ライフサイエンスコーパス: signaling mechanism

1 e linked to differentiation by a yet-unknown signaling mechanism.

2 acting independently of this canonical cAMP signaling mechanism.

3 e, which has implications for the inside-out signaling mechanism.

4 is unknown whether they can exploit this new signaling mechanism.

5 esistance through a compensatory prosurvival signaling mechanism.

6 , suggesting the possibility of an alternate signaling mechanism.

7 lt in lower DegU-P levels through an unknown signaling mechanism.

8 AR requirement is consistent with a nonionic signaling mechanism.

9 nsory neurons via a noncanonical necroptotic signaling mechanism.

10 tion Signal Binding Protein Jkappa-dependent signaling mechanism.

11 o offers improved insights into EAB sensors' signaling mechanism.

12 echanical stimuli through a two-part calcium signaling mechanism.

13 d ubiquitylation is used as an intracellular signaling mechanism.

14 facilitates interrogation of native neuronal signaling mechanisms.

15 t by suppressing AKT and other proliferative signaling mechanisms.

16 etter understand its function and downstream signaling mechanisms.

17 act in upstream drought-related sensing and signaling mechanisms.

18 suggest new paradigms in cardiac adrenergic signaling mechanisms.

19 r other proteins directly involved in GTPase signaling mechanisms.

20 ough two molecularly and temporally distinct signaling mechanisms.

21 nhibiting NETosis via receptor-mediated cell signaling mechanisms.

22 ovel ischemia/reperfusion-induced microglial signaling mechanisms.

23 iveness of ovarian cancer, including hypoxic signaling mechanisms.

24 rve as lipid recognition and controlled cell signaling mechanisms.

25 are likely recognized through highly similar signaling mechanisms.

26 odulation (AON) integrated with nitrogen (N) signaling mechanisms.

27 erent cAMP sources are involved in different signaling mechanisms.

28 e role of the recently described ER membrane signaling mechanisms.

29 ced airway disease (AIAD) and its underlying signaling mechanisms.

30 vagal afferents and the possible downstream signaling mechanisms.

31 nd other methods to determine the underlying signaling mechanisms.

32 nts led to a number of new insights into Pep signaling mechanisms.

33 tein-dependent and internalization-dependent signaling mechanisms.

34 level, little is known about the underlying signaling mechanisms.

35 ct through a combination of TLR7/8/9 and ERK signaling mechanisms.

36 lassification and the realization of diverse signaling mechanisms.

37 omain, has enabled the discovery of a common signaling mechanism - a tethered agonist - for this clas

38 To elucidate the signaling mechanism, a gene expression time course revea

39 ture, is analogous to innate immune receptor signaling mechanisms across kingdoms, drawing particular

40 Little is known regarding the molecular signaling mechanisms activated by CCL28 chemokine via it

41 emonstrate a prominent role of Rap1-mediated signaling mechanisms activated by low CS in acceleration

42 Thus, we have identified a novel signaling mechanism activating PKA in diabetes (downregu

43 d Orai1 binding interfaces have been mapped, signaling mechanisms activating STIM1 recruitment of Ora

44 al Journal, advance our understanding of the signaling mechanism, although the physiological signific

45 The signaling mechanism and therapeutic implication of p85be

46 blocks Galpha(i) protein activation, but the signaling mechanisms and consequences of JNK activation

47 progress in the study of non-enzyme-assisted signaling mechanisms and crosstalk choreographed by nati

48 ons (Ca(2+)) are essential for many cellular signaling mechanisms and enter the cytosol mostly throug

49 However, the signaling mechanisms and modes of regulation of this rec

50 ces in understanding fundamental neuroimmune signaling mechanisms and novel therapeutic targets in ro

51 that dysregulate N-arachidonoylethanolamine signaling mechanisms and reduce neuronal inhibitory cont

52 A limited understanding of ANG signaling mechanisms and the orphan receptor Tie1 has hi

53 However, the signaling mechanisms and the role of individual arms of

54 better understand cell- and tissue-specific signaling mechanisms and their disease-relevant phenotyp

55 cavity is regulated by multiple cell types, signaling mechanisms, and matrix interactions.

