ライフサイエンスコーパス: simultaneous binding

1 st that clashes between SspB and ClpX weaken simultaneous binding.

2 using stopped flow fluorimetry, demonstrate simultaneous binding and bending of a TATA box by TBP wi

3 inds DNA rapidly, which is consistent with a simultaneous binding and bending of the DNA.

4 acterized by high affinity (Kd < or = 5 nm), simultaneous binding and DNA bending, and rapid formatio

5 her uncovered a structural mechanism for the simultaneous binding and recognition of diverse diacetyl

6 itizing consumption of carbohydrates through simultaneous binding and regulation of multiple polysacc

7 Our data argue against simultaneous binding and show that Galphaq and Gbetagamm

8 similar to MPP+, which allowed separate and simultaneous binding and transport measurement.

9 isolate strains, allowing rapid, facile and simultaneous binding and visualization of pathogens.

10 nd 2) design bifunctional analogs capable of simultaneous binding at the computer-determined low affi

11 parated by 2 bp or less, which suggests that simultaneous binding at these sites is inhibited.

12 und by at least one factor demonstrated that simultaneous binding by all five factors was the most en

13 Those results also suggested, however, that simultaneous binding by all nine zinc fingers of TFIIIA

14 of the DNA that is necessary to accommodate simultaneous binding by all nine zinc fingers of TFIIIA.

15 In contrast, simultaneous binding by both proteins results in large s

16 ing, confinement to a membrane, and multiple simultaneous binding) can lead to nonlinearities (rate e

17 A phase boundary model based on simultaneous binding equilibria of hydroxide ions with t

18 The structure of the dimer is such that simultaneous binding for both recognition helices to DNA

19 TdCD and AS-MS analyses support simultaneous binding implying existence of a novel non-I

20 further evaluate this three-receptor model, simultaneous binding isotherms of (125)I-factor X and (1

21 This research indicates a "simultaneous binding mechanism" for the interactions of

22 In this study we use viSNE to analyze the simultaneous binding of 15 fluorophore-conjugated Abs an

23 We could demonstrate simultaneous binding of 4 IgE antibodies in close vicini

24 In order to analyze simultaneous binding of a ligand to different competing

25 nformational rearrangement is needed for the simultaneous binding of a monoglucosylated glycan to bot

26 rgeted protein degradation (TPD) through the simultaneous binding of a protein of interest (POI) and

27 ned by two-dimensional (2D) crowding through simultaneous binding of a second protein on the bilayer

28 lementation of the strategy necessitates the simultaneous binding of a single target molecule with tw

29 m-negative bacteria, a process that requires simultaneous binding of a synergistic anion.

30 conformation similar to that induced by the simultaneous binding of all substrates.

31 proximately 100 nM for x = 2 and y = 4) with simultaneous binding of all three RNA recognition motifs

32 nucleation by similar mechanisms and require simultaneous binding of Arp2 and Arp3.

33 he same face of the dimer; this should allow simultaneous binding of at least two integrins and, thus

34 Actin bundling occurs due to simultaneous binding of both ABDs to separate actin fila

35 Simultaneous binding of both COOH-terminal peptides had

36 teracts with three MED25 sites, allowing for simultaneous binding of both domains in full-length ETV4

37 hese experiments support the hypothesis that simultaneous binding of both dsRBMs of PKR occurs on kin

38 ed that the ternary complex can form through simultaneous binding of both Gle2 and TAP to adjacent si

39 This atomic conflict would likely prevent simultaneous binding of both inhibitor and peptide, cons

40 Both enzymes are profoundly inhibited by the simultaneous binding of both PCNA and polymerase to prim

41 es a scaffold function of G(M) that involves simultaneous binding of both PP1C and glycogen synthase.

42 ndependent interaction with CBP/p300 or pRb, simultaneous binding of both proteins is required for ma

43 arranged in a manner that seems to preclude simultaneous binding of both sites by NF-kappaB, althoug

44 The mechanism depends on simultaneous binding of both uPA and plasminogen to the

45 Displacement of alpha-actinin results in the simultaneous binding of calmodulin and CaMKII to NR1 C0.

46 The simultaneous binding of CAP and RNAP occurs with 10-fold

47 The simultaneous binding of Cdc14p and Mob1p to the SPB in e

48 NMDA receptors are activated upon simultaneous binding of coagonists glycine and glutamate

49 on is induced during immune responses by the simultaneous binding of complement-tagged antigens to th

50 l was questioned based on the observation of simultaneous binding of complexin-I and a fragment conta

51 LSPR carbohydrate sensing chip to probe the simultaneous binding of ConA to mannose and galactose-fu

52 Simultaneous binding of distinct regions of the RSPO Fu1

53 raction appears sterically incompatible with simultaneous binding of DNA polymerase epsilon (Polepsil

54 hrombin catalytic site senses individual and simultaneous binding of exosite I and II ligands differe

55 Ezrin binding to F-actin requires the simultaneous binding of ezrin to PIP(2).

56 that RACK1 forms a homodimer that allows the simultaneous binding of Fyn and NR2B.

