ライフサイエンスコーパス: simultaneous

1 observed decline of HBsAg and HDV, which was simultaneous.

2 A first analysis of simultaneous (68)Ga-prostate-specific membrane antigen (

3 Methods: Simultaneous (89)Zr-radiolabeling and protein conjugatio

4 ely quantified HSC localization with up to 4 simultaneous (9 total) BM components in 152 full-bone se

5 Simultaneous ablation of Pol nu and Pol theta resulted i

6 ive phagocytes could be recapitulated by the simultaneous absence of TLR7, 9, and 13 but not by the a

7 All quantum dots are simultaneous absorbers and scatterers in the UV-vis wave

8 nclusion: The NanoSPECT/CT(PLUS) enables the simultaneous acquisition of 3 radioisotopes with high qu

9 bstructive coronary artery disease underwent simultaneous acquisition of coronary pressure and flow d

10 ic detector properties were suitable for the simultaneous acquisition of up to 3 isotopes with limita

11 Molecular neuroimaging studies incorporating simultaneous acquisitions of GABA concentrations and GAB

12 Simultaneous activation of carboxylates and phosphates p

13 lectromyograms provided strong evidence that simultaneous activation of paired protractor muscles acc

14 cues heralding winter, suppress branching by simultaneous activation of TFL1 and repression of the LA

15 Simultaneous activation of the heterodimer partners PPAR

16 This work identifies a simultaneous activity of neuronal and lymphoid CB(2)that

17 ects, this is of little use because of their simultaneous acute channel blocking effect.

18 Simultaneous administration of acetazolamide fully preve

19 ample (Na/Ca_0.27), a comprehensive study on simultaneous adsorption of the three CMMs was performed,

20 The method offered simultaneous advantages of high supramolecular recogniti

21 The wines produced by simultaneous AF/MLF showed the highest contents of some

22 in functional properties as a result of the simultaneous alteration of both atomistic and electronic

23 late-life ejaculate performance, indicating simultaneous amelioration of both somatic and reproducti

24 Simultaneous analysis by mass cytometry of 28 PTMs in >1

25 racking platform (WF-NTP), which enables the simultaneous analysis of hundreds of worms with respect

26 th a sensitive, rapid and precise method for simultaneous analysis of MX i.e. Theobromine (TB), Theop

27 cent advances in phosphoflow basically allow simultaneous analysis of protein phosphorylation in B ce

28 A microfluidic device for simultaneous analysis of total flavonoids and total phen

29 Simultaneous and independent measurements of electronic

30 prevent a bilateral cerebrum giving rise to simultaneous and potentially competing outputs.

31 olecular-method-based syndromic test for the simultaneous and rapid (~70-min) detection of 18 viral a

32 systems are commonly studied through sets of simultaneous and time-spaced measurements of the observa

33 asm about ATTR-CM has grown as a result of 3 simultaneous areas of advancement: Imaging techniques al

34 Simultaneous arterial and jugular venous bulb blood gas

35 (G-3-P) as the most significant correlate of simultaneous arterial FGF23 levels.

36 screens, we showed that teratomas can enable simultaneous assaying of the effects of genetic perturba

37 Our study supports the feasibility of a simultaneous assessment of collagen-related extracellula

38 of 47,714 adults in Alberta, Canada, who had simultaneous assessments of urine ACR and PCR.

39 alone or in the presence of others, and when simultaneous attention of the participants to the same s

40 n limits of 500 fg of protein (250 pM) while simultaneous baseline separation resolution was achieved

41 nts, and analysis is generally confounded by simultaneous bidirectional transitions and asymmetric pr

42 Simultaneous bilateral EDL force and hindlimb blood flow

43 Simultaneous binding of IgE to FcepsilonRI and CD23 is b

44 binding to assembled retromer coats through simultaneous binding of two VPS29s.

45 closely related tetrameric lectins, DC-SIGN (simultaneous binding to one GNP) and DC-SIGNR (intercros

46 mixed sequences can form double duplexes by simultaneous binding to two complementary DNAs, one to t

47 tomy-assisted orthodontic therapy (CAOT) and simultaneous bone augmentation while the other two recei

48 ntraarterial blood pressure, heart rate, and simultaneous brachial artery diameter and blood velocity

49 standardized speech/arithmetic stressors and simultaneous brain imaging with high-resolution positron

50 The simultaneous carbonization and sulfidation of an iron-ba

51 ered in the early postoperative period after simultaneous cataract and LRI incisions shown by TBUT me

52 s unclear how fast-growing hyphae coordinate simultaneous cell extension and expansion in the tip cel

53 We present a method for simultaneous cellular-resolution two-photon calcium imag

54 performed due to deep anemia, who underwent simultaneous cesarean section and subtotal gastrectomy.

