ライフサイエンスコーパス: signaling factor

1 and extrinsic signals (e.g., soluble growth/signaling factors).

2 EGF-CFC protein Cripto can act as a secreted signaling factor.

3 ficient and stringent regulation of a potent signaling factor.

4 ine 701 in STAT1, the activity switch of the signaling factor.

5 d to release Endostatin, an antiangiogenesis signaling factor.

6 ly by the inheritance of the Gal3p and Gal1p signaling factors.

7 we detect altered levels of selected soluble signaling factors.

8 Y) sites for the binding of a diverse set of signaling factors.

9 scription factors, proto-oncogenes, and cell signaling factors.

10 nd shows dependence upon the same downstream signaling factors.

11 rs, extracellular ligands, and intracellular signaling factors.

12 pends on the actions of several hormones and signaling factors.

13 ding a member of the Wnt family of cell-cell signaling factors.

14 rs for the ubiquitous family of secreted WNT signaling factors.

15 ted genes that encode secreted extracellular signaling factors.

16 nvolved in transducing signals for any known signaling factors.

17 e to regulate the surface recruitment of key signaling factors.

18 luence of neurotransmitters and a variety of signaling factors.

19 M1 and KDM5Bi to induce IFN-I and downstream signaling factors.

20 ming, which we alleviate by adding exogenous signaling factors.

21 romolecules such as drug targets and cascade signaling factors.

22 n by genes encoding extracellular matrix and signaling factors.

23 get gene deletion and expression of critical signaling factors.

24 ped expression patterns of transcription and signaling factors.

25 ail, even in the absence of externally added signaling factors.

26 microenvironment by secretion of an array of signaling factors.

27 ion by controlling the fate of intracellular signaling factors.

28 nd there are different requirements for some signaling factors.

29 D88 but not in macrophages deficient in both signaling factors.

30 helium that function by releasing diffusible signaling factors.

31 abiotic (environmental porosity) and biotic (signaling) factors.

32 n mice deficient for SMAD2, an intracellular signaling factor activated by TGF-beta signals.

33 at heat disrupts or alters the regulation of signaling factors activated by IR, the effect of heat sh

34 lly regulated translation of a maternal cell-signaling factor along the vertebrate dorsal-ventral axi

35 led that CDK6 knockout regulated a series of signaling factors, among them, PI3K 110alpha and 110beta

36 inhibited phosphorylated FLT3 and downstream signaling factors and also induced cell cycle arrest in

37 ingestion: they express a host of metabolic signaling factors and are integrated into an extended ne

38 division is tightly controlled via secreted signaling factors and cell adhesion molecules provided f

39 xpansion by continuously diluting inhibitory signaling factors and maintaining stem cell density.

40 We then investigated which potential signaling factors and pathways are capable of modulating

41 Also included are signaling factors and some pigment cell differentiation

42 E), which contains diverse cell populations, signaling factors and structural molecules that interact

43 ng on the example of dynamic measurements of signaling factors and their impacts on cellular outcomes

44 e nuclear accumulation rate of change of the signaling factor, and not actual protein levels, correla

45 and transcriptional regulators, splicing and signaling factors, and glucose/mitochondria regulators.

46 functions to recruit and spatially organize signaling factors, and was recently identified as a supp

47 pothalamic neurohormone; BAX, a proapoptotic signaling factor; and CDK4 and PAL31, cell cycle progres

48 rowth and cell fates, and genes encoding Wnt-signaling factors are expressed in the pancreas.

49 of red blood cells, and at least 15 distinct signaling factors are now known to assemble within activ

50 Nodal-related signaling factors are required for axis formation and ge

51 ts provide further evidence implicating MAPK signaling factors as obligate regulators of cardiac grow

52 es self-renewal (e.g., representative of Wnt signaling factors), as well as a long-range inhibitor of

53 tems biology approach to identify functional signaling factors associated with a cellular phenotype,

54 d microtubules (MTs), as well as a number of signaling factors at the leading edge.

55 mes in cell lines deficient in each of three signaling factors, ATM, ATR, and DNA-PK(CS), orchestrati

56 oxin (TRX) is a cytoplasmic, redox-sensitive signaling factor believed to participate in the regulati

57 e ECM, including Nanos3, Vasa, PIWI, and the signaling factors BMP2/4, Nodal, and Wnt8.

