives a number of cancers through regulation

111 Our results indicate that Smad4-mediated signaling drives the functional maturation and connectiv

112 3) cells, dysregulated integrin beta(3)-KRAS signaling drives tumor progression.

113 s known about the molecule(s) regulating FGF signaling during nephron development.

114 roduced different patterns of RelA and c-Rel signaling dynamic features, such as variations in durati

115 tworks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on e

116 s and a Posterior Medial cortical network in signaling event boundaries.

117 The signaling events activate the transcription factors AP-1

118 polymerization and activation of downstream signaling events.

119 xus (ChP) epithelium is a source of secreted signaling factors in cerebrospinal fluid (CSF) and a key

120 SC is Notch1(low)/ Numb(+) and repressed by signaling from gastrin-expressing endocrine (G) cells.

121 MALT1 mediates signaling from many immune receptors in mammals, but was

122 we determined the relative importance of MEN signaling from the SPB that is delivered into the daught

123 Both hydrolytic and signaling functions require precise regulation of lysoso

124 Although Wnt signaling has been intensively studied in colorectal can

125 w rotavirus (RV) subverts host innate immune signaling has greatly increased over the past decade.

126 No activators of cGAMP signaling have yet been identified, and the signaling pa

127 In the absence of STAT1 signaling, however, depletion of CD8 T cells resulted in

128 nd extracellular signal-regulated kinase 1/2 signaling; however, the clinical efficacy of inhibitors

129 ing pathway activation and ligand-responsive signaling hyperactivation by ACVR1-R206H.

130 We show that the increased cytokinin signaling in ARR1 gain-of-function transgenic lines is a

131 ted pathways for cell survival and apoptosis signaling in cancer remain to be elucidated.

132 monstrate that TETRAC promotes PPARgamma/RXR signaling in cell-free, cellular, and in vivo settings.

133 at RSPOs 2 and 3 potentiate WNT/beta-catenin signaling in cells lacking leucine-rich repeat-containin

134 xpression as well as the role of NOTCH1-DLL4 signaling in collective bladder cancer invasion.

135 nule localization and/or priming and calcium signaling in concert.

136 nt physiological impact of amylin/calcitonin signaling in CTR-POMC neurons on energy metabolism and d

137 Thus, purinergic signaling in differentiating T cells can be targeted to

138 rate that the capacity for rapid Na(+)-based signaling in eukaryotes is not restricted to animals or

139 Specifically, FGF21 signaling in glutamatergic neurons is necessary for prot

140 ositions within functional niches, cell-cell signaling in homeostatic health, the responses to injury

141 nstrating a functional link between CD56 and signaling in human NK cells.

142 in non-metastatic melanoma protein B (GPNMB) signaling in human PD SN.

143 om Msi1-overexpressing mice implicated Notch signaling in inducing enterocyte differentiation.

144 Aberrant NLRC5 signaling in macrophages can promote B-cell lymphomagene

145 findings suggest a pivotal role of caspase 3 signaling in mediating spine injury and the modulation o

146 Notably, selective abrogation of EGFR signaling in myeloid cells was sufficient to protect aga

147 ptor tyrosine kinase AXL to induce oncogenic signaling in ovarian cancer.

148 dii and Neospora caninum activated GABAergic signaling in phagocytes.

149 Here, we study the roles of GABA and insulin signaling in starvation-dependent modulation of olfactor

150 Activation of EGFR signaling in the ALA neuron has previously been suggeste

151 e and protracted withdrawal dysregulate 5-HT signaling in the CeA.

152 , their role in controlling VEGF A and FGF 2 signaling in the CL of water buffalo is not known.

153 Therefore, agonist-induced signaling in this system involves two distinct receptor-

154 dings imply a simple phenotypic model of TCR signaling in which multiple T cell responses share a com

155 Estrogen receptor -alpha signaling increased IL-33 release and ILC2-mediated airw

156 In the presence of O(2) , Aer2 signaling increases the autophosphorylation of the histi

157 We report that (1) calcium signaling increases with the application of ultrasound;

158 o PERK and selectively attenuated downstream signaling independently of PERK activity and the broader

159 n smoothened, the obligate transducer of Shh signaling, indicating that Inpp5e functions within the c

160 r tumors having deregulated Wnt/beta-catenin signaling induced by this mutation.

