ライフサイエンスコーパス: signaling system

1 ASS (cyclic oligonucleotide-based anti-phage signaling system).

2 inked to the powerful BDNF-TrkB neurotrophic signaling system.

3 plays a crucial part in the function of GPCR signaling system.

4 ed mutation in Shank3 partially impairs this signaling system.

5 rocessing components, and changes in the Wnt signaling system.

6 an alpha-ketoglutarate (alpha-KG) paracrine signaling system.

7 a (TGFbeta)/bone morphogenetic protein (BMP) signaling system.

8 tion in light of its similar phosphorylation signaling system.

9 ell migration, due to activation of the uPAR signaling system.

10 ulated by the MprAB-sigma(E) envelope-stress-signaling system.

11 that noise suppression is encoded within the signaling system.

12 ther, introducing allosteric 'bias' into the signaling system.

13 xogenous chemicals that can disrupt hormonal signaling system.

14 ting a potential physiological role for this signaling system.

15 gene regulatory functions of the entire Wnt-signaling system.

16 cross-regulation of this pathway by the cAMP signaling system.

17 tory effects were targeted to the Rag-MTORC1 signaling system.

18 factor 2)/ARE (antioxidant response element) signaling system.

19 es, generating a complex organization of the signaling system.

20 three previously overlooked features of this signaling system.

21 eceptor, as a novel modulator of the Wnt/PCP signaling system.

22 output relationship of this model eukaryotic signaling system.

23 and thus govern information flow through the signaling system.

24 dy, suggesting multifunctionality of the Crz signaling system.

25 he Ras-Raf system, a well-characterized cell signaling system.

26 ow pH induces expression of the SPI-2 SsrA/B signaling system.

27 erae biofilm formation through the NspS-MbaA signaling system.

28 eep learning will be related to the cellular signaling system.

29 te cell densities and to prime the LuxI/LuxR signaling system.

30 y histidine kinases as part of two-component signaling systems.

31 aining multiple strains utilizing homologous signaling systems.

32 is is a regulated process analogous to other signaling systems.

33 asticity consist of multi-component hormonal signaling systems.

34 es is a commonly occurring theme in multiple signaling systems.

35 ing behavior of in vitro reconstituted H-Ras signaling systems.

36 onse regulators from bacterial two-component signaling systems.

37 ble the comprehensive understanding of other signaling systems.

38 regulated processes interact with other cell signaling systems.

39 process in biological energy conversion and signaling systems.

40 enes, ChIPseq identified novel WT1-dependent signaling systems.

41 cidating biochemical mechanisms of UB-driven signaling systems.

42 implementation of synthetic light-controlled signaling systems.

43 cycle, GBS encodes a number of two-component signaling systems.

44 othesis that PrP(C) serves as a scaffold for signaling systems.

45 eep hierarchical models to simulate cellular signaling systems.

46 d muscle cells are stabilized by homeostatic signaling systems.

47 ity is used to generate precise responses in signaling systems.

48 ements for artificial molecular machines and signaling systems.

49 activation that are orthogonal to endogenous signaling systems.

50 cilitate the engineering of complex cellular signaling systems.

51 ility for a range of molecular processes and signaling systems.

52 enesis in NV AMD via the complement and VEGF signaling systems.

53 es of complement, lipid metabolism, and VEGF signaling systems.

54 e deleterious crosstalk with closely related signaling systems.

55 astic spring mechanism), is involved in both signaling systems.

56 nd imply broad applicability to other kinase signaling systems.

57 eved through the positive modulation of both signaling systems.

58 any interesting features of these widespread signaling systems.

59 strategies tuned to the needs of individual signaling systems.

60 understood molecular interaction language in signaling systems.

61 hat uncover additional potential peptidergic signaling systems.

62 re transforming quantitative studies of cell-signaling systems.

63 n an approach applicable for exploring other signaling systems.

64 le and likely to occur in natural biological signaling systems.