57 The simultaneous binding of Gal repressor (GalR), catabolite

58 s, with the channel opening dependent on the simultaneous binding of glycine and glutamate to the ext

59 g apical domains reorient to accommodate the simultaneous binding of GroES and an incompletely folded

60 actor 53BP1, which engages chromatin through simultaneous binding of H4K20me2 and H2AK15ub.

61 varying helical turns of DNA did not affect simultaneous binding of HNF-3beta and HNF-4 nor did it i

62 properties of Tomm34 TPR domains thus enable simultaneous binding of Hsp70 and Hsp90.

63 Simultaneous binding of IgE to FcepsilonRI and CD23 is b

64 at both neutral and acidic pH, prevents the simultaneous binding of IgG, and reduces circulating IgG

65 esting that the III-1 module can support the simultaneous binding of III-10 and 70 kD.

66 Lyme antibody detection, which relies on the simultaneous binding of individual antibody molecules to

67 conclude that the mutant enzyme facilitates simultaneous binding of INDOPY-1 and ATP to the post-tra

68 Simultaneous binding of inorganic pyrophosphate in the I

69 These structures accommodate simultaneous binding of Int to direct-repeat arm sites a

70 ing mode of KaiB explains the observation of simultaneous binding of KaiA and KaiB to KaiC, and provi

71 e Lac repressor (LacR) is accompanied by the simultaneous binding of LacR to two operators and the fo

72 It is well established that the simultaneous binding of LEDGF/p75 to chromatin and to HI

73 binding sites may be a mechanism to promote simultaneous binding of ligands from the same family, pr

74 These results illustrate how simultaneous binding of ligands with opposing functions,

75 TLR4 activation requires simultaneous binding of MD-2 to endotoxin (E) and the ec

76 Simultaneous binding of MDC1 and RNF8 to the highly cons

77 ooperative effects on MDZ metabolism through simultaneous binding of MDZ and effector near the CYP3A4

78 f all-atom MD simulations to investigate the simultaneous binding of Mg(2+) and Na(+) cations to inac

79 The simultaneous binding of Mg(2+), PEP, and FBP to YPK is f

80 The simultaneous binding of MinD and MinE to membranes revea

81 rgy term, deltaG(Mn-PEP-FDP), indicates that simultaneous binding of Mn2+, PEP, and FDP is considerab

82 Higher activity could be achieved through simultaneous binding of more than one divalent metal ion

83 icles" such that we can directly measure the simultaneous binding of multiple aptamers to a target pr

84 multivalent interactions, which involve the simultaneous binding of multiple ligands on one entity t

85 ion and that multimerization is required for simultaneous binding of multiple membrane protein ligand

86 irst direct evidence, to our knowledge, that simultaneous binding of multiple partners to PCNA is unn

87 These simulations demonstrate that simultaneous binding of multiple PIP molecules by PH dom

88 Furthermore, KREs allow simultaneous binding of multiple receptors, thus providi

89 odomains, thereby creating opportunities for simultaneous binding of multiple S proteins that subsequ

90 The simultaneous binding of N at both the terminal cap and t

91 ssociation of hC5aR from toxin complexes and simultaneous binding of new ligands.

92 This prolonged attachment promotes simultaneous binding of NM II heads to actin, thereby in

93 lying mechanism behind this behavior is that simultaneous binding of Org 27569 produces a unique agon

94 peats of beta-catenin and thus precludes the simultaneous binding of other beta-catenin partners in t

95 The tether is proposed to involve the simultaneous binding of p115 to giantin on one membrane

96 To monitor the simultaneous binding of Pf and Et to QacR, as well as to

97 kinase) (GRK2) is mediated, in vitro, by the simultaneous binding of PIP2 and the betagamma subunits

98 suspenders" protection mechanism to prevent simultaneous binding of protons and drug that enforce No

99 te, an open conformation is suggested by the simultaneous binding of PTH(1-14) and PTH(3-34).

100 Whereas no evidence for simultaneous binding of Pur alpha and T antigen to singl

101 Binding is compatible with simultaneous binding of Ras and does not interfere with

102 open coordination sites of nonheme Fe enable simultaneous binding of reaction partners, offering oppo

103 Structural analyses show simultaneous binding of REGN5713, REGN5714, and REGN5715

104 es (proximal, rim, and distal), facilitating simultaneous binding of sRNAs and target mRNAs.

105 he currently held kinetic mechanism requires simultaneous binding of substrate and peroxide.