55 c approaches lack single-cell resolution and simultaneous characterization of cellular phenotype.

56 For example, the simultaneous characterization of the catalyst under the

57 spectrometry (SLIM IMS-MS) for the rapid and simultaneous characterization of the drug load profile (

58 pants, in whom instead we found evidence for simultaneous clustered reactivation.

59 time a hardware set-up capable of achieving simultaneous co-localized imaging of spatially correlate

60 g the substances used across the lifespan to simultaneous co-use of substances that span similar and

61 We describe procedures for simultaneous collection of both spatial and social data,

62 Simultaneous collection of electrochemical and fluoresce

63 h for improved and computationally efficient simultaneous color visualization of multiple spectral co

64 Simultaneous comprehensive scale-up of interventions cou

65 le to introns, provide the rationale for the simultaneous consideration of both exon and intron data.

66 latation and highlight the importance of the simultaneous consideration of nitric oxide production an

67 Elbow-to-elbow retraining and simultaneous content development was performed utilizing

68 can help realize the long-cherished goal of simultaneous control of absolute and relative configurat

69 histone tails and regulatory proteins in the simultaneous coordination of DNMT3A activity remains obs

70 dependent on the presence of darT(Mtb) , but simultaneous deletion of both darT(Mtb) -darG(Mtb) does

71 More importantly, simultaneous delivery and activity presentation of prote

72 Genomic instability was rescued by simultaneous depletion of macroH2A1.1 or alt-EJ factors,

73 sor was developed for the first time for the simultaneous detection of anti-Trypanosoma cruzi and ant

74 portable microanalytical flow system for the simultaneous detection of free SO(2) and acetic acid dur

75 l electrochemical immunosensor microchip for simultaneous detection of insulin (I) and cortisol (C) b

76 els and working electrodes could be used for simultaneous detection of multiple metals in PM.

77 untreated serum samples indicated favorable simultaneous detection of picomolar (pM) insulin and nan

78 Simultaneous detection of the proteolysis of cathepsin B

79 me sequencing method (CoDE-seq) that enables simultaneous detection of whole-exome copy number variat

80 A stability-indicating HPLC-DAD method for simultaneous determination of all nine main water-solubl

81 This paper describes the simultaneous determination of Ba, Co, Fe, and Ni in nuts

82 An analytical method for the simultaneous determination of ethylene glycol and diethy

83 S) at a rate of 6 s per sample, allowing for simultaneous determination of five different drugs spike

84 ped sensor exhibits excellent performance in simultaneous determination of FLU and NF with a linear r

85 A sensitive and fast method for simultaneous determination of gaseous ammonia (NH(3)) an

86 uid chromatography) method was developed for simultaneous determination of phenolics.

87 A method for the simultaneous determination of three commonly used coccid

88 at UPLC-ESI-QTOF-MS(E) was effective for the simultaneous determination of twenty metabolites, putati

89 The optimum chips were then used for the simultaneous determination of two mycotoxins, aflatoxin

90 y accommodated by the alternate, rather than simultaneous, development of faults with different trend

91 Simultaneous digestion and in situ biogas upgrading in h

92 Here we propose an ensemble method for simultaneous dimensionality reduction and feature gene e

93 Simultaneous distillation-extraction (SDE) using the Lik

94 y via two major modes of transformation: (a) simultaneous disturbance-driven decreases in Evergreen F

95 enetic interaction between Ube3a and Mef2 as simultaneous dosage manipulation in different tissues in

96 alone because estimates may be confounded by simultaneous DPC formation from CLZ.