65 e approach for investigating the dynamics of signaling systems.

66 tifs sufficient to explain data from complex signaling systems.

67 The nuclear factor kappa B (NF-kappaB) signaling system, a key regulator of immunologic process

68 lly, coupling active mechanical and chemical signaling systems across different timescales may provid

69 ither single mutant, suggesting that the two signaling systems act independently and in parallel to d

70 reases during aging and that the homeostatic signaling system adjusts its response to accommodate the

71 ptations underlying the evolution of the two signaling systems among distantly related taxa.

72 plantation embryo possesses a functional WNT signaling system and activation of the canonical pathway

73 This highlights a new follicular signaling system and confirms that bimatoprost offers a

74 d new light on the complexity of the WNT/FZD signaling system and have substantial implications for o

75 with reduced abundance of megalin transport/signaling system and indicate that these changes may con

76 decomposing a complex, dynamically evolving signaling system and revealed evolving paths of causal i

77 een structural and biochemical features of a signaling system and the shape of the signal-response re

78 eroprotection that focus on the central IL-6 signaling system and ultimately on inhibition of the IL-

79 ng between different response states in cell signaling systems and enables multiple outcomes for cell

80 ngs should be applicable to a broad range of signaling systems and instrumental in synthetic TCS rewi

81 ion that B. burgdorferi utilizes its limited signaling systems and regulators to govern multiple cell

82 luminate the interface between developmental signaling systems and the fundamental machinery of cell

83 gand/receptor interactions are ubiquitous in signaling systems and their steady-state properties are

84 etwork of interactions between ciliogenesis, signaling systems and tissue patterning.

85 es suggest that manipulating the Dach2-Hdac9 signaling system, and Gdf5 in particular, might be a goo

86 T aggregation, potentiation of the BDNF-TrkB signaling system, and support of mitochondrial integrity

87 ight into the design principles of the Notch signaling system, and the specific developmental process

88 gies are being used to quantify UB-dependent signaling systems, and to integrate UB signaling with re

89 The output of this signaling system appears to be the combined phosphorylat

90 This signaling system appears to represent an ancestral mecha

91 further investigate the relationship between signaling system architecture and biological noise.

92 ad of bacterial processes, the two-component signaling systems are now found far beyond the bacterial

93 Histidine-aspartate phosphorelay signaling systems are used to couple stimuli to cellular

94 mbined action of different Plexin/Semaphorin signaling systems, are required for the formation of a f

95 ssential processes in plants to more complex signaling systems as new adaptive traits developed and h

96 regulation (e.g. co-regulation via the same signaling system), as well as gene-specific determinants

97 show that plants also possess a rapid stress signaling system based on Ca(2+) waves that propagate th

98 Here we review some of the key signaling systems behaviors that have been discovered re

99 these results indicate that the CB1 receptor signaling system both on inhibitory and excitatory neuro

100 e been identified as part of the cannabinoid signaling system: both phytocannabinoids and endocannabi

101 mits a better characterization of the Ca(2+) signaling system but also allows us to further understan

102 tes with exquisitely tailored perception and signaling systems, but equally important are the enzymes

103 bditis elegans, and Mus musculus, a complete signaling system can be genetically dissected, from the

104 Analysis of the time-dependent behavior of a signaling system can provide insight into its dynamic pr

105 However, most known signaling systems can be restricted by low light levels-

106 ts of cyclic oligonucleotide-based antiphage signaling systems (CBASS) that sense cyclic oligonucleot

107 dently identified two components of a Ca(2+)-signaling system, Cbl10 (for calcineurin B-like protein)

108 aled important roles for the endocannabinoid signaling system, comprising G protein-coupled cannabino

109 refore a vital component of the plant oxygen signaling system, connecting environmental stimulus with

110 3 quorum sensing (QS) system-a peptide-based signaling system conserved in sequenced isolates of S. p

111 Cannabinoids are part of an endogenous signaling system consisting of cannabinoid receptors and

112 ology, and electrophysiology, we find that a signaling system consisting of PLCbeta, inositol triphos

113 The Fat/Dachsous/Four-jointed (Ft/Ds/Fj) signaling system contributes to orienting those MTs.

114 Here we report a vesicle-based signaling system controlled by a metal cation binding ev

115 ption factors thereby revealing the upstream signaling systems controlling transcriptional responses.

