ライフサイエンスコーパス: sirtuin

1 two were acetylated but not deacetylated by sirtuin.

2 lso an efficient deacetylation substrate for sirtuins.

3 exity in the crosstalk between two different sirtuins.

4 the range of hydrolytic activities of human sirtuins.

5 NAD(+)-dependent deacylase activities of the sirtuins.

6 logical functions regulated by mitochondrial sirtuins.

7 e four amino acids is not conserved in human sirtuins.

8 o increase ER and DAF-12 coactivation by the sirtuins.

9 etylation that is regulated by both Gcn5 and sirtuins.

10 Sirtuin 1 (SIRT) mRNA levels were lower in PLAC when com

11 factor 1 (HES1) and the protein deacetylase sirtuin 1 (SIRT1) at the Isl1 gene.

12 Sirtuin 1 (SIRT1) binds, deacetylates, and thereby inact

13 und that higher abundance of the deacetylase sirtuin 1 (SIRT1) correlated with lower acetylation occu

14 eptor nuclear translocator-like (Arntl), and sirtuin 1 (Sirt1) expression.

15 of the NAD(+)-dependent lysine deacetylase, sirtuin 1 (SIRT1) in fibrogenesis in the cell culture, a

16 Sirtuin 1 (Sirt1) is a NAD(+)-dependent deacetylase capa

17 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide

18 The class III NAD-sirtuin 1 (SIRT1) is an important negative regulator of

19 Sirtuin 1 (SIRT1) is an NAD(+)-dependent deacetylase tha

20 The NAD(+)-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative b

21 Sirtuin 1 (SIRT1) is involved in both aging and circadia

22 The NAD(+)-dependent deacetylase Sirtuin 1 (SIRT1) regulates cell metabolism, proliferati

23 Sirtuin 1 (SIRT1) regulates liver regeneration and bile

24 Here, we propose that the nutrient sensor sirtuin 1 (Sirt1) regulates the production of CRH post-t

25 iency, along with significant suppression of sirtuin 1 (SIRT1) signaling pathway in the liver.

26 In animal studies, sirtuin 1 (SIRT1) was associated with protection against

27 We investigated how Sirtuin 1 (SIRT1), a conserved mammalian NAD(+)-dependen

28 ed activation of KRAS and over-expression of Sirtuin 1 (SIRT1), a histone deacetylase and gene silenc

29 The NAD(+)-dependent protein deacetylase sirtuin 1 (SIRT1), a key regulator of mammalian metaboli

30 e their known interaction in transactivating Sirtuin 1 (SIRT1), a NAD(+)-dependent histone deacetylas

31 Sirtuin 1 (SIRT1), an NAD(+) (nicotinamide adenine dinuc

32 evidence demonstrates the beneficial role of Sirtuin 1 (SIRT1), an NAD(+) dependant deacetylase, in i

33 Sirtuin 1 (SIRT1), an NAD(+)-dependent deacetylase, is a

34 leotide (NAD+)-dependent deacetylase enzyme, Sirtuin 1 (SIRT1), can prevent activation of these pathw

35 y several energy sensing pathways, including sirtuin 1 (SIRT1), forkhead box O (FoxO), AMP-activated

36 cers of fatty acid beta-oxidation, including sirtuin 1 (SIRT1), sirtuin 3 (SIRT3), and Nrf-1.

37 how that HAS2 expression can be modulated by sirtuin 1 (SIRT1), the master metabolic sensor of the ce

38 inhibitors and RA reduced HDAC1, HDAC4, and sirtuin 1 (SIRT1), which were involved in chromatin remo

39 eraction with the metabolic sensing protein, Sirtuin 1 (SIRT1).

40 ical and genetic approaches to show that the sirtuin 1 (SIRT1)/FoxO1 signaling pathway in the hypotha

41 ic ischemia-reperfusion and posttreated with sirtuin 1 activator, SRT1720 (20 mg/kg), or vehicle.