106 These antibodies allow for simultaneous binding of surface antigens on malignant ce

107 Simultaneous binding of SWR to both H2A nucleosome and f

108 ic channels, we now show that Ca(2+) induces simultaneous binding of synaptotagmin to phospholipid me

109 In focal-adhesions, vinculin is activated by simultaneous binding of talin to its head domain and act

110 Simultaneous binding of the BsAb to both receptors was c

111 ce the spacer is not long enough to permit a simultaneous binding of the hybrid molecules to the colc

112 The other involves simultaneous binding of the N-terminal zinc finger (N-fi

113 fully understood but has been linked to the simultaneous binding of the pentameric B subunit to mult

114 Here we show that simultaneous binding of the polymerase at the canonical

115 We propose a novel model whereby simultaneous binding of the TRF2 B-domain to the HJ core

116 CAR) versus too short (CD4-10-17b) to permit simultaneous binding of the two moieties to a single gp1

117 compared with PAI-1 alone, is due solely to simultaneous binding of the uPA moiety in the complex to

118 arly identical domains are oriented to allow simultaneous binding of their active regions to the ice

119 This synergy was dependent upon simultaneous binding of these factors to their cognate s

120 The indispensable simultaneous binding of these ligands to the two differe

121 e saturated by the other partner, indicating simultaneous binding of these two partners to Pgamma.

122 The 3site state is a result of simultaneous binding of three camphor molecules in three

123 The simultaneous binding of TM4SF proteins to the extracellu

124 that can redirect cytotoxic T cells through simultaneous binding of tumor cells.

125 Our experimentation proved (i) that the simultaneous binding of two aptamers after linkage achie

126 ate that ATP hydrolysis does not require the simultaneous binding of two ATP molecules, and under the

127 tic actions are noncompetitive and allow for simultaneous binding of two different activators on the

128 ding task due to limited space available for simultaneous binding of two different antibodies.

129 , and cell bridging experiments demonstrated simultaneous binding of two different antigens.

130 The principles for simultaneous binding of two different drugs discerned he

131 Bridging two binding sites enables simultaneous binding of two galactose moieties, which st

132 bisPNA and steric conflicts that complicate simultaneous binding of two inward projecting strands.

133 at Cyclin-dependent kinase 2 (CDK2) requires simultaneous binding of two Mg(2+) ions for catalysis of

134 We demonstrate that although the simultaneous binding of two Mg(2+) ions is essential for

135 The structural basis of simultaneous binding of two or more different drugs by a

136 The structures show how the simultaneous binding of two separate domains of lambda-i

137 However, simultaneous binding of two ssDNA segments to a type IA

138 ble-duplex invasion strategy, which requires simultaneous binding of two strands of pseudocomplementa

139 s may be explained by a model which includes simultaneous binding of two substrate molecules in the a

140 lins promote excitatory synapse formation by simultaneous binding of two unrelated presynaptic ligand

141 binding to assembled retromer coats through simultaneous binding of two VPS29s.

142 -1 isolates with great potency, showing that simultaneous binding of viral envelope glycoproteins by

143 Simultaneous binding promotes structural changes in AsiA

144 Structural analysis indicates that simultaneous binding through all binding sites to surfac

145 ces in the same orientation and coplanar for simultaneous binding to an ice crystal surface.

146 onist-stimulated ubiquitination of GPCRs via simultaneous binding to betaarrestins.

147 Bicoid-dependent enhancers, we propose that simultaneous binding to both enhancers and promoters ind

148 e of B cells and demonstrated a preferential simultaneous binding to both receptors on the same cell.

149 glues for Galpha and Gbetagamma that combine simultaneous binding to both subunits with inhibition of

150 tabilize an extended T-shaped IR through the simultaneous binding to both the L1 domain of one protom

151 Paxillin binding to BE6 excludes simultaneous binding to E6-AP.

152 odomain in a dimeric form that is induced by simultaneous binding to FGF1 and a heparin decasaccharid

153 duced with high expression yields and showed simultaneous binding to IGF-1R and EGFR with high affini

154 all 12 SH3 domains in the tetramer, allowing simultaneous binding to multiple targets.

155 ated against intestinal microbes assures the simultaneous binding to multiple, diverse commensal-deri

156 closely related tetrameric lectins, DC-SIGN (simultaneous binding to one GNP) and DC-SIGNR (intercros

157 tural features of arrestin-2 that may enable simultaneous binding to phosphorylated receptor, SH3 dom

158 ociate with the tri-snRNP resulting in their simultaneous binding to pre-mRNA.

159 ein-protein interactions may instead reflect simultaneous binding to shared RNA targets.

160 d by a linker of proper length, to allow the simultaneous binding to these different sites.

161 ize that Aip1p-severing activity may involve simultaneous binding to two actin subunits with cofilin

162 mixed sequences can form double duplexes by simultaneous binding to two complementary DNAs, one to t

163 mixed sequences can form double duplexes by simultaneous binding to two complementary DNAs, one to t

164 Simultaneous binding to two kinds of sites in the origin

165 The simultaneous binding with Rad4 and TFIIH was permitted b