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1 l antiangiogenic and antitumor strike with a single drug.
2 tance genes, each coding for resistance to a single drug.
3 ions, but few studies were available for any single drug.
4 ations may act as a more potent version of a single drug.
5 tration with drug combinations compared with single drugs.
6 te 28-folds of conducted doses compared with single drugs.
7 crease white-blood-cell toxicity compared to single drugs.
8 rug efficacy and less patient variation than single drugs.
9 dent on the Hill-slope and maximal effect of single-drugs.
10 ncluded patients, 495 (61.6%) received EAAT (single-drug, 25.4%; combination, 36.2%).
11 w for the treatment of two conditions with a single drug (a so-called twofer).
12 ruton's tyrosine kinase inhibitor, has shown single-drug activity in relapsed or refractory B-cell ma
13 single-stranded oligonucleotide containing a single drug adduct at a T residue and to study its effec
14 y holds the promise of a lasting cure with a single drug administration.
15  85% White, 11% Hispanic ethnicity), 29 with single drug allergy labels and 50 with multiple drug all
16 tic inhibition of tumor growth compared to a single drug alone.
17 that the study was based on deaths involving single drugs alone and changes in deaths involving presc
18 onth, 17.1% of all children were dispensed a single drug and 6.4% were dispensed two or more.
19 el, we predicted viability responses of many single drug and drug combinations in agreement with expe
20 nd compared them with patients allergic to a single drug and with healthy controls (HC).
21 profiles (exposure) observed in patients for single drugs and combinations, by evaluating exposure me
22  may be useful for measuring the activity of single drugs and drug combinations during evaluation of
23 ourse RNAseq profiling of cells treated with single drugs and their combinations and found that the t
24 otein, it could better inform development of single-drug and precision therapies addressing the root
25 longed survival compared with results in the single-drug and vehicle control groups.
26 e relies largely on mass administration of a single drug, and the development of new drugs and vaccin
27 binations and improve outcome, we proposed a single drug approach to block multiple overlapping effec
28                       Currently, there is no single drug approved for the simultaneous treatment of b
29  be made a priority, as there is still not a single drug approved specifically for a nonclear cell in
30 nd may be beneficial even in tumors in which single drugs are inactive, as exemplified by the effect
31  tachycardia in infants can be refractory to single-drug as well as standard combination medical ther
32 orosis treatments are generally limited to a single drug at a fixed dose and frequency.
33 ries without low-income subsidies who take a single drug before and after the doughnut hole closes.
34 on at the same ratio as well as a mixture of single-drug BPDs in the same ratio.
35 ping toxicity profiles so that doses of each single drug can be reduced below toxicity levels.
36 , a powerful tool to determine affinities of single drug candidates toward chosen targets, were recen
37 s for 35 cycles (pembrolizumab group), or to single-drug chemotherapy per investigator's choice of ca
38    All groups contained multiple hits from a single drug class, and several comprised multiple struct
39 available, so the emergence of resistance to single drug classes and now multidrug resistance greatly
40 molecular interactions and properties within single drug classes are lacking.
41 an state-of-the-art methods; and a set of 13 single-drug CNNs (SD-CNN) with AUCs 80.1-97.1% and highe
42  articles published in symposia sponsored by single drug companies and articles from the parent journ
43                        Symposia sponsored by single drug companies had more articles without methods
44            Articles in symposia sponsored by single drug companies were similar in quality and clinic
45 overage and demonstrate that even very small single-drug compartments lead to dramatically higher res
46                               Although their single-drug components are well studied, the mechanisms
47 nation with first-line chemotherapy and as a single-drug continuation treatment for 18 cycles.
48         The results also show that anomalous single-drug cooperativity, as well as multi-drug synergy
49 icacy, or augmented toxicity compared to the single drug counterparts.
50 el in which the frequencies of resistance to single drugs, cross-resistance, and epistasis combine to
51 ns between different cell cycle phases, with single drug data constraining how drug doses affect tran
52                     Relaxation times for any single drug decrease with increasing tubulin concentrati
53 , but the proportion of children dispensed a single drug decreased (slope -.02%, p= .001).
54                      Our study showed that a single drug delivery device loaded with a proprietary hy
55 ese methods capture drug features based on a single drug description (e.g. drug structure), without c
56                                        For a single drug development project, we estimate that severa
57 or example, we find some mutants that resist single drugs do not resist their combination, while othe
58 els that were detectable after 16 hours of a single drug dose before any evidence of in situ cellular
59  hypothesized that by combining knowledge of single drug dose responses and cell state transition net
60 ter six cycles of treatment, patients in the single-drug doxorubicin group were followed up expectant
61 d not improve overall survival compared with single-drug doxorubicin in patients with locally advance
62 rgistic combinations using easily obtainable single drug efficacy, no detailed mechanistic understand
63              ARVs were primarily detected as single drug exposure across genital tract tissue section
64 itaxel (36- to 93-fold) was selected by this single drug exposure in all 9 stably resistant mutants.