97 We further conducted simultaneous EEG recordings using specific saliency emph

98 In order to predict the simultaneous effect of these degrading mechanisms on FCD

99 We aimed to determine the independent and simultaneous effects of OSE and ER on satiation and asso

100 Flexible dielectrics operable under simultaneous electric and thermal extremes are critical

101 to develop an open access device capable of simultaneous electrical and mechanical stimulation of hu

102 transcranial magnetic stimulation (TMS) and simultaneous electroencephalography (EEG) to characteriz

103 Simultaneous electromyography recordings also showed mus

104 Simultaneous elimination of YAP suppresses the cortical

105 Simultaneous endo-epi phase mapping of prolonged human p

106 Our results demonstrate that simultaneous engagement of TLR7 and RIG-I pathways using

107 The Notch-dependent effects required simultaneous engagement with OP9 stromal cells and were

108 sing both locus-specific genetic editing and simultaneous epigenetic silencing of multiple ERVs, we d

109 stimation"), which allows for the first time simultaneous estimation of the genetic effect of a singl

110 is process causes rapid Y/W degeneration and simultaneous evolution of dosage compensation, provided

111 In contrast, upon simultaneous ex-pression of GDE3 and cannabinoid recepto

112 ilation parameters, in inpatients undergoing simultaneous examination under anesthesia were reviewed.

113 Simultaneous expansion of treatment, imaging, and qualit

114 iated protein (RB) and hypothesized that the simultaneous expression of RB and S18-2 is essential for

115 ntially limiting/sequestered pool of RXR and simultaneous expression of several RXR partners, we hypo

116 ts are perceived as having occurred prior to simultaneous externally triggered events.

117 d hot water extraction (PHWE) method for the simultaneous extraction of multi-mycotoxins from maize a

118 These results provide evidence of early, simultaneous feature-specific neural responses during ep

119 During simultaneous feeding on the different substrate types, F

120 We further review methods for simultaneous fine-mapping of multiple datasets, either e

121 nd sex-comparable control subjects underwent simultaneous fluorodihydroxyphenyl-l-alanine PET (18F-DO

122 Here, we used simultaneous functional magnetic resonance imaging and e

123 s significantly greater than where there was simultaneous genetic loss of both (n = 87) (mean surviva

124 Conclusion: Simultaneous HDACIs and AI dosing in patients with cance

125 uality degradation kinetics by integrating a simultaneous heat and mass transfer model with Maxwell's

126 rstanding of the physical effects of IMCD on simultaneous heating and mass transfer as well as qualit

127 cal NRR are significant challenges, making a simultaneous high NH(3) formation rate and high Faradic

128 Here we developed simultaneous high-throughput ATAC and RNA expression wit

129 ipid A-MSI (LLA-MSI) method, compatible with simultaneous host-pathogen lipid imaging following acid

130 - preferentially react with each other upon simultaneous hybridization to the same RNA target strand

131 ygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners

132 Simultaneous imaging of all active genes bound by Pol I

133 Simultaneous imaging of the local density of states N(r,

134 Inactivation of clpP or simultaneous inactivation of clpC and clpE stabilized th

135 > epsilon-h.c.p. transformation leading to a simultaneous increase in strength and ductility.

136 ncrease in cereal intake lowers SBP by 3%; a simultaneous increase of 10% in fruit-vegetable can furt

137 Simultaneous inhibition of A(2A) and A(2B) pathways with

138 Simultaneous inhibition of multiple parallel RTKs furthe

139 We show that this leads to simultaneous inhibition of virus release, and immune-med

140 ll as by 2D HyperW NMR spectra acquired upon simultaneous injection of hyperpolarized water and hypox

141 actions: one between A33 and A34 and another simultaneous interaction between all three of the glycop

142 t-generation sequencing assays allow for the simultaneous interrogation of extended sets of somatic s

143 nary heart disease was preventable at all by simultaneous intervention on several risk factors; that

144 r optical techniques cannot reliably perform simultaneous intracellular recordings from more than a f

145 In a patient with focal epilepsy, simultaneous intracranial stereoencephalography recordin

146 Simultaneous intraoperative mapping of endo- and epicard

147 ation when trade-off costs among traits make simultaneous investment in multiple traits either more b

148 bserved that MCT1 mediates bidirectional and simultaneous inward and outward lactate fluxes, which we

149 The simultaneous IR and Raman microscopy with submicrometer

150 lated core-shell hydrogel was fabricated for simultaneous iron overload clearance and bone marrow mes

151 Simultaneous knock-out of Mlh1, the ortholog of a third

152 ly minimally influenced invasion in culture, simultaneous knockdown of both isoforms strongly reduced

153 These simultaneous label-free and real-time measurements allow

154 Elemental lead, caffeine, and simultaneous lead and caffeine analysis via LA-LS-APGD-M

155 Simultaneous lentiviral knockdown of SCARA3 and MARCO re

156 y reduction of [bipy-Ru(III) Cl(4) ](-) with simultaneous ligand exchange from Cl(-) to CO.