58 tal muscle, known as myokines, are important signaling factors, but it is largely unknown whether the

59 luding both chromatin-associated and diffuse signaling factors, but may not be universal.

60 pression of cell adhesion and cell migration signaling factors by increasing chromatin access at pois

61 coupled by localized secretion of paracrine signaling factors by the differentiating hMSCs and ECFCs

62 During development, secreted signaling factors, called morphogens, instruct cells to

63 We show that developmentally relevant signaling factors can induce mouse embryonic stem (ES) c

64 suggest that the Wnt-5A functional class of signaling factors can interact with the Wnt-1 class in a

65 tumor microenvironment-derived extracellular signaling factors capable of provoking such a phenotypic

66 d at least three-fold in response to Eyeless+signaling factors compared to Eyeless alone; (3) based o

67 ) is involved in the retention of repair and signaling factor complexes at sites of DNA damage.

68 Chlamydomonas orthologs of UVR8 and the key signaling factor CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1)

69 protein tyrosine phosphatase 2 (SHP-2) is a signaling factor critical for regulating sympathetic neu

70 s the post-transcriptional expression of key signaling factors critical for the regulation of the ang

71 s the post-transcriptional expression of key signaling factors critical for the regulation of the ang

72 Although much is known about signaling factors downstream of Rho GTPases that contrib

73 vator receptor (uPAR) and activation of cell signaling factors downstream of uPAR, including Akt and

74 ch cell types are affected, as well as which signaling factors drive cell lineage decisions, provides

75 cterium, mediated by a fatty acid Diffusible Signaling Factor (DSF), is required to colonize insect v

76 The diffusible signaling factor (DSF)-based quorum sensing (QS) system

77 ontexts, leading to multifunctional roles of signaling factors during development.

78 We examined these signaling factors during hyperinsulinemic-euglycemic cla

79 nal cytoskeletal proteins and apoptotic cell signaling factors during hypoxia-induced retinal cell de

80 the myofiber, facilitating the evaluation of signaling factors during muscle remodeling.

81 acts in the localization of determinants and signaling factors during oogenesis.

82 However, our knowledge of bystander signaling factors, especially those having long half-liv

83 log of FHY1 named FHL (FHY1-like) as a novel signaling factor essential for complete responsiveness t

84 a and notum, encoding conserved antagonistic signaling factors expressed at opposite brain poles.

85 Here, we identify a set of signaling factors expressed in mouse embryonic mesenchym

86 nals come from a surprisingly limited set of signaling factor families, indicating that the competenc

87 entiation including myocardin/Mrtf-B and the signaling factor Fgf10.

88 for the expression of Bmp4, which is the key signaling factor for progression to the next step of too

89 circulating estrogen hormone, is a critical signaling factor for the growth, differentiation, and fu

90 emonstrate the potential utility of myogenic signaling factors for decreasing EOM strength.

91 s identical to that of mouse; therefore, the signaling factors for SSC self-renewal are conserved in

92 Here, we present evidence that signaling factors for the WNT, TGF-beta, and JAK/STAT pa

93 AF2-TRAF3 E3 complex also targets additional signaling factors for ubiquitin-dependent degradation, t

94 rs (inheritance), or later in development by signaling factors from neighboring tissues (induction).

95 onse factors revealed a role for the glucose signaling factor GSF2 in resistance to hydroxyurea, high

96 the genes upregulated in response to Eyeless+signaling factors had a greater diversity of functions c

97 The FGF family of extracellular signaling factors has been proposed to play multiple rol

98 essel structures, and disruption of critical signaling factors has dramatic effects on blood vessel d

99 Few families of signaling factors have been implicated in the control of

100 larly in vertebrates, the conserved core PCP signaling factors have recently been found to be associa

101 This study demonstrates that PIF light signaling factors help plants utilize optimal amounts of

102 ith what has been reported before, the light signaling factor HY5 negatively regulates ABA-mediated i

103 to apoptosis, the cell cycle and DNA repair, signaling factors, immune modulators, cytokines and grow