65 stration, little work has investigated how a single drug exposure paired with withdrawal influences c
66 acokinetic parameters calculated following a single drug exposure.
67 nd the District of Columbia, was queried for single drug exposures in individuals 12 years and older
68 xy-Delta12,14-prostaglandin J2 compared with single drug exposures on the adenocarcinoma cell line A5
69                                              Single drug exposures to methiothepin or scopolamine did
70 the combined drug exposure, as compared with single-drug exposures.
71  and AG879, respectively, were compared with single drugs for inhibition of cell growth.
72  advantageous than a combination of targeted single drug formulations administered at the same drug r
73 ences of individual drugs between 3-in-1 and single drug formulations were eliminated.
74  was only one third of that achieved for the single drug formulations.
75 as optional crossover for patients in either single-drug group to receive combination treatment.
76  model in vivo than free DOX and GEM and the single drug HA conjugates.
77            Previous pharmacologic studies of single drugs have suggested that one factor contributing
78             Pharmacokinetic variability to a single drug in the regimen is significantly associated w
79 ic arterial and portal venous infusions of a single drug, in a cross-over fashion, at two dose rates
80 nce in Escherichia coli under selection with single drugs, including chloramphenicol, doxycycline and
81                                              Single-drug-induced and cross-reactive NSAID-Hs were pro
82                      One simple reason why a single drug is indicated for so many age-related disease
83         Standard methodologies assume only a single drug is used, it acts only in its unconverted for
84 isease even with models developed based on a single drug known to treat the disease.
85 es of DMQ-MSs to their equivalent individual single-drug loaded MSs mixture (MSsmix), empty MSs, no-t
86 rs of 17-AAG were similar in both 3-in-1 and single drug-loaded PEG-b-PLA micelle formulations.
87                 In contrast, when 3-in-1 and single drug-loaded PEG-b-PLA micelles were administrated
88                                              Single-drug maintenance after salvage therapy might be a
89 nsolidation with whole-brain radiotherapy or single-drug maintenance.
90 utations on the bacterial chromosome using a single drug marker.
91                                            A single drug, MCC-134, opens surface K(ATP) channels but
92                Outcomes were reported for 42 single-drug measures in the independent RCTs, with just
93                                 Binding of a single drug molecule is observed to cause a 2.4 A decrea
94                       We hypothesized that a single drug molecule-a novel Toll-like receptor 9 (TLR9)
95 bility of MdfA to exchange two protons for a single drug molecule.
96 s (n=7), patients with hypersensitivity to a single drug (monoallergic, n=6), and healthy controls (H
97 tective effect was observed in empty MSs and single-drug MSs treated groups.
98 r gentamicin (n = 11), or doxycycline as the single drug (n = 6) was used for treatment.
99 s with multiple drugs outperform mixtures of single-drug nanocarriers at the same dose.
100                                        These single-drug nanoparticles demonstrate excellent pharmaco
101                                           As single drugs, nifedipine retard use resulted in a greate
102 t examined the effects of approximately 1300 single drugs on several human cancer cell lines.
103 acilitated crimes (DFCs) entail the use of a single drug or a mixture of drugs to render a victim una
104 eted dual-drug combination NPs over NPs with single drug or nontargeted NPs.
105                                Rather than a single drug or procedure, insufficient net immune contro
106  Within this group, selective responses to a single drug or responders to several APs may exist, sugg
107  disaggregated ES-2 tumor spheroids, whereas single drugs or 2-drug combinations only slowed growth o
108 ogue carrier and cytotoxic radical AN-201 as single drugs or as an unconjugated mixture) had no signi
109 iotic resistance under treatment regimens of single drugs or drug combinations.
110 o combined menin and FLT3 inhibition than to single-drug or vehicle control treatment, whereas AML ce
111   In contrast to the limited efficacy of the single drugs, or any two drugs in combination, the three
112                                              Single-drug oral selinexor induced durable responses and
113 ed antibody-drug conjugates (ADCs) contain a single-drug payload.
114 Treatment of schistosomiasis has relied on a single drug - praziquantel (PZQ) - for decades.
115                    The treatment relies on a single drug, praziquantel (PZQ), making the discovery of
116                                            A single drug, praziquantel, is used to treat schistosome
117 eatment relies predominantly on the use of a single drug, praziquantel.
118 y designs (US and international claims data, single drug pregnancy registries, case-control studies,
119 erated by DMEA were better than the original single-drug rankings in all tested data sets.
120 aimed to assess the efficacy and safety of a single-drug regimen with oral rivaroxaban compared with
121                         A major concern with single-drug regimens is the emergence of drug-resistant
122 l, toxic effects were tolerable with the two single-drug regimens.
123 Triple antithrombotic therapy emerged as the single drug-related predictor of GIB in addition to pati
124 rtant bacteria are characterized not only by single drug resistance but also by multiple antibiotic r
125 g selection and their rapid selection as the single drug resistance mutation during therapy with gefi
126 tment failure is caused by the fixation of a single drug resistance mutation.
