ライフサイエンスコーパス: signalosome

1 s the triad of CARMA3, Bcl10, and MALT1 (CBM signalosome).

2 ediates RSPO-LGR4's interaction with the Wnt signalosome.

3 stasis and thrombosis by stabilizing the LAT signalosome.

4 the expression of key components of the TCR signalosome.

5 ved protein-protein interactions of the BRL3 signalosome.

6 m of the kinases must also be present in the signalosome.

7 ogues in the proteasome lid complex and COP9 signalosome.

8 stabilization of the SP-NK(1)R-beta-arrestin signalosome.

9 nses by recruiting effector molecules to the signalosome.

10 ta-catenin signaling by stabilizing the LRP6 signalosome.

11 g partner of TA, the subunit 4 (CSN4) of CSN signalosome.

12 ( approximately 1500 kDa) known as the ASK1 signalosome.

13 g evidence that XIAP associates with the NOD signalosome.

14 nteracts with Csn12, a component of the COP9 signalosome.

15 poptotic mechanism activated within the RANK signalosome.

16 interaction with the I kappa B kinase (IKK) signalosome.

17 an essential component of the IKK complex or signalosome.

18 mily, whereas CSN-5 is a subunit of the COP9 signalosome.

19 is, was identified as a key component of the signalosome.

20 g axis and the composition of the c-Kit/STAT signalosome.

21 of Rbpj through an association with the IKK signalosome.

22 CD247 and ZAP70, encoding members of the LAT signalosome.

23 expression of COPS7B, a subunit of the COP9 signalosome.

24 t-receptor signal transducers into a complex signalosome.

25 ulates TBK1 ubiquitination through the NLRP4 signalosome.

26 alytic activity and association with the LAT signalosome.

27 TP synthesis in the presence of the PKCdelta signalosome.

28 ibitory destruction complex to a stimulatory signalosome.

29 into interaction, sometimes by forming large signalosomes.

30 goes head-to-tail polymerization to assemble signalosomes.

31 ination at B-cell receptor microclusters and signalosomes.

32 w but persistent increases in F-actin at BCR signalosomes.

33 SH2-containing inositol 5-phosphatase to BCR signalosomes.

34 AP2 were required for the formation of LRP6 signalosomes.

35 ted tonic signaling and the formation of BCR signalosomes.

36 daptor protein 2 (AP2) were part of the LRP6 signalosomes.

37 on of Erk1/2 downstream of NOD alphabeta-TCR signalosomes.

38 icity by forming selective complexes, termed signalosomes.

39 ity and subcellular localization of receptor signalosomes.

40 brane translocation of the IKK and NF-kappaB signalosomes.

41 f membrane domains segregating receptors and signalosomes.

42 to scaffold and localize activated ERK1/2 to signalosomes.

43 to form a previously unknown antiapoptotic "signalosome."

44 for the assembly of "intracellular membrane signalosomes."

45 Constitutive photomorphogenesis 9 (COP9) signalosome 5 (CSN5), an isopeptidase that removes neura

46 We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-kappaB p65, is requi

47 PKA complex acts as cilium-compartmentalized signalosome, a concept that now needs to be considered i

48 CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemic

49 Here, we show that the viral signalosome activated by HCMV binding to its entry recep

50 indispensable for downstream FcvarepsilonRI signalosome activity.

51 Multiple cytosolic innate sensors form large signalosomes after activation, but this assembly needs t

52 of the kinase with key components of the TCR signalosome and abrogates ITK function in T cells.

53 tion of the linker of activated T-cell (LAT) signalosome and activation of downstream signaling prote

54 sites for the coordinated recruitment of the signalosome and are propagated during B cell spreading.

55 Mice with a functional PKCdelta signalosome and elevated retinoid levels (PKCdelta(+/+)h

56 mmune cells to assemble a CARMA3-Bcl10-MALT1 signalosome and mediate G protein-coupled receptor activ

57 thermore, the feedback inhibition of the BCR signalosome and most of its proteins, as well as most ot

58 ffect of SIRPalpha1 receptor on the EGFRvIII signalosome and phenotypes.