161 n of oncogenic c-Jun N-terminal kinase (JNK) signaling, induced by the latent membrane protein 1 (LMP

162 ore, the observed carbamazepine-mediated Wnt signaling inhibition may help to explain the phenomenon

163 Therefore, TrkB signaling is a key regulator of a previously uncharacter

164 Here, we determined whether mTORC1 signaling is also a target for decanoic acid, a key comp

165 Wnt signaling is dependent on four Wnts (Wg, Wnt5, 6,10) tha

166 rproliferation when the canonical TIR1 auxin signaling is disrupted.

167 hromatin functions associated with ubiquitin signaling is emerging.

168 the commensal fungus Candida albicans IL-17R signaling is essential to prevent OPC in mice and humans

169 Dysregulation of TrkB signaling is implicated in neurodegenerative disorders a

170 t genotoxic agent-activated Wnt/beta-catenin signaling is independent of the FZD/LRP heterodimeric re

171 ration of these functions, and failure of RA signaling is perhaps associated with normal cognitive de

172 thematical model demonstrating growth factor signaling is sufficient to guarantee this robustness and

173 selective engagement and activation of FZD7 signaling is sufficient to promote mesendodermal differe

174 Given these crucial roles, mGluR5 signaling is under the tight control of glutamate releas

175 hermore, optoRaf and optoAKT differ in their signaling kinetics during regeneration, showing a gated

176 Effective application of signaling kinetics to developing new therapeutics requir

177 paxillin and focal adhesion kinase from the signaling layer of focal adhesions, whereas vinculin rem

178 The mutant quenches light-induced rhodopsin signaling like wild type, demonstrating that in vivo mon

179 e linked to differentiation by a yet-unknown signaling mechanism.

180 However, the function of GPR139 and its signaling mechanisms are poorly understood.

181 TPS1) catalyzes the synthesis of the sucrose-signaling metabolite trehalose 6-phosphate (Tre6P) and i

182 nd guidance is to understand how cytoplasmic signaling modulates the cytoskeleton to produce directed

183 expression of Lypd6, an endogenous nicotinic signaling modulator, enhances ocular dominance plasticit

184 We propose that the EPFL2 signaling module evolved to control the initiation and r

185 seedling development in Arabidopsis A shoot signaling module that includes HY5, the phytochromes and

186 However, many motile cells rely on both signaling modules and actin cytoskeleton to break symmet

187 We identified cell signaling molecular targets by meta-analysis of microarr

188 Carbon monoxide (CO) is a cell-signaling molecule (gasotransmitter) produced endogenous

189 s are consistent with NAE 18:3 being a lipid signaling molecule in plants with a requirement for G-pr

190 ellular levels and stability of intermediate signaling molecules are a crucial hijacking point for a

191 Lipo-chitooligosaccharides (LCOs) are signaling molecules produced by rhizobial bacteria that

192 In this report, we suggest that the auxin signaling must be controlled harmoniously by two counter

193 M-1 is required for the longevity of insulin signaling mutants, but surprisingly, loss of PQM-1 incre

194 ivates the unfolded protein response (UPR)-a signaling network that ultimately determines cell fate.

195 ies targeting a single node of the oncogenic signaling network.

196 s reveals cell-type- and cell-state-specific signaling networks in stem, Paneth, enteroendocrine, tuf

197 ulatory mechanisms driving complex mammalian signaling networks.

198 barrier function, the NE acts as a critical signaling node for a variety of cellular processes, whic

199 e is known about mechanisms of regulation or signaling of the longer isoform.

200 iggered increased microglial process calcium signaling, often concomitant with process extension.

201 denosine significantly downregulated TGFbeta signaling on fibroblasts, an effect regulated by A(2A) a

202 , but was not previously implicated in IL-17 signaling or nervous system function.

203 ellular (eg, transcription, translation, and signaling), organ (eg, contractility and metabolism), an

204 creening revealed that inhibition of MEK/ERK signaling overcame the HIF1a-mediated block in oligodend

205 reveal additional new compound families and signaling paradigms.

