ライフサイエンスコーパス: signalling

1 associated with differential changes in WNT signalling.

2 works and provide positional information for signalling.

3 regulation of translation, and oxytocinergic signalling.

4 ling emergent organization principles of Rho signalling.

5 tworks, T-cell kinetic proofreading, and ERK signalling.

6 ng), rap1-signaling, axon-guidance and hippo-signalling.

7 ithelium are regulated by p38-MAPK and NF-kB signalling.

8 bioavailability and spatiotemporal cellular signalling.

9 ubs of this network were associated with ABA signalling.

10 intraspecies, interspecies, and interkingdom signalling.

11 c beta-catenin acetylation downstream of WNT signalling.

12 ent diversity in Na(V) channel-mediated itch signalling.

13 IFN-, inflammation- and FOXP3/IL2-associated signalling.

14 helial function, likely through nitric oxide signalling.

15 restrains commitment by antagonising ERK1/2 signalling.

16 all of which can potentially activate immune signalling.

17 PIP3 scaffold and central amplifier of PI3K signalling.

18 ifferentiation stimuli, particularly FGF-MEK signalling.

19 etabolic dysregulation, and impaired insulin signalling.

20 escargot, or overactivation of mTor or Toll signalling.

21 pe 2 (cDC2) due to reduced type 1 interferon signalling.

22 l modifications (PTM) are ubiquitous in cell signalling.

23 fferentiation by limiting the duration of RA signalling.

24 A1.3 controls stomatal closure during immune signalling.

25 ACh or ATP to augment endothelium-dependent signalling.

26 docytosis, which is thought to terminate TCR signalling.

27 ct upon muscle protein synthesis or anabolic signalling.

28 entified YAP as a critical mediator of ERBB2 signalling.

29 of most drugs developed to modulate receptor signalling.

30 ut environment in ICP to alter enterohepatic signalling.

31 s found to cross-talk positively with IL-17A signalling.

32 he absence of fibroblast growth factor (FGF) signalling.

33 ng, promoting bone morphogenic protein (BMP) signalling.

34 isrupts homodimer formation and impacts PI3K signalling.

35 and concomitantly corrupted prediction error signalling.

36 e FLS2-BAK1 complex and activation of immune signalling.

37 uppression of advanced glycation end-product signalling.

38 bound sites that suppress Toll-like receptor signalling.

39 llular branching as a direct response to FGF signalling.

40 rom in-phase to anti-phase behaviour occurs, signalling a reorganization of the climate-carbon cycle

41 e that removal of SMAX1, resulting from D14L signalling activation, de-represses essential symbiotic

42 ism, which can give rise to a moving zone of signalling activity at the division site.

43 P9 yields BMP10-like ligands with diminished signalling activity in C2C12 cells, validating the tripa

44 Adult muscles show basal JAK-STAT signalling activity in the absence of any immune challen

45 riants in cultured cells demonstrate reduced signalling activity, allowing variant reclassification.

46 gnalling, such as through tonic or sustained signalling after ligand engagement.

47 We critically assess the role of various signalling agents in linking different pathways upon per

48 TGF-beta1 signalling also reversed the AnxA8 loss-induced cell mor

49 sociated surface receptors, and impaired BCR signalling and cellular adhesion.

50 ebrates, is central to physiological calcium signalling and cellular calcium balance.

51 or organism collectively influences receptor signalling and drug responses.

52 wn-regulated as a result of IL-6/IL-6R/STAT3 signalling and epigenetic mechanisms, effects that might

53 inome-knockdown confirmed dependency on ERBB-signalling and G2/M-checkpoint proteins such as WEE1, to

54 c IFITM3(Y20E) mutant induced oncogenic PI3K signalling and initiated the transformation of premalign

55 e mechanistic basis of this microbiota-brain signalling and its physiological relevance are largely u

56 ce weight gain by altering the BA pool, host signalling and lipid metabolism.

57 ic growth results from the modulation of Tor signalling and lysosomal homeostasis within interstitial

58 ces, increased our understanding of cellular signalling and metabolic networks and resulted in variet

59 a significant number of genes involved in N signalling and metabolism.

