ライフサイエンスコーパス: single ventricle

1 ge, 13-17 years; 24 girls; 18 with palliated single ventricle).

2 cases of hypoplastic left heart syndrome and single ventricle.

3 mproved patient outcomes for patients with a single ventricle.

4 eloped for the palliation of children with a single ventricle.

5 m and extends along the entire length of the single ventricle.

6 erm advantage for patients with a functional single ventricle.

7 cal management of patients with a functional single ventricle.

8 intensive care management of patients with a single ventricle.

9 are less well understood in patients with a single ventricle.

10 procedures were performed in patients with a single ventricle.

11 <0.001) but not in children with a palliated single ventricle.

12 g HT evaluation in children with a palliated single ventricle.

13 the first years of life among patients with single ventricle.

14 erformance in young patients with functional single ventricles.

15 tive palliation for patients with functional single ventricles.

16 s performed in 35 patients with a functional single ventricle (1 week to 12 years old) at various sta

17 T burden was highest in complex CHD, such as single ventricle (22.8%) and d-transposition of the grea

18 Primary diagnosis included single ventricle (36%), d-transposition of the great art

19 .0% (95% confidence interval, 32.6 to 43.5); single ventricle, 56.1% (95% confidence interval, 49.9 t

20 Diagnoses included single ventricle (74%), Kawasaki disease (14%), and othe

21 Infants with single ventricle anatomy and ductal-dependent pulmonary

22 Patients with single ventricle anatomy and ductal-dependent pulmonary

23 ast decade, as the majority of patients with single ventricle anatomy who have undergone the Fontan o

24 In patients with single-ventricle anatomy and ductal-dependent pulmonary

25 0 feet) were analyzed for patients born with single-ventricle anatomy who would now be of adult age.

26 Of 149 patients with single-ventricle anatomy, 103 underwent the Fontan proce

27 t highest risk are infants with a functional single ventricle and patients with suprasystemic pulmona

28 ot, four with Ebstein's anomaly and two with single ventricle and pulmonary stenosis.

29 She was diagnosed with functional single ventricle and very limited pulmonary blood flow.

30 The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patie

31 great arteries, 123 tetralogy of Fallot, 132 single ventricle, and 130 other CHD).

32 ties are commonly present in patients with a single ventricle, and detection of these lesions increas

33 ultivariate analysis, weight <4 kg, having a single ventricle, and emergency status were significantl

34 pulmonary atresia intact ventricular septum, single ventricle, and tricuspid atresia born in 1996 to

35 ence of a large ventricular septal defect, a single-ventricle approach to repair should be considered

36 and performance changes occur in functional single ventricles as they progress through staged Fontan

37 d randomized clinical trials in infants with single ventricle CHD and 270 controls from The Cancer Ge

38 Several CNVs likely to be causative of single ventricle CHD were observed, including aberration

39 with transposition of the great arteries and single-ventricle CHD (median: 1.63 [IQR: 0.56-3.27] in t

40 Males and children with severe or single-ventricle CHD demonstrated higher incidence rates

41 vival was similar for biventricular and most single-ventricle CHD patients, and notably better for bi

42 t arteries and median: 1.28 [IQR: 0-2.42] in single-ventricle CHD) compared with 2-ventricle CHD (med

43 with CHD and destigmatizing most subtypes of single-ventricle CHD.

44 uals with transposition of great arteries or single-ventricle CHD.

45 y portend impaired functional reserve of the single-ventricle circulation.

46 s associated with lower WM other than in the single ventricle cohort, where VAD was associated with h

47 lack of information, gaps in clinical care, single ventricle complications, and heart failure in the

48 stemic circulation in neonatal patients with single ventricle congenital heart defects, but this comp

49 Single ventricle congenital heart disease like hypoplast

50 brane oxygenation or mechanical ventilation, single ventricle congenital heart disease on VAD support

51 iomyopathies; resuscitation of patients with single ventricle congenital heart disease; management of

52 eric scaffolds, hold promise toward treating single-ventricle congenital heart defects (SVCHDs).

53 Without large-scale analyses of adults with single-ventricle congenital heart disease (CHD) undergoi

54 tion to innate abnormalities associated with single-ventricle congenital heart disease exposes these

55 peration is the current standard of care for single-ventricle congenital heart disease.

56 heart surgeries currently performed to treat single-ventricle congenital heart disease.