59 ility of ADAP to interact with the NF-kappaB signalosome and regulate NF-kappaB activation.

60 mice with a different status of the PKCdelta signalosome and retinoid levels.

61 ent to the protein kinase C theta (PKCtheta) signalosome and subsequent c-Jun kinase (JNK)-mediated C

62 motes internalization of the Wnt9a-Fzd9b-LRP signalosome and subsequent signal transduction.

63 ignaling cascade as a participant in the LAT signalosome and suggest that the THEMIS-GRB2 complex mig

64 CRADD as a negative regulator of the CARMA1 signalosome and suppressor of Th1- and Th17-mediated inf

65 e endosomal mitogen-activated protein kinase signalosome and terminate signaling.

66 e CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which

67 immune activation that associates with STING signalosomes and interferes with the nuclear translocati

68 consequent MR aggregation, forming MR redox signalosomes and mediating redox signaling in CAECs.

69 ruitful in generating a detailed map of cAMP signalosomes and reveal new details of compartmentalized

70 ction in non-membrane-enclosed compartments (signalosomes), and it points to novel potential strategi

71 KKgamma, the regulatory component of the IKK signalosome, and a requirement for BCL10 in both canonic

72 by posttranslational modifications, the COP9 signalosome, and BTB/POZ-domain proteins that link culli

73 architectural elements: the proteasome, COP9 signalosome, and eukaryotic translation initiation facto

74 Key mediators are grouped together as the signalosome, and failure of any single member of this gr

75 ASK1 participated in the IRE1alpha signalosome, and removing ASK1 abrogated the proapoptoti

76 mblies, including amyloids, various kinds of signalosomes, and cellular granules.

77 actions were proposed, the entire TIR-domain signalosome architecture has not been worked out, possib

78 CARMA1/Bcl10 complex and the endogenous CBM signalosome are filamentous morphologically.

79 events that subsequently turn off the CARMA1 signalosome are unknown.

80 BCR signalosomes are dynamic and transient and are subsequen

81 STAT5 phosphorylated by signalosomes are loaded on kinesins and glide along the

82 ed by the protease activity of the CSN (COP9 signalosome), are required to control ubiquitin ligase a

83 rder assemblies on membranes, exemplified by signalosomes, are a paradigm for the regulation of many

84 The results identify the endocannabinoid signalosome as a molecular substrate for fragile X syndr

85 energy homeostasis establishes the PKCdelta signalosome as a promising target for therapeutic interv

86 l-regulating kinase-1/MAPK kinase-3/p38 MAPK signalosome assembled on Rab5a and phosphorylated EEA-1

87 transduced by dynamic signaling complexes ("signalosomes") assembled by oligomerizing hub proteins f

88 t models of T-cell receptor (TCR) triggering signalosome assembly and immune synapse formation invoke

89 eins 5 and 6 (LRP5/6), Dishevelled, and Axin signalosome assembly and provide a more complete model f

90 ly and provide a more complete model for Wnt signalosome assembly both intracellularly and at the mem

91 mbled complexes, which were required for TLR signalosome assembly during DC activation.

92 How Wnt triggers signalosome assembly is unknown.

93 itment, post-translational modifications and signalosome assembly of IL-1 receptor-associated kinase

94 e Wnt co-receptor LRP6, an essential step in signalosome assembly.

95 ction complex activity, but also by impeding signalosome assembly.

96 promotes the formation of an AKT-inhibitory signalosome at TJ and regulates epithelial-mesenchymal p

97 through B-cell antigen receptor (BCR)-based signalosomes at the B-cell surface.

98 onse to prevent aggregation of innate immune signalosomes, but whether HRI acts as a general sensor o

99 , suggesting that it is recruited to the TLR signalosome by multitypic TIR-TIR interactions.