104 iological role in macrophage responses, is a signaling factor in CD3(+)NK1.1(+) iNKT cells and mediat

105 ever, Cripto can also function as a secreted signaling factor in cell coculture assays, suggesting th

106 suPAR may function as an important paracrine signaling factor in EGFRvIII-positive GBMs, inducing an

107 hlights the potential importance of Akt as a signaling factor in leukemia survival, and supports the

108 In contrast, CKIepsilon is a mandatory signaling factor in the Fz/PCP pathway, possibly through

109 ntify a novel function of the TR enzyme as a signaling factor in the regulation of AP-1 activity via

110 argeted T98G cells and plays a key role as a signaling factor in the RIBE by further inducing free ra

111 sease, Dishevelled (Dvl) proteins act as key signaling factors in beta-catenin-dependent and beta-cat

112 Here, we examined insulin signaling factors in brains of insulin-resistant high-fa

113 bB2 activity and its interactions with other signaling factors in carcinoma cells.

114 xus (ChP) epithelium is a source of secreted signaling factors in cerebrospinal fluid (CSF) and a key

115 1 implicates these polysulfides as important signaling factors in immune regulation through the kynur

116 leotides function as autocrine and paracrine signaling factors in many tissues.

117 l migration and the involvement of a host of signaling factors in orchestrating the migration, as wel

118 sed concurrently with Aurora A and NF-kappaB signaling factors in patients with de novo AML relative

119 ether the proteome of secreted cytokines and signaling factors in peripheral blood can be used to dis

120 ytes accumulate in the microvasculature, and signaling factors in the angiogenesis pathway (Akt and e

121 reased expression of EGFR and its downstream signaling factors in the lung of Tip30(-/-) mice.

122 We observed that circulating long-range signaling factors in the old systemic environment lead t

123 talk between salt stress response and other signaling factors including H2O2.

124 regulatory activity and competes with animal signaling factors, including BMP2/4, to specify the endo

125 ofluids of the body, EVs can contain various signaling factors, including coding and noncoding RNAs (

126 gnaling, or by targeting uPAR-activated cell signaling factors, including phosphatidylinositol 3-kina

127 was not simply a result of enhanced soluble signaling factors, including vascular endothelial growth

128 Multiple signaling factors, including Wnt proteins, operate durin

129 is, we sought to determine the pro-apoptotic signaling factors induced by RANKL in IKKbeta-null osteo

130 ds into each cerebral ventricle and secretes signaling factors into the CSF.

131 phyrin IX, which may act as a light-specific signaling factor involved in coordinating intercompartme

132 enriching system that enables us to identify signaling factors involved in germ cell-fate induction f

133 Reactive oxygen species (ROS) are signaling factors involved in many intracellular transdu

134 APPswe) mice and non-transgenic (NT) mice on signaling factors involved in neuronal plasticity and su

135 derate hypoxia and expression of the primary signaling factors involved in the process.

136 ct of active study, the underlying paracrine signaling factors involved remain largely uncharacterize

137 To identify the signaling factors involved, cerebral cortical cultures p

138 signaling via negative feedback input to the signaling factor IRS-1.

139 ound that the relationship between these two signaling factors is not symmetric: loss of Fgf9 in XX W

140 PDGFRalpha with binding sites for these two signaling factors is sufficient for this activity.

141 transcription factor, Relish, and the stress signaling factor JNK, encoded by the gene basket in Dros

142 dent of DLK-1/DLK, KGB-1/JNK, and other MAPK signaling factors known to mediate regeneration in Caeno

143 NF receptors involves the recruitment of key signaling factors, leading to the activation of both the

144 on, which is independent of known amino acid signaling factors, limits the lysosomal surface availabl

145 orally and spatially regulated expression of signaling factors, many of which are synthesized and/or

146 e layers and highlights how an environmental signaling factor may coordinate growth across tissue typ

147 ined release of BMP-4 suggests that myogenic signaling factors may provide a more biological method o

148 Nitric oxide (NO), a pro-inflammatory signaling factor, may regulate COX-2 expression and acti

149 understanding of the molecular mechanism and signaling factors mediating transcellular activation of

150 d growth via the regulation of two important signaling factors, microphthalmia-associated transcripti

151 l-established potent autocrine and paracrine signaling factor modulating a variety of cellular functi

152 n in order to maintain the proper balance of signaling factors necessary for pituitary organogenesis.

