ライフサイエンスコーパス: silicone oil

1 d samples, most of the particles were due to silicone oil.

2 er's solution and the epithelium bathed with silicone oil.

3 lices in a tank filled with a high-viscosity silicone oil.

4 ectomy with intravitreal injection of gas or silicone oil.

5 luid, and the outer surface was covered with silicone oil.

6 rcation, scleral buckle, and vitrectomy with silicone oil.

7 one oil and 2 (5.6%) remained detached under silicone oil.

8 an be complicated by prior scleral buckle or silicone oil.

9 e mixture of polydimethylsiloxane (PDMS) and silicone oil.

10 tures of adsorbed BsAb and mAb antibodies on silicone oil.

11 surgery, particularly in patients exposed to silicone oil.

12 retinal detachment requiring vitrectomy with silicone oil.

13 eated by a circulating working fluid such as silicone oil.

14 F(6)], and perfluoropropane [C(3)F(8)]), and silicone oil.

15 ns when using fragmatome in eyes filled with silicone oil.

16 the metal tip during phacoemulsification in silicone oil.

17 ignificantly in patients who received 5000cs silicone oil.

18 heavy silicone oil and conventional 'light' silicone oil.

19 moving droplet in direct contact with heated silicone oil.

20 fluoride (SF6), 2.2% with air, and 0.4% with silicone oil.

21 seen between heavier- and lighter-than-water silicone oils.

22 between the lighter- and heavier-than-water silicone oils.

23 trectomy, and most common tamponade used was silicone oil (100%).

24 ponaded with 20% sulfur hexafluoride gas and silicone oil 1000 centistokes, respectively.

25 When silicone oil 200 cSt (SO200) was added to the systems, t

26 Complications included subretinal silicone oil (5%), choroidal neovascularization (5%), at

27 of these biologically active compounds into silicone oil, acting as lipophilic binder of glassy carb

28 We tested the straylight caused by silicone oil adhesion to different IOLs and examined whe

29 Silicone oil adhesion to IOLs can induce amounts of stra

30 with higher cataract risk (if repaired with silicone oil: adjusted hazard ratio [aHR], 10.37; 95% CI

31 ter functional outcomes compared to PPV with silicone oil, although both tamponades yielded comparabl

32 emonstrates that even a polydimethylsiloxane silicone oil, although highly viscous, can be effectivel

33 t testing: 12 lenses with lighter-than-water silicone oil and 12 with heavier-than-water oil (Densiro

34 ut tamponade, 10 (26.3%) were attached under silicone oil and 2 (5.6%) remained detached under silico

35 However, the interaction between silicone oil and antibody molecules could lead to the ad

36 icone oil endotamponade (DSOE) of both heavy silicone oil and conventional 'light' silicone oil.

37 etinal reattachment were similar between the silicone oil and gas tamponade groups (P = .89).

38 Fibres were immersed in silicone oil and illuminated with 365 nm light.

39 of medical records for intraoperative use of silicone oil and postoperative occurrence of GRAE, defin

40 go(ethylene glycol) to be solubilised within silicone oil and provide hydrogen bond acceptor sites to

41 s, and miscellaneous therapies (intravitreal silicone oil and TNF-alpha inhibitors).

42 s of patients treated with gas tamponade vs. silicone oil and with air vs. SF(6) showed no significan

43 model systems were studied: a polymer melt (silicone oil) and a molten (borosilicate) glass of compa

44 distinguish between buoyant particles (e.g., silicone oil) and dense particles (e.g., protein particl

45 luoride, 1.8% were with air, 17.9% were with silicone oil, and 10.7% were with cataract surgery.

46 atients analyzed, 64 (34.4%) were exposed to silicone oil, and 102 developed GRAE (54.8%).

47 ergoes amorphization at about 0.6 GPa, while silicone oil as a PTM delays amorphization until 12 GPa

48 A complication of using silicone oil as an intraocular endotamponade is its adhe

49 propose a microscale gasometric assay using silicone oil as matrix.

50 mary PVR (p = 0.0003), and in the group with silicone oil as the primary tamponade (p = 0.0001).

51 An increase in intravitreal silicone oil associated with bevacizumab prepared with i

52 idence interval [CI] 3.53-7.37), intraocular silicone oil at the conclusion of the PK (HR = 4.28, 95%

53 A new silicone oil-based tamponade was developed with a viscos

54 was majorly increased in IOLs with adherent silicone oil (baseline vs adherent oil median 3.1 [2.1,

55 Viscosity and elasticity of various silicone oil blends (Siluron 1000, Siluron 2000, Siluron

56 ments with PVR, tamponade with either gas or silicone oil can be considered.