100 mechanism to negatively regulate the CARMA1 signalosome by the "death" adaptor protein caspase and r

101 in is directly recruited to the alpha(1D)-AR signalosome by the C-terminal domain of alpha-dystrobrev

102 tochondrial-associated adaptor molecule MAVS signalosome by usurping PCBP2 and the HECT domain E3 lig

103 y transduced by Dishevelled, which assembles signalosomes by dynamic head-to-tail DIX domain polymeri

104 there are significant differences in how the signalosomes communicate with their cognate receptors.

105 and CONSTITUTIVE PHOTOMORPHOGENESIS1 (COP1) signalosome complex (csn) mutants.

106 The COP9 signalosome complex (CSN) regulates CRLs by removing the

107 ain binding protein 1), integrated into COP9 signalosome complex (CSN), induces protein instability o

108 CARD9, a component of the CARD9-Bcl10-MALT1 signalosome complex involved in NF-kappaB translocation.

109 We further show that the signalosome complex is imported into the nucleus in time

110 ma membrane, and the SP-NK(1)R-beta-arrestin signalosome complex trafficked by a dynamin-mediated mec

111 of the cullin-RING E3 ligase-regulating COP9 signalosome complex, attenuates proinflammatory NF-kappa

112 We found that CSN-5, a component of the COP9 signalosome complex, binds to UNC-98 and -96 using the y

113 Jab1, the fifth component of the COP9 signalosome complex, has a central role in the degradati

114 r disruption of the CARMA1-BCL10-MALT1 (CBM) signalosome complex, most tumour-infiltrating T(reg) cel

115 lymphoma translocation gene 1 (MALT1 [CBM]) signalosome complex.

116 d that cocaine activates a DC-SIGN mediated 'signalosome' complex by enhancing its association with L

117 Although one other COP9 signalosome component, CSN-6, also has a Mov34 domain, C

118 ic transcripts by the RNAi pathway, and COP9 signalosome components Csn1 and Csn2, whose role in hete

119 in-protein interactions between Bam and COP9 signalosome components regulate cell fate decisions with

120 amics by enabling phosphorylation of key BCR signalosome components, including the kinases SYK and BT

121 Thus, unlike Btk and other signalosome components, RasGRP1 deficiency selectively a

122 BCL10, MALT1, and other IkappaB kinase (IKK)-signalosome components.

123 of resting B cells where it associates with signalosome components.

124 mRNA splicing, which is independent of other signalosome components.

125 ctors Sos1 and Sos2, which are essential LAT signalosome components.

126 Defects in CD20/BCR signalosome conformation might predispose to the spectru

127 immediate downstream trafficking-associated signalosome, consequently routing KSHV toward lysosomal

128 notion that modulation of the mAKAPbeta-SRF signalosome could be a new therapeutic approach for huma

129 The constitutively photomorphogenic9 (COP9) signalosome (CSN) acts as a molecular switch of CRLs act

130 tion of free NEDD8 Q40E, inhibiting the COP9 signalosome (CSN) allows Q40E to form only on NEDD8 atta

131 700) portion of the 26S proteasome, the COP9 signalosome (CSN) and a novel complex that includes the

132 e critical in ubiquitinating Myc, while COP9 signalosome (CSN) controls neddylation of Cullin in CRL.