206 ting that TrkA is an important player in the signaling pathway activated by eotaxin-1 during eosinoph

207 , is dispensable for both ligand-independent signaling pathway activation and ligand-responsive signa

208 cytometric analysis of monocyte subsets and signaling pathway activation patterns in conventional mo

209 nd mutations leading to excessive pro-growth signaling pathway activations frequently occurs in cance

210 are negative regulators of the Ras/Raf/MAPK signaling pathway and involved in regulation of organoge

211 ose the mammalian target of rapamycin (mTOR) signaling pathway as a candidate mechanism.

212 Investigation of whether a certain signaling pathway can confer bistability involves a subs

213 beta3-integrin, FAK and cofilin constitute a signaling pathway downstream of MMP activation that is i

214 content release, we sought to elucidate the signaling pathway downstream of PAR4 activation that lea

215 e show that PIFs positively regulate the ABA signaling pathway during the seedling stage specifically

216 by an increased activation of the NF-kappaB signaling pathway in bone marrow and BM-MSC of DeltaNC16

217 results uncover a role for the beta-catenin signaling pathway in fine tuning the granulocytic produc

218 me and establishes the importance of the WNT signaling pathway in the mTORC1-driven lung phenotype.

219 an hepatocyte growth factor receptor (c-MET) signaling pathway is dysregulated in several malignancie

220 Here we report that the IKK2/NF-kappaB signaling pathway modulates metastasis-associated protei

221 on were connected by a novel synapto-nuclear signaling pathway that surprisingly invoked mechanisms a

222 The Wnt signaling pathway triggers human BTSC proliferation in v

223 binds to a protein in the type I interferon signaling pathway Tyk2 and inhibits the expression of ge

224 th MAP3K4, an upstream regulator of the MAPK signaling pathway, and regulates its transcription in ci

225 c mutations in factors governing the hypoxia signaling pathway, resulting in metabolic dysregulation,

226 dition to known components of the interferon signaling pathway, we found that replication termination

227 n about the evolutionary roots of this major signaling pathway, will shed light on the origins of reg

228 nic events associated with the hedgehog (hh) signaling pathway.

229 ses, placing ethylene epistatic to the auxin signaling pathway.

230 ine motifs and is present in a wide range of signaling pathways across different evolutionary taxa.

231 t PG specifically inhibits NF-kappaB and Akt signaling pathways and promotes accelerated cell death i

232 lases are a vital element within ADP-ribosyl signaling pathways and they hold the potential for novel

233 mical nature of the hormones themselves, the signaling pathways are diverse.

234 ) levels are elevated, mTOR and IRF/IFN-beta signaling pathways are enhanced, leading to cellular sen

235 ern recognition receptors, internal cellular signaling pathways are induced to ultimately fend off th

236 oblasts and early activation of pro-fibrotic signaling pathways before adverse ventricular remodeling

237 signaling have yet been identified, and the signaling pathways for cGAMP have been inferred to displ

238 Signaling pathways in cells were analyzed by immunoblots

239 rize evidence that overactivation of SMAD2/3 signaling pathways in MDSs causes anemia due to impaired

240 mechanisms integrating light and temperature signaling pathways in plants remain poorly understood.

241 Differences in cell-signaling pathways in the uterine tissues of G12D and G1

242 astid-to-nucleus communication by retrograde signaling pathways is essential for fine-tuning of respo

243 abilities of opioids to activate downstream signaling pathways normally depend on the binding betwee

244 nd by influencing the activities of multiple signaling pathways that are known to regulate HF stem ce

245 dies of model organisms defined intersecting signaling pathways that converge to promote HSC emergenc

246 As such, discovering signaling pathways that modulate albuminuria is desirabl

247 ge polarization and the interactions between signaling pathways that regulate the pathogenesis of UC

248 tor (CBF)-dependent and CBF-independent cold signaling pathways to tolerate cold.

249 pathways, transcriptional networks, hormone signaling pathways, and plant developmental processes.

250 d agonists, preferentially targeting various signaling pathways, have the potential to become drug ca

251 t also explain the operation of other immune signaling pathways.

252 ells do not depend on type I IFN or on IL-22 signaling, pathways responsible for protection against a

253 ghlights a thus-far unexplored long-distance signaling phenomenon that may regulate soil conditioning

254 Fibroblast growth factor (FGF) signaling plays pivotal roles in generating and maintain

255 yses to evaluate sphingolipid metabolism and signaling post-MI.