153 on zebrafish have clarified the role of two signaling factors, Nodal and Gdf3, during the early stag

154 s from the mesoderm and to the intercellular signaling factor noggin.

155 nduction requires neither host innate immune signaling factors nor involvement of the RNAPIII master

156 At these low levels of insulin/IGF-1 signaling, factors normally provided by the somatic gona

157 Moreover, studies to identify the PRRs and signaling factors of the host cell that mediate inflamma

158 Mutations in epigenetic modifiers and signaling factors often co-occur in myeloid malignancies

159 g the impact of drugs, growth substrates and signaling factors on cell receptors and subcellular syst

160 to virtually any bioactive molecule such as signaling factors or drugs.

161 The involvement of signaling factors or integrins was probed using specific

162 Dynamic spatial patterns of signaling factors or macromolecular assemblies in the fo

163 is by measuring the local concentration of a signaling factor, or morphogen, that is secreted by an o

164 The signaling factors orchestrating these events remain inco

165 ression of the BR-synthesis gene D11 or a BR-signaling factor OsBZR1 results in higher sugar accumula

166 These data reveal that Mdka and Mdkb are signaling factors present in the retinal stem cell niche

167 rently, in vivo and ex vivo studies of these signaling factors present some inherent ambiguity.

168 The model accounts for protein signaling factors produced by cells in lineages, and nut

169 Thus, ATP may function as an autocrine signaling factor promoting Cl- secretion in normal but n

170 Our studies indicate that ROS is a signaling factor promoting maintenance of normal as well

171 s resulting from co-misexpression of Eyeless+signaling factors provide a more complete picture of eye

172 Redox-sensitive signaling factors regulate multiple cellular processes,

173 To determine whether TGFbeta2 or other signaling factors regulate Slug expression during EMT in

174 xclusively expressed in adipose tissue, is a signaling factor regulating body weight homeostasis and

175 way intersects with the complex interplay of signaling factors regulating dental morphogenesis has be

176 n CNS homeostasis as well as Spz3 as a novel signaling factor required for maintenance of cortex glia

177 In this study, we examined signaling factors required for insulin-stimulated glucos

178 about the downstream events following Notch signaling, factors responsible for negatively regulating

179 ially depends on two novel activities of the signaling factor retinoic acid (RA): one specifying the

180 A secondary siRNA screen of the identified signaling factors revealed several new mediators of HIV-

181 mas, it suggests that a unique mitochondrial signaling factor(s) is responsible for the defect in cyt

182 echanisms, including targeted proteolysis of signaling factors, sequestering cellular factors, and up

183 I expression is increased and its downstream signaling factor, SMAD1, is activated in reovirus-infect

184 ) expression is increased and its downstream signaling factor, SMAD3, is activated in the brains of r

185 s region to recruit a suppressor of cytokine signaling factors SOCS1 and SOCS3.

186 ultipotent stem cells, suggesting that local signaling factors specify cell fate.

187 helial/mesenchymal interactions, mediated by signaling factors such as Bmps made in both cell populat

188 ic allele display reduced phosphorylation of signaling factors such as Chk1, but not of chromatin-ass

189 Notch signaling factors such as Hes1 and Mash1 are present in

190 oduction of IFN-gamma-inducing extracellular signaling factors such as IL-12 and TNF-alpha.

191 ated by growth factors such as TGF-B1 and by signaling factors such as Myc, Cyclin E, and the retinob

192 For example, signaling factors such as redox factor-1 (Ref-1) and tra

193 ancer: TGFbeta is an autocrine and paracrine signaling factor that drives cell invasion and metastasi

194 st growth factor 10 (FGF10) is a mesenchymal signaling factor that guides the morphogenesis of multip

195 es induced by added pMesogenin1 is Xwnt-8, a signaling factor that induces a similar repertoire of ma