157 We use simultaneous liver and kidney (SLK) transplant, a type o

158 This is the first case report of simultaneous liver and pancreas transplantation as treat

159 isk factors, and posttransplant outcomes for simultaneous liver kidney (SLK) transplant recipients de

160 Experience in simultaneous liver-kidney transplant (SLK) using DCD don

161 derived and kidney derived, he proceeded to simultaneous liver-kidney transplantation.

162 n the use of induction immunosuppression for simultaneous liver/kidney transplantation (SLKT).

163 om temperature phosphorescence material with simultaneous long lifetime and high phosphorescence quan

164 the embryo-lethal phenotype associated with simultaneous loss of all three mtACP genes.

165 Surprisingly, the simultaneous loss of RAP80 and failure therein of BRCA1

166 burden of malnutrition (DBM), defined as the simultaneous manifestation of both undernutrition and ov

167 At the network level we demonstrate, via simultaneous manipulation of BLA and mPFC, that experien

168 Furthermore, DRR detect all markers in a simultaneous manner instead of scanning one marker at a

169 te-based peroxyl radical clock to enable the simultaneous measurement of both k(H) and k(add).

170 Proof-of-principle studies showing simultaneous measurement of cytosolic calcium and protei

171 erline rejection across 11 US centers with a simultaneous measurement of dd-cfDNA.

172 Simultaneous measurement of diffusion at multiple length

173 on of the system is demonstrated in vitro by simultaneous measurement of glucose and lactate, pH, and

174 conventional calibration curve, quantitative simultaneous measurement of multiple cardiac biomarkers

175 cent reporters to be efficiently adapted for simultaneous measurement of multiple nodes of a signal t

176 tes, we used wireless telemetric systems for simultaneous measurement of neuronal activity of male ze

177 modal laser spectrometer (MLS) to enable the simultaneous measurement of optoacoustic, absorbance, an

178 protein profiling technology has facilitated simultaneous measurement of thousands of proteins in lar

179 asses of individual ions are determined from simultaneous measurements of each ion's m/z ratio and ch

180 Simultaneous measurements of resonant X-ray scattering a

181 The monolithic device allows simultaneous measurements of the orthogonal components o

182 Simultaneous measurements of transcriptomic and epigenom

183 ne ion-currents (perforated patch-clamp), or simultaneous membrane-current (ruptured patch-clamp) and

184 se findings pave the way for CKM and for the simultaneous microneedle-based monitoring of multiple di

185 generating aberrant cytoplasmic DNA, however simultaneous miR-181a mediated inhibition of STING allow

186 Two types of 3D printed devices for simultaneous mixing of small volumes (e.g., 50-500 muL)

187 Proposed sparse mCIA achieves simultaneous model estimation and feature selection and

188 This allowed the simultaneous modeling of tumor dynamics and inter-animal

189 ,8-bis(dicarboximide), and found to act as a simultaneous molecular dopant and morphology-additive.

190 satile quantitative technique for continuous simultaneous monitoring of individual cellular component

191 ctra corresponding to each area allowing the simultaneous monitoring of the bioreactions taking place

192 ibility, particularly during tasks involving simultaneous motor and cognitive engagement.

193 both sources of information when performing simultaneous movements of the limbs?

194 Using simultaneous multi-area population imaging of projection

195 Simultaneous multi-isotope acquisitions slightly degrade

196 Non-invasive simultaneous multiparametric monitoring allows the in vi

197 Conclusion The axially reformatted simultaneous multislice protocol was rated highest for i

198 etylation site at lysine K136, we found that simultaneous mutations at all five acetylation sites (p5

199 observed decline in species diversity under simultaneous N and CO(2) enrichment was associated with

200 roscopy based experimental procedure for the simultaneous nanomechanical and morphological analysis o

201 neuECG, the simultaneous noninvasive recording of ECG and skin sympa

202 throughput magnetic tweezers has enabled the simultaneous observation of dozens of viral RdRp elongat