56 plified (G protein) versus linear (arrestin) signaling mechanisms, and nonequilibrium effects in a dy

57 Although many of the underlying signaling mechanisms are becoming clearer, the binding m

58 However, the underlying homeostatic signaling mechanisms are distinct.

59 We propose that male-specific signaling mechanisms are involved in establishing sex bi

60 veral other cancers, its functional role and signaling mechanisms are largely unknown.

61 an behavioral rhythms in Drosophila, but its signaling mechanisms are not well understood.

62 However, the function of GPR139 and its signaling mechanisms are poorly understood.

63 own as HIMF or FIZZ1) can induce PH, but the signaling mechanisms are still unclear.

64 als reduce PC barrier function; however, the signaling mechanisms are unknown.

65 discussion, we fundamentally elucidated the signaling mechanism as a seldom used electrostatic shiel

66 anisms allow CA1 neurons to flexibly utilize signaling mechanisms best tuned to temporal pattern of s

67 However, the biochemical signaling mechanisms between 40 Hz neural activity and i

68 ing this wave front requires fast and robust signaling mechanisms between CMs.

69 The molecular signaling mechanisms between glomerular cell types durin

70 To elucidate the signaling mechanisms between human NSCs and endothelial

71 bB3 responsive to HRG-beta1-induced enhanced signaling mechanism, but also analysis by siRNA-knockdow

72 r, we identified a novel membrane-to-nucleus signaling mechanism by which DSCAM receptors can alter t

73 Together, these data outline a new signaling mechanism by which KCa1.1 regulates beta1-inte

74 We have identified a unique signaling mechanism by which RSK2 promotes cell motility

75 These findings reveal an unprecedented signaling mechanism by which two protein kinases fulfill

76 CRs) exhibit highly conserved activation and signaling mechanisms by which agonist stimulation leads

77 Understanding the molecular signaling mechanisms by which SE transforms a brain from

78 hepatocyte cytoplasm, and define the distal signaling mechanisms by which trehalose induces autophag

79 ed Ca(2+) entry (SOCE), a fundamental Ca(2+) signaling mechanism, by affecting the translocation of t

80 ins exemplifies how ancient nucleotide-based signaling mechanisms can be repurposed as TA modules dur

81 However, signaling mechanisms causing increased expression of TRP

82 nstrate a FOXC1-elicited non-canonical WNT5A signaling mechanism comprising NF-kappaB and MMP7 that i

83 The signaling mechanism connecting graded TCR signaling to t

84 How these signaling mechanisms contribute to neuronal dysfunction

85 emonstrate that distinct transcriptional and signaling mechanisms control peri-weaning development an

86 t/beta-catenin and sonic hedgehog-Smoothened signaling mechanisms control the specification and expan

87 ed if TLR activation regulates NGF and which signaling mechanisms control this response in interverte

88 c support to gliotransmitter release through signaling mechanisms controlled by Ca(2+) Despite intens

89 g the emergence of stochastic concurrency in signaling mechanisms controlling leukocyte trafficking.

90 The signaling mechanisms controlling somatic cell reprogramm

91 that, in the early embryonic heart tube, the signaling mechanism coordinating beats is mechanical rat

92 ly-conserved intercellular and intracellular signaling mechanisms critical for learning-related plast

93 ike receptor and C-type lectin-like receptor signaling mechanisms culminating in the activation of th

94 th different Arabidopsis genotypes, we found signaling mechanisms dependent on the plant hormones eth

95 nfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial hom

96 of phosphoproteomics technology to identify signaling mechanisms downstream from a G-protein-coupled

97 The exact signaling mechanisms downstream of LAG3 and interplay wi

98 cal and phosphoproteomics methods to profile signaling mechanisms downstream of the immunotyrosine ac

99 ciated with tissue repair, understanding the signaling mechanisms downstream of Trem2 in coordinating

100 Our work defines a new signaling mechanism driven by a cell polarity kinase tha

101 However, little is known about the synaptic signaling mechanisms during stress that eventually culmi

102 with the shape defined by the regulation of signaling mechanisms (e.g. receptor desensitization, sig

103 ities, yet recent studies indicated distinct signaling mechanisms (e.g. tumor-derived VEGF-C promoted

104 These findings define astroglial Ca(2+) signaling mechanisms encoding sleep need and reveal dyna

105 In this study, we describe a cell-autonomous signaling mechanism explaining how tenascin-C promotes c

106 The TOR pathway mediates a key signaling mechanism for controlling cell size and number

107 ase-mediated cleavage provides an additional signaling mechanism for numerous human RTKs.