60 ur necrosis factor-alpha (TNF-alpha)-induced signalling and prevention of cell death.

61 riptional factor, as well as by PHY-mediated signalling and proper plastid biogenesis.

62 yces cerevisiae Timeless protein Tof1 in DRC signalling and resolution of DNA topological stress requ

63 and pluripotency genes, while repressing WNT signalling and somatic markers.

64 f the specific roles of these proteins in SA signalling and their potential for engineering plant imm

65 lipid metabolism, but with immune function, signalling and transcriptional regulation.

66 ises from Toll-like receptor (TLR) 4 or TLR2 signalling and, in the case of protease allergens, the a

67 nscriptomic analysis indicate that intact SA signalling, and not JA signalling, is required for potat

68 critical for stomatal closure during immune signalling, and OSCA1.3 does not regulate stomatal closu

69 1, fibroblast growth factor receptor and WNT signalling are similar to the effects of altered thyroid

70 ase 7/matrix metallopeptidase 9 (MAPK7/MMP9) signalling as a driver for primary bone cancer metastasi

71 , we identify a requirement for unpaired-JAK signalling as a metabolic regulator in healthy adult Dro

72 gs show that Gli1(+) MSCs integrate hedgehog signalling as a rheostat to control BMP activation in th

73 g response invigoration, suggesting surprise signalling as a shared driver of inhibitory and motivate

74 s such as nucleoli, Cajal bodies and various signalling assemblies represent membraneless organelles,

75 w modulatory axis of STING and innate immune signalling at the ER membrane.

76 pe I interferons through the STING-TBK1-IRF3 signalling axis(7-11).

77 hibitor of the antiphagocytic CD47-SIRPalpha signalling axis.

78 Signalling between the basement membrane and these tissu

79 rom total-flux feedback mediated by cAMP-Crp signalling but also requires inhibition by the regulator

80 play role in maintaining the balance of ABA signalling by controlling their level and/or activity.

81 3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor F

82 alamocortical axonogenesis, probably through signalling by microbially modulated metabolites to neuro

83 dulated by additional inhibition of the PI3K signalling cascade, there is no apparent benefit of bloc

84 the encapsulation effect into intracellular signalling cascades promoting differentiation.

85 depend on IFITM3 to assemble PIP3-dependent signalling complexes and amplify PI3K signalling for mal

86 The core ABA signalling components are snf1-related protein kinase2s

87 elial cells express Wnt-Planar Cell Polarity signalling components following bile duct injury and pro

88 n provides a robust approach for identifying signalling components that impact microvascular network

89 (C-TERMINALLY ENCODED PEPTIDE)-CEP RECEPTOR signalling controls RSA, the gravitropic set-point angle

90 Furthermore, we demonstrate that FGF signalling controls the phase and period of oscillations

91 Readout from a Two Component Signalling cytokinin-specific reporter (TCSn::GFP) close

92 cta, while isoform 2 ameliorated the calcium signalling defect compared to green fluorescence protein

93 ns in extracellular nucleotide and adenosine signalling determine outcomes of inflammation and healin

94 Specifically, we show that Nodal signalling directs the generation and dynamic distributi

95 ovial tissue organoids, we found that NOTCH3 signalling drives both transcriptional and spatial gradi

96 How LTbetaR signalling drives chronic tissue damage particularly in

97 thesis that increasing endothelium-dependent signalling during exercise in older adults can improve s

98 l infection and in endogenous cyclic GMP-AMP signalling during viral infection and anti-tumour immuni

99 a rare gastrointestinal cancer in which WNT signalling dysregulation has been previously reported.

100 The eyes are important in signalling emotions, with the act of narrowing the eyes

101 ta demonstrate that blocking platelet CLEC-2 signalling enhances liver recovery from acute toxic live

102 criptional responses, here we manipulate the signalling environment and activity of the histone demet

103 at bind protein kinase A and other important signalling enzymes determining cardiac myocyte function

104 predators and their prey has led to complex signalling, especially in groups that benefit from the s

105 available for binding, rather than specific signalling events.

106 de insight into ALK1-mediated BMP9 and BMP10 signalling, facilitating therapeutic targeting of this i

107 tabolites to protect skeletal muscle insulin signalling following 7 days' HFHC diet.