256 ic approaches directed towards specific TLR2 signaling processes might be developed for treatment of

257 onocytes and pMos revealed distinct baseline signaling profiles and far greater heterogeneity than pr

258 evaluation of the phosphorylation status of signaling proteins across different B cell subpopulation

259 tion of USP7 interactions with innate immune signaling proteins TRAF3 and TRAF6, and that vIRF-2 targ

260 In mouse models of SS, inhibition of BMP6 signaling reduced phosphorylation of SMAD1/5/8 in the mo

261 NPY, and we therefore hypothesized that NPY signaling regulates activity in the IC.

262 It is clear that BMP signaling regulates GI function and disease progression

263 ini, despite the importance of the latter in signaling, regulation, and bias.

264 d causal inference tools, >300 site-specific signaling relations were mapped from phosphoproteomics d

265 cued by attenuation of oxytocin and androgen signaling, respectively.

266 e suggested that NO plays a vast and diverse signaling role in molds.

267 ese results provide a blueprint for decoding signaling selectivity and advance our understanding of m

268 In response to Ras-activating cell signaling, SOS autoinhibition is released and is followe

269 d ubiquitin complex that attenuates Hedgehog signaling strength and genetically interact to regulate

270 aken together, our data indicated that IL-25 signaling subverts the induction of protective immunity

271 ally design a DNA-based artificial molecular signaling system that uses the confined microenvironment

272 These data suggest a model whereby guidance signaling systematically shapes the intrinsic, stochasti

273 was Traf3, a negative regulator of NF-kappaB signaling that has never previously been linked to densi

274 depends on the integration of extracellular signaling through multiple receptors, including the T-ce

275 ants critical for agonist binding and biased signaling through PAR4.

276 ivates the EGF receptor to induce downstream signaling through the ERK serine/threonine kinase and th

277 This identifies autocrine purinergic signaling, through Cx43 hemichannels, as a critical path

278 A literature survey indicated signaling time course data usually conform to one of fou

279 microbial elicitors and drive intracellular signaling to limit or facilitate microbial colonization.

280 h adulthood, and requires ongoing type I IFN signaling to maintain it.

281 c factor that uses canonical dSmad2-mediated signaling to regulate wing size.

282 BCR signaling triggers a cascade of intracellular mediators

283 ay provide insights into understanding miRNA signaling underlying cancer cell metabolism and developm

284 s, that this interaction modulates antiviral signaling via disruption of USP7 interactions with innat

285 s suggest that FL3 inhibits Wnt/beta-catenin signaling via PHB1-dependent activation of Axin1.

286 rd to the ability of this molecule to induce signaling via rhesus macaque CD200R, as well as the pote

287 We uncovered a role for Xinbeta in signaling via the Hippo-YAP pathway by recruiting NF2 to

288 In this study, we demonstrate that MDA5/MAVS signaling was essential for host resistance against pulm

289 togen-activated protein kinases and NFkappaB signaling was unaffected by global or HDAC3/6-selective

290 is specifically defective for fMAPK pathway signaling, was defective for interaction with Bem4p, the

291 transcription 5, a downstream molecule of PL signaling, was observed in islets from Adipoq (-/-) dams

292 Because caspase-8 mediates CD95 signaling, we applied genetic approaches to dissect the

293 Fbeta stimulation, is a prerequisite for TGF signaling, we investigated the role of protein diaphanou

294 se to EtOH, while defense responses and PPAR signaling were upregulated.

295 me reversion and normalized T(H)17 cell/IL23 signaling, whereas dupilumab led to a stronger increase

296 activates hypoxia-inducible factor-dependent signaling, which in turn regulates metabolic reprogrammi

297 hrough mechanical activation of p38-YAP-TEAD signaling, which likely contribute to myofibroblast hete

298 s, we examined associations of brain insulin signaling with diabetes, AD, and level of cognition.

299 (RAP2.12), indicating convergence of oxygen signaling with epigenetic regulation of gene expression.

300 ood intake, understanding the role of opioid signaling within the OFC is fundamental for a mechanisti