ライフサイエンスコーパス: silent

1 ausally implicated in keeping bivalent genes silent.

2 e active, while others are transcriptionally silent.

3 ting unit to make all phosphate groups MS/MS silent.

4 ng, and most of these lesions are clinically silent.

5 at even the cloak can become immunologically silent.

6 ns onto compass neurons are actually weak or silent.

7 cally in sperm cells but are translationally silent.

8 ized electrical synapses, which are normally silent.

9 e of day-nighttime-when most SCN neurons are silent.

10 me) renders embedded genes transcriptionally silent(1-3).

11 and the electronic circular dichroism (ECD)-silent 2,5-di(1-naphthyl)-terephthalaldehyde-based probe

12 However, these recommendations are either silent about HF or fail to differentiate between the pre

13 al, the matured silent synapses become AMPAR-silent again, followed by re-maturation ~6 h later, defi

14 to characterize the binding to alpha7 by the silent agonist 1,4-diazabicyclo[3.2.2]nonan-4-yl(5-(3-(t

15 ogen bond to tyrosine (Y115) is required for silent agonist activity of NS6740 at the alpha7 nicotini

16 This interaction is necessary for the silent agonist activity of NS6740; when the hydrogen bon

17 f NS6740; when the hydrogen bond is blocked, silent agonist NS6740 converts to a conventional partial

18 Silent agonists are an emerging class of drugs that bind

19 Silent agonists may be able to target a subset of alpha7

20 pes of agonists (agonists, partial agonists, silent agonists, and ago-PAMs).

21 Non-PAV SPE genes with expression of the silent allele in hybrids are more likely to exhibit abov

22 n level than hybrids that do not express the silent allele, leading to non-additive expression.

23 The expression of parentally silent alleles in hybrids of non-PAV SPE genes was relat

24 (2,3,5,6TMP-TQS), previously published as a "silent allosteric modulator" and an antagonist of alpha7

25 surrounding the transcription start site for silent and actively transcribed genes, at the single-cel

26 use solely echolocation for the detection of silent and motionless prey resting directly on foliage d

27 on of IgE-mediated food allergy in humans is silent and only diagnosed upon manifestation of clinical

28 sed celiac disease appeared to be clinically silent and remained undetected, but long-term outcomes h

29 most pancreatic cancers are immunologically silent and resistant to currently available immunotherap

30 Therefore, these findings shed light on this silent and serious threat never assessed in the Mediterr

31 ification of individuals carrying clinically silent and undetectable liver-stage parasites, called hy

32 Latency is not antigenically silent, and viral proteins are sporadically expressed at

33 ll-death forms disjunct from immunologically silent apoptosis are, in theory, more likely to be relev

34 y pyroptotic cell death into immunologically silent apoptotic cell death.

35 ated that these defective proviruses are not silent, are capable of transcribing novel unspliced form

36 Groups also perform a coordinated silent ascent in an unpredictable direction, covering a

37 tration Aspiration Scale score = 6 or 7) and silent aspiration (Penetration Aspiration Scale score =

38 at least one bolus, 13.6% (n = 29) exhibited silent aspiration, and 23.8% (n = 50) exhibited nonsilen

39 y at 35 degrees C and at 10 degrees C but is silent at intermediate temperatures.

40 n S=0 total spin, these are effectively XMCD-silent at low temperature and high magnetic field, allow

41 The pFRG is silent at rest and becomes rhythmically active during th

42 paminergic pathway is likely physiologically-silent at this stage in development.

43 gMA allows discrimination between active and silent axons.

44 dence of the Raman-active E(2g) mode and the silent B(1g) mode of Ru to be determined.

45 ch can be maintained efficiently in activity-silent brain states.

46 n satellite II (HSATII) repeats are normally silent but can be actively transcribed in tumor cells, w

47 on of the thoracic aorta, which is generally silent but can precipitate aortic dissection or rupture

48 nodes are glutamatergic synapses containing silent but ready-to-use gap junctions.