116 olded protein response (UPR), a multifaceted signaling system coordinating translational control and

117 r abstractions have with the cancer cellular signaling system could have a significant impact on the

118 The TGF-beta/Smad signaling system decreases its activity through strong n

119 is of interactions in the nephrin-Nck-N-Wasp signaling system, demonstrating how multivalent layered

120 The signaling system described here has far reaching implica

121 In the NFkappaB signaling system, distinct kinases mediate inflammatory

122 on is tightly coupled to activation in these signaling systems: dominant entropy-producing trajectori

123 This HARE signaling system during continuous HA clearance could mo

124 The endocannabinoid signaling system (ECSS) is altered by exposure to stress

125 leic acids, kissing motifs, and enzyme-based signaling systems, ELAKCA opens up new prospects for dev

126 There are three intercellular signaling systems employed by P. aeruginosa, and one of

127 ociated with increased activity of two lipid signaling systems (endocannabinoids [ECs] and ceramides)

128 ty of the effects of activating mutations on signaling systems, even at the level of a single protein

129 Many cellular stress-responsive signaling systems exhibit highly dynamic behavior with o

130 ins, thus indicating the existance of a dual signaling system for KARs.

131 By uncovering a signaling system from the Wnt5 guidance cue to an actin

132 er function of saturable, heterogeneous cell signaling systems from basal activity.

133 l membrane receptors constitute an elaborate signaling system fulfilling important functions in immun

134 The Wnt signaling network, an ancient signaling system governing ontogeny and homeostatic proc

135 The sphingosine-1-phosphate (S1P) receptor signaling system has biological and medical importance a

136 f the dynamic phosphorylation states of cell signaling systems have been applied extensively in cell

137 Several signaling systems have been linked to regulation of T4P-

138 Although NE and mediated signaling systems have been studied in relation to suici

139 t mutant phenotypes indicated that these two signaling systems have distinct and non-overlapping role

140 dorferi possesses a sophisticated chemotaxis signaling system; however, the roles of the majority of

141 upon circuit formation, suggesting that the signaling system implicated in gatekeeping puberty becom

142 n systems biology is to reconstruct cellular signaling system in a data-driven manner.

143 Using a mathematical model of the NF-kappaB-signaling system in B cells, we demonstrated that kineti

144 trate the existence of a functional c-di-GMP signaling system in B. subtilis that directly inhibits m

145 tor ligands activate a conserved cannabinoid signaling system in C. elegans and also modulate monoami

146 This study defines a conserved cannabinoid signaling system in C. elegans, demonstrates the cannabi

147 Our results define a new pheromone signaling system in Drosophila that shares characteristi

148 little is known about the effectors of this signaling system in Gram-positive species.

149 eveal that activation of the canonical TAS2R signaling system in myometrial cells produces profound r

150 uggesting that early loss of this beneficial signaling system in preclinical AD development may contr

151 Total functions of the Wnt-signaling system in regulatory gene expression throughou

152 delta, allow fine-tuning of the cell-surface signaling system in response to extracellular heme level

153 erized the basic mechanism for a Phr-peptide signaling system in S. pneumoniae and found that it indu

154 the involvement of the proteasome-ubiquitin signaling system in temperature stress response, the dyn

155 lopmental Cell, Liang et al. (2015) report a signaling system in which positional cues from muscle ar

156 The lumicrine system is a postulated signaling system in which testis-derived (upstream) secr

157 Here, we developed a synthetic signaling system in which the extracellular domains of t

158 gether, these findings reveal an intertissue signaling system in which Wingless acts as an effector o

159 gate the physiological roles of neuropeptide signaling systems in A. japonicus.