57 Short-term (14)C uptake (silicone oil centrifugation) and CO(2) release (membrane

58 Induction of the CCM, as measured by silicone oil centrifugation, was hindered in the presenc

59 ea (Pisum sativum) thylakoid membranes using silicone-oil centrifugation.

60 5 mum in the inner diameter) and a rotating, silicone oil-coated Teflon filter substrate at 1 rpm to

61 he fragmatome tip increased significantly in silicone oil compared to BSS in the experiment.

62 nalized microstructured surfaces coated with silicone oil create locally disordered regions within a

63 itrectomy for inferior PVR with use of heavy silicone oil (Densiron 68) between March 2021 and Octobe

64 The incidence of silicone oil droplet injections was 0.03% (1 of 3230) fr

65 uble protein via protein adsorption onto the silicone oil droplet surface.

66 ptomatic floaters from presumed intravitreal silicone oil droplets after injections of pegcetacoplan

67 To determine the incidence of presumed silicone oil droplets after intravitreal bevacizumab was

68 R system can potentially distinguish between silicone oil droplets and protein particles in a size ra

69 injection had a higher risk of intravitreal silicone oil droplets compared with priming the syringe

70 Here, we present an emulsion system in which silicone oil droplets in a nematic liquid crystal sponta

71 on is further complicated by the presence of silicone oil droplets in solution.

72 of 60 patients who experienced intravitreal silicone oil droplets in the eye after intravitreal beva

73 ool for monitoring the effects of subvisible silicone oil droplets on the stability of protein formul

74 Silicone oil droplets were reported in 109 eyes (71.7%).

75 eneous protein aggregates due to exposure to silicone oil droplets, although oil droplets with surfac

76 emoval revealed RPE cells with intracellular silicone oil droplets, singly dispersed membrane-bound m

77 d protein from adsorbing onto the surface of silicone oil droplets.

78 tension (67.4% vs 66.7%), keratopathy due to silicone oil emulsification and migration to the anterio

79 serum albumin (BSA) aggregate particles and silicone oil emulsion droplets with adsorbed BSA.

80 we developed a support material made from a silicone oil emulsion.

81 Flow cytometric analyses revealed that silicone oil emulsions induced the loss of soluble prote

82 was also used to investigate the effects of silicone oil emulsions on the stability of BSA, lysozyme

83 ith pars plana vitrectomy (PPV) and a double silicone oil endotamponade (DSOE) of both heavy silicone

84 Eyes that received silicone oil endotamponade during the second RRD repair

85 Double silicone oil endotamponade is a safe and effective treat

86 neventful primary pars plana vitrectomy with silicone oil endotamponade on the same day of presentati

87 vitrectomy for retinal detachment and later silicone oil endotamponade owing to redetachment.

88 Additionally, 62.5% received silicone oil endotamponade.

89 (95% confidence interval [CI]: 0.3, 7.7) for silicone oil exposure in patients vs. 25.3 months (95% C

90 in vitreoretinal (VR) surgery, positing that silicone oil exposure increases GRAE risk.

91 Further, polydimethylsiloxane silicone oil failed to serve as an adjuvant in the immun

92 thy (PVR), and/or the necessity of a primary silicone oil fill.

93 phacoemulsification for a dropped lens in a silicone oil-filled vitreous.

94 wever, patients with primary PVR and primary silicone oil fills were at a significantly increased ris

95 e in eyes undergoing vitrectomy surgery with silicone oil for PVR.

96 0 patients requiring vitrectomy surgery with silicone oil for retinal detachment with established PVR

97 deviation from target volume): Zero Residual Silicone Oil-free (+ 0.70%), Zero Residual 0.3 ml (+ 4.4

98 idual (1.53 +/- 1.15 muL), and Zero Residual Silicone Oil-free (1.40 +/- 1.16 muL) syringes showed th

99 ificant difference between the Zero Residual Silicone Oil-free syringe and all other syringes (P < 0.

100 difficult to differentiate microdroplets of silicone oil from particles formed by aggregated protein

101 We conclude that the simple and scalable silicone oil grafted coatings reported here provide simi

102 erties of the outermost surface by different silicone oil grafting fabrication parameters, the evapor

103 ration can be additionally controlled by the silicone oil grafting procedure adopted.

104 up (113 of 142; 80%) compared with the light silicone oil group (180 of 284; 63%), with an adjusted o

105 etter in the gas tamponade group than in the silicone oil group (weighted mean difference [WMD] = 0.1

106 cell layer was significantly thinner in the silicone oil group compared to the gas tamponade group (

107 the temperature of the fragmatome tip in the silicone oil group increased from 22.0 to 43.0 oC.