49 erregional glutamatergic synapses containing silent but ready-to-use gap junctions.SIGNIFICANCE STATE

50 The bare complex is CD-silent, but coordination of an enantioenriched substrate

51 of these proviruses remain transcriptionally silent, but mechanisms responsible for viral latency are

52 ancers through T cell factors (TCF) and kept silent by Groucho/TLE co-repressors.

53 at the "tumor microenvironment is not just a silent bystander, but rather an active promoter of cance

54 information are transferred from a series of silent cassettes in the vls locus to generate an express

55 s genetic information from several different silent cassettes, resulting in ~10(40) possible vlsE seq

56 gene, an inverse orientation of vlsE and the silent cassettes, the presence of nearly perfect inverte

57 high concentration of G runs in vlsE and the silent cassettes.

58 P1-mediated H1 eviction for induction of the silent CD40 gene and further demonstrates that H1 evicti

59 ce development with rapid, transcriptionally silent cell divisions, with genome activation delayed un

60 s include ischemic stroke, both apparent and silent, cerebral microinfarcts, cerebral hemorrhage, and

61 oupling of the dark exciton and an optically silent chiral phonon enables the intrinsic photoluminesc

62 hylated on lysine 27 (H3K27me3), a marker of silent chromatin conformation is present at the ADGRB1 p

63 The establishment of silent chromatin, a heterochromatin-like structure at HM

64 both by the direct perinuclear attachment of silent chromatin, and by an active retention of CBP-1/p3

65 histone H3K27 trimethylation, a hallmark of silent chromatin.

66 Although originally thought to be silent chromosomal regions, centromeres are instead acti

67 Constitutive heterochromatin is a largely silent chromosome compartment characterized in part by H

68 are highly variable, ranging from clinically silent clonal hematopoiesis (CH) to leukemic progression

69 e that this regulation constitutes a global 'silent code' mechanism that controls the functional dive

70 ements promote similar -1 PRF rates and that silent coding mutations in the slippery sites and in all

71 There was a case of a clinically silent coil prolapse into the parent artery.

72 EMG showed silent contractures in approximately half of the patient

73 'inquisitive' behaviour, compared to during silent control trials.

74 sion occurs between one of the several donor silent copies located in distinct loci and the recipient

75 fied in the mechanism that gives rise to the silent coupling between Ala and phosphoenolpyruvate.

76 However, in this "silent coupling" scenario, the presence of effector caus

77 n two-thirds of patients remained clinically silent, despite a large number (51%) with previous arter

78 In embryonic stem cells (ESCs), a subset of silent developmental gene promoters are primed for activ

79 Since DR is a silent disease that may cause no symptoms or only mild v

80 HCV often causes silent disease, and eventually progresses to end-stage l

81 he levels of silent polymorphism relative to silent divergence, as well as a site frequency spectrum

82 nded strongly to object motion, but remained silent during global image motion.

83 expression during lytic replication, remains silent during reactivation.

84 TR of nitrate transporter NarK whose gene is silent during standard aerobic growth.

85 If so, can silent electrical synapses be activated to be detected?

86 rs of chains of local transmissions, fueling silent epidemics in the community.

87 ishment and maintenance of transcriptionally silent epigenetic states or heterochromatin.

88 y dynamics, we studied AMPA receptor (AMPAR)-silent excitatory synapses, which are generated in the n

89 cognized a glycan-dominated epitope on Env's silent face and was potent against clade AE viruses, whi

90 can therefore be raised against HIV-1 Env's silent face, suggesting their potential for HIV-1 preven

91 ly 100% of these patients develop clinically silent fibrosis by adolescence.

92 s fasten feathers across bird species except silent fliers, whose feathers also lack the associated V

93 e task was performed but kept it relatively "silent" for other different tasks; and (3) simultaneousl

94 f EHS to contribute to the development of a 'silent' form of cardiovascular disease using a preclinic

95 ing extracellular ribosomes are probably not silent from an immunological perspective and could possi

96 ds on reliable production of immunologically silent functional iPSC derivatives.

97 sound-evoked activity that filled in the 5-s silent gap preceding the US.

98 identification of an as-yet uncharacterized silent gene cluster of the fungus Aspergillus fumigatus,

99 but understanding of both the activation of silent gene clusters and the ecological function of the

100 pecific enrichment of long-lived variants at silent gene loci.