57 clude atrioventricular septal defects, DORV, single ventricle defects as well as abnormal position of

58 Patients with single ventricle defects undergoing the Fontan procedure

59 ticles regarding management of newborns with single-ventricle defects have been published during the

60 rience in newborns undergoing palliation for single-ventricle defects, in particular, hypoplastic lef

61 Other single-ventricle defects, transposition of the great art

62 A single ventricle diagnosis (P=0.06), longer postoperativ

63 c Surgery (STAT) category, site, admit time, single-ventricle diagnosis, Vasoactive-Inotropic Score,

64 or whom SCPC was performed for palliation of single ventricle disease who underwent chest MRI between

65 n coarctation of the aorta, late outcomes in single-ventricle disease, cognitive and psychiatric issu

66 y/plastic bronchitis (HR: 2.37; P = 0.0082), single-ventricle end-diastolic volume index >104 mL/m(2)

67 Patients with a single ventricle experience a high rate of brain injury

68 ress test results of all preadolescents with single ventricle Fontan physiology.

69 g improves aerobic capacity in patients with single ventricle Fontan physiology.

70 and predictive value of EOV in patients with single ventricle Fontan physiology.

71 Morbidity in patients with single-ventricle Fontan circulation is common and includ

72 enic CNVs seem to contribute to the cause of single ventricle forms of CHD in >/=10% of cases and are

73 gement strategy for patients with functional single ventricle has evolved to include staging bidirect

74 Infants with functional single ventricle have a high risk of death during the ea

75 Patients with a single ventricle have multiple risk factors for central

76 ts with congenital heart disease, those with single ventricles have the highest risk of early mortali

77 ; P<0.001) but not in those with a palliated single ventricle (hazard ratio, 1.3; 95% confidence inte

78 Children with single ventricle heart disease (SVHD) experience morbidi

79 Patients with single ventricle heart disease (SVHD) require multiple p

80 ing patient, who had borderline functionally single ventricle heart disease (unbalanced atrioventricu

81 Most candidates have single ventricle heart disease and limited transvenous o

82 ailure (FCF) is a chronic state in palliated single ventricle heart disease with high morbidity and m

83 palliative technique for patients born with single ventricle heart disease.

84 ndrome (n = 10) or other forms of functional single-ventricle heart (n = 19).

85 ported to improve outcomes for patients with single-ventricle heart disease during the period between

86 ontan procedure, the prognosis of congenital single-ventricle heart disease has improved, with many a

87 nent among males and children with severe or single-ventricle heart disease.

88 ocus of improving outcomes for patients with single-ventricle heart disease.

89 ptal defects [ASD], aortic arch defects, and single-ventricle heart) and subgroups of specific heart

90 cedure for the palliation of patients with a single-ventricle heart, there have been very few reports

91 Advances in the care of children with single ventricle hearts have resulted in remarkably impr

92 extrocardia), ventral looping and no looping/single ventricle hearts.

93 Surgical strategies for patients with single ventricle include intermediate staging or early F

94 This review suggests that the diagnosis of single ventricle, initiation of ECMO in the operating ro

95 factors: age, ventricular morphology (right single ventricle, left single ventricle [RV/LV]), fenest

96 (MBT) shunt, the first palliative stage for single-ventricle lesions with systemic outflow obstructi

97 ren who had undergone Fontan corrections for single-ventricle lesions.

98 icular repair and which are better served by single ventricle management.

99 The long-term outcome of single-ventricle management in these patients is not kno

100 n young pediatric patients with a functional single ventricle, matrix-array 3DE measurements of mass

101 odes of strain-curve variation regardless of single ventricle morphology and type of strain investiga

102 entricular septal defect (n=3), functionally single ventricle (n=3) and ventricular septal defect wit

103 s anomaly (n=44), septal defects (n=39), and single ventricle (n=36).

104 We then compared our subcohort of high-risk single ventricle neonates palliated with PFRs with a sim

105 d cerebral blood oxygenation in fetuses with single ventricle or aortic obstruction.

106 Long-term single-ventricle outcomes among neonatal survivors of th

107 al defect in 95% (n = 142 of 149), and prior single ventricle palliation in 68% (n = 89 of 149).

108 perioperative implications of the stages of single ventricle palliation is critical.

109 proposed as a means of improving outcomes of single ventricle palliation.

110 diameter was pre-specified for patients with single ventricle palliation.

111 tients with LH hypoplasia who have undergone single-ventricle palliation (SVP).

112 the entire population of newborns undergoing single-ventricle palliation are unclear.

113 In infants requiring 3-stage single-ventricle palliation for hypoplastic left heart s

114 urgical management consisted of a functional single-ventricle palliation in 38 patients (83%) and biv

115 Failed single-ventricle palliation is a growing indication for

116 nd of a spectrum of LV hypoplasia, mandating single-ventricle palliation or cardiac transplantation.

117 pair: 7 g/dL (biventricular repair), 9 g/dL (single-ventricle palliation), or 7 to 9 g/dL (uncorrecte

118 nital heart surgery, especially after failed single-ventricle palliation, is presenting new obstacles

119 e Fontan is typically not the final stage of single-ventricle palliation.

120 All 134 patients had a form of single ventricle pathological anatomy.

121 articular interest, conduit reoperations and single ventricle pathway modifications are still an art

122 ne arrhythmic death related to asystole in a single ventricle patient.

