ライフサイエンスコーパス: sinusoid

1 ons during the organization of the primitive sinusoid.

2 accessible to sporozoites entering the liver sinusoid.

3 rger response than the most effective bar or sinusoid.

4 the "capillarization" process of the hepatic sinusoid.

5 steatosis and in its development across the sinusoid.

6 ncounter the microenvironment of the hepatic sinusoid.

7 d in enlarged hepatocytes and narrowed liver sinusoids.

8 cumulation of malignant cells in the hepatic sinusoids.

9 retention of tumor cells because of narrower sinusoids.

10 e accumulation of leukocytes within enlarged sinusoids.

11 onal zones where arterioles emptied into the sinusoids.

12 eral membrane of hepatocytes adjacent to the sinusoids.

13 phages (Kupffer cells) that line the hepatic sinusoids.

14 , with fibrin thrombi in some maternal blood sinusoids.

15 bone marrow are found in the parenchyma and sinusoids.

16 ortals in the lymphatic endothelium of these sinusoids.

17 f NKT cells results in arrest within hepatic sinusoids.

18 and EGFP(+) platelet-like depositions in the sinusoids.

19 ge intravascular macrophage bed in the liver sinusoids.

20 , leading to the formation of new functional sinusoids.

21 gregation and subsequent entrapment in liver sinusoids.

22 the lack of recovery of endothelial Jag2 at sinusoids.

23 rounded by inflammatory cells in the hepatic sinusoids.

24 ne marrow (BM) and release platelets into BM sinusoids.

25 s present primarily inside blood vessels and sinusoids.

26 e overall vascular architecture in the liver sinusoids.

27 d severe liver hemorrhage and destruction of sinusoids.

28 he endothelium was disrupted in most hepatic sinusoids.

29 e in portal veins, hepatic arteries, and the sinusoids.

30 here to endothelial cells in the bone marrow sinusoids.

31 h vessels are largely derived from the liver sinusoids.

32 56% of portal blood flow bypasses the liver sinusoids.

33 ress imposed by navigating small vessels and sinusoids.

34 steal niches and megakaryocyte apposition to sinusoids.

35 te infiltration in the periportal fields and sinusoids.

36 of transplanted cells that enter the hepatic sinusoids.

37 mulation, primarily within the centrolobular sinusoids.

38 carcinoma (CRC) cells arrest within hepatic sinusoids.

39 liver regeneration during the reformation of sinusoids.

40 gration of primed neutrophils sequestered in sinusoids.

41 ncluding the sequestration of neutrophils in sinusoids.

42 tion to endothelial cells lining the hepatic sinusoids.

43 region, leukocyte adherence, and nonperfused sinusoids.

44 nuclear lobulation and reduced contact to BM sinusoids.

45 pendent transmigration of entire MKs into BM sinusoids.

46 nsformed by hepatic glutathione in the liver sinusoids.

47 ase of immature hematopoietic cells into the sinusoids.

48 li and bronchioli, kidney tubules, and liver sinusoids.

49 as restored normal bud size and release into sinusoids.

50 ecture around MDPs and their localization to sinusoids.

51 g, microtubule-rich proplatelets into vessel sinusoids.

52 n promoting the development of discontinuous sinusoids.

53 ne marrow (BM) and release platelets into BM sinusoids.

54 toplasmic protrusions (proplatelets) into BM sinusoids.

55 ssays that mimic in vivo shear stress in the sinusoids.

56 IgA-secreting cells and have IgA deposits in sinusoids.

57 abnormal vascular architecture, and dilated sinusoids.

58 evels of serum IgA and IgA deposits in liver sinusoids.

59 o reticular cells lining and interconnecting sinusoids.

60 njury from significant distances through the sinusoids.

61 and requires deposition of cells in hepatic sinusoids.

62 tes were found in a greater number of distal sinusoids.

63 profoundly contribute to remodeling of liver sinusoids.

64 patic I/R induced CD4+ T cell recruitment in sinusoids.

65 portal blood flow and pressure within liver sinusoids.

66 t IL-17A(+) T cell subset in the human liver sinusoids.

67 or so-called proplatelets, into bone marrow sinusoids.

68 , respectively, to adhere within the hepatic sinusoids.

69 gulfment of B cells circulating in the liver sinusoids.

70 volving hemorrhagic infiltration via widened sinusoids.