196 TMS1/ASC is a novel proapoptotic signaling factor that is subject to epigenetic silencing

197 Extracellular ATP is a potent signaling factor that modulates a variety of cellular fu

198 These findings establish NIK as an important signaling factor that regulates Th17 differentiation and

199 C-derived HOCl as a small-molecule paracrine signaling factor that trans-inhibits IKK in melanoma tum

200 e mandibular arch were investigated, and two signaling factors that act as repressors were identified

201 approaches, including identification of key signaling factors that act during the initial stages of

202 e degranulation of neutrophils by generating signaling factors that are expressed differentially depe

203 s of the extracellular matrix and associated signaling factors that are linked to the observed non-ce

204 Pituitary organogenesis is dependent on signaling factors that are produced in and around the de

205 domain (BET) proteins function as epigenetic signaling factors that associate with acetylated histone

206 Signaling factors that associate with activated erythrop

207 h of information on potential regulatory and signaling factors that bear future investigation.

208 To determine the source of other signaling factors that could modulate increased hedgehog

209 Morphogens are signaling factors that direct cell fate and tissue devel

210 ances in understanding cell lineages and the signaling factors that drive cell fate changes provide a

211 ittle is known about the transcriptional and signaling factors that drive pulmonary endothelial cell

212 e of these mutant genes appear to be general signaling factors that function in other Ras1 pathways,

213 activation of other PI 3-kinase-independent signaling factors that have been found to be required du

214 ltures, we treated the cultures with various signaling factors that have been shown to be present in

215 The rise in adipocyte number is triggered by signaling factors that induce conversion of mesenchymal

216 vasation but the microenvironmental cues and signaling factors that induce invadopodia formation duri

217 ather is triggered by increased transport of signaling factors that initiate myelination, such as neu

218 cardial infarction, epicardial cells secrete signaling factors that modulate fibrotic, vascular, and

219 C (aPKC) and protein kinase B (PKB), two key signaling factors that operate downstream of phosphatidy

220 of cytosolic free Ca2+ activates downstream signaling factors that promote long term survival of unm

221 Several extracellular signaling factors that regulate hippocampal neurogenesis

222 on of genes encoding secretory machinery and signaling factors that regulate insulin release.

223 itary gland, which is an essential source of signaling factors that regulate pituitary organogenesis.

224 hat components of the immune response act as signaling factors that regulate the cell-non-autonomous

225 We identified 147 transcription and signaling factors that varied in spatial and temporal ex

226 ype classifier and an atlas of subtype-based signaling factors that we also validate in mouse data.

227 nists regulate the activity of intercellular signaling factors, thereby modulating cell fate specific

228 y act in combination with a variety of other signaling factors to determine neuronal phenotype specif

229 racellular matrix, these fibroblasts provide signaling factors to facilitate tumor survival and alter

230 ar factor kappaB and interacts with the IL-1 signaling factors Toll-interacting protein and tumor nec

231 TNFR1 signaling factors TRADD and Fas-associated death domain

232 rchical clustering revealed that the Eyeless+signaling factor transcriptomes are closer to the eye co

233 lated ischemia/reperfusion and characterized signaling factors triggering cytoprotection by NO.

234 es this life history trajectory,(10) but the signaling factors underlying this major life transition

235 al polarity, they exhibited many of the same signaling factors used by the vitelline and cardiovascul

236 A recently identified class of signaling factors uses critical cysteine motif(s) that a

237 To identify candidate nipple-specific signaling factors, we compared gene expression signature

238 require Ire1p or Hac1p, and Ca2+ influx and signaling factors were not required for initial UPR sign

239 ind cell-type-specific enhancers, as well as signaling factors, which bring extracellular stimuli to

240 aling is mediated in part by the IDRs of the signaling factors, which cause these factors to partitio

241 response to TGF-betas may explain why these signaling factors wield such diverse cellular effects.

242 genes identified as potential targets of Ey+signaling factors will provide novel insights to our und

243 of the spatiotemporal expression of the Wnt signaling factors with respect to the different tissue l

244 al progenitors which transiently express the signaling factor Wnt1.

245 We identify WNT-signaling factors (WNT2, R-SPONDIN-3) and a hitherto una

246 We demonstrate that embryos lacking the signaling factor Wnt3 exhibit defects in this axial real

247 it does so by regulating a Hedgehog-related signaling factor, WRT-10.