108 endent signalling complexes and amplify PI3K signalling for malignant transformation.

109 plications of manipulating nerves and neural signalling for the prevention and treatment of cancer.

110 other reactive species are involved in redox signalling, for instance nitric oxide, hydrogen sulfide

111 An improved understanding of FGF signalling from a structural biology perspective, and of

112 e data support the proposition that afferent signalling from skin wetness enhances the desire to enga

113 etabolism mediated by aberrant growth factor signalling fuels tumour growth and progression.

114 g biological significance to their G protein signalling function still presents a major challenge.

115 be broadly applicable for understanding the signalling functions of numerous S-palmitoylation events

116 catalytic activity while inhibiting any PKM2 signalling functions.

117 ation, MOMP engages various pro-inflammatory signalling functions.

118 Conversely, mutations in signalling genes often occur more than once in distinct

119 sterol-and in particular, whether oncogenic signalling has a role-is unclear.

120 Tissue factor (TF) signalling has been associated with alterations in Akt a

121 TGFbeta signalling has key roles in cancer progression: most car

122 Two modes of indole signalling have been described: persistent and pulse.

123 lecular and cellular effects of dopaminergic signalling have been extensively studied(3), the effects

124 act sites constitute important intracellular signalling hotspots to mediate a plethora of cellular pr

125 ewly discovered, multidimensional MAPK7/MMP9 signalling hub in primary bone cancer metastasis that is

126 The Insulin/IGF-1 signalling (IIS) pathway plays an essential role in the

127 dative stress and Nox isoform-specific redox signalling important in vascular dysfunction associated

128 learning and reward-related prediction error signalling improved most.

129 ting T cells and interferon-gamma (IFNgamma) signalling, improves the response of patients with melan

130 1 binding of all tested RIFINs and abolishes signalling in a reporter assay.

131 the first time we show that IKBKE drives AR signalling in advanced PC.

132 Hormonal signalling in animals often involves direct transcriptio

133 acrophage colony-stimulating factor (GM-CSF) signalling in astrocytes drives the expression of MAFG a

134 ab7a siRNA inhibition enhances IGF-1 and HGF signalling in beta cells and increases expression of the

135 sence of 25 mm KCl, implicating enhanced EDH signalling in BRJ- treated animals.

136 circulating insulin and to abrogate insulin signalling in cancer cells.

137 srupt nucleosome binding alter cGAS-mediated signalling in cells.

138 gation that revealed new insights into X-ROS signalling in disease including changes in MT network de

139 molecule Nlgn3 results in impaired oxytocin signalling in dopaminergic neurons and in altered behavi

140 ve phosphoinositide 3-kinase (PI3K)/AKT/mTOR signalling in early human embryos, and in both primed an

141 Together, our experiments identify AHR signalling in enteric neurons as a regulatory node that

142 anation of the origin of cyclic dinucleotide signalling in mammalian innate immunity.

143 ter proximity to eNOS limits TRPV4(EC) -eNOS signalling in MAs.

144 Global disruption of calcitonin receptor signalling in mice causes atrial fibrosis and increases

145 Recently, characterizing calcium signalling in neurons related to interactions with nanom

146 ing a critical role for this resting form of signalling in regulation of synaptic efficacy and neuron

147 tes known to disrupt skeletal muscle insulin signalling in sedentary and obese individuals.

148 ates a gene important in abscisic acid (ABA) signalling in seeds.

149 Given the importance of inappropriate NOTCH1 signalling in T-cell acute lymphoblastic leukaemia (T-AL

150 he design of small molecules that could bias signalling in the beta-adrenoceptors.

151 distinct mechanisms to potentiate inhibitory signalling in the brain.