108 r results validate a trimerization-dependent signaling mechanism for PRL and offer proof of concept f

109 oncogenic scaffolds and demonstrate a novel signaling mechanism for pseudokinases whereby homotypic

110 These results define a novel signaling mechanism for TGFbeta-mediated fibrous differe

111 cascade and, therefore, constitutes a novel signaling mechanism for this receptor.

112 ta suggest that mouse NK cells use different signaling mechanisms for cytotoxicity compared with othe

113 Our data shed light on new signaling mechanisms for dependence receptors' control o

114 This dataset of fine-tuned signaling mechanisms for diverse GPCRs is a valuable res

115 nfant outcomes and identifies some potential signaling mechanisms for investigation in future and lar

116 biota on ASD-associated symptoms, drawing on signaling mechanisms for reciprocal interactions among t

117 recent studies investigating the use of ABA signaling mechanisms for the manipulation of stomatal co

118 mory, it did so by activating different cell-signaling mechanisms from ERalpha, ERbeta, or 17beta-est

119 of autophagy by glycoconjugates focusing on signaling mechanisms from the extracellular surface and

120 Collectively, these signaling mechanisms function to tightly regulate the se

121 on of Parkinson's disease (PD), but the cell-signaling mechanisms governing chronic neuroinflammation

122 The primary signaling mechanism has long been identified as electric

123 nd cleavage-dependent and -independent aGPCR signaling mechanisms have been described.

124 generate these hormones and their downstream signaling mechanisms have been extensively studied, the

125 Most studies of its angiogenic signaling mechanisms have been in endothelial cells.

126 cell surface receptors as well as underlying signaling mechanisms have been unclear.

127 nal that initiate this behavior-that is, the signaling mechanism-have not been definitively identifie

128 A central common signaling mechanism in cancer is proline-directed phosph

129 Ca(2+) entry (SOCE), the fundamental Ca(2+) signaling mechanism in myogenesis, is mediated by stroma

130 operated Ca(2+) entry (SOCE), a major Ca(2+) signaling mechanism in non-myocyte cells, has recently e

131 on OA-MSC and OAC, and revealed its lateral signaling mechanism in OA.

132 interestingly, we discover a new electronic signaling mechanism in the metal nanoparticle affinity,

133 work has investigated an activity-dependent signaling mechanism in the peripheral nerve.

134 Taken together, our data suggest a drought signaling mechanism in which drought stress relieves ABI

135 Here, we describe a novel physiological signaling mechanism in which ROS, such as hydrogen perox

136 rther evidence for the complexity of calcium signaling mechanisms in CNS astroglia.

137 door to understanding the origins of hormone signaling mechanisms in plants beyond these few model sy

138 Blockade of Ca(2+)-dependent signaling mechanisms in populations of astrocytes that r

139 arper identification of mitochondrial-driven signaling mechanisms in specific lung cell types will be

140 erization and understanding of the intricate signaling mechanisms in stem-like cells is crucial for t

141 ective observations suggest that neuroimmune signaling mechanisms in the NAc are shaped by early-life

142 e insights into hormone and neurotransmitter signaling mechanisms, in particular those mediated by th

143 Classical signaling mechanisms, including Ca-activated protein kin

144 Last, we discuss how non-Smad signaling mechanisms, initiated by distinct ligand-activ

145 t intercellular communication is an emerging signaling mechanism involved in tissue repair and regene

146 differences in both health and disease, the signaling mechanisms involved are complex and are not ye

147 cells and detached cells suggest distinctive signaling mechanisms involved in collective and individu

148 The intracellular signaling mechanisms involved in differential effects of

149 racellular traps (NETs) and to elucidate the signaling mechanisms involved.

150 properties, and elucidated the intracellular signaling mechanisms involved.