127 lity at each sequence position suggests: (i) single drug resistance mutations are likely to occur at
128 in cancer therapy for potentially overcoming single drug resistance.
129 so had equivalent potency against a panel of single-drug resistant strains of Mtb and remarkably sele
130 DR mutations rapidly became undetectable and single-drug-resistant (SDR) viruses emerged as minority
131         We show that statistical modeling of single drug response from drug combination data can help
132 ee-based models to improve the accuracy of a single drug response model and demonstrate that tree-bas
133 as a convolutional neural network (CNN), for single drug response problems.
134 s are resolved by linearly interpolating the single drug responses, while for the antagonistic drug p
135 benznidazole-resistant clones derived from a single drug-selected population.
136                          This method takes a single drug sensitivity data matrix as its sole input an
137 ny therapies in clinical trials are based on single drug-single target relationships.
138 ical trials of patients with cancer assigned single-drug sorafenib at 400 mg twice daily with data on
139                      Antiretroviral changes (single drug substitutions and regimen switches) limit tr
140 persaturation attained by dissolution of the single drug systems.
141 sed in doping control is more efficient than single drug target analysis (SDTA).
142 points per drug pair and two data points per single drug test were available.
143 corresponded to patients' renin profile vs a single drug that corresponded to patients' age-race subg
144 ieving goal DBP (<90 mm Hg) in response to a single drug that corresponded to patients' renin profile
145 is the first biological treatment given as a single drug that has survival benefits in patients with
146                                          For single drugs, the best GEA method (Precision: .92/Recall
147                              Compared to the single drugs, the combined molecules showed a superior a
148 to be more effective in curing patients than single drugs, the impact of such treatments on the evolu
149                      BQR was the most potent single drug: the 4.0 or 8.0 mg/kg/day BQR doses delivere
150 ay improve the prediction of the efficacy of single-drug therapies and support further evaluation of
151 n sometimes treat recalcitrant diseases when single-drug therapies fail.
152                                              Single-drug therapies with monoclonal antibodies against
153 demonstrated greater antitumor efficacy than single drug therapy in both in vitro and in vivo setting
154  or additive antiviral effects compared with single drug therapy.
155  or hepatitis B surface antigen) compared to single drug therapy.
156 ADCT), and adequate empirical and definitive single-drug therapy (AESD, ADSD).
157 wledge of biochemical targets has brought to single-drug therapy and creates a statistical and experi
158 ows significantly better average accuracy on single-drug therapy compared to two bulk-cell-based drug
159 filing and age-race subgroup may help select single-drug therapy for stage 1 and stage 2 hypertension
160  not reduce the mortality risk compared with single-drug therapy in PA bloodstream infections.
161 lity testing is not routinely performed, and single-drug therapy is used for the treatment of most in
162                                              Single-drug therapy with paclitaxel or suramin did not r
163 (P<.001) significantly predicted response to single-drug therapy, whereas renin profile was of border
164 py is less likely to yield an advantage over single-drug therapy.
165 s, because they often have poor responses to single-drug therapy.
166 enously with chemotherapy and continued as a single drug thereafter (total 54 weeks).
167 tem is believed to belong to the category of single-drug transporters.
168 xtent than either ATM-proficient controls or single drug treatment.
169 essed dose-dependent activity of rifampin in single-drug treatment during 3 weeks.
170 as well as enhanced apoptosis, compared with single-drug treatment in models of human and murine NPM1
171 and potentiator activities may be useful for single-drug treatment of cystic fibrosis caused by Delta
172 0-min intravenous infusion every 3 weeks) or single-drug treatment of physician's choice.
173 tion of PTXNR-TTZ compared with the doses of single-drug treatment.
174 ation was observed for rifampin after 3-week single-drug treatment.
175                                              Single drug treatments were cytostatic, but only DDP and
176                                 Responses to single-drug treatments were temporary, whereas combinati
177 ects on strengthening muscles, compared with single-drug treatments.
178 elated pathologies compared with vehicle and single-drug treatments.
179  in different genes than under corresponding single-drug treatments.
180 ltiple drugs of abuse could be detected in a single drug user hair scan with confirmation of identity
181 l benefit than does co-administration of two single-drug variants in xenograft mouse models represent
182 stic combinations, most drugs average extant single-drug variations in therapeutic response.
183                                  However, no single drug was able to alleviate both phenotypes.
184 eroid dehydrogenase type 1(17beta HSD1) by a single drug was explored, starting from in-house 17beta
185 ystemically trigger HIV-1 reactivation using single drugs were unsuccessful.
186 , or 150 mg/m(2)/d) administered as a 3-day, single-drug window before initiation of standard, multid
187                                        Thus, single drugs with durable antiviral activity can provide
188 tiple genes, each coding for resistance to a single drug, within a single cell.
189 herefore took an epigenetic approach where a single drug would simultaneously affect the expression o

 
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