152 hlight the crucial role of cyclic nucleotide signalling in the conflict between viruses and their hos

153 Here we identify a critical role for NOTCH3 signalling in the differentiation of perivascular and su

154 e show that GBM-initiating cells induce mTOR signalling in the microglia but not bone marrow-derived

155 How glycolysis regulates WNT signalling in the tail bud is currently unknown.

156 rap selectively inhibited T(H) cell TGF-beta signalling in tumour-draining lymph nodes, causing reorg

157 introduce the mechanisms underlying TGFbeta signalling in tumours and their microenvironment and dis

158 showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in

159 Therapeutic inhibition of LTbetaR signalling in young and aged mice disrupted smoking-rela

160 R-CD3zeta complex, while maintaining CD3zeta signalling, in endosomal vesicles that contain the insul

161 in neuronal-glial plasticity, monoaminergic signalling, inflammatory homoeostasis, cellular metaboli

162 Mechanistically, FGF4-ERK1/2-RSK signalling inhibits EPHA2 via Ser/Thr phosphorylation, w

163 This demonstrates that signalling insights from human blastocysts can be used t

164 To further analyse in vivo signalling interplay, a CCK-1 antagonist (lorglumide) wa

165 otent ERBB2-mediated YAP mechanotransduction signalling, involving EMT-like characteristics, resultin

166 Growth factor signalling is also controlled at the cell surface level

167 Growth factor signalling is dependent on the presence of cell surface

168 Fibroblast Growth Factor (FGF) dependent signalling is frequently activated in cancer by a variet

169 Nitric oxide signalling is integral to NVC in humans, providing a new

170 nical and nontranscription-mediated receptor signalling is more common than hitherto appreciated.

171 anscriptomic analysis we show that intact SA-signalling is required for potato defences against the n

172 G-protein-mediated signalling is terminated by phosphorylation of the C ter

173 Dynamic regulation of ion signalling is, therefore, essential for sperm cells to a

174 dicate that intact SA signalling, and not JA signalling, is required for potato defences against the

175 LMP1 signalling leads to overexpression of many cellular anti

176 Inhibition of TGFbeta signalling leads to reversal of age-associated HSC plate

177 We also show in mouse models that tonic signalling leads to superior morphogenetic activity, wit

178 Inhibition of RAGE but not TLR4 signalling may protect against airway neutrophilia and A

179 n mechanism, and targeting cancer methionine signalling may provide an immunotherapeutic approach.

180 e full-length receptor and its transmembrane signalling mechanism remain unknown.

181 ment and discuss approaches to inhibit these signalling mechanisms as well as the use of these approa

182 The vascular signalling mechanisms capable of functional sympatholysi

183 nts to probe the relative roles of different signalling mechanisms in LTP induction.

184 e design of further experiments to elucidate signalling mechanisms within the core signalling unit an

185 tions act as pacemakers, and if so, by which signalling mechanisms, and finally the nature of the rec

186 ponents of biological membranes, but also as signalling mediators.

187 Pattern-triggered immune signalling, MIN7 and CAD1 are found in major land plant

188 n, protein synthesis, anabolic and catabolic signalling, mitochondrial phenotype and gene expression.

189 uR1s and GluR2s predicted by the biochemical signalling model.

190 gy source, major gluconeogenic precursor and signalling molecule but there is no ipso facto evidence

191 an interaction of EMP3 with the cell surface signalling molecule CD44.

192 highlight the multifaceted role of MADD as a signalling molecule in different organs and reveal its p

193 Indole is a signalling molecule produced by many bacterial species a

194 rigolactones are an important class of plant signalling molecule with both external rhizospheric and

195 , these data provide novel insights into the signalling molecules and mechanisms regulating trophobla

196 ology, and there are a host of intracellular signalling molecules that tune different aspects of Ca(V

197 Aberrant activation of this signalling network is one of the most frequent events in

198 e used a differential equations model of the signalling network to assess which set of channels can e

199 udies, the composition and regulation of the signalling network underlying the cytosolic calcium fluc

200 The work then focuses on cellular signalling networks including various post-translational

201 ust impact on synaptic efficacy and neuronal signalling, neuronal resting Ca(2+) signals warrant furt

202 Pathological malfunction of GPR52 signalling occurs primarily through the heterotrimeric G

203 and pharmacological inhibition of myostatin signalling on the disease phenotype in a mouse model of

204 ts indicated that CEP-CEP receptor-dependent signalling outputs in Arabidopsis and Medicago control o

205 rd learning (P = 0.001) and prediction error signalling (P = 0.004) were both associated with symptom

206 for the exploration of tissue secretions and signalling pathway activation as well as the oxidative s

207 at activation of the non-canonical NF-kappaB signalling pathway by AZD5582 results in the induction o

208 act-free domain, nuclear expression of Hippo signalling pathway effectors and restricted expression o

209 osomes act as platforms for a new phagocytic signalling pathway in which FcgammaR activation recruits

210 ls through G-protein coupled receptors, this signalling pathway provides an interesting therapeutic t

211 ammalian Cyclin B also scaffolds a localised signalling pathway to help preserve genome stability.