71 dles with rigid probes driven with steps and sinusoids (0.5-500 Hz) and recorded whole-cell responses

72 samine/ET induced neutrophil accumulation in sinusoids (515 +/- 30 neutrophils/50 high power fields)

73 idal endothelial cells (LSEC) which line the sinusoids activate RNase L in response to NS2(H126R) The

74 spose to high infiltration of PMN in hepatic sinusoids after high-dose endotoxin administration were

75 ine hepatocytes are localized in the hepatic sinusoids after surgery and subsequently migrate out of

76 ritic cells; dendritic cells migrated out of sinusoids, after a delay, via the chemokine CX3CL1.

77 in portal vein radicles, as well as in liver sinusoids, albeit integration of cells in the liver pare

78 binding of circulating HCV within the liver sinusoids allowing subsequent transfer of the virus to u

79 lanted hepatocytes immediately entered liver sinusoids, along with attenuation of portal vein radicle

80 During embryonic development, discontinuous sinusoids also allow circulating hematopoietic progenito

81 stimulus sequence, rapidly presented random sinusoids, also produced the same effect, with layer 2/3

82 o showed significant dilatation of the liver sinusoids and an increase in inflammatory cells surround

83 ux of microbial product from the gut via the sinusoids and biliary tree.

84 atelets, neutrophils, and lymphocytes within sinusoids and central venules were also observed.

85 stribution of EPHB4 receptors in bone marrow sinusoids and ephrin B2 ligands in hematopoietic cells.

86 lls in the perfused rBELs colonize the liver sinusoids and express sinusoidal endothelial markers sim

87 om thymic-independent T cells of the hepatic sinusoids and intestinal mucosa.

88 ar cues that control MK polarization towards sinusoids and limit transendothelial crossing to proplat

89 be facilitated by CCL19 and CCL21 on hepatic sinusoids and lymphatics.

90 for both amplitude modulated and unmodulated sinusoids and matched across-ear intensity difference se

91 tissue-resident macrophages that line liver sinusoids and play an important role on host defense.

92 In particular, extravasation from sinusoids and portal venules (PV) was reduced by 91% and

93 5 mm in diameter by extrinsic compression of sinusoids and portal venules and narrowing caused by adh

94 ear stress were directly measured in hepatic sinusoids and postsinusoidal venules at 2-day intervals

95 al arrest, CD8 TE actively crawl along liver sinusoids and probe sub-sinusoidal hepatocytes for the p

96 or the two main modes of fly courtship song, sinusoids and pulse trains.

97 -dependent extravasation of neutrophils from sinusoids and reactive oxygen formation.

98 othelial proplatelet (PP) extensions into BM sinusoids and shed new platelets into the blood.

99 icrotubules with a 40 nm diameter within the sinusoids and space of Disse, consistent with immunotact

100 he liver and by preventing their egress from sinusoids and traversal of hepatocytes.

101 PP extensions from the interstitium into BM sinusoids and triggering the subsequent shedding of PPs

102 ctin was selectively up-regulated in hepatic sinusoids and veins where it was necessary for phagocyto

103 BM sinusoids and venules, but not adjacent bone vessels, su

104 ls promote cancer cell adhesion within liver sinusoids and, thereby, influence metastasis.

105 ollagen type IV (highly exposed in the liver sinusoids) and collagen type IV-dependent activation of

106 eukocyte accumulation, number of nonperfused sinusoids, and autofluorescence of reduced nicotinamide

107 o different blood-vessel structures known as sinusoids, and displays lineage-specific spatial and clo

108 initially develop normally together with the sinusoids, and HSPCs home to the resulting niche, but st

109 ormal nodal architecture, collapsed cortical sinusoids, and macrophage accumulation in malformed sinu

110 ncluding plasma exudation, filling of venous sinusoids, and mucosal edema were not induced in these n

111 th leukocyte endothelial adherence, occluded sinusoids, and new vessel formation in vivo.

112 rointestinal tract, renal tubules, and liver sinusoids, and their application to modeling organ-speci

113 -LDL, Ac-LDL was specifically endocytosed by sinusoids, and Tie2 expression was more pronounced in th

114 y revealed a mixing of blood and bile in the sinusoids, and validated the presence of increased serum

115 LPS-induced structural changes in the liver sinusoid are mediated by an LPS-induced Kupffer cell act

116 Hepatic sinusoids are an environment rich in antigen cross-prese

117 transplantation, hepatocytes entering liver sinusoids are engrafted, whereas cells entrapped in port

118 at control the positioning of B cells in the sinusoids are not understood.