133 The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 fro

134 ch desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an associa

135 e COnstitutively Photomorphogenic-9- (COP9-) signalosome (CSN) in somatic support cells disrupted ger

136 The COP9 signalosome (CSN) is a conserved protein complex consist

137 The COP9 signalosome (CSN) is a conserved protein complex known t

138 We discovered that the COP9 signalosome (CSN) is a crucial player in the DSB respons

139 The COP9 signalosome (CSN) is a multi-protein complex that regula

140 The COP9 signalosome (CSN) is an evolutionarily conserved eight-s

141 The COP9 signalosome (CSN) is an evolutionarily conserved multi-p

142 The COP9 signalosome (CSN) is an evolutionarily conserved multisu

143 The COP9 signalosome (CSN) is an evolutionarily conserved protein

144 The COP9 signalosome (CSN) is an evolutionarily conserved regulat

145 The COP9 signalosome (CSN) is thought to maintain the stability o

146 9 (constitutive photomorphogenesis mutant 9) signalosome (CSN) may regulate the UPS, but this has not

147 COP9 signalosome (CSN) mediates deconjugation of the ubiquiti

148 The constitutive photomorphogenesis 9 (COP9) signalosome (CSN) plays key roles in many biological pro

149 The COP9-Signalosome (CSN) regulates cullin-RING ubiquitin ligase

150 Here we report that the COP9 signalosome (CSN), a general modulator of diverse cellul

151 Here, we investigated the role of the COP9 signalosome (CSN), a general regulator of protein degrad

152 The COP9 (Constitutive photomorphogenesis 9) signalosome (CSN), a large multiprotein complex that res

153 ian constitutive photomorphogenesis 9 (COP9) signalosome (CSN), a protein complex involved in embryon

154 fication is critically dependent on the COP9 signalosome (CSN), an eight-subunit protein complex cont

155 the zinc metalloprotease subunit of the COP9 signalosome (CSN), which is an important regulator of cu

156 In this study, we show that the COP9 signalosome (CSN)-associated protein CSN5 quantitatively

157 ctivity and gene expression through the COP9 signalosome (CSN).

158 activity is inhibited by binding to the COP9 signalosome (CSN).

159 ease following SCF deneddylation by the COP9 signalosome (CSN).

160 lar to those found in components of the COP9 signalosome (CSN).

161 table to Sirt1-dependent suppression of COP9 signalosome (Csn)5 expression in response to CG-12, lead

162 ated expression of the fifth subunit of COP9 signalosome (CSN5) in early HCC as compared with dysplas

163 The presence of clathrin and AP2 in the LRP6 signalosomes depended on PtdIns(4,5)P(2), and both clath

164 propagation that differs from the classical, signalosome-dependent pathway.

165 of multivesicular bodies into which the Wnt signalosome/destruction complex becomes localized upon W

166 ctivation, but signaling events that trigger signalosome dissociation from CRL4 have been unclear.

167 Previously, it was unknown how the TLR4 signalosome distinguished between HMGB1 isoforms.

168 By degrading SP and destabilizing endosomal signalosomes, ECE-1 has a dual role in controlling endoc

169 pha-solenoid-like fold and a proteasome COP9/signalosome eIF3 (PCI) module in a right-handed suprahel

170 Eight subunits having PCI (proteasome, COP9 signalosome, eIF3) or MPN (Mpr1, Pad1, amino-terminal) d

171 lternate pathway for BCR signaling, in which signalosome elements are bypassed for downstream events

172 heme-regulated inhibitor (HRI) controls NOD1 signalosome folding and activation through a process req

173 ial behaviors, and potentially constitutes a signalosome for mediation of sex-reward mechanism in mal

174 esults highlight the importance of mAKAPbeta signalosomes for regulating MEF2D activity in striated m

175 nto large oligomeric signaling complexes, or signalosomes, for signal propagation.

176 Both receptor clustering and signalosome formation are among the rate-limiting steps

177 res actin reorganization and its role in BCR signalosome formation in mAg- and sAg-stimulated B cells

178 gnaling region and linker adaptor for T cell signalosome formation in this region are limiting CLEC-2

179 tor clustering leading to the membrane-based signalosome formation is a critical element required for

180 anism by which PtdIns(4,5)P(2) regulates the signalosome formation remains unclear.

181 5)bisphosphate (PtdIns(4,5)P(2)) production, signalosome formation, and LRP phosphorylation.