108 line visits and subsequent visits for either silicone oil groups.

109 Patients exposed to silicone oil had a 52% increased risk of GRAE compared t

110 Postoperative complications included silicone oil in a deep anterior chamber (3 eyes in each

111 nor S-nitroso-acetylpenicillamine (SNAP) and silicone oil in commercial medical grade silicone rubber

112 al outcomes compared with conventional light silicone oil in eyes with inferior retinal pathology and

113 ilure rate between tamponade with gas versus silicone oil in patients with grade B or C-1 PVR.

114 The retina was well-attached with silicone oil in place on the first post-operative day.

115 This shows that for the silicone oil in question the dynamics are determined by

116 actors, large retinal lesion size and use of silicone oil in retinal detachment repair are potentiall

117 onths after PPV in the Gas Group, and during silicone oil in situ and 3 months after SO removal, in t

118 % underwent further RD surgery, and 8.3% had silicone oil in situ at last review.

119 olecular interactions between antibodies and silicone oil in situ in real time.

120 ies that were followed for one year with the silicone oil in situ.

121 mplications associated with the use of heavy silicone oil in the management of inferior PVR.

122 investigate droplet dynamics in concentrated silicone oil-in-water nanoemulsions using light scatteri

123 Recently, we established silicone oil-induced ocular hypertension (SOHU) mouse mo

124 slatomes of RGCs in naive mice and mice with silicone oil-induced ocular hypertension (SOHU)/glaucoma

125 s in our study have shown direct or indirect silicone oil-induced toxicity, especially in the inner r

126 oach to cell sheet release surfaces based on silicone oil-infused polydimethylsiloxane.

127 rcation as an alternative to vitrectomy with silicone oil injection in macula-sparing cytomegalovirus

128 s with medically uncontrolled glaucoma after silicone oil injection may require oil removal with or w

129 isk PRRD underwent pars plana vitrectomy and silicone oil injection with scleral buckle divided into

130 e treated by pars plana vitrectomy (PPV) and silicone oil injection.

131 aser, intravitreal antibiotic injection, and silicone oil injection.

132 last patient had a pars plana vitrectomy and silicone oil instillation combined with phacoemulsificat

133 y centrifugation of cells through a layer of silicone oil into a denser solution of trichloroacetic a

134 or migration of emulsified or nonemulsified silicone oil into the anterior chamber.

135 Injecting 50 mm KCl or silicone oil into the intercellular spaces also caused s

136 optimum surgery was the injection of liquid silicone oil into the vitreous cavity to dissect fibrous

137 Silicone oil is commonly used as a lubricant coating mat

138 side of the eye; however, drug solubility in silicone oil is poor and release from this hydrophobic d

139 wing that to prevent antibody aggregation on silicone oil it is not necessary to add surfactant to a

140 Additionally, as silicone oil-lubricated prefilled syringes become a favo

141 findings underscore that direct contact with silicone oil may affect the behavior of the RPE, which m

142 There was no significant difference between silicone oil microdroplet severity between BD 1.0-mL pol

143 The severity of silicone oil microdroplets in eyes using BD 1.0-mL polyc

144 The severity of silicone oil microdroplets was significantly greater in

145 Silicone oil microdroplets were graded on a scale from 0

146 Silicone oil microdroplets were observed in 78.3% of eye

147 in protein aggregates and is contaminated by silicone oil microdroplets.

148 ith aflibercept cause a higher likelihood of silicone oil microdroplets.

149 ecture and composition to play a role in the silicone oil miscibility of the targeted polymers.

150 The insertion of silicone oil offers the opportunity to also deliver drug

151 f small sample volumes that uses layering of silicone oil on solution surfaces but still allows the u

152 The effects of silicone oil on the retina remain uncertain; however, mo

153 o the vitreous cavity; the direct effects of silicone oil on the RPE are only beginning to be underst

154 en combined with lens removal, endolaser, or silicone oil or anterior vitrectomy with lensectomy (p=0

155 The device is equipped to use either silicone oil or coconut oil.

156 g the efficacy and safety of PPV with either silicone oil or gas tamponade in the setting of uncompli

157 y(alpha-olefins), mineral oil, low-viscosity silicone oils or supercritical CO(2) are discussed in de

158 final anatomical success without the use of silicone oil (P < 0.01 and 0.04 respectively).

159 lacement was the use of gas tamponade versus silicone oil (P = 0.001), whereas no significant associa

160 5% CI: 3.6, N/A) for patients not exposed to silicone oil (P = 0.0045).