123 ary collateral (SPC) flow occurs commonly in single ventricle patients after superior cavo-pulmonary

124 lmonary arterial collateral (SPC) vessels in single ventricle patients are poorly understood.

125 Single ventricle patients not requiring an intervention

126 tment with phosphodiesterase-5 inhibitors in single ventricle patients with heart failure, including

127 on is routinely used as a diagnostic tool in single ventricle patients with superior cavopulmonary co

128 rends toward worse outcomes were observed in single ventricle patients, biventricular patients with l

129 ion of VADs in complex circulations, such as single ventricle patients, remains infrequent and is ass

130 Model performance was lowest in functionally single ventricle patients.

131 inition 1, 86% for definition 2, and 75% for single ventricle patients.

132 edback mechanisms, 12 intubated, ventilated, single-ventricle patients in SCPC physiology (age 2.2+/-

133 Compared to biventricular CHD, single-ventricle patients showed significantly reduced s

134 the total cavopulmonary connection (TCPC) in single-ventricle patients undergoing Fontan can be calcu

135 In single-ventricle patients, a staged approach is employed

136 tients exhibited similar 10-year survival as single-ventricle patients, except for those with hypopla

137 s display severe OFT and RV hypoplasia and a single ventricle phenotype due to decreased proliferatio

138 The most common diagnosis was single ventricle physiology (52%), 9 palliated by Fontan

139 logy of Fallot (n=8), cor triatriatum (n=7), single ventricle physiology (n=2), among others.

140 standardized segmentation for patients with single ventricle physiology across multiple centers.

141 ties may progress in select individuals with single ventricle physiology after Fontan completion, and

142 Single ventricle physiology and failure to separate from

143 Newborns with prenatal diagnosis of single ventricle physiology and transposition of the gre

144 Current approaches to single ventricle physiology as well as areas of controve

145 operation improves survival in patients with single ventricle physiology but is associated with Fonta

146 T FINDINGS: Infants following palliation for single ventricle physiology have persistent growth failu

147 livery of adequate nutrition in infants with single ventricle physiology is essential to improve outc

148 ents undergoing cavopulmonary palliation for single ventricle physiology may be impacted by living at

149 cess for transvenous ventricular pacing (eg, single ventricle physiology or Eisenmenger syndrome), th

150 In multivariable analysis, single ventricle physiology was associated with worse mo

151 e whether pathogenic CNVs among infants with single ventricle physiology were associated with inferio

152 with transposition of the great arteries and single ventricle physiology were included in this analys

153 n is particularly relevant for patients with single ventricle physiology who often develop Fontan-ass

154 atrial septal defects, tetralogy of Fallot, single ventricle physiology, and following cardiac trans

155 heart malformations are those with so-called single ventricle physiology, in which there is only one

156 ndergoing Fontan procedures as palliation of single ventricle physiology, the addition of a fenestrat

157 of congenital heart defects characterized by single ventricle physiology, yet it predisposes individu

158 rvival and quality of life for patients with single ventricle physiology.

159 tion is performed for surgical palliation of single ventricle physiology.

160 June 2012 to February 2023 in patients with single ventricle physiology.

161 d the management of children with functional single ventricle physiology.

162 ant improvement in survival of patients with single ventricle physiology.

163 ansposition of the great arteries and 57 had single ventricle physiology.

164 heart disease, and 80% of these patients had single ventricle physiology.

165 n patients with systemic right ventricles or single ventricle physiology.

166 .3]) underwent a PFR procedure; 15 (88%) had single ventricle physiology; 15 (88%) were high-risk sur

167 espiratory support; 4) expanding research of single ventricle physiology; 5) advances in the treatmen

168 In particular, all patients with single- ventricle physiology currently undergo diagnosti

169 (hazard ratio, 3.66; 95% CI, 2.26-5.92) and single-ventricle physiology (hazard ratio, 1.98; 95% CI,

170 erformance in children and young adults with single-ventricle physiology after the Fontan operation.

171 PL through the TCPC may play a role in single-ventricle physiology and is a function of cardiac

172 odynamically detrimental in circumstances of single-ventricle physiology and should be used with caut

173 zation is standard practice in patients with single-ventricle physiology before bidirectional Glenn a

174 First, the standard model of single-ventricle physiology can be reexpressed in a form

175 Among adult CHD transplant recipients, single-ventricle physiology correlated with higher short

176 In neonatal lambs with single-ventricle physiology created in utero, epinephrin

177 iorespiratory deterioration in children with single-ventricle physiology during their interstage hosp

178 ratory deterioration events in children with single-ventricle physiology during their interstage peri