101 ator support long-range interactions between silent gene promoters that rely on FBXL19 for their indu

102 To study the maintenance of silent gene states, we investigated how the Cd4 gene is

103 Transcriptionally silent genes must be activated throughout development.

104 the surface of a nucleosome and thus access silent genes that are inaccessible to other transcriptio

105 ethylation at H3K4 (expressed genes), H3K27 (silent genes), and H3K9 (silent transposons).

106 sue of one inbred and an additional ~10 000 "silent" genes that are not expressed in any tissue of an

107 However, the mechanisms that activate the silent genome after fertilization are poorly understood.

108 ntiretroviral therapy (ART) as an integrated silent genome in long-lived memory CD4(+) T cells.

109 ymoma, a lethal pediatric brain tumor with a silent genome, is dependent upon metabolic changes assoc

110 efined as cells containing transcriptionally silent genomes able to produce infectious virus once rea

111 r results demonstrate that transcriptionally silent genomes in M s can contribute to viral rebound af

112 omposed of cells harboring transcriptionally silent genomes, recent evidence indicates that several b

113 del, although off-target analysis detected a silent genomic alteration in one model.

114 enome occupies the nuclear interior, whereas silent genomic loci are preferentially associated with t

115 ogenesis and the generation of AMPA receptor-silent glutamatergic synapses in the adult nucleus accum

116 H3K9me3 domains, which are transcriptionally silent, H3K9me2 domains are transcriptionally active, co

117 as boundary elements at the edges of a 20-kb silent heterochromatic domain where nucleosomes are meth

118 th active euchromatin enriched centrally and silent heterochromatin at the nuclear periphery(1).

119 d nociception, even in apparently clinically silent heterozygotes.

120 Normally silent heterozygous Shh null mutations exacerbated PBO t

121 activity but can be maintained in 'activity-silent' hidden states, such as synaptic efficacies endow

122 Cs the vector mediated the activation of the silent human gamma-globin gene and in CD34(+) cells, inc

123 bbed happy hypoxia but more precisely termed silent hypoxemia-is especially bewildering to physicians

124 s can account for most, if not all, cases of silent hypoxemia.

125 virus disease (COVID-19) are associated with silent hypoxia and poor oxygenation despite relatively m

126 that human lymphoid tissues can be sites of silent IAV infections with possible impact on virus shed

127 erepressed in PRC2-null villus cells, remain silent in intestinal stem cells (ISCs).

128 n wherein HIV-1 can remain transcriptionally silent in latently infected CD4+ T cells.

129 cross-linking of L402C/L403C is functionally silent in macroscopic currents.

130 ave to be thin, lightweight and acoustically silent in operation.

131 ity of the genes active in one cell type and silent in the other tend to share demethylated promoters

132 hat inherited NOS2 deficiency was clinically silent in this patient until lethal infection with CMV.

133 B signal transduction pathway that is nearly silent in V. cholerae of the El Tor biotype.

134 One hurdle is the use of covert (silent) in-scanner recall to study autobiographical memo

135 In addition, with TDM, silent inactivation and allergic-like reactions were ide

136 action to PEGasparaginase, of which 40% were silent inactivations.

137 umans and animals following long, clinically silent incubation periods.

138 ocardial infarctions, fatal coronary events, silent infarctions, revascularization procedures, or res

139 Clinically silent infarcts among the 1,390 patients without a histo

140 Clinically silent infarcts were defined as infarcts on brain MRI in

141 unction, even among patients with clinically silent infarcts.

142 drome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COV

143 ndividual clinical variability, ranging from silent infection to lethal disease.

144 e further quantified the effect of isolating silent infections in addition to symptomatic cases, find

145 omatic cases, finding that over one-third of silent infections must be isolated to suppress a future

146 repressed, in part by the histone-modifying silent information regulator (SIR) complex.

147 ascularization was found to be bolstered via Silent information regulator 1 (SIRT1) and peroxisome pr

148 lish a large population of typical optically silent interlayer excitons.