160 for studies to elucidate the roles of these signaling systems in human physiology and disease.

161 urther our understanding of neuropeptidergic signaling systems in Lepidoptera and aid in the design o

162 the architecture and diversity of chemotaxis signaling systems in model beneficial plant-associated b

163 atenin signaling pathway is one of the major signaling systems in stem and progenitor cells, and aber

164 es the interplay between two neuromodulatory signaling systems in the brain through which nicotine ac

165 s of cannabinoids and endogenous cannabinoid signaling systems in the regulation of biological proces

166 ceptor form a key component of intercellular signaling systems in the SCN and critically control cell

167 ich is one of the most important and complex signaling systems in vascular development.

168 echanism may also operate at other levels in signaling systems in which a slow activation step couple

169 m sensing and signaling (PRESS), operates in signaling systems in which the kinetics of ligand-recept

170 ototypical G protein-coupled receptor (GPCR) signaling system, in which light-activated rhodopsin (Rh

171 nd satiety, exerting their influence through signaling systems including mammalian/mechanistic target

172 ith bladder mechanosensory, transduction and signaling systems including pannexin 1 (Panx1) and Gja1

173 vels of several components of the purinergic signaling system, including the P2Y2 and P2X5 receptors,

174 olecules through activation of innate immune signaling systems, including toll-like receptor 4 (TLR4)

175 PilA to activate the PleC-PleD two-component signaling system, increase cellular c-di-GMP levels, and

176 gher false alarm metric in this abnormal TNF signaling system indicates perceiving more cytokine sign

177 with respect to this axis, but how these two signaling systems interact during C and E is unclear.

178 ause severe short stature, but how these two signaling systems interact to regulate bone growth is po

179 Therefore, signaling systems involved in detecting and interpreting

180 d a surprising conservation in the intrinsic signaling systems involved in early patterning of bilate

181 , one key challenge in engineering molecular signaling systems involves the design and construction o

182 The phosphoinositide signaling system is a crucial regulator of neural develo

183 gth is not known, despite the fact that this signaling system is an important target for the developm

184 t-derived growth factor receptor(PDGFR)-beta signaling system is both necessary and sufficient to cau

185 InC. elegans, the ephrin-Eph signaling system is conserved and is best characterized

186 tivity engages and maintains this retrograde signaling system is not well understood.

187 The BR signaling system is well established in Arabidopsis (Ara

188 Thus, the posttranscriptional attenuation of signaling systems is a prerequisite for proper segregati

189 lators activation in two-component bacterial signaling systems is the "Y-T coupling" mechanism, where

190 RcsB, the response regulator of this signaling system, is a pleiotropic transcription regulat

191 e, we used the IDA peptide HAE/HSL2 receptor signaling system known to regulate floral organ abscissi

192 The core and Fat-Dachsous signaling systems locally align planar cell polarities i

193 Two distinct but interrelated pheromone-signaling systems, LuxI/LuxR and AinS/AinR, positively c

194 otic genomes possess at least one chemotaxis signaling system, many of those genomes contain multiple

195 opose a model illustrating how the NspS-MbaA signaling system may communicate exogenous polyamine con

196 velope stress response, suggesting that this signaling system may elicit the repair of division machi

197 Assembly of this signaling system may have been facilitated by the bifunc

198 Two different signaling systems may emerge depending on Nature's most

199 aenorhabditis elegans contains a cannabinoid signaling system mediated by a canonical cannabinoid rec

200 he origin and evolution of the two-component signaling system members in plants, we conducted a compr

201 udy has revealed that an interleukin-17-like signaling system modulates a neural circuit that control

202 The endocannabinoid (eCB) signaling system modulates neurotransmission and inflamm

203 Here, we show that a robust endocannabinoid signaling system modulates synaptic transmission between

204 between these central and peripheral emotion-signaling systems, most prominent at the level of cardia

205 S T (FT), components of the plant florigenic signaling system, move long-distance through the phloem

206 activation of the broadly projecting novelty signaling system of the locus coeruleus initiates new ne

207 netic circuitries that control the stringent signaling systems of a copiotroph, a bacteriovore, an ol

208 Bacterial two-component signaling systems offer a rich diversity of sensory syst

209 Biological signaling systems often rely on complexes of biological

210 ) networks, derived from the T-cell receptor signaling system, on supported membranes.