42 id hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signal

43 Pharmacologic stimulation of sirtuin 1 attenuates liver injury after hepatic ischemia

44 Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lys

45 tly inhibited the TLR4 activation, increased sirtuin 1 expression, and inhibited the subsequent infla

46 Sirtuin 1 is an energy-sensing enzyme known to modulate

47 ypothesized that pharmacologic activation of sirtuin 1 is protective after hepatic ischemia-reperfusi

48 in injury after SAH, primarily by increasing sirtuin 1 levels and inhibiting the TLR4 signaling pathw

49 The inhibitory action on Sirtuin 1 of approximately half of the proposed compound

50 However, sirtuin 1 was downregulated and so the accumulation of N

51 in liver PAFR was associated with increased sirtuin 1 while relocalized PAFR expression was limited

52 cade involving AMP-activated protein kinase, sirtuin 1, PGC-1alpha, sirtuin 3, estrogen-related recep

53 arget biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach,

54 NAMPT inhibits CXCR4 through a NAD/Sirtuin 1-mediated inactivation of HIF1alpha-driven CXCR

55 neurons, an effect that was reversed by the sirtuin 1-specific inhibitor sirtinol.

56 We observed that both sirtuins 1 and 7 (SIRT1 and SIRT7) are able to deacetyla

57 Sirtuin-1 (Sirt-1) plays a crucial role in various biolo

58 y decreased levels of the histone deactylase Sirtuin-1 (SirT-1) which has been previously shown to fu

59 chloroethylamide inhibited the expression of Sirtuin-1 (Sirt1) and Rictor, a component of mechanistic

60 NAD-dependent deacetylase sirtuin-1 (SIRT1) is a class III histone deacetylase tha

61 ducer, its role in OLT and interactions with sirtuin-1 (SIRT1), a key autophagy regulator, have not b

62 in states of nutrient and oxygen deprivation-sirtuin-1 (SIRT1), AMP-activated protein kinase (AMPK),

63 s activate low-energy sensors, which include sirtuin-1 (SIRT1), AMP-activated protein kinase (AMPK),

64 ue in response to lipolytic stimulation in a sirtuin-1 (SIRT1)-dependent manner via a mechanism that

65 Sirtuin-1 also inhibits cancer metastasis via increasing

66 miR-570 is also involved in reduction of sirtuin-1 and cellular senescence and is activated by p3

67 In summary, activation of hepatic AMPK/sirtuin-1 and FGF21/beta-klotho signaling pathways combi

68 3 expression and prevented downregulation of Sirtuin-1 and Foxo3alpha expression in IRPTCs by high gl

69 In vitro, hnRNP F overexpression stimulated Sirtuin-1 and Foxo3alpha with downregulation of acetylat

70 Loss of key antiaging molecules sirtuin-1 and sirtuin-6 may be important in acceleration

71 ithelial cells, using an antagomir, restores sirtuin-1 and suppresses markers of cellular senescence

72 AP, above 0.001%, enhanced the expression of sirtuin-1 and thermogenic uncoupling protein 1 (UCP-1) i

73 ors, AMP-activated protein kinase (AMPK) and sirtuin-1 are activated.

74 ve stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes.

75 as to determine whether differences exist in sirtuin-1 expression/activity in old vs. young liver gra

76 AMPK/sirtuin-1 inhibit the activity of STAT3 (signal transduc

77 Importantly, treating AAV-NT mice with a sirtuin-1 inhibitor markedly reversed many of the observ

78 iption via hnRNP F-responsive element in the Sirtuin-1 promoter.

79 tudies using inhibitors of PPARbeta/delta or sirtuin-1 showed that the tubulogenic effect of GW0742,

80 ervals, increasing NAD-dependent deacetylase sirtuin-1 signaling important for glucose and lipid meta

81 Transfection of Sirtuin-1 small interfering RNA prevented hnRNP F stimul

82 hnRNP F stimulated Sirtuin-1 transcription via hnRNP F-responsive element i

83 esis and ketogenesis is activation of SIRT1 (sirtuin-1) and its downstream mediators: PGC-1alpha (pro

84 roblast growth factor 21 (FGF21), targets of sirtuin-1, and beta-klotho, which can acts as