203 The simultaneous occurrence of multiple stress conditions sh

204 Simultaneous OCT and QME were performed on the margins o

205 s of successive cortical areas, we undertook simultaneous optical imaging of intrinsic signals in mac

206 Simultaneous optical monitoring of CaCC activity and Ca(

207 Simultaneous optimization of side chain conformations ac

208 Simultaneous optimization of these control parameters yi

209 graphic variability in listing practices for simultaneous pancreas and kidney (SPK) transplant and de

210 The first simultaneous pancreas and kidney (SPK) transplant was pe

211 In simultaneous pancreas-kidney (SPK) transplant recipients

212 s/encephalitis (FA-M/E) panel permits rapid, simultaneous pathogen detection.

213 ngle fixation target vs fixation target plus simultaneous perimetry testing and provide information o

214 Background During simultaneous PET/MRI, flexible MRI surface coils that la

215 ourse changes of pre-corneal tear film after simultaneous phacoemulsification and limbal relaxing inc

216 Simultaneous pharmacological inhibition of KDM7A and UTX

217 by utilizing field-based tents allowing for simultaneous phenotyping of popular winter wheat varieti

218 ns in the Perhentian Islands, Malaysia while simultaneous photo-quadrat surveys were performed to cha

219 We find spermatocytes exhibit simultaneous pole-to-chromosome shortening (anaphase A)

220 rtal vein embolization (PVE) and radiologica simultaneous portohepatic vein embolization (RASPE) for

221 Their simultaneous positive effects on various immediate, unde

222 ed solid-phase extraction (MISPE) method for simultaneous preconcentration of imazapyr (IMP), imazapi

223 h, we demonstrated a facile approach for the simultaneous preparation of a bi-functional PEDOT interf

224 t-handed single gyroids, we propose that the simultaneous presence of both R- and S-atropisomers is a

225 The quadrupole moment is quantized by the simultaneous presence of crystalline symmetry and broken

226 ed UC from cultured macrophages, and, in the simultaneous presence of HDL, a rapid transfer of the ra

227 he cells' chromogenic reaction indicated the simultaneous presence of the 2 biomarkers.

228 Sepsis initiates simultaneous pro- and anti-inflammatory processes, the p

229 on with sub-13 fs 1300 nm driving pulses and simultaneous production of sub-5 fs pulses centered at 8

230 fragmentation characteristics hinder facile simultaneous quantification by liquid chromatography and

231 LD, respectively) has been developed for the simultaneous quantification of 32 phenolic compounds (PC

232 ly, we developed an efficient method for the simultaneous quantification of 6 isoflavones (daidzin, g

233 This provides simultaneous quantification of diffusion or protein reco

234 Simultaneous quantification of four protein biomarkers i

235 Here, we developed a CRISPR-based system for simultaneous quantification of mRNA and protein of a giv

236 dem mass spectrometry (LC-MS/MS) enables the simultaneous quantification of numerous enzymatically mo

237 These results demonstrate successful simultaneous quantification of perfusion and T(2)* in sk

238 The simultaneous quantification of protein and RNA makes pos

239 edure using propionic anhydride that enables simultaneous quantification of unconjugated l-DOPA, cate

240 RS-based muPAD with multi-reaction zones for simultaneous quantitative detection of multiple cardiac

241 single-cell RNA-Seq experiments, supporting simultaneous queries on both the GFF and expression file

242 Here we present unique simultaneous radiocarbon age measurements of inland wate

243 xperimentally feasible solution requiring 14 simultaneous reaction interventions.

244 We verify the sensitivity of the method by simultaneous readout of fluorescent signals from bacteri

245 technologically relevant molecular route for simultaneous realization of a ternary memristor and a bi

246 These data demonstrate that simultaneous recognition of PE and PS maximizes PS recep

247 ing because of the stringent requirement for simultaneous recognition of the pY motif and the surroun

248 demonstrate the application of our probes in simultaneous recording and optical/chemical modulation o

249 e-Amplitude-Modulation ("e-PAM") enables the simultaneous recording of the produced photocurrent and