212 Mechanoelectrical transduction is a cellular signalling pathway where physical stimuli are converted

213 Hippo pathway is an evolutionarily conserved signalling pathway with key roles in organ development,

214 mutations in APC, a key component in the Wnt signalling pathway, can bias neutral drift and can also

215 pects of causation with respect to the Notch signalling pathway.

216 rmity via a largely unexplored plant nuclear signalling pathway.

217 sm involving PDGFRB and associated oncogenic signalling pathways (PI3K-AKT/ERK), which may also invol

218 ed cell death process is mediated by several signalling pathways (referred to as intrinsic and extrin

219 owth factor (HGF)) and the activation of the signalling pathways (STAT3, c-jun n-terminal kinases (JN

220 ptor 4-regulated cytokines, immune cells and signalling pathways - contributes to the pathogenesis of

221 The different tissues changed their signalling pathways and adipokine/cytokine secretions, s

222 rum of genomic defects that hijack essential signalling pathways and foster T cell transformation.

223 suggest that FgCdc25 modulates cAMP and MAPK signalling pathways and further regulates fungal develop

224 f pathogens by macrophages engages conserved signalling pathways and transcription factors to coordin

225 n) that alter inflammatory cell function and signalling pathways characteristic of AKI, and tested th

226 changes coincided with greater activation of signalling pathways controlling muscle growth and greate

227 current state of knowledge of the different signalling pathways coupled to the IL-4R complexes and e

228 cific to each tissue source, to identify key signalling pathways driving fibrosis and to screen for a

229 uromodulatory activity, define mechanisms of signalling pathways from the gut microbiota to the brain

230 fication and quantification of intercellular signalling pathways has become a common analysis perform

231 on of ER stress sensors and their downstream signalling pathways have therefore emerged as key regula

232 n understanding the insulin receptor and its signalling pathways in cancer, and a number of lessons h

233 nerate somatic-transgenic rodents to monitor signalling pathways in diseased organs using whole-body

234 a gene network, including components of the signalling pathways of auxin, brassinosteroids (BRs) and

235 brosis, and about the precise mechanisms and signalling pathways underlying the autophagy response in

236 y's enrichment analysis, wherein 37 enriched signalling pathways were obtained.

237 biological interactions reflecting receptor signalling pathways.

238 , adhesion and migration properties and cell signalling pathways.

239 ROS molecules with specific targets in redox signalling pathways.

240 and differentiation, and in IGF and TGFbeta signalling pathways.

241 wing to concomitant activation of cell death signalling pathways; these cells are poised to apoptose

242 ecoy-resistant' IL-18 (DR-18) that maintains signalling potential but is impervious to inhibition by

243 Lymphotoxin beta-receptor (LTbetaR) signalling promotes lymphoid neogenesis and the developm

244 function were enhanced by blocking TGF-beta signalling, promoting bone morphogenic protein (BMP) sig

245 ares no structural homology with other known signalling proteins(6-9), which has limited attempts at

246 We show that Hh signalling regulates the differentiation of some neurons

247 findings suggest that inhibition of LTbetaR signalling represents a viable therapeutic option that c

248 id (SA) and jasmonic acid (JA)/ethylene (ET) signalling resulting in trade-offs between defence again

249 on may arise from impaired cyclic nucleotide signalling, resulting from compromised phosphodiesterase

250 partitioning, while the relatedness among co-signalling species provides cues on the ecological overl

251 We propose that manipulating CEP signalling strength or CEP receptor downstream targets m

252 P3/IL2-, inflammation- and finally type1 IFN-signalling subnetworks, forming a single highly integrat

253 oach does not directly prevent intracellular signalling, such as through tonic or sustained signallin

254 ctivity was abolished at high levels of AP-1 signalling, suggesting contextual regulation of AP-1 dri

255 veratrol non-monotonically modulates sirtuin signalling, suggesting that it may induce hormesis, i.e.