149 ed chromatin state that is transcriptionally silent, is a critical regulator of gene expression.

150 renal disease, prior myocardial infarction, silent ischemia, history of stroke, and multivessel dise

151 Recent symptomatic or silent ischemic stroke was diagnosed on the basis of cli

152 The electrically silent (KvS) members of the voltage-gated potassium (Kv)

153 nding of TBP, TAF1, and Pol II to previously silent late promoters.

154 iently establish lifelong, transcriptionally silent latency states in sensory neurons to escape host

155 The ability of HIV to establish a reversibly silent, "latent" infection is widely regarded as the mai

156 The unmasking of silent lead malfunction in the internal cardioversion gr

157 Three cases of pre-existing silent lead malfunction were unmasked by internal shock,

158 indings demonstrate that the brain can use a silent lip-read signal to synthesize a coarse-grained au

159 score remained similar when only clinically silent LNCCIs were considered (24.9 +/- 3.1 vs. 25.8 +/-

160 MRV-3 in South America and a hypothesis of a silent long-term circulation of this virus in Brazil has

161 n, can activate expression from the normally silent maternal allele of SNORD116 in neurons derived fr

162 This is dependent on silent mating type information regulation 2 homolog 5 (S

163 itor of class III histone deacetylase SIRTs (silent mating type information regulation 2 homologs) an

164 ring mnemonic periods interact with activity-silent mechanisms in the prefrontal cortex (PFC).

165 sory cortices, neglecting potential activity-silent mechanisms, such as connectivity-dependent encodi

166 that integrates activity-based and activity-silent mechanisms.

167 A 21-year-old woman with a silent medical history was admitted to the Emergency Dep

168 ar neutrophil (hPMN) autophagy regulates the silent mode of parasite transfer to macrophages by influ

169 A suggestion has now been made that "silent modulators" are ideal drug leads because they can

170 at interrupt the flow of a sentence and fill silent moments between ordinary (non-filler) phrases.

171 rategies can override acoustic camouflage by silent, motionless prey, thus providing new insights int

172 ed with ac4C at multiple discrete sites, and silent mutagenesis of these ac4C sites led to decreased

173 In-frame deletions in BMD and a DMD non-silent mutation (C3340Y) resulted in defects in the abil

174 This trend was prominent for nonsense and silent mutations or mutations with neutral functional im

175 A total twelve SNPs resulted in silent mutations, with five conferring the amino acid su

176 triction enzyme sites created by introducing silent mutations.

177 experiments suggest that the immunologically silent nature of the natural glycans is due to specific

178 Silent new lesions were detected in 14% of MOG-IgG posit

179 recruited together with associated genes to silent nuclear regions.

180 BC59 differ by an additional 31 noncoding or silent nucleotide changes.

181 ate for the loss of SMN1 because of a single silent nucleotide difference in SMN2 exon 7.

182 neurons show synchronous alterations between silent (OFF) and active (ON) periods.

183 The target article is almost silent on both.

184 some implicit responses, they are generally silent on other forms of learning and on the interface o

185 mall rather than gross and, I argue, largely silent on the pervasiveness and persistence of the pheno

186 Qualitative researchers have been silent on the risk of apophenia and hence on exploring h

187 presence of strong social ties, but they are silent on whether a causal mechanism exists, how it oper

188 Darobactin is coded by a silent operon with little production under laboratory co

189 rotein-coding genes as either constitutively silent or able to be expressed.

190 sterol synthesis genes are transcriptionally silent or mutated, meaning that cholesterol uptake from

191 crustaceans and then either kept this neuron silent or used a long-term voltage clamp protocol to art

192 ashamed of them and hiding disgust away as a silent part of care.

193 rovements correlated with increased cortical silent period and short-interval intracortical inhibitio

194 Cortical silent period was significantly prolonged in writer's cr

195 the input-output recruitment curve, cortical silent period, and amplitude of the motor evoked potenti

196 ds, or firing several bursts then entering a silent period.

197 ing switching between firing rates, entering silent periods, or firing several bursts then entering a

198 in vivo, that reveal previously unrecognized silent pH-sensitive electrical synapses coexisting in on

199 racterized by brain-wide periodic active and silent phases.