119 These sinusoids arose around locally invasive tumors and were

120 ll progenitor cells (BM SPCs) repopulate the sinusoid as liver sinusoidal endothelial cells (LSECs).

121 tion of dimethylnitrosamine, repopulated the sinusoid as LSECs and reduced liver injury.

122 pid metabolism is presented which treats the sinusoid as the repeating unit of the liver rather than

123 in targets CD33(+) cells residing in hepatic sinusoids as the mechanism for its hepatic toxicity.

124 ectron microscopy showed the constriction of sinusoids associated with swollen or ruptured mitochondr

125 transcriptomics to map the heterogeneity of sinusoid-associated cells in healthy and injured livers

126 known as CSPG4)(+) pericytes, distinct from sinusoid-associated leptin receptor (LEPR)(+) cells.

127 M3 intensity changes were approximately sinusoid at low temperatures but became increasingly dis

128 through to the organization of the primitive sinusoid at single-cell resolution.

129 nits in M1 cortex were modulated solely as a sinusoid at the repetition rate of the stimulus for freq

130 panied by ultrastructural changes within the sinusoid at this time.

131 ocytes travel via lung capillaries and liver sinusoids at an extremely rapid rate with the average re

132 s do deliver insulin directly to the hepatic sinusoid because approximately 80% of the insulin is ext

133 square, 0.403 for triangular, and 0.421 for sinusoid), but underestimated the number of cycles requi

134 ing immature B cells leaving the bone marrow sinusoids, but above 90% of cloned apoptotic transitiona

135 t that sporozoites are first arrested in the sinusoid by binding to extracellular matrix proteoglycan

136 that circulating CD8 TE arrest within liver sinusoids by docking onto platelets previously adhered t

137 planted cells are rapidly cleared from liver sinusoids by proinflammatory cytokines/chemokines/recept

138 epithelial shunt between bile canaliculi and sinusoids by which bile constituents leaked into blood.

139 to form are greatly enlarged, pericyte-poor sinusoids, called mother vessels (MV), that originate fr

140 c changes that affect liver function such as sinusoid capillarization or loss of metabolic zonation a

141 Ductular proliferation, metabolic zonation, sinusoid capillarization, and hepatic stellate cell acti

142 ial cell signaling for angiogenesis or liver sinusoid capillarization, the mechanism for initiating t

143 cytes, while reducing the number of perfused sinusoids (capillary no-reflow).

144 portal inflammation, congested or compressed sinusoids, cell atrophy) correlated with leukocyte endot

145 LPS produced ultrastructural changes in the sinusoid characterized by morphological evidence of Kupf

146 large MK preplatelet fragments shed into the sinusoid circulation before terminal proplatelet remodel

147 transmission electron microscopy (TEM) show sinusoid compression resulting from increased hepatic pl

148 ed, small and has: iron deposition; immature sinusoids congested with blood; persistent erythropoieti

149 al of the flow direction without significant sinusoid constriction.

150 ), and significantly decreased the number of sinusoids containing blood flow per microscopic field (6

151 lded as a layered boustrophedon, with planar sinusoids containing interspersed CENP-A-rich and H3-ric

152 redistributed to form granulomas outside the sinusoids, creating an open sinusoidal niche that was gr

153 in-GFP+ or Mds1GFP/+Flt3Cre HSCs proximal to sinusoids, Cxcl12 stroma, megakaryocytes, and different

154 d), while 5 (square), 15 (triangle), and 10 (sinusoid) cycles were observed experimentally.

155 -associated pathologic findings (ie, swollen sinusoids, dehydrated cells, and hemorrhagic infiltrate)

156 Organoid-derived hepatocyte- and sinusoid-derived coagulation factors enable correction o

157 first 24 h after implantation in the hepatic sinusoid determines its potential to colonize the liver.

158 Liver sinusoid diameters decreased significantly with antiheps

159 gration of primed neutrophils sequestered in sinusoids during endotoxemia in vivo.