179 The lack of animal models of single-ventricle physiology has hindered the understandi

180 Patients with single-ventricle physiology have a significant risk of c

181 Children and young adults with single-ventricle physiology have abnormal exercise capac

182 Infants with single-ventricle physiology have poor growth and are at

183 Bone marrow transplant recipients and single-ventricle physiology have the poorest outcomes.

184 Administration of enalapril to infants with single-ventricle physiology in the first year of life di

185 Single-ventricle physiology is characterized by parallel

186 ouble-blind trial involving 230 infants with single-ventricle physiology randomized to receive enalap

187 Five-year survival for single-ventricle physiology was 47.2% (95% CI, 34.3-59.1

188 A reproducible fetal animal model of single-ventricle physiology was created to examine the e

189 Of 110 neonates with functionally single-ventricle physiology who underwent stage I pallia

190 volumes and mass in pediatric patients with single-ventricle physiology would aid clinical managemen

191 lnerability indicators, renal insufficiency, single-ventricle physiology, and coagulation disorder.

192 ly fatal disorder occurring in children with single-ventricle physiology, and other diseases, as well

193 tors for reintervention included anticipated single-ventricle physiology, lack of prior balloon pulmo

194 rdization: patient age, renal insufficiency, single-ventricle physiology, procedure-type risk group,

195 osition of the great arteries and 12 who had single-ventricle physiology--with the use of magnetic re

196 ion of complex congenital heart disease with single-ventricle physiology.

197 the goal in the management of patients with single-ventricle physiology.

198 doses in the resuscitation of patients with single-ventricle physiology.

199 ll enable better management of patients with single-ventricle physiology.

200 ollected physiological data of subjects with single-ventricle physiology.

201 ransplant recipients with CHD, 185 (48%) had single-ventricle physiology.

202 ratification and surgical decision-making in single-ventricle physiology.

203 l after surgical palliation in children with single-ventricle physiology.

204 is a successful palliation for children with single-ventricle physiology; however, many will eventual

205 ted the most from this progress has been the single-ventricle population.

206 from both the Pediatric Heart Network (PHN) Single Ventricle Reconstruction (SVR) trial and Extensio

207 The Pediatric Heart Network's (PHN) single ventricle reconstruction (SVR) trial compared shu

208 The Pediatric Heart Network's Single Ventricle Reconstruction (SVR) trial randomized i

209 The Single Ventricle Reconstruction (SVR) trial randomized s

210 In the Single Ventricle Reconstruction (SVR) trial, 1-year tran

211 e physiologic requirements for success after single ventricle reconstruction has resulted in dramatic

212 As the Single Ventricle Reconstruction study was based on the i

213 th of stay using the Pediatric Heart Network Single Ventricle Reconstruction trial dataset.

214 Since 2010, the Single Ventricle Reconstruction trial has matured and ha

215 Examining the available data in light of the Single Ventricle Reconstruction trial is insightful as f

216 In the Single Ventricle Reconstruction trial of the Norwood pro

217 and Blood Institute Pediatric Heart Network Single Ventricle Reconstruction Trial public data set wa

218 The multi-institutional Single Ventricle Reconstruction trial randomly assigned

219 dary analysis of the Pediatric Heart Network Single Ventricle Reconstruction trial.

220 549 participants enrolled in the SVR trial (Single Ventricle Reconstruction), 200 of the 237 SVRIII

221 In the SVR trial (Single Ventricle Reconstruction), newborns with hypoplas

222 multi-institutional Pediatric Heart Network Single-Ventricle Reconstruction Trial, interstage mortal

223 epair (closure of septal defects) instead of single-ventricle repair (Norwood palliation and Fontan o

224 Infants with single ventricle require staged cardiac surgery, with st

225 lar morphology (right single ventricle, left single ventricle [RV/LV]), fenestration open (FO) or clo

226 Patients with single-ventricle, shunt-dependent physiology are at incr

227 ations for surgical palliation of functional single ventricle since the initial report by Fontan and

228 hypoplastic left heart syndrome after staged single ventricle surgical palliation.

229 tality rate and an increase in the number of single-ventricle survivors.

230 with CHD were categorized into those with a single ventricle (SV) or two ventricles (TVs) and those

231 dies in zebrafish, a lower vertebrate with a single ventricle, that latent TGF-beta binding protein 3

232 monary artery shunt alone in patients with a single ventricle to facilitate ventricular volume unload

233 e 5-year survival in infants with functional single ventricle, to define factors associated with surv

234 nts (median age, 7 months) with a functional single ventricle undergoing CMR under general anesthesia

235 ional echocardiography (3DE) measurements of single-ventricle volumes, mass, and ejection fraction wi

236 Single ventricle was the pretransplantation diagnosis fo

237 Patients who had a single ventricle, weight <4 kg, or who underwent an emer

238 Patients with a single ventricle were studied with magnetic resonance im

239 Preadolescents with single ventricle who undergo volume unloading surgery at