200 ntually leads to genetic assimilation of the silent phenotype by mutations that reduce or abolish URA

201 f polymorphism, and a spike in the levels of silent polymorphism relative to silent divergence, as we

202 s of the parasite that target the clinically silent pre-erythrocytic stages of infection have emerged

203 rst-hit mutation that initiates a clinically silent pre-leukemia in utero.

204 , that has been considered for many years a 'silent presence' or the 'stone guest' of protein aggrega

205 nt; apoptotic cells are removed in an immune silent process, whereas necroptotic cells leak cellular

206 We propose the term silent progression to describe the insidious disability

207 that each displays a single peak in the cell-silent Raman spectral window; when combined with availab

208 etent rDNA loci but not to transcriptionally silent rDNA loci, thereby increasing rRNA synthesis by a

209 nts involving acrocentric p-arms and observe silent, rDNA-containing NORs that are dissociated from n

210 This means that first fixations during silent reading are lengthened when the CCVs require a gr

211 on of the first fixations on the CCVs during silent reading correlate with the duration of the transi

212 Silent reading is a cognitive operation that produces ve

213 ration (AMD) on short out-loud and sustained silent reading speeds, and reading comprehension.

214 Sustained gazing, such as in silent reading, has a measurable negative impact on visu

215 After silent reading, the dry eye patients had decreased readi

216 ecognition of infrequent text strings during silent reading.

217 different IReST excerpts following 30-minute silent reading.

218 ver, as prior studies have relied on covert (silent) recall procedures, current understanding may be

219 This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid

220 with distinct signals in the cellular Raman-silent region (1800-2800 cm(-1)) has attracted great int

221 intrinsic Raman imaging agents in the Raman-silent region (without any Raman enhancer), and the flex

222 -of-origin and may represent tissue-specific silent regions which tolerate instability at the epigene

223 For each region, we tested whether silent rehearsal of sentences involved reactivation of s

224 The gut microbiome harbors a 'silent reservoir' of antibiotic resistance (AR) genes th

225 ion occurs when population activity is in a 'silent' response mode in which neurons increase informat

226 tation of recovery from inactivation via the silent route.

227 o ACKR3/CXCR7 range from those of a strictly silent scavenger receptor eventually modulating CXCR4 si

228 arvalbumin interneurons express functionally silent serotonin 5A receptors, which translocate to the

229 in a subset of HIV(+) patients termed SLAMF7 silent (SF7S).

230 SAD is a complex and silent signature of asthma that is likely to be directly

231 T3A-deficient cells, bearing glycans on five silent sites in addition to the normal glycosylation sit

232 Ca(2+) transients in the otherwise silent soma were secondary to this peripheral hyperactiv

233 ilation with a lower percentage of dependent Silent Spaces (p = 0.02), whereas PEEPPL was characteriz

234 rtion of poorly or nonventilated lung units (Silent Spaces) less than or equal to 15% (PEEPEIT).

235 e-spine excitation than wild-type, with more silent spines.

236 Because of the high risk for silent spread by asymptomatic persons, it is imperative

237 this unique functional readout of a hitherto silent state enabled us to examine cross-linked cysteine

238 ubset of messenger RNAs in a translationally silent state, which react 'on demand' to intracellular a

239 Theory predicts that activity-silent states are confined to passive storage and cannot

240 Nuclear spin singlet states are silent states in nuclear magnetic resonance (NMR).

241 rturb the memory network has implicated such silent states in the retention of line orientations in v

242 scious "working" memory, argue that activity-silent states merely support passive short-term memory,

243 overdiagnosis and overtreatment of so-called silent stroke.

244 its ability to protect the white matter from silent strokes remains unknown.

245 Despite this, the prevalence of silent strokes was 37.4% by the age of 14 in this cohort

246 ed this deficit using principles of receptor silent substitution to present images in which visibilit

247 nt proposals argue for alternative 'activity-silent' substrates.

248 n by insertion at different positions within silent subtelomeric chromatin in otherwise isogenic Sacc

249 ll telomeric expression sites (ESs) and from silent subtelomeric VSG arrays.