161 ves and/or fillers (silica, silicone resins, silicone oil, PEG, etc.) altered the crystallization kin

162 t the release of all-trans retinoic from the silicone oil phase was extended to >72days.

163 rectomy, lensectomy, choroidal drainage, and silicone oil placement, visual acuity (VA) at last follo

164 retinopexy [PR], pars plana vitrectomy with silicone oil [PPV+SO], or scleral buckling).

165 Here, a long-standing challenge in silicone oil production is addressed, in which residual

166 had straylight measured before contact with silicone oils, providing a baseline for subsequent testi

167 rent rhegmatogenous retinal detachment after silicone oil removal (35.3% versus 12.5%, p = 0.06).

168 atogenous retinal detachment (RRD) (n = 17), silicone oil removal (n = 16), dislocated intraocular le

169 t risk factor for retinal redetachment after silicone oil removal (OR 4.8, 95%CI [1.5;19.0], p = 0.02

170 Silicone oil removal combined with targeted endolaser ph

171 achment occurred in 14.9% of eyes undergoing silicone oil removal following rhegmatogenous retinal de

172 four patients, combined cataract surgery and silicone oil removal in one patient, and combined epiret

173 and combined epiretinal membrane peeling and silicone oil removal in one patient.

174 retinal proliferations peeled at the time of silicone oil removal revealed RPE cells with intracellul

175 The mean silicone oil removal time was 15.1 +/- 15.2 (7-70) month

176 The rate of retinal detachment after silicone oil removal was 14.9%.

177 Silicone oil removal was performed in 72 of 112 patients

178 and concomitant air or gas tamponade during silicone oil removal were not found to affect the redeta

179 Seventeen (10.6%) eyes underwent silicone oil removal within 3 months of surgery, with a

180 anatomical success (retinal attachment after silicone oil removal) was achieved in 20 (83.3%) eyes at

181 At the time of silicone oil removal, the pigmented membranes were prese

182 ely, which was moderately resolved following silicone oil removal.

183 rent rhegmatogenous retinal detachment after silicone oil removal.

184 us retinal detachment surgery and subsequent silicone oil removal.

185 umber of eyes that ultimately had successful silicone oil removal.

186 ss was defined as retinal reattachment after silicone oil removal.

187 t the time of (1) vitrectomy surgery and (2) silicone oil removal.

188 ar PFCL retainment was 14 days before gas or silicone oil replacement.

189 h heterogenous causes of glaucoma, eyes with silicone oil responded to a greater extent.

190 sing a fluid PTM, as Nujol or high-viscosity silicone oil, results in a slight lattice expansion and

191 cities (n = 8), endophthalmitis (n = 4), sub-silicone oil retinal detachment (n = 3), retained lens m

192 r glaucoma (38%), open-angle glaucoma (28%), silicone oil secondary glaucoma (17%), and others (18%).

193 can develop after intravitreal injection of silicone oil secondary to pupillary block, inflammation,

194 low-concentration feeds using both lab-grade silicone oil (Sigma-Aldrich) and an industrial-grade fee

195 nal diseases, but concerns emerged regarding silicone oil (SiO) contamination, which may cause floate

196 This study aimed to evaluate the impact of silicone oil (SO) and perfluoropropane gas (C3F8) tampon

197 Previous studies have reported silicone oil (SO) applied to needles and syringes in the

198 The internal tamponade was silicone oil (SO) in 16 patients (72.7%), and perfluorop

199 randomized in a 1:1 ratio to undergo PPV and silicone oil (SO) injection with or without intravitreal

200 Eyes treated with primary silicone oil (SO) tamponade were compared to eyes with p

201 er pars plana vitrectomy (PPV) combined with silicone oil (SO) tamponade.

202 ous retinal detachment (RRD) during or after silicone oil (SO) tamponade.

203 based on liquid D4 and high-molecular-weight silicone oil sorption data in crosslinked PDMS.

204 idual cyclic oligosiloxanes are removed from silicone oil streams through permeation of CO(2) across

205 amics of a bispecific antibody (BsAb) onto a silicone oil surface without and with different concentr

206 Eyes with silicone oil tamponade <= 3 months showed an increased,

207 Eyes with silicone oil tamponade <= 3 months tended to have a high

208 istics, fates and complications of long-term silicone oil tamponade after par plana vitrectomy (PPV),

209 In this cohort of patients with long-term silicone oil tamponade after PPV to treat retinal detach

210 acoemulsification with IOL implant, PPV with silicone oil tamponade associated with 180 degrees infer

211 All patients subsequently underwent PPV and silicone oil tamponade at our Institution.

212 tachment or foveal attachment with long-term silicone oil tamponade at the endpoint.