211 We infer that a DA-dependent signaling system operates in hemocytes to mediate phagoc

212 represented, or encoded, in the output of a signaling system over time.

213 nts with sepsis lack this standby purinergic signaling system owing to defects in mitochondrial funct

214 Ubiquitin (UB)-driven signaling systems permeate biology, and are often integr

215 ain mathematically, how even in the simplest signaling systems, perturbation methods may lead to para

216 The orexin/hypocretin peptide signaling system plays a neuromodulatory role in motivat

217 The Wingless/Int1 (Wnt) signaling system plays multiple, essential roles in embr

218 Silencing this novelty signaling system prevented the appearance of new network

219 This signaling system promotes rapid paternity enforcement wi

220 pressions of emotion provide a sophisticated signaling system, questioning the widely accepted notion

221 gene rpfR RpfR uniquely integrates two major signaling systems-quorum sensing and the motile-sessile

222 l steps in the Renin-Angiotensin-Aldosterone signaling System (RAAS) involve binding of the corticost

223 Coupled, but mutually inhibitory, Wnt-FGF signaling systems regulate proto-neuromast formation in

224 nd the contribution of several two-component signaling systems regulating developmental transcription

225 hank3 is a key component of a zinc-sensitive signaling system, regulating synaptic strength that may

226 Such signaling systems rely on the interaction between recept

227 The TYRA-2/osas#9 signaling system represents an inter-organismal communic

228 We highlight the signaling systems required for pollen tube navigation an

229 are part of an evolutionary ancient genetic signaling system, resemble the plant pathogens known as

230 under tonic inhibition by a local purinergic signaling system responding to changes in dietary sodium

231 -proteobacteria, the PhoQ-PhoP two-component signaling system responds to low extracellular Mg(++) an

232 Thus, homeostatic signaling systems responsible for rebalancing ion channe

233 tterning cues normally provided by a Wnt/Fgf signaling system, rosettes still self-organize in the pr

234 We review how these signaling systems sense and relay these signals to drive

235 Cell signaling systems sense and respond to ligands that bind

236 Bacterial signaling systems such as protein kinases and quorum sen

237 dynamics of processes relying on juxtacrine signaling systems, such as axon guidance mediated by Eph

238 e parallels between this mechanism and other signaling systems suggest that diverse organisms may per

239 ubunit pilA requires the PilSR two-component signaling system (TCS).

240 uggest a greater diversity of the chemotaxis signaling system than previously thought.

241 plest strategies, is able to evolve a costly signaling system that allows individuals to respond appr

242 lipid, regulated tightly enough to control a signaling system that can cause birth defects and cancer

243 the P. tricornutum P-responsive sensory and signaling system that combines bacterial two-component s

244 yrosine phosphatase Lar function in a planar signaling system that coordinates leading and trailing e

245 protein response (UPR) is an essential cell signaling system that detects the accumulation of misfol

246 cell has a complex, hierarchically organized signaling system that encodes and assimilates diverse en

247 attraction represents a novel, non-classical signaling system that has therapeutic potential as a dis

248 Thus, PPARgamma represents a signaling system that is not crucial for normal cognitio

249 tagonist IL-36Ra (IL-1F5) constitute a novel signaling system that is poorly understood.

