ライフサイエンスコーパス: signaling via

1 emonstrate that rapamycin-insensitive mTORC1 signaling via 4E-BP1 is a critical pathway for TGF-beta(

2 n acts as a molecular switch for Drd3-biased signaling via a GIPC1-dependent route, which is likely t

3 GFBP-3 or its peptide blocks hyaluronan-CD44 signaling via a mechanism that depends on both p53 and a

4 brane-bound IL-6 receptor (IL-6R), and trans-signaling via a naturally occurring soluble IL-6R.

5 trimeric G-proteins during non-canonical Wnt signaling via a novel G-protein binding and activating (

6 butes to the transcriptional outcomes of SHH signaling via a novel molecular mechanism.

7 lity complex (MHC), and induce intracellular signaling via a TCR-like signal after binding with a cog

8 for metallothioneins and autocrine/paracrine signaling via A(3)Rs.

9 ltimately requires tumor-intrinsic IFN-gamma signaling, via a mechanism that is distinct from other t

10 CR activation, in which Rictor regulates BCR signaling via actin reorganization.

11 is by promoting CSC phenotype through Notch1 signaling via activation of c-Jun and indicate that JNK/

12 IL-6.sIL-6R complexes initiate IL-6 trans-signaling via activation of the ubiquitously expressed m

13 me dependent on a small increase in TGF-beta signaling via activin receptor-like kinase 5 to maintain

14 In this study, we discovered that signaling via activin-like kinase 3 (ALK3/BMPR1A), a BMP

15 g early postnatal development in mice, NMDAR signaling via activity of long-range synaptic inputs ont

16 ow that endothelial beta-adrenergic receptor signaling via adrenergic nerve-derived noradrenaline in

17 In sum, G-protein signaling via AGB1/AGG1/AGG2 is essential for Ca(o) -reg

18 loss of INPP4A in HAP1 cancer cells perturbs signaling via AKT kinase and mTOR complex 1.

19 the insulin secretory pathway downstream of signaling via all GPCRs and glucose.

20 )), which suppresses angiotensin II receptor signaling via allosteric transinhibition.

21 signaling in leukocytes and suppressed IFN-I signaling via an AKT/FOXO3/IFN regulatory factor 3/7 pat

22 M cells and simultaneously neutralize ICAM-1 signaling via an antibody blockade, demonstrating signif

23 Moreover, inhibition of S100a4 signaling via antagonism of its putative receptor, RAGE,

24 Cytokines activate signaling via assembly of cell surface receptors, but it

25 on of MTG8 and MTG16 were repressed by Notch signaling via ATOH1 in organoids and intestine tissues f

26 atty acid receptor FFA2 is able to stimulate signaling via both Gi- and Gq/G11-promoted pathways.

27 This regulation is mediated by signaling via both paracrine and autocrine diffusible fa

28 cription of the Met gene we propose that MET signaling via BRAF fuels a positive feedback loop, which

29 demonstrated activation of noncanonical WNT signaling via C-JUN as a downstream target of WNT5B, whi

30 Hepatocyte growth factor (HGF) signaling via c-Met is known to promote endothelial cell

31 Genetic dissection of HGF signaling via c-MET reveals that the incorporation of th

32 genitor cell proliferation by modulating Wnt signaling via c-Myc.

33 pression and subsequent integrin alpha3beta1 signaling, via c-Jun-N-terminal kinase (JNK), inhibited

34 e mechanism for IP(3)-dependent hypertrophic signaling via Ca(2+)-sensitive transcription factors suc

35 ntracellular calcium machinery and impairing signaling via calmodulin, melanin drives an immunometabo

36 ate a role for endoplasmic reticulum calcium signaling via calreticulin in the differentiation of ESC

37 rinsulinemic hypoglycemia, and catecholamine signaling via cAMP-dependent protein kinase and phosphor

38 ough they display different sensitivities to signaling via cAMP/protein kinase A (PKA) and protein ki

39 lection of B cells by augmenting pre-BCR/BCR signaling via CD19 surface retention, whereas limiting n

40 TIMP1 signaling via CD63 leads to activation of HSCs, which cr

41 Strategies to block TIMP1 signaling via CD63 might be developed to prevent PDAC me

42 lating sENG might preferentially direct BMP9 signaling via cell-surface ENG at the endothelium.