160 D8 T cells in the liver poorly attach to the sinusoids (e.g., 1 wk after immunization with radiation-

161 mplement-activation fragments throughout the sinusoids, elevated transaminase levels, increased hepat

162 evious work, two anatomically distinct-liver sinusoid endothelial cells (LEC): LEC-1 and LEC-2, have

163 hich is orchestrated with the development of sinusoid endothelial, stellate, and Kupffer cells.

164 that GT3-Nano accumulates in CD105-positive sinusoid epithelial cells.

165 ream, Plasmodium sporozoites cross the liver sinusoid epithelium, enter and exit several hepatocytes,

166 on their relative spatial location along the sinusoid from the portal triad to the central vein.

167 re was well fit by an exponentially decaying sinusoid function with a period of 4.5 A for distances g

168 R, a type 2 C-type lectin expressed on liver sinusoids, has been shown to bind with high affinity to

169 nd circulating leukocytes within the hepatic sinusoids have direct access to liver-resident cells, wh

170 typically crawl on the luminal side of liver sinusoids (i.e., are in the blood); simulating T cell mo

171 Upon infusion, sinusoid ILCPs can effectively restore peripheral ILC in

172 Sinusoid ILCPs emigrate from the BM to circulate the per

173 in digital structures derived from the liver sinusoids illustrates that liver structure alone is suff

174 ation of blood flow-dependent cell exit from sinusoids improved intrahepatic retention of LSEC to 89

175 by altered diameter of the hepatic veins and sinusoids in Bmpr2(+/-) mice.

176 associated with vascular injury in the liver sinusoids in clinical studies.

177 he waveform of the molecular clockworks from sinusoids in free-running conditions to highly asymmetri

178 led leukocytes and the number of nonperfused sinusoids in livers of control and adhesion molecule-def

179 correlates with erythrocyte-filled vascular sinusoids in marrows.

180 In mice it localizes to capillaries and sinusoids in most organs and in lung to larger vessels a

181 s of tonsil tissue, by cells associated with sinusoids in perifollicular areas of spleen tissue, and

182 s postinfection: diffuse spreading along the sinusoids in PIR-B(-/-) mice vs nodular restricted local

183 cells transition from the parenchyma to the sinusoids in the bone marrow of NOD mice and enter the p

184 selectively localize to a subset of VCAM1(+) sinusoids in the center of the diaphysis.

185 increase in the number and volume of venous sinusoids in the marrow that was associated with a reduc

186 and Tcf21(+) stromal cells, primarily around sinusoids in the red pulp, while Cxcl12 was expressed by

187 mation in vitro and enhanced HSC coverage of sinusoids in vivo.

188 ose frequency domain magnitude spectrum is a sinusoid increasing in frequency from one waveform to th

189 membrane capacitance (Cm) using two voltage sinusoids indicates that shifts in VpkCm induce Cm chang

190 mechanism by which the destruction of liver sinusoids, induced by the Jo2-mediated co-engagement of

191 that is necessary to maintain megakaryocyte-sinusoid interactions.

192 f zonated enzyme expression by splitting the sinusoid into periportal to pericentral compartments.

193 caused transformation of discontinuous liver sinusoids into continuous capillaries.

194 These cells translocated from sinusoids into liver plates between 16 and 20 hours afte

195 rms, which are released through the vascular sinusoids into the bloodstream.

196 atic artery was seen circulating through the sinusoids into the central venules.

197 The hepatic sinusoid is a unique vascular bed lined by hepatic sinus

198 ensions from megakaryocytes into bone marrow sinusoids is the best-described mechanism explaining the

199 ation potential waveforms (square, triangle, sinusoid) is demonstrated.

200 required for vascular homeostasis of hepatic sinusoids; it maintains quiescence and differentiation o

201 fully perfused human vessels with functional sinusoid-like features.

202 Spectroscopy reveals a sinusoid-like position-velocity structure that is well d

203 Here we report that the amplitude and the sinusoid-like shape of the variability of the light curv

204 led by ingrowth of blood vessels, displaying sinusoid-like structures and stabilized by pericytic cel

205 e to micropattern the self-assembly of liver sinusoid-like structures with micrometer resolution in v

206 Host livers contained large clusters of sinusoids lined by dipeptidyl peptidase IV positive endo

207 clearance by KC during locomotion inside the sinusoid lumen, before crossing the barrier.