250 We demonstrate simultaneous recordings from 20 sensors in parallel in h

251 Here, simultaneous recordings from motor cortices show that in

252 However, without simultaneous recordings from thousands of cortical neuro

253 Simultaneous recordings of intracellular Ca(2+) and APs

254 Using simultaneous recordings of rodent motor (M1) and premoto

255 TPLATE and the AtEH/Pan1 proteins exhibited simultaneous recruitment at the PM.

256 of anionic redox, that is, the sequential or simultaneous redox of the cation and anion in a transiti

257 Simultaneous reduction of Lgp2 and either Rig-I or Mda5

258 Fungal N:P varied comparatively less due to simultaneous reductions in mycelial N and P contents.

259 Simultaneous removal of bilateral cataract in children s

260 D or bvFTD, and in healthy controls, using a simultaneous resting-state fMRI and (18)F-FDG PET.

261 h important mechanisms for the prevention of simultaneous rival queen emergence.

262 talyze the formation of imine bonds, and the simultaneous salting-out effect (induced precipitation b

263 ncy of ~20% at physiological pH of 7.0, have simultaneous self-ratiometric and ratiometric features v

264 nslationally modified protein substrates via simultaneous sensing of both chemo- and stereoselectivit

265 gnition of mature mRNA is facilitated by the simultaneous sensing of multiple, spatially distant mRNA

266 Such real-time simultaneous sensing provides distinct unique informatio

267 Simultaneous simulation of all three GHGs in a parsimoni

268 and non-allelic target sites and report that simultaneous single-stranded DNA break formation at dono

269 to hundreds of droplets) and allows for the simultaneous sizing of a single droplet using its Mie sc

270 is inexpensive practice, in conjunction with simultaneous social distancing, quarantine, and contact

271 In this study, we experimentally demonstrate simultaneous solvent regeneration and CO(2) desorption i

272 Simultaneous sputum liquefaction, bacteria heat inactiva

273 hed multi-color perception was possible with simultaneous stimulation of paired electrodes.

274 ight (such as from a rainbow) can evoke this simultaneous stimulation.

275 Its scale uniquely supports simultaneous study from physiology and yield to soil pro

276 report an entirely laser-engraved sensor for simultaneous sweat sampling, chemical sensing and vital-

277 of poly(l-lysine) cationic polymer (PLL) for simultaneous synergistic thermo-chemotherapy treatment a

278 ystems by leveraging the concept of multiple simultaneous synthetic dimensions.

279 study, we evaluated i.m., aerosol (Aer), and simultaneous systemic and respiratory immunization (SIM)

280 in imaging technique based on time-efficient simultaneous T(1) /T(2) relaxometry and proton density m

281 We postulate that simultaneous targeting of these activated and repressed

282 This trial provides a template for future simultaneous testing of multiple disease-modifying medic

283 respectively, compared with 46% and 49% with simultaneous testing.

284 In this study, we performed simultaneous TG and PG analysis in blood plasma samples

285 Simultaneous thermal analysis-pulse thermal analysis-Fou

286 e using [(18)F]fluoro-deoxyglucose (FDG) and simultaneous time-of-flight (TOF) PET/MRI with hippocamp

287 l RNA sequencing (scRNA-seq) has enabled the simultaneous transcriptomic profiling of individual cell

288 ases colony food intake, potentially because simultaneous transmission of olfactory information also

289 A metal-free, simultaneous triple C-C coupling cyclization reaction be

290 configurations, providing a rational for the simultaneous tuning of E(T(1)) and E(S(1)) along an appr

291 ominent model of the attentional blink - the Simultaneous Type/Serial Token model.

292 om temperature phosphorescence material with simultaneous ultralong lifetime, high phosphorescence qu

293 ith characteristic mesenchymal features show simultaneous up-regulation of vimentin and high basal Ra

294 (0.2 ug mL(-1)), MF application (35 mT) and simultaneous use of mycotoxin and MF.

295 Under the simultaneous use of pressure-driven flow and DC electric

296 received neoadjuvant chemotherapy, 105 (89%) simultaneous venous resections, and 101 (85.5%) arterial

297 Using simultaneous video recording, we demonstrate that the le

298 cent Ca(2+) indicators like GCaMP to provide simultaneous voltage and Ca(2+) imaging.

299 an atomic force microscope (AFM), providing simultaneous volumetric imaging with high spatiotemporal

300 by enhancing diagnostic sensitivity, but its simultaneous weakness has been a lack of specificity due