43 the Cys23Ser alters 5-HT(2C)R intracellular signaling via changes in subcellular localization in vit

44 ity, synthetic lethality was specific to ATR signaling via Chk1 and did not occur with ATM inhibition

45 gs suggest an obligate requirement for IL-11 signaling via constitutive pS-STAT3 in Helicobacter-indu

46 -induced arousal requires Nmu receptor 2 and signaling via corticotropin releasing hormone (Crh) rece

47 have demonstrated that reactivation of MAPK signaling via CRAF overexpression and dysregulation is a

48 Furthermore, PGD2 signaling via CRTH2 was found to diminish the suppressiv

49 ntegrity, injury, microglial activation, and signaling via CX3CR1 and CCR2 receptors, or following di

50 Impaired signaling via CX3CR1, the fractalkine receptor, promotes

51 lin at the cell surface and transduces rapid signaling via cytoplasmic kinases.

52 oss of NUAK2 activity led to decreased Hippo signaling via cytoplasmic YAP retention.

53 ative regulator of TLR and cytokine receptor signaling via degradation of the receptor-signaling comp

54 r by termination of mu-opioid receptor (MOR) signaling via desensitization and internalization.

55 ctions in microchannels, as well as for cell signaling via diffusing molecules.

56 Endocan facilitated EGFR signaling via direct binding and enhancing of the EGF-EG

57 s, that this interaction modulates antiviral signaling via disruption of USP7 interactions with innat

58 We now show that enhanced stimulation of ABA signaling via distinct ABA receptors can result in plant

59 The data implicate purinergic signaling via DORN1 in the control of stomatal aperture

60 Specifically, DAB2IP inhibited WNT signaling via downregulation of WNT5B, an important stem

61 e small GTPase Rab5 plays a role in neuronal signaling via early endosomal transport.

62 ogenin can be blocked by inhibition of HIF-1 signaling via echinomycin.

63 tically, this effect is mediated by parallel signaling via either calcium or protein kinase C.

64 Here, we review emerging modes of GPCR signaling via endosomal membranes and the physiological

65 Signaling via endosomal TLRs was required for autophagy

66 vivo role for dynein in limiting LET-23 EGFR signaling via endosomal trafficking.

67 Interestingly, this betaAR signaling via Epac is involved in long term potentiation

68 how that STAT3 negatively regulates TGF-beta signaling via ERBB2-interacting protein (ERBIN), a SMAD

69 emotaxis and Ca(2+) mobilization, as well as signaling via ERK1/2 and the small GTPase Rac1); however

70 Intercellular signaling via extracellular vesicles (EVs) is an underap

71 astasis and suggest that disruption of lipid signaling via FABP5 inhibition may constitute a new aven

72 r matrix and are the origin of intracellular signaling via FAK and paxillin.

73 vel, mural-cell beta3-integrin loss enhances signaling via FAK-p-HGFR-p-Akt-p-p65, driving CXCL1, CCL

74 at required fibroblast growth factor (FGF)19 signaling via FGF receptor 4 for survival were more sens

75 is dispensable for KLA binding and for cell signaling via FGFRs.

76 odent models of early adversity is increased signaling via forebrain Gq-coupled neurotransmitter rece

77 Initially viewed as receptors whose signaling via G proteins is delimited to the plasma memb

78 edial habenular neurons revealed that GPR139 signaling via G(q/11) is necessary and sufficient for co

79 ) proteins play a central role in modulating signaling via G-protein coupled receptors (GPCRs).

80 G(i/o), G(q/11), and G(12/13)) that mediate signaling via G-protein-coupled receptors (GPCRs), princ

81 CMV-encoded GPCR, also displays constitutive signaling via Galpha(q), Galpha(i), and Galpha(s) protei

82 stance, Galphaq-coupled Histamine 1 Receptor signaling via Galphaq-dependent activation of RhoGEFs su

83 ium spiny neurons (MSNs) triggered astrocyte signaling via gamma-aminobutyric acid B (GABA(B)) recept

84 bromin 1 (NF1), as a direct effector of GPCR signaling via Gbetagamma subunits in the striatum.