208 ated close to Cxcl12 stroma and farther from sinusoids/megakaryocytes.

209 might increase portal pressure by promoting sinusoid microthrombi.

210 Most HCT-116-GFP-RFP cells remained in sinusoids near peripheral portal veins.

211 led leukocytes and the number of nonperfused sinusoids (NPS) were monitored (by intravital microscopy

212 assed by vessels similar to the capillarized sinusoids observed in the cirrhotic liver in humans.

213 ive pore size for sinusoids of 47 nm and non-sinusoids of 37 nm, with estimated maximum pore sizes of

214 models to predict an effective pore size for sinusoids of 47 nm and non-sinusoids of 37 nm, with esti

215 rem, signals can be decomposed into a sum of sinusoids of different frequencies.

216 Furthermore, neutrophils were observed in sinusoids of enlarged livers and spleens, suggesting tha

217 S. mansoni eggs lodge in the hepatic sinusoids of infected mice, resulting in hepatocyte deat

218 receptor agonist FTY720 emptied the cortical sinusoids of lymphocytes, blocked lymphatic endothelial

219 n the circulation for quiet transport to the sinusoids of spleen and liver where resident macrophages

220 vations that some "proplatelets" form in the sinusoids of the bone marrow before transmigration of in

221 hes an inductive vascular niche in the liver sinusoids of the Id1(-/-) mice, initiating and restoring

222 blood travel via capillaries in the lung or sinusoids of the liver and only 5% migrate to secondary

223 ings consisting of isoluminant red and green sinusoids of the same spatial frequency combined out-of-

224 and a rim of pale cytoplasm infiltrated the sinusoids of the spleen, liver, and bone marrow.

225 transplanted hepatocytes present in hepatic sinusoids or integrated in the parenchyma was greater in

226 of receptor-mediated cell adhesion in liver sinusoids or the manipulation of blood flow-dependent ce

227 This sinusoid pattern is more pronounced at higher latitudes

228 Electric fields were generated by sinusoid patterns at slow frequency (0.8, 1.25 or 1.7 Hz

229 After cell transplantation in hepatic sinusoids, perturbations in hepatic microcirculation alo

230 d receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind

231 of capillaries, high endothelial venule, and sinusoids produced abundant gp-Fy.

232 cies (ROS) state, whereas the more permeable sinusoids promote HSPC activation and are the exclusive

233 Sinusoids rapidly re-endothelialize within 48 hours of t

234 eneralized estimating equations, 4-parameter sinusoid regression, and generalized linear models were

235 to I/R and smaller increments in nonperfused sinusoids, relative to C57B1 mice.

236 itiates the release of platelets into vessel sinusoids remains largely elusive.

237 ronal populations, with the amplitude of the sinusoid representing the length of the vector and its p

238 t T cell accumulation in lymph node cortical sinusoids required intrinsic S1P1 expression and was ant

239 forces exist in high endothelial venules and sinusoids, respectively.

240 ncreased deposition of transplanted cells in sinusoids resulted in greater cell engraftment.

241 HL shows a sinusoid seasonal incidence pattern (p < 0.001).

242 of blood into bone marrow compartments, and sinusoids serve as a conduit to the bloodstream and as n

243 ransplanted hepatocytes entering the hepatic sinusoids showed superior survival.

244 ction in close association with bone VEC and sinusoids, signals mediating their interactions are not

245 s of T cells approached and engaged cortical sinusoids similarly in the presence or absence of FTY720

246 ing tumor cells, but may also injure hepatic sinusoids (sinusoidal obstruction syndrome; SOS).

247 Stromal cells lining the hepatic sinusoids, such as liver sinusoidal endothelial cells (L

248 ce was associated with reduced numbers in BM sinusoids, suggesting a role for S1P in BM egress.

249 thelial cells (LEC-1) located in the hepatic sinusoids support in vitro megakaryocytopoiesis from mur

250 re that neutrophils accumulated in the liver sinusoids suppress cytokine and chemokine mRNA expressio

251 canal electrode and low-frequency (<300 Hz) sinusoids that delivered maximally ~1% of the transcrani

252 al dominant disorder characterized by venous sinusoids that predispose to intracranial hemorrhage.

253 VVRs were also produced by single sinusoids that transiently increased BP and HR, by 70-90

254 tress, occurring in proximity to nonperfused sinusoids, that may contribute to liver injury.