151 The signaling mechanism involves the proteolytic unmasking o

152 A multistep signaling mechanism involving D2 receptors and CX3CL1 me

153 lant's ability to respond to shade through a signaling mechanism involving the plant stress hormone a

154 rite formation evoked by serum starvation by signaling mechanisms involving Galpha12/13 but not Galph

155 nmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (V

156 The signaling mechanism is based on the interactions between

157 The KAR signaling mechanism is hypothesized to be very similar t

158 demonstrate that although IL-6 and the trans-signaling mechanism is mandatory for cellular infiltrati

159 or subpattern cell location, suggesting this signaling mechanism is necessary for aligned collagen fo

160 We show that a Ca(2+)-dependent glial cell signaling mechanism is responsible for regulating capill

161 One of these main signaling mechanisms is the nuclear factor-kappa B (NF-k

162 l stresses, eukaryotes have evolved a set of signaling mechanisms known as the unfolded protein respo

163 olarization being largely mediated by a G(q) signaling mechanism leading to Ca(2+)-dependent activati

164 erging were cellular responses to stress and signaling mechanisms linked to immune cell migration and

165 However, the signaling mechanisms linking TJ to the induction of EMT

166 This novel signaling mechanism may have a major impact on understan

167 mechanism mediated by distinct intracellular signaling mechanisms may account for this regulation by

168 These results further elucidate molecular signaling mechanisms mediating receptor-inactivating KOR

169 nsity and memory consolidation, yet the cell-signaling mechanisms mediating these effects remain uncl

170 hosphate (ATP) production to fuel purinergic signaling mechanisms necessary for adequate T cell respo

171 These results elucidate the signaling mechanism of extracellular H2O2 in the colonic

172 thogonal autoinducer AI-1 and AI-2 cell-cell signaling mechanisms of bacterial quorum sensing (QS) to

173 There are striking parallels in the signaling mechanisms of karrikins, strigolactones, and o

174 , we examined the functional involvement and signaling mechanisms of MAGEA1 in breast and ovarian can

175 Unraveling the regulation and signaling mechanisms of MRGPRX2 on basophils and eosinop

176 ECs provides a novel platform to investigate signaling mechanisms of normal and perturbed EC function

177 or a deeper understanding of the fundamental signaling mechanisms of opioid receptors.

178 cholinergic fibers, the distribution and the signaling mechanisms of receptor subtypes, and the dynam

179 ed insights into the regulatory networks and signaling mechanisms of the ER stress responses in plant

180 potential sites of phosphorylation, but the signaling mechanisms of these systems are unknown.

181 naptic plasticity, little is known about the signaling mechanisms of this regulation.

182 that could be used as tools to probe RPTPs' signaling mechanisms or to manage cancers driven by RTK

183 L-associated hypertrophy stems from aberrant signaling mechanisms originating in developing endocardi

184 rovide an assay to assess the structural and signaling mechanisms patterning the human gastrula.

185 Thus, signaling mechanisms previously ascribed to the immune s

186 These signaling mechanisms produce arterial hyperpolarization

187 sources, and we hypothesize that pleiotropic signaling mechanisms regulate allocation of that resourc

188 on the nature of proteins and the integrated signaling mechanism regulating growth of motile cilia.

189 Our data uncover a novel signaling mechanism regulating TRPM3 channels.

190 ng with mGluRs and mERalpha, suggesting that signaling mechanisms regulating analgesic effectiveness

191 These studies reveal age-dependent signaling mechanisms regulating human beta cell prolifer

192 We provide important insight into the signaling mechanisms regulating myelination and propose

193 of growth-defense tradeoffs, the underlying signaling mechanisms remain obscure.

194 tte-like superstructures, but the underlying signaling mechanisms remain obscure.

195 However, these signaling mechanisms remain unknown.

196 tors in thymocyte emigration, the downstream signaling mechanism remains poorly defined.

197 dissecting the integration of these ancient signaling mechanisms remains a challenge.

198 dative stress and by initiating ROS-mediated signaling mechanisms required for the differentiation of

199 mains involved in a proliferation-associated signaling mechanism(s), we constructed chimeric Kv1.3-Kv

200 de production and metabolism, as well as its signaling mechanisms; second, this work will detail the

201 t PNP- and vertebrate NP-receptors and their signaling mechanisms share surprising similarities.