182 We evaluated BCR signalosome formation, internalization, and signaling in

183 e of signaling networks, including mAKAPbeta signalosome formation, may constitute an effective thera

184 potential to promote Dvl polymerization and signalosome formation, rather than antagonize it as prev

185 T cell protein phosphorylation and membrane signalosome formation, which resulted in the activation

186 s associated with the BCR but dissociates on signalosome formation.

187 ers, illustrating a key principle underlying signalosome formation.

188 , SIGIRR, and ST2) interfere with TIR domain signalosome formation; 2) major deubiquitinases such as

189 BCAP is recruited to the TLR signalosome forming multitypic interactions with the MAL

190 ome shares features with a CARMA1-containing signalosome found in lymphocytes, there are significant

191 mAKAPalpha signalosome function is explored using new molecular too

192 ctivation, the CARMA3-containing endothelial signalosome functions completely independent of 3-phosph

193 tional reorganization of the beta(3)-AR/cGMP signalosome happens in heart failure and should be consi

194 re likely to cooperate, forming pathways or "signalosomes." Here we report the potential to generate

195 The highly sensitive signalosome identified here provides a regulatory mechan

196 cytokines transduce signals through the TCR signalosome in a manner that requires Fyn activity and s

197 picua may be an important target of the COP9 signalosome in cancer.

198 ignal complex and the downstream trafficking signalosome in endothelial cells and suggest that simult

199 nto the regulatory role of WHIP-TRIM14-PPP6C signalosome in enhancing RIG-I-mediated viral RNA sensin

200 i, and demonstrate a novel role for the COP9 signalosome in heterochromatin regulation.

201 holamban (PLB), and AKAP18 in a multiprotein signalosome in human sarcoplasmic reticulum (SR).

202 y, endogenous MKK6 was found within the ASK1 signalosome in intact cells and in addition copurified w

203 nalosome, underscoring the importance of the signalosome in mediating one of the most significant pro

204 syndecan-1 as a crucial component of the Wnt signalosome in MM cells, binding Wnts and R-spondins to

205 Disruption of CD5 signalosome in mutant mice reveals that it modulates TCR

206 However, the role of the CO2-sAC-cAMP-PKA signalosome in regulating COX activity and mitochondrial

207 ein-1 (PELP1) as one of the components of ER signalosome in the cytoplasm.

208 and ERK1/2 and helped IQGAP1 to form a large signalosome in the perinuclear region.

209 est that HSP27, p38, and NFkappaB-p65 form a signalosome in virus-infected cells and influence downst

210 es the formation of membrane raft (MR) redox signalosomes in a process that depends on a local acid m

211 zation, is required for the formation of BCR signalosomes in response to both mAg and sAg.

212 results suggest that FZD receptors may form signalosomes in response to Wnt binding through the CRDs

213 The signalosome includes requisite Galpha(s), Gbetagamma and

214 rature review of other manuscripts about the signalosome, inflammasome, apoptosis, or mechanisms of s

215 CSN1), which belongs to the Proteasome, COP9 signalosome, Initiation factor 3 (PCI) domain containing

216 In NOD DNs, alphabeta-TCR signalosomes instead behave like pre-TCRs, resulting in

217 iously undescribed ligand that engages a key signalosome involved in the pathogenesis of human immune

218 Furthermore, the concept of a signalosome involving disease-associated factors, such a

219 paB pathway via the CARD11/BCL10/MALT1 (CBM) signalosome involving key, yet ill-defined roles for lin

220 te CD4(+) T-cells through the formation of a signalosome involving TRAF2/PKC- leading to NF-kB activa

221 Here we show that the reconstituted CBM signalosome is a helical filamentous assembly in which s

222 The OX40 signalosome is formed in membrane microdomains irrespect

223 This signalosome is pirated in the activated B-cell-like subg

224 propose that CD20 dissociation from the BCR signalosome is pivotal to BCR-mediated calcium mobilizat