256 nd, remained unaltered upon manipulating Wnt signalling, suggesting Wnt-related genes to be downstrea

257 Galanin signalling suppresses insulin secretion in animal models

258 usly been predicted to be important for Rheb-signalling suppression.

259 tting highly detailed understanding of their signalling, synthesis and biological roles - or so it se

260 bserved behaviour supporting a shared facial signalling system in primates.

261 dline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcri

262 e innate immune system and how intracellular signalling systems are consequently activated and integr

263 disease progression on the previous androgen signalling-targeted inhibitor, and timing of the previou

264 hibitor, and timing of the previous androgen signalling-targeted inhibitor.

265 mpared with treatment with a second androgen signalling-targeted inhibitor.

266 proach for attenuating cell-surface receptor signalling, termed receptor inhibition by phosphatase re

267 w avenues for discovery of modulators of FGF signalling that can slow or stop the progression of oste

268 canonical to a context-specific view of GPCR signalling that considers how combinatorial expression o

269 l level and the endoplasmic reticulum stress signalling that contributes to beta-cell failure in T1DM

270 a complex repertoire of intracellular Ca(2+) signalling that evolves in space and time within single

271 terials are too small to admit either guest, signalling the importance of host dynamics for guest ent

272 TF is also shown to induce signalling through activation of the protease activated

273 hanges in haematocrit influence nitric oxide signalling through alterations in shear stress stimuli a

274 hat Na(+) controls OXPHOS function and redox signalling through an unexpected interaction with phosph

275 sed TGFbeta expression and autocrine TGFbeta signalling through effects on gene expression, release o

276 Calcium signalling through NMDA-type glutamate receptors (NMDARs

277 additional deficits in somatostatin-related signalling through SSTR2, may contribute to some of the

278 use exploitative mimicry to modulate sirtuin signalling through steroid receptors.

279 complex capable of modulating innate immune signalling through the cGAS-STING pathway.

280 rrestin 2), which displaces G(s) and induces signalling through the MAP kinase pathway(2).

281 ranslocation and transcriptional activity by signalling through the receptor Ptger4.

282 s to restore disrupted myocardial calcitonin signalling thus may offer therapeutic avenues for patien

283 symptoms of gastric distension) in part via signalling to the paraventricular hypothalamus.

284 Furthermore, little is known about the cell signalling triggered by heterotypic cancer cell-fibrobla

285 a molecular model of the transmembrane core signalling unit and enables spatial localisation of its

286 cidate signalling mechanisms within the core signalling unit and larger array.

287 e a three-dimensional map of a complete core signalling unit, with visible densities corresponding to

288 gical levels and their central role in redox signalling via different post-translational modification

289 Reducing apoptosis signalling via in situ vaccination could be a versatile

290 wever, augmentation of endothelium-dependent signalling via infusion of ACh or ATP during moderate in

291 Additionally, we find that TGF-beta signalling via Smad3/Smad4 is sufficient for the express

292 Here, to test whether the evolution of Edn signalling was a driver of NCC evolution, we used CRISPR

293 These findings suggest that Edn signalling was activated in NCCs before duplication of t

294 These findings indicated that BDNF/TrkB signalling was disrupted in the OC of Nhe6 KO mice, prob

295 knockdown results in activation of NFkappaB signalling, which is linked to an increase in intracellu

296 hrough which S-palmitoylation regulates cell signalling, which might be broadly applicable for unders

297 mmation may result in aberrant adenosinergic signalling, which serves to sustain inflammasome activat

298 Here, we investigate plant defence signalling with a focus on salicylic acid (SA) and jasmo

299 the microdomain as well as enhanced phospho-signalling within, leading to a submicron gradient of ac

300 that manipulation of resting neuronal Ca(2+) signalling yielded pronounced homeostatic synaptic plast