202 o induce plant thermomorphogenesis through a signaling mechanism similar to shade, as both destabiliz

203 rotein Signaling-12 (RGS12), via independent signaling mechanisms, simultaneously attenuates G protei

204 he JAK/STAT3 signaling pathway by IL-6 trans-signaling mechanisms, so promoting cancer aggressiveness

205 the molecular determinants of this essential signaling mechanism still remain largely unknown.

206 s of breast cancer cells, but the underlying signaling mechanisms still remain elusive.

207 activity by HIF-2alpha was not via canonical signaling mechanisms such as Src (non-receptor tyrosine

208 mporal regulation of H(2)O(2) is key to this signaling mechanism, suggesting a role for ascorbate-dep

209 y shown to be controlled by a rapid systemic signaling mechanism termed the reactive oxygen species (

210 that GPER enhances memory via different cell-signaling mechanisms than E2.

211 However, the signaling mechanism that activates p300 in response to c

212 y, our study identifies a novel Fyn-mediated signaling mechanism that amplifies neuroinflammation in

213 am1 to define membrane identity, revealing a signaling mechanism that can be exploited by human mucos

214 suggest that GR expression is an alternative signaling mechanism that can bypass AR blockade.

215 s emerging as a key evolutionarily conserved signaling mechanism that controls organ size.

216 s, we reveal an evolutionarily conserved Wnt signaling mechanism that coordinates gene regulatory cha

217 These findings thus reveal a YAP/TAZ signaling mechanism that coordinates stem cell expansion

218 (2020) identify a feedforward signaling mechanism that couples neuronal activity to th

219 Thus, mitochondrial remodeling is a signaling mechanism that instructs T cell metabolic prog

220 important consequence of gliotransmission, a signaling mechanism that involves glial release of activ

221 Before fusion, the cells use an unusual signaling mechanism that involves the coordinated and al

222 The Notch pathway is a cell-to-cell signaling mechanism that is essential for tissue develop

223 2X1 receptors represent a standby purinergic signaling mechanism that is necessary for antigen recogn

224 this interaction and thus identify an active signaling mechanism that maintains quiescence in the air

225 ns led us to discovery of a network-buffered signaling mechanism that mediates HR signaling and is st

226 Thus, our results identify a compensatory signaling mechanism that prevents lineage-fate errors by

227 es showed that BMX is part of a compensatory signaling mechanism that promotes AML cell survival duri

228 suggesting a postsynaptic nongenomic steroid signaling mechanism that stimulates the release of a ret

229 However, the signaling mechanisms that activate C/EBPbeta in the canc

230 enable the inhibition of other TNF receptor signaling mechanisms that are associated in a wide range

231 Here, we review the fundamentals of the signaling mechanisms that are initiated upon TGF-beta li

232 the most physiologically relevant molecular signaling mechanisms that are involved in growth factor

233 ecause it is critical to impede compensatory signaling mechanisms that can engender drug resistance t

234 The signaling mechanisms that choreograph the assembly of th

235 vide an opportunity to define intrinsic cell signaling mechanisms that chronically drive SA in pain p

236 However, the signaling mechanisms that directly regulate this process

237 ent genes between hybrids suggests conserved signaling mechanisms that either cause or are the conseq

238 However, signaling mechanisms that govern epithelial FPR1 activit

239 Understanding the intracellular signaling mechanisms that govern growth cone motility wi

240 ries with a focus on the central phytochrome signaling mechanisms that have a profound impact on plan

241 the microbiota-triggered pattern recognition signaling mechanisms that impact thrombosis are poorly d

242 hese data provide new insights into cellular signaling mechanisms that influence resistance to PI3K/m

243 While signaling mechanisms that limit IFN-I induction and func

244 er the evolutionary influences and potential signaling mechanisms that maintain or end pregnancy in e

245 Marine phytoplankton thus possess unique signaling mechanisms that may be key to environmental se

246 Little is known about intracellular signaling mechanisms that persistently excite neurons in

247 onic low-grade inflammation, yet homeostatic signaling mechanisms that prevent and/or are affected by

248 , or biological insults can initiate complex signaling mechanisms that promote kidney repair and func

249 Fundamental cell signaling mechanisms that regulate dynamic remodeling of

250 nce in malignancies; however, the underlying signaling mechanisms that regulate EMT are poorly unders

251 s that facilitate pollination responses, the signaling mechanisms that regulate functions of these pr

252 Signaling mechanisms that regulate mammary stem/progenit

253 Similarly uncertain are signaling mechanisms that regulate PKD2 channels in arte

254 s, we must increase our understanding of the signaling mechanisms that regulate proliferation and dif

255 Our aims were to delineate the upstream signaling mechanisms that regulate the TNF-alpha modulat

256 cells that drive stomatal movements and the signaling mechanisms that regulate them.