250 ical and biochemical basis of a dynamic GnRH signaling system that is robust to changes in pulse ampl

251 fore, Reelin functions as part of a polarity signaling system that links dendritogenesis in the MZ wi

252 hank3 is a key component of a zinc-sensitive signaling system that regulates excitatory synaptic tran

253 GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors

254 The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues from extracellular

255 ally design a DNA-based artificial molecular signaling system that uses the confined microenvironment

256 Plants exhibit rapid, systemic signaling systems that allow them to coordinate physiolo

257 d receptors (GPCRs) are remarkably versatile signaling systems that are activated by a large number o

258 in particular on the functions of a class of signaling systems that are ubiquitous in bacteria.

259 on for four-layered phosphorelays, which are signaling systems that are ubiquitous in prokaryotes and

260 ch regulation should be a general feature of signaling systems that assemble through multivalent inte

261 man genome encodes proteins used to assemble signaling systems that can transduce signals with divers

262 "Hippo" pathways are ancient protein kinase signaling systems that control cell proliferation and mo

263 there is great interest in understanding the signaling systems that control MAPK function.

264 tuberculosis constitutes very sophisticated signaling systems that convert the environment signals i

265 e latter term describing the brain's chronic signaling systems that function to slowly degrade molecu

266 GIRK) channels are targets of G(i/o)-protein-signaling systems that inhibit cell excitability.

267 raction between the nicotinic and neurokinin signaling systems that may form the basis for some sympt

268 uxtacrine signaling is an important class of signaling systems that plays a crucial role in various d

269 idated in Drosophila, is one of these iconic signaling systems that plays many roles during embryogen

270 ining trials recruits distinct growth factor signaling systems that promote LTM formation.

271 sequently, extensive research has focused on signaling systems that promote myelinating activity of o

272 ucidating brain circuits and neuromodulatory signaling systems that regulate sociability could facili

273 ryotic cells commonly use protein kinases in signaling systems that relay information and control a w

274 en the TOR kinase and inositol polyphosphate signaling systems that we propose governs carbon metabol

275 In this spatially constrained signaling system, the dynamics of Ras nanocluster assemb

276 In the bacterial chemotaxis two-component signaling system, the histidine-containing phosphotransf

277 As a sensitive signaling system, the mitotic checkpoint ensures faithfu

278 Like other signaling systems, the ability of signal-receiving cells

279 By analogy to natural signaling systems, the insights from this study further

280 The two-component signaling system--the major signaling pathway of bacteri

281 O to feedback regulation of the cell surface signaling system through HasA allows P. aeruginosa to ra

282 ns suggests that PRESS operates in many cell signaling systems throughout biology.

283 Vibrio fischeri uses the AinS/AinR pheromone-signaling system to control bioluminescence and other sy

284 ously unknown peptide-mediated intercellular signaling system to control SpeB production, alter globa

285 e the inherent non-linearity of a biological signaling system to identify functions that can potentia

286 ptional repression may alter the activity of signaling systems to generate distinct spatial domains o

287 roach, which sees ethnic group building as a signaling system, to place it within a framework that dr

288 Cell signaling systems transmit information by post-translati

289 Basal activity is widespread in signaling systems under physiological conditions, has ph

290 ese targets included components of the Hippo signaling system, underscoring the power of genome-wide

291 To better understand the mechanism of GPCR signaling system, we integrated five independent genome-

292 Wnt signaling represents a highly versatile signaling system, which plays critical roles during deve

293 Wnt signaling represents a highly versatile signaling system, which plays critical roles in developm

294 ey features of the juxtacrine EphA2-ephrinA1 signaling system while maintaining the ability to pertur

295 nce the cAMP response element-binding (CREB) signaling system, while higher, neurotoxic doses stimula

296 nctional nature of ROC provides the RA-based signaling system with robustness by safeguarding appropr

297 tion has been studied extensively as a model signaling system with similarity to processes of hyphal

298 We have identified a number of neuropeptide signaling systems with both oncogenic and tumour-suppres

299 able strategy for construction of allosteric signaling systems with inputs and outputs of choice.

300 from individual phosphorylation events endow signaling systems with plasticity that evolution may exp