225 The function of BCR signalosomes is one of the determining factors for the f

226 we now show that the formation of mAKAPbeta signalosomes is required for MEF2D dephosphorylation, de

227 diacylglycerol lipase-alpha (endocannabinoid signalosome), is disrupted and metabotropic glutamate re

228 e, a key component of the Carma1/Bcl10/MALT1 signalosome, is critical for NF-kappaB signaling in mult

229 We found that CSN6, a subunit of COP9 signalosome, is overexpressed in CRC samples and that CS

230 a2 (PLCgamma2), a key constituent of the BCR signalosome, is stimulated by activated Rac through dire

231 isoform, which targets a different subset of signalosomes, leaves memory undisturbed.

232 ammatory signaling pathways branching at the signalosome level to Mal/MyD88 and TRAM/TRIF pro- and an

233 Palpha1 inhibitory receptor and the EGFRvIII signalosome may facilitate the identification of novel t

234 Targeting of calcineurin 'signalosomes' may provide a rationale for inhibiting the

235 The CARMA1/Bcl10/MALT1 (CBM) signalosome mediates antigen receptor-induced NF-kappaB

236 The PKCdelta/p66Shc/cytochrome c signalosome might have evolved to effect site-directed o

237 al NF-kappaB by forming a novel Akt(+)NIK(+) signalosome on Rab5(+) endosomes.

238 the formation of the signaling complex, the signalosome, on the IL-7 receptor cytoplasmic domains.

239 adation were found to interact with the ASK1 signalosome once MKK6 activation was completed.

240 These endocannabinoid-producing signalosomes operate in phasic and tonic modes, thereby

241 type 3) and PP2A (protein phosphatase 2A) at signalosomes organized by the scaffold protein mAKAPbeta

242 tal response kinetics suggested that the ABA signalosome partially affects the CO2-induced stomatal r

243 me subunit 5 (CSN5), a component of the COP9 signalosome previously reported to functionally interact

244 est a more complex picture in which distinct signalosomes, previously unrecognized proteins, and newl

245 easing MKK6 binding affinity within the ASK1 signalosome prior to induction of inactivation and degra

246 MP regulatory proteins to form discrete cAMP signalosomes, proteomics and phosphoproteomics analysis

247 ied a new molecular switch, namely mAKAPbeta signalosome-regulated SRF phosphorylation, that controls

248 The COP9/Signalosome regulates CDT2 stability through CUL4 denedd

249 PC imparts functionality to the alpha(1D)-AR signalosome remains a mystery.

250 The COP9 signalosome removes Nedd8 modifications from the Cullin

251 rate, pre-assembled, ligand-independent GPCR signalosome represents a new paradigm in GPCR signalling

252 s define the WHIP-TRIM14-PPP6C mitochondrial signalosome required for RIG-I-mediated innate antiviral

253 AKT and promoting the assembly of JAK2/STAT3 signalosome, respectively.

254 work in concert to initiate an HCMV-specific signalosome responsible for the atypical activation of A

255 ization of BCRs and associated proteins into signalosomes, resulting in BCR-activated calcium entry.

256 e find that although this CARMA3.Bcl10.MALT1 signalosome shares features with a CARMA1-containing sig

257 hat target the B-cell antigen receptor (BCR) signalosome show clinical efficacy in the treatment of B

258 cilitated the binding of topoIIalpha to COP9 signalosome subunit (Csn)5 by way of topoIIalpha phospho

259 e show that mutations in the Drosophila COP9 signalosome subunit 1b (CSN1b) gene increase the activit

260 Here, we show that the COP9 signalosome subunit 5 (CSN5) is required for activation

261 Moreover, COP9 signalosome subunit 5 (CSN5), a component of the COP9 si

262 We show for the first time that COP9 signalosome subunit 6 (CSN6) associates with COP1 and is

263 ding of p27(kip1) to its inhibitor, the COP9 signalosome subunit jun activation-domain binding protei

264 ocyte hypertrophy are inhibited by mAKAPbeta signalosome targeting.