213 ltiple RD surgeries before CE and those with silicone oil tamponade before cataract surgery were excl

214 rectomy, 180 degrees inferior retinotomy and silicone oil tamponade combined with phacoemulsification

215 an intravitreal tamponade, one patient with silicone oil tamponade developed band keratopathy and ph

216 eaks, number of detached clock hours, use of silicone oil tamponade for pars plana vitrectomy, histor

217 undergone large relaxing retinectomies with silicone oil tamponade for PVR-related retinal detachmen

218 se series of eyes undergoing vitrectomy with silicone oil tamponade for retinal detachment by a singl

219 lowing vitrectomy surgery with endolaser and silicone oil tamponade for retinal detachment.

220 the right eye and vitreoretinal surgery with silicone oil tamponade for the left eye.

221 Silicone oil tamponade has become a mainstay in treatmen

222 Silicone oil tamponade is more frequently reserved for c

223 Vitrectomy with adjunct scleral buckle and silicone oil tamponade provided the highest single-surge

224 Long term silicone oil tamponade remains a viable option in certai

225 Silicone oil tamponade should be considered in patients

226 th membrane peel, laser photocoagulation and silicone oil tamponade was performed.

227 with retinectomy, laser photocoagulation and silicone oil tamponade was performed.

228 Silicone oil tamponade was positively associated with hi

229 Silicone oil tamponade was significantly associated with

230 rventions included pars plana vitrectomy and silicone oil tamponade with or without scleral buckle, d

231 s undergoing pars plana vitrectomy (PPV) and silicone oil tamponade with or without scleral buckling

232 igation, with retinectomy, if necessary, and silicone oil tamponade, allows anatomical and functional

233 trectomy, combined with scleral buckling and silicone oil tamponade, appears to provide the best anat

234 though MME was significantly associated with silicone oil tamponade, it showed no relationship with p

235 Excluding patients who had silicone oil tamponade, postoperative BCVA improved from

236 During silicone oil tamponade, there was approximately 11% and

237 Six eyes in the SB/PPV group received silicone oil tamponade.

238 eatment for both eyes through vitrectomy and silicone oil tamponade.

239 and surgery, particularly in the absence of silicone oil tamponade.

240 nal detachment (RD) repair with longstanding silicone oil tamponade.

241 ternal limiting membrane peeling, and gas or silicone oil tamponade.

242 group required a third vitrectomy with heavy silicone oil tamponade.

243 aoperative lenticular trauma; (3) the use of silicone oil tamponade; (4) history of trauma or pseudoe

244 s paper presents physical-aging data for the silicone oil tetramethyl-tetraphenyl trisiloxane.

245 s humour within the eye and replacement with silicone oil to aid healing of the retina.

246 f TTR105-115 amyloid fibrils in water and in silicone oil to be 2.6 and 8.1 GPa, respectively.

247 ents (GRAEs) in pediatric patients following silicone oil use in vitreoretinal (VR) surgery, positing

248 cated by formulation components, such as the silicone oil used for the lubrication of prefilled syrin

249 V), and to compare the outcomes of different silicone oil viscosities used in a cohort of consecutive

250 ect of decreasing the H(2) partial pressure, silicone oil was added to the reactor at an OLR of 138 a

251 fibres from rabbit psoas muscle immersed in silicone oil was measured using a linked enzyme assay th

252 Silicone oil was removed 4 months later.

253 Silicone oil was removed after 5 months followed by cata

254 etected in 12 (33.3 %) patients in which the silicone oil was used as an intravitreal tamponade, one

255 Silicone oil was used for tamponade in 33 (97.1%) cases

256 takes place at the triple interface between silicone oil, water, and a penetrating solder-patterned

257 as well as a monoclonal antibody (mAb) onto silicone oil were measured.

258 droplet generation (FC-70 Fluorinert oil and silicone oil) were also tested against the different sol

259 isk of GRAE compared to those not exposed to silicone oil when adjusted for age at VR surgery (hazard

260 micron-sized droplets of water surrounded by silicone oil where each microdroplet contains <1 enzyme

261 The bundles were then transferred to silicone oil, where [Ca2+]free, tension, and sarcomere l

262 ratio of perfluoropropane (C(3)F(8)) gas to silicone oil which was applied as intraocular tamponade

263 of flow cytometry were exploited by staining silicone oil with BODIPY 493/503 and model proteins with

264 Subsequently, the silicone oil with epiretinal membrane removal was perfor

265 speed of a helix in a high-molecular weight silicone oil with predictions for the swimming speed in

266 Both BsAB and mAB denature on silicone oil without a surfactant.

267 stable retinal reattachment with removal of silicone oil without additional vitreoretinal surgical i