255 lexity of studying individual regions of the sinusoid, the causes of this zone specificity and its im

256 induces neutrophil sequestration in hepatic sinusoids, the activation of proinflammatory transcripti

257 tocytes and endothelial cells lining hepatic sinusoids, the adrenal glands, and the ovary hydrolyzes

258 s accompany the formation of the caudal vein sinusoids, the other main component of the CHT niche, an

259 sence shows high protein expression in liver sinusoids, the venous sinuses of the red pulp in spleen,

260 eveal that when immature B cells are near BM sinusoids their motility is reduced, their morphology is

261 transplanted islets delivered to the hepatic sinusoids (therefore effectively restoring a portal mode

262 nd immature B cells entering and crawling in sinusoids; these immature B cells were displaced by CB2

263 e intestine, and in distinctive, thin-walled sinusoids this mixture passes over a large macrophage po

264 cession was fitted with a single-mode damped sinusoid to extract the Gilbert damping parameter.

265 enetrate cell barriers in the skin and liver sinusoid to reach their target cell, the hepatocyte, whe

266 ransmigration of leukocytes from the hepatic sinusoid to sites of tissue damage during the inflammato

267 onment before extending proplatelets through sinusoids to deliver platelets in the bloodstream.

268 ng the temporal information of low-frequency sinusoids to locations in the cochlea tuned to high freq

269 ategies to deposit cells into distal hepatic sinusoids, to disrupt sinusoidal endothelium for facilit

270 eye or ear, efficiency for detecting a short sinusoid (tone or grating) with few features is a substa

271 ophils relevant for the injury accumulate in sinusoids, transmigrate, and adhere to hepatocytes.

272 tional communication between hepatocytes and sinusoids underlies the self-organization of liver tissu

273 om the adult endothelium also led to dilated sinusoids, vascular shunts, and necrosis, albeit milder

274 Once mature, MK pierces through the sinusoid vessel, and the initial protrusion further elon

275 e in the bone marrow redistributed away from sinusoid vessels.

276 ron-microscopic examination of the rat liver sinusoid was performed in this study after in vivo treat

277 In addition, early adhesion within liver sinusoids was inhibited in the absence of neutrophils an

278 etic aplasia and erythrocyte-filled vascular sinusoids were apparent in marrows.

279 labeled leukocytes and number of nonperfused sinusoids were monitored by intravital microscopy in liv

280 f sinusoidal lining cells and destruction of sinusoids were observed, consistent with the characteris

281 resembled arterioles and bypassed the normal sinusoids were observed.

282 The numbers of perfused sinusoids were significantly reduced at each time point.

283 The liver sinusoids were the only capillaries in which EPCR was ex

284 phi, between the force and tip displacement sinusoids, were measured in the frequency range f ~ 0.2-

285 resistance to blood flow through the hepatic sinusoids when portal hypertension occurs in the absence

286 the vasculature, extending proplatelets into sinusoids, where circulating blood progressively fragmen

287 gely expressed on endothelial cells in liver sinusoids, whereas DC-SIGN is expressed on dendritic cel

288 e increased transplanted cell entry in liver sinusoids, whereas labetalol, nifedipine, CGRP, and gluc

289 n terms of idealized oscillators (modeled as sinusoids), which differ from biological oscillators in

290 They are located in hepatic sinusoid, which allows them to remove foreign materials,

291 For example, in the liver, discontinuous sinusoids, which are fenestrated capillaries with interc

292 ells are also involved in the contraction of sinusoids, which leads to increased intrahepatic pressur

293 ns of both glutathione and cysteine in liver sinusoids, which transforms the nanoparticle surface che

294 cted 2 (square), 3 (triangle), and 5 cycles (sinusoid), while 5 (square), 15 (triangle), and 10 (sinu

295 e chair and video image always resulted in a sinusoid with a peak velocity of 50 degrees /s.

296 Coating of cells or of liver sinusoids with natural collagen, natural laminin, or an

297 The fit of sinusoids with the 3.6 residues per turn period of ideal

298 tly after deposition of hepatocytes in liver sinusoids, with clearance of a significant fraction of t

299 s are best described as harmonically related sinusoids, with periods of approximately 1,000, 500 and

300 /N629D yolk sac vessels and aorta consist of sinusoids without normal arborization.