257 Our understanding of the signaling mechanisms that regulate tooth innervation dur

258 Autophagy is one of the many signaling mechanisms that regulate tumor regrowth.

259 e platelet surface and through intracellular signaling mechanisms that remain systematically undefine

260 e maintenance of energy homeostasis, but the signaling mechanisms that stimulate LD metabolism in hep

261 As expected given the proposed sensor signaling mechanism, the magnitude of the binding-induce

262 our results reveal a diverse activation and signaling mechanism, the structural basis of CB2-selecti

263 Kinase oxidation is a critical signaling mechanism through which changes in the intrace

264 presynaptically and recruits a noncanonical signaling mechanism to reduce glutamatergic synaptic eff

265 Successful pathogens use complex signaling mechanisms to monitor their environment and re

266 However, the upstream signaling mechanism triggered by YM155 remains unclear.

267 However, the molecular signaling mechanisms triggered by TG2 that mediate this

268 V2 cells, suggesting the MAPK pathway as the signaling mechanism underlying the effect of DMP.

269 They also define a signaling mechanism underlying these effects.

270 Molecular signaling mechanisms underlying Alzheimer's disease (AD)

271 ynthesis and release in conjunction with the signaling mechanisms underlying DA's inhibition of GSIS.

272 To determine the signaling mechanisms underlying incomplete tumor cell ki

273 AR that mediates this effect, as well as the signaling mechanisms underlying increased tumor cell dis

274 We study the signaling mechanisms underlying sensorimotor integration

275 ide new insights into the role of macrophage signaling mechanisms underlying sex dimorphism in CIPN,

276 Understanding the molecular signaling mechanisms underlying the development of TLE m

277 The signaling mechanisms underlying the observed cellular ef

278 The signaling mechanisms underlying this, however, are also

279 s pathogen, although the oxygen-sensing and -signaling mechanisms underpinning this response have rem

280 , we provide an updated view of inflammasome signaling; mechanisms underpinning IL-1alpha, IL-1beta,

281 Here, we identify a signaling mechanism, unlike that previously known for an

282 review, we discuss the different signals and signaling mechanisms used by the parasites to carry out

283 ply that aCRY might have evolved a different signaling mechanism via a light-triggered redox cascade

284 ogy evidence supporting an early temperature signaling mechanism via dynamic assembly/disassembly of

285 e observed that in GPX8 knockout cells, this signaling mechanism was impaired as sIL6R failed to acti

286 hemical biosensor architectures rely on this signaling mechanism, we believe that electrochemical pha

287 To better understand the signaling mechanism, we carried out a large-scale geneti

288 o test tissue specificity of this nongenomic signaling mechanism, we tested retinal and bronchial hum

289 To identify the cellular source of potential signaling mechanisms, we assessed HBC activation after n

290 To identify underlying E2 signaling mechanisms, we intrathecally applied BSA-conju

291 Our findings reveal an extracellular signaling mechanism whereby a cell-surface receptor for

292 r results provide new insights into the CD40 signaling mechanisms whereby Ser-11 phosphorylation cont

293 man et al. (2016) demonstrate a feed-forward signaling mechanism wherein F-actin and integrin recepto

294 We describe a root-shoot-root signaling mechanism which simultaneously enables the pla

295 umor growth that orchestrates a feed-forward signaling mechanism with EGFRvIII and STAT3 to drive tum

296 Thus, TransComp-R identified an integrin signaling mechanism with potential therapeutic implicati

297 dney injury (AKI) and the underling cellular signaling mechanisms with focus on the Nrf2/HO-1.

298 Integration of knowledge of signaling mechanisms with that of phytobiome members and

299 sible protein ubiquitination is an essential signaling mechanism within eukaryotes.

300 Thus, this study shows how distinct stromal signaling mechanisms within the prostate cooperate to re