ライフサイエンスコーパス: siroheme

1 factor II), and iron insertion (factor II to siroheme).

2 hesis, xylan degradation and biosynthesis of siroheme.

3 elatase, a catalyst that inserts Fe(2+) into siroheme.

4 holoenzyme in the case of limiting cellular siroheme.

5 ion of uroporphyrinogen III (Uro'gen-III) to siroheme.

6 ts that cannot synthesize B12 but still make siroheme.

7 nd to an iron-containing porphyrinoid called siroheme.

8 ved in synthesis of both cobalamin (B12) and siroheme (a cofactor required for SO3(2-) and NO2(2-) re

9 he cluster are tuned by association with the siroheme, accessibility to solvent, and hydrogen bonds s

10 Later, evolution of the pathway produced siroheme, (allowing use of inorganic electron acceptors)

11 himurium, precorrin-2 is a precursor of both siroheme and B12.

12 tants are defective in the synthesis of both siroheme and cobalamin.

13 ligands decrease the bond length between the siroheme and the proximal cysteine thiolate shared with

14 red for the production of heme, vitamin B12, siroheme, and chlorophyll precursors.

15 naerobically on nitrate, proving the role of siroheme as a precursor to another cofactor.

16 alternative-haem-synthesis pathway, involves siroheme as an intermediate, which was previously though

17 the B12 defect but inhibits ability to make siroheme; B12 synthesis is inhibited by added iron.

18 R83 is primarily responsible for siroheme binding.

19 inding domain and Ser-755 within the (Fe4S4)-siroheme-binding domain of the nitrite reductase demonst

20 ion of a cDNA construct encoding the (Fe4S4)-siroheme-binding domain resulted in extracts possessing

21 Cys-757 within the (Fe4S4)-siroheme-binding domain was essential for native enzyme

22 uggest that an alternative enzyme allows for siroheme biosynthesis in CysG-deficient strains of Klebs

23 The CysG protein performs all three steps of siroheme biosynthesis in the enteric bacteria Escherichi

24 pha-proteobacteria as the terminal enzyme of siroheme biosynthesis.

25 nzyme B(12), suggesting that the alternative siroheme biosynthetic pathway proceeds by a different ro

26 ed side chains, ordered water molecules, and siroheme carboxylates coordinates, polarizes, and influe

27 ne side chains, ordered water molecules, and siroheme carboxylates provides preferred locations for r

28 in several different pathways to form heme, siroheme, chlorophyll, F(430) and vitamin B(12).

29 e counterparts, sulfite reductases require a siroheme cofactor for catalysis.

30 se) and nasF (required for nitrite reductase siroheme cofactor formation), constitute the nas operon.

31 nitrite reductases fall into three classes: siroheme-containing enzymes (NirBD), cytochrome c hemopr

32 d tetrapyrroles include chlorophylls, hemes, siroheme, corrins (including vitamin B(12)), coenzyme F(

33 While CysG is coregulated with the siroheme-dependent nitrite reductase, the cysF gene is r

34 and FAD-binding diflavin flavoprotein and a siroheme/Fe(4)S(4) cluster-containing hemoprotein.

35 In the oxidized (siroheme Fe3+, Fe4S42+) SiRHP crystal structure, the hig

36 groups two iron-sulfur (Fe4S4) clusters, two siroheme groups, and two FAD molecules.

37 ral partial activities in vitro, including a siroheme-independent NAD(P)H-cytochrome c reductase acti

38 eduction of the cofactors couples changes in siroheme iron coordination geometry to changes in active

39 ds studied, induces a spin transition in the siroheme iron, flips an active-site arginine, and orders

40 d by the protein always covalently links the siroheme (iron isobacteriochlorin) to the Fe4S4 cluster,

41 consisting of 3 alpha/beta domains with the siroheme-iron sulfur cofactor at the interface of the th

42 The siroheme is located at a distance of 4.2 A from the clus

43 An intermediately reduced enzyme, where the siroheme is mainly ferrous (+2) and the cluster cubane i

44 In Salmonella enterica serovar Typhimurium, siroheme is produced by a trifunctional enzyme, siroheme

45 The siroheme is surrounded by several ionizable amino acid r

46 Siroheme is the central cofactor in a conserved class of

47 nd K217) mitigate the negative charge on the siroheme macrocycle.

48 E. coli, containing FAD, FMN, [4Fe-4S], and siroheme moieties.

49 Cobalt toxicity results in decreased siroheme production, increased expression of the Fur reg

50 e purified protein suggest that DCP68 is the siroheme protein sulfite reductase, a ferredoxin-depende

51 The distorted conformation of the siroheme recognized by the protein potentially destabili

52 which require d1 -haem), the pathway to make siroheme remained to be identified.

53 s in the binding pocket is stabilized by the siroheme's sixth axial ligand-an exogenous phosphate ani

54 and the C-terminal half a dissimilatory-type siroheme sulfite reductase, and Fsr catalyzes the corres

55 oheme is produced by a trifunctional enzyme, siroheme synthase (CysG).

56 Gene cysF, encoding an alternative siroheme synthase homologous to CysG, has been identifie

57 alternative regulation of the CysF and CysG siroheme synthases in Klebsiella and for the loss of the

58 G gene (encoding the rate-limiting enzyme in siroheme synthesis) and co-transformation with plasmid p

59 pantotrophus that catalyses the last step of siroheme synthesis.

60 g that this chelatase can act in the in vivo siroheme synthesis.

61 iron-specific chelatase in the final step of siroheme synthesis.

62 r plants, which directs intermediates toward siroheme synthesis.

63 idines, His127 and His187, are essential for siroheme synthesis.

64 Siroheme, the cofactor for sulfite and nitrite reductase

65 Siroheme, the prosthetic group for both nitrite and sulf

66 On binding the siroheme, the substrate sulfite provides an oxygen atom

67 of a negatively charged porphyrinoid called siroheme whose central iron atom is coupled to a proxima