265 Cofilin within MBn, nucleating a forgetting signalosome that is downstream of dopaminergic inputs th

266 Thus, we have identified a neutrophil Btk signalosome that is involved in a signaling pathway trig

267 together constitute a signaling complex (CBM signalosome) that mediates antigen-dependent activation

268 a pre-assembled, constitutively active GPCR signalosome, that couples the relaxin receptor, relaxin

269 HEMIS-mediated recruitment of SHP to the TCR signalosome, THEMIS knock-down increased TCR-induced CD3

270 uncovering a novel vascular role for the CBM signalosome, these findings illustrate that CBM-dependen

271 couple ASK2 S964 phosphorylation to the ASK1 signalosome through dual engagement of 14-3-3.

272 cal cancer cells by associating with the IKK signalosome through IKKalpha.

273 brane-associated guanylate kinase 1 (CARMA1) signalosome through the coordinated assembly of complexe

274 couples JNK signaling components to the BCR signalosome, thus facilitating JNK activation.

275 interacted with both FZD and LRP6 of the Wnt signalosome to enhance LRP6 phosphorylation and potentia

276 udies suggest that DeltaCCDC170 engages Gab1 signalosome to potentiate growth factor signalling and e

277 enotypes revealed a requirement for the COP9 signalosome to prevent ectopic expression of Epidermal g

278 estabilizes Dishevelled, which assembles Wnt signalosomes to inhibit the beta-catenin destruction com

279 However, the relevance of mAKAPbeta signalosomes to pathological remodeling and heart failur

280 res an intact endothelial CARMA3.Bcl10.MALT1 signalosome, underscoring the importance of the signalos

281 nucleates a macromolecular complex or a "PKA signalosome." Using the RIIbeta holoenzyme as a prototyp

282 tdIns(4,5)P(2) promotes the assembly of LRP6 signalosomes via the recruitment of AP2 and clathrin and

283 nning ks-vFLIP-induced activation of the IKK signalosome, we have determined the crystal structure of

284 molecules are recruited to the alpha(1D)-AR signalosome, we performed an extensive proteomic analysi

285 onents of the proximal B cell receptor (BCR) signalosome were enriched within teHSP90 complexes.

286 In addition, WNT3A-induced LRP6 signalosomes were primarily localized at cell surfaces,

287 romotes its incorporation into SERCA2/AKAP18 signalosomes, where it regulates a discrete cAMP pool th

288 4 promote the initial assembly of the CARMA1 signalosome, whereas later phosphorylation at S649 trigg

289 sion of the IkappaB kinase (IKK) complex (or signalosome), which involves a physical interaction betw

290 ough stimulus-coupled assembly of the CARMA3 signalosome, which contains the adaptor protein BCL10.

291 Here, we identify a TJ-based signalosome, which controls AKT signaling and EMT in bre

292 ent assembly of the CARMA1-BCL10-MALT1 (CBM) signalosome, which coordinates downstream activation of

293 r the assembly and function of the IRE1alpha signalosome, which forms a positive feedback loop with A

294 m effector beta-catenin, and the Dishevelled signalosome, which inactivates the Axin complex and thus

295 A paradigm is the Wnt signalosome, which is assembled by Dishevelled via rever

296 te with alpha(1D)-ARs to create a functional signalosome, which is essential for alpha(1D)-AR regulat

297 activation of the focal adhesion associated signalosome, which triggers Rho GTPase signaling.

298 target cells are sequestered into "circadian signalosomes," whose compositions differ between E and M

299 hypothesis that Nkd1 is recruited to the Wnt signalosome with Dvl2, where it becomes activated to mov

300 cently discovered that alpha(1D)-ARs form a "signalosome" with multiple members of the dystrophin-ass