250 vS by allowing the presence of more than one silent subunit.

251 pses, which however remain post-synaptically silent, suggesting that completion of early synaptogenes

252 now analysed the mechanisms underlying this "silent survival" effect.

253 P-alpha2delta-1 signaling in cocaine-induced silent synapse generation as well as the behavioral impa

254 act of astrocyte-mediated synaptogenesis and silent synapse generation.

255 Preventing silent synapse re-maturation within the destabilization

256 ities opening and closing, respectively, the silent synapse-mediated destabilization window.

257 e found that junk-food consumption increases silent synapses and subsequently increases CP-AMPAR leve

258 These results establish that silent synapses are generated by an astrocyte-mediated s

259 eval after prolonged withdrawal, the matured silent synapses become AMPAR-silent again, followed by r

260 Thus, cocaine-generated silent synapses constitute a discrete synaptic ensemble

261 insertion of CP-AMPARs and the maturation of silent synapses in males.

262 ndicate that CP-AMPAR-mediated maturation of silent synapses in the NAc is a signature of drug-contex

263 oidance learning and causes the formation of silent synapses in the prefrontal-amygdala pathway.

264 Thus, the OF-generated silent synapses likely enable plasticity that may enhanc

265 dition to boosting synaptogenesis or induces silent synapses.

266 elective recruitment of previously active or silent synapses.

267 ith a concomitant upregulation of NMDA-only, silent synapses.

268 ithdrawal were associated with generation of silent synapses.

269 aptic distribution with a finite fraction of silent synapses.

270 ta-1, prevents cocaine-induced generation of silent synapses.

271 Ca(2+) blocks cocaine-induced generation of silent synapses.

272 f a genetic tool in silico, synthesize an RM-silent "SyngenicDNA" tool, and propagate the tool as min

273 f the protein identified as changing in this silent system (Ala as the effector) were included in cha

274 two origins overlap with a constitutive or a silent tissue-specific promoter.

275 od, with effects ranging from hypomorphic to silent to hyperfunctioning.

276 echanism of proteins but has remained mostly silent to protonation changes in the aqueous medium.

277 een trials, but remained present in activity-silent traces inferred from spiking synchrony in the PFC

278 ely between neurons to activate an otherwise silent transcription factor.

279 nics in Zambia to understand the reasons for silent transfers and disengagement from care was underta

280 ajority of incidences may be attributable to silent transmission from a combination of the presymptom

281 ssed genes), H3K27 (silent genes), and H3K9 (silent transposons).

282 rboplatin, reported to cause immunogenically silent tumor cell death.

283 esmoplastic, angiogenic, and immunologically silent tumors through derepression of Mmp14.

284 Many of their encoding gene clusters are silent under standard laboratory conditions because for

285 t biosynthetic gene clusters in bacteria are silent under standard laboratory growth conditions, maki

286 genome, but mostly remain transcriptionally silent under strict epigenetic regulation, yet can poten

287 concern that healthcare workers could act as silent vectors.

288 Participants watched a silent video depicting a crime (original event) and were

289 visual input (audio-only), and when seeing a silent video of a speaker articulating another story (vi

290 characters' faces and bodies were masked in silent videos, viewers inferred the affect of the invisi

291 d families by 18- to 210-fold, including the silent virulence factor malleilactone.

292 d colaughter between strangers preceded by a silent visual scene depicting one of two different socia

293 But how the brain extracts meaning from, silent, visual speech is still under debate.

294 hich was sufficient to open the chromatin of silent VSG expression sites, to disrupt VSG monoallelic

295 f the genome are generally transcriptionally silent, while euchromatin is more prone to transcription

296 Early in embryogenesis, P1 is silent, while P2 is strongly activated.

297 Ser, Thr, Asp, and Glu, which are relatively silent with regard to (.) OH.

298 reprogrammed genes remain transcriptionally silent with their impact on metabolism not revealed unti

299 Activity-silent WM in particular might also underlie the recently

300 n sustained neural firing, and (ii) activity-silent WM, for which firing returns to baseline, yet mem