85 e show that disruption of paracrine Hedgehog signaling via genetic ablation of Smoothened (Smo) in st

86 By manipulating NMDAR signaling via GluN2B knockdown, we show that ketamine's

87 Notch signaling via Hes1 regulates maintenance of mature renal

88 ls for high-throughput screening of TGF-beta signaling via high-content imaging of nuclear translocat

89 rplasia in diabetes is mainly due to insulin signaling via homo-IR, associated with increased Has2 ex

90 cells (HSCs) serve as a hub of intrahepatic signaling via HSC-derived stellakines and their responsi

91 responses independently of B-cell-intrinsic signaling via HVEM or BTLA.

92 ucosal sites of both the intestine and lung, signaling via IFNLR can be fully explained by the activi

93 e for known type III interferon cytokines in signaling via IFNLR to mediate antiviral effects at muco

94 ere that this antibody specifically inhibits signaling via IL-1, IL-33 and IL-36 in vitro.

95 f keratinocyte IL-1alpha and IL-36alpha, and signaling via IL-1R and IL-36R was required for inductio

96 pathogen, C. rodentium, we demonstrate that signaling via IL-36 receptor (IL-36R) orchestrates a cru

97 The role of Be2 cells and signaling via IL-4Ralpha in B cells is not clearly defin

98 n, CA-MSC activate ovarian cancer cell STAT3 signaling via IL6 and LIF and increase tumor cell stemne

99 Acetylated SOD2 promotes hypoxic signaling via increased mitochondrial reactive oxygen sp

100 tal outcomes by increasing endogenous ROL/RA signaling via increased Stra6 expression and ROL oxidati

101 s (tumoroids) by inhibiting Wnt/beta-catenin signaling via induction of Axin1 expression.

102 a positive feed-forward loop to activate MYC signaling via induction of miR-33b.

103 Cell signaling via inositol phosphates, in particular via the

104 te that cell contractility mediates integrin signaling via inside-out signaling and emphasizes the im

105 ng behavior by coupling pheromone sensing to signaling via insulin-like peptides.

106 dent manner and is involved in intracellular signaling via interacting with integrin beta6.

107 odel whereby Lrp4 modulates Wnt/beta-catenin signaling via interaction with Wnt ligands and antagonis

108 Therapy-resistant tumors often retain ER signaling, via interaction with critical oncogenic coreg

109 rsistent signaling in receptor-mediated RhoA signaling via intricate temporal regulation.

110 providing long-range control of endothelial signaling via IP(3)-evoked local Ca(2+) release in intac

111 These data indicate that signaling via IR is more important than IGF1R in control

112 quantitative example of differential biased signaling via isoforms of the same G protein-coupled rec

113 We conclude T cell receptor signaling via Itk controls the development of natural Th

114 ExoT also affects PI3K signaling via its ADP-ribosyltransferase activity but do

115 1 are mediated by induction of intracellular signaling via its cell surface receptor CD63, a tetraspa

116 ata indicate that Semapimod desensitizes TLR signaling via its effect on the TLR chaperone gp96.

117 s upon TCR stimulation, inhibiting NF-kappaB signaling via its effects on the IkappaB kinase complex

118 The cytokine IL-17, and signaling via its heterodimeric IL-17RA/IL-17RC receptor

119 signals using two distinct modes: classical signaling via its membrane-bound IL-6 receptor (IL-6R),

120 which ultimately triggered intrinsic reverse signaling via its nuclear-targeted intracellular domain

121 Regulation of ERalpha signaling via its phosphorylation by growth factors is w

122 (CSF-2) in decidual cells triggers paracrine signaling via its receptor (CSF2R) in trophoblasts, prom

123 opoietic cells and suppresses thrombopoietin signaling via its receptor myeloproliferative leukemia v

124 airment of brain-derived neurotrophic factor signaling via its receptor, TrkB.

125 BDNF signaling via its transmembrane receptor TrkB has an imp

126 y symbiotic receptor kinases, and downstream signaling via its ubiquitination activity to fine-tune b

127 Notch signaling, via Jagged1 ligand on Sus cells and Notch1 an

128 i, but not cgt mutants, blocked IFNG-induced signaling via JAK and STAT.

129 of pancreatic cell lines with PRL activated signaling via JAK2-signal transducer and activator of tr

130 results indicate that conserved IL-2Rgammac signaling via JAK3 plays a key role during early zebrafi

131 subsequent increase in integrin alpha3beta1 signaling, via JNK, inhibits expression of the gemcitabi

132 eta-adrenergic signaling, and altered Ca(2+) signaling via leaky RyR2 channels.

133 Here we show that signaling via ligand-induced receptor dimerization-a ver

134 Neuropeptide Y (NPY) signaling via limbic NPY1 and 2 receptors (NPY1R and NPY

135 Soluble klotho regulates TRPC6 calcium signaling via lipid rafts, independent of the FGFR-FGF23

136 ults suggest that autocrine and/or paracrine signaling via locally generated SPMs in the vasculature

137 Carbohydrate perception activates symbiosis signaling via Lysin-motif RLKs and subsequently the comm

138 IFN-gamma signaling via Mal was required for phagosome maturation

139 ress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1

140 demonstrate that PRRSV nsp11 antagonizes IFN signaling via mediating STAT2 degradation and provide fu

141 Our findings provide rationale for targeting signaling via MET and CD44 during anti-EGF receptor ther

142 ZBTB46, which is negatively regulated by AR signaling via microRNA (miR)-1-mediated downregulation.

143 trafficking and promotes novel membrane TNF signaling via microvesicles.

144 nd transforming growth factor beta (TGFbeta) signaling via miRNA in breast cancer as pathways downstr

145 tudies have highlighted the role of nutrient signaling via mTOR complex 1 (mTORC1) regulation that co

146 Syk/Zap70 family kinases are essential for signaling via multichain immune-recognition receptors su

147 his inflammasome priming was due to oxLDL IC signaling via multiple receptors, because inhibition of

148 s: abducens neurons use bidirectional ephrin signaling via mutant alpha2-chimaerin to direct growth,

149 , inducing novel unconventional membrane TNF signaling via MVs without direct cell-to-cell contact.

150 o the dsRNA mimetic poly I:C is dependent on signaling via MyD88 when it is delivered centrally, wher

151 R1 receptor complex, induction of downstream signaling via MyD88/TIRAP, phosphorylation of IRAK4, and

152 ned adjuvant is dependent upon TLR4 and TLR7 signaling via myeloid differentiation primary response g

153 ta promotes invasion and crosstalks with Eph signaling via N-cadherin to drive collective migration o

154 -conditional mTOR deficiency interrupts TACI signaling via NF-kappaB and cooperation with TLRs, there

155 It should have read "TNF-alpha signaling via NF-kappaB".

156 A label on the heatmap read "TGF-alpha signaling via NF-kappaB".

157 s no detectable role, but that glutamatergic signaling via NMDA receptors is required for OSN synapti

158 pecifically opens by cleavage of NPY by CD26 signaling via NPY2 and NPY5 receptors.

159 findings demonstrate that the central GLP-1R signaling via NTS DBH neurons counteracts the developmen

160 or [Formula: see text] ([Formula: see text]) signaling via nuclear factor kappa-B ([Formula: see text

161 ing a facilitation of endogenous cannabinoid signaling via one of its metabolites.

162 ERK1/2 cascade was activated by Ca(2+) signaling via opening of the calcium-homeostasis modulat

163 Conversely, signaling via other C-type lectin receptors did not alte

164 TLR3 knockdown promoted double-stranded RNA signaling via other intracellular RNA receptors in endot

165 otif to TIR modules inhibits proinflammatory signaling via other TLRs, suggesting a convergent paradi

166 prisingly, loss of RhoA causes increased Rho signaling via overcompensation by RhoB because of reduce

167 Targeting biased PAR-1 signaling via parmodulin-2 restricted mTORC1 and Nlrp3 i

168 ein C), independently modulate intracellular signaling via partially distinct receptors.

169 Sfrp inhibitors, together with intercellular signaling via PCP proteins, polarize node cells along th

170 In conclusion, internalization as well as signaling via PDGFRbeta are controlled by ubiquitination

171 s suggest that FL3 inhibits Wnt/beta-catenin signaling via PHB1-dependent activation of Axin1.

172 to a smaller extent, due to enhanced insulin signaling via phosphatidylinositol 3,4,5-triphosphate (P

173 ere important negative regulators of insulin signaling via phosphatidylinositol 3-kinase regulation.

174 d ERK1/2-Sox2 signaling and was dependent on signaling via PI3K/AKT, in GC stem-like cells distinguis

175 dney disease has been linked to dysregulated signaling via PKC in kidney cells such as podocytes.

176 ger mechanisms in common, action at TLR4 and signaling via PKCepsilon, HDM-induced analgesia, and pri

177 dentified due to its ability to suppress ABA signaling via plant immune signaling components.

178 of these cells is associated with decreased signaling via PPAR and TGF-beta/Smad.

179 naling appeared to be unaffected, as calcium signaling via protease-activated receptor 2 remained una

180 Furthermore, matriptase elicited signaling via protease-activated receptor-2 (PAR-2), and

181 2 in hepatocytes, impacting insulin receptor signaling via protein kinase B/AKT (AKT).

182 re action at Toll-like receptor 4 (TLR4) and signaling via protein kinase C epsilon (PKCepsilon) in c

183 aling pathways, including ERK, mTOR, and Akt signaling, via PTPN13-mediated phosphorylation.

184 e-KO mice, without restoring ligand-mediated signaling via RAGE, suggesting that the major effector o

185 9cRA signaling via RARalpha impacts the allergen-specific imm

186 was mediated by tumor necrosis factor (TNF) signaling via receptor interacting protein kinase 1 (RIP

187 Signaling via receptor-interacting serine/threonine prot

188 is inhibited canonical nuclear factor-kappaB signaling via reduced phosphorylative activation, reduci

189 nases mediate inflammatory and developmental signaling via RelA and RelB, respectively.

190 In this case, classical signaling via RelA was essential for proliferating cells

191 or the activation of epithelial beta-catenin signaling via repression of Wnt antagonists.

192 rd to the ability of this molecule to induce signaling via rhesus macaque CD200R, as well as the pote

193 Signaling via Rho-family small GTPases, their upstream g

194 r, we also demonstrate that RM CD200 induces signaling via RM CD200R, and is more robust than RRV vCD

195 V vCD200 does not appear to induce efficient signaling via RM CD200R.

196 that KSHV vCD200 does not efficiently induce signaling via RM CD200R.IMPORTANCE Viral CD200 homologue

197 lar transportation of S1P and its inside-out signaling via S1P1.

198 Targeting LCK signaling via saracatinib, an inhibitor currently underg

199 This reduction required intracellular signaling via second messengers-cytosolic calcium, react

200 Our results suggest that signaling via SH2 domain binding is buffered over a rela

201 te pro-inflammatory activities by activating signaling via sigma receptor 1, inositol-requiring enzym

202 lpha, IFNbeta, IFNL1, IFNL2, or Janus kinase signaling via signal transducer and activator of transcr

203 TGFbeta signaling via SMAD proteins and protein kinase pathways

204 n-A-induced TFH programming was dependent on signaling via SMAD2 and SMAD3 and was blocked by pharmac

205 t transforming growth factor-beta (TGF-beta) signaling via Smad3 integrates with the trithorax comple

206 stream of the upregulated miRNAs and TGFbeta signaling via SMADs and Notch signaling as pathways of t

207 mouse genetics, we show increasing Hedgehog signaling via Smoothened M2 expression rescues some Inpp

208 physical basis for intra- and intercellular signaling via sound waves at interfaces, where not molec

209 domain family 7 member A (CLEC7A or DECTIN1) signaling via spleen-associated tyrosine kinase (SYK), a

210 organoids, inhibitors of Janus kinase (JAK) signaling via STAT1 (glucocorticoids, tofacitinib, or fi

211 Activation of IFNL signaling via STAT1 was measured in areas of no, mild, m

212 In contrast to typical signaling via STAT3, IL6 in OCCA signaled via a noncanon

213 clinical success, the inactivation of kinase signaling via stimulation of endogenous phosphatases has

214 KRAS (KRAS(G12D)) also regulates tumor cell signaling via stromal cells.

215 Succinate signaling via SUCNR1 guides divergent responses in immun

216 and p40(2) in which it attenuates autoimmune signaling via suppression of IL-12Rbeta1 internalization

217 Instead, signaling via surface receptors expressed on NK-92 cells

218 ominantly recognition via Fcgamma receptors, signaling via Syk, PI3K, and protein kinase C to trigger

219 ion of lung fibroblasts by inhibiting NFATc2 signaling via targeting Frizzled receptor 4/6 and the TG

220 of lung fibroblasts by inhibition of SMAD2/3 signaling via targeting the TGF-beta receptor 1.

221 Pathway analysis indicated decreased signaling via TGF-beta/Smad (a family of proteins named

222 n of mitogen-activated protein kinase (MAPK) signaling (via the MAPKs ERK1 and ERK2; hereafter referr

223 By contrast, 5-HT signaling (via the RNi-related pathways) is associated w

224 eprogramming of the kinome through HER2/HER3 signaling via the activation of multiple tyrosine kinase

225 Endothelin signaling via the activation of the endothelin-A recepto

226 tin ligases down-regulate JAK2 stability and signaling via the adaptor protein LNK/SH2B3.

227 s for arrestin recruitment with those for Gq signaling via the AT(1) receptor.

228 a (i)-signaling pathways and is dependent on signaling via the beta-arrestin-1/2 and Ras homolog fami

229 tween the fractional helicity and potency in signaling via the cAMP pathway.

230 ability is reversible and dependent on CCL5 signaling via the chemokine receptor, CCR5.

231 ion state with time, providing evidence that signaling via the DCC intracellular domain triggers DCC

232 Lastly, dysregulated IL-33 signaling via the decoy receptor, sST2, predicts C. diff

233 choline, a lipid product of cellular injury, signaling via the G protein-coupled receptor G2A on myel

234 ment, required sphingosine 1-phosphate (S1P) signaling via the G protein-coupled S1P receptor 1 in th

235 tream activators and downstream effectors of signaling via the GEF Epac2 in the neuroendocrine NS-1 c

236 We uncovered a role for Xinbeta in signaling via the Hippo-YAP pathway by recruiting NF2 to

237 Type 1 IFN signaling via the IFN-1 receptor (IFNAR) was essential f

238 In both the intestine and the lung, signaling via the IFN-lambda receptor (IFNLR) controls c

239 Without signaling via the IL-17 receptor, activated FRCs underwe

240 s and activators of transcription (JAK/STAT) signaling via the IL-22 receptor, resulting in enhanced

241 he striatum, markers of medium spiny neurons signaling via the indirect pathway, associated with beha

242 Signaling via the inducible costimulator ICOS fuels the

243 aired mechanistic target of rapamycin (mTOR) signaling via the inhibitory REDD1/TSC2 axis.

244 Signaling via the insulin-like growth factor (IGF) pathw

245 Endogenous dynorphin signaling via the kappa-opioid receptor (KOR) in the nuc

246 ved IL-10 production and prevented excessive signaling via the kinases PI(3)K (phosphatidylinositol-3

247 Although signaling via the lipid kinase PI(3)K (phosphatidylinosi

248 ndria-mediated reactive oxygen species (ROS) signaling via the mammalian target of the mTOR complex 2

249 myces pombe), and this response is driven by signaling via the MAPK Sty1.

250 tion at BDNF-responding sites and downstream signaling via the MAPK-phosphatase DUSP1 triggers tau ph

251 , which results in an increase in downstream signaling via the mitogen-activated protein kinase and A

252 Plant microRNAs play vital roles in auxin signaling via the negative regulation of auxin response

253 sm of azithromycin through its alteration of signaling via the NF-kappaB and STAT1 pathways.

254 an canonical signaling through beta-catenin, signaling via the non-canonical Wnt receptor Ryk regulat

255 Simultaneously, RCalphabeta-triggered signaling via the NRP1-MET axis increased EC monolayer p

256 Hence, blocking signaling via the NRP1-VEGF axis significantly reduced t

257 Auxin signaling via the nuclear AUXIN RESPONSE FACTOR7 (ARF7)/

258 In this article, we show that signaling via the p110delta isoform of PI3K is critical

259 ow that in advanced ovarian cancers NFkappaB signaling via the RelB transcription factor supports TIC

260 entiate NMDAR activity, induces metabotropic signaling via the Rho/ROCK pathway.

261 Caveolae activate RhoA-ROCK1/PKN2 signaling via the RhoA guanidine nucleotide exchange fac

262 ads to reduced sphingosine-1-phosphate (S1P) signaling via the S1P receptor 1 (S1PR1) in the vascular

263 Signaling via the secreted protein norrin through the fr

264 ally dependent on interleukin-6 (IL-6) trans-signaling via the soluble IL-6 receptor (IL-6R) and robu

265 Variable strengths of signaling via the T cell antigen receptor (TCR) can prod

266 ar bodies, as a key sensor of thresholds for signaling via the T cell antigen receptor (TCR) that was

267 eficient T cells displayed enhanced proximal signaling via the T cell antigen receptor (TCR) without

268 ressor function of Treg cells separable from signaling via the T cell antigen receptor.

269 during logarithmic growth and reduced stress signaling via the TORC1-Rim15-Msn2/Msn4 axis.

270 inhibited interferon-regulatory factors and signaling via the transcription factor NF-kappaB by degr

271 iquitin-chain-assembly complex that promotes signaling via the transcription factor NF-kappaB.

272 IL-1 receptor signaling via the transcription factors AhR and RORgamma

273 Signaling via the transient receptor potential (TRP) ion

274 unctional retinal changes by disrupting BDNF signaling via the TrkB receptor.

275 egakaryocyte function by inducing downstream signaling via the tyrosine phosphatases Shp1 and Shp2.

276 east in part by enhancing Toll-like receptor signaling via the up-regulation of WDFY1.

277 be made more informative by applying costly signaling via the virtual physics of rating devices.

278 ools is driven primarily by lithocholic acid signaling via the vitamin D receptor.

279 gle member of this group leads to failure of signaling via this classical pathway.

280 -viral and anti-proliferative responses, but signaling via this interaction can be detrimental if dys

281 APC signaling via this novel pathway can regulate cell proli

282 Signaling via this receptor results in reduced lung infl

283 downstream effector of TGF-alpha but not EGF signaling via threonine 308-phosphorylated Akt.

284 complex in platelets and activate downstream signaling via TIRAP (Toll-interleukin 1 receptor domain

285 ein to the plasma membrane important for LPS signaling via TLR4.

286 trafficking of CpG and TLR9 to lysosomes and signaling via TLR9 were enhanced in DCs and in mice foll

287 The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible

288 described the critical role of innate immune signaling via Toll-like receptor 4 (TLR4) in the pathoge

289 ion directly disrupts cilium maintenance and signaling via Tulp3, essential for intraflagellar transp

290 proliferation, tissue development, and cell signaling via two pathways: a nuclear receptor mechanism

291 Here we found that deficiency in signaling via type I interferon receptor led to deregula

292 Endothelial TGFbeta1 signaling via type I receptors and endothelin-1 contribu

293 a cell proliferation by activating NF-kappaB signaling via UNC5A, netrin-1 may be a potential therape

294 g angiogenesis and lymphangiogenesis through signaling via VEGF receptor (VEGFR)-2 and VEGFR-3, respe

295 VEGF signaling via VEGF receptor-2 (VEGFR2) is a major regula

296 rough increasing activation of p38MAPK/STAT1 signaling via VEGFR2.

297 Conversely, inhibiting BMP signaling via viral overexpression of noggin in the hipp

298 l role for Wave complex- and actin-regulated signaling via Wnt and SOX9 in skin development.

299 We investigated the effects of hippo signaling via YAP on chromosome stability and hepatocarc

300 T3 pathway was a downstream effector of KRAS signaling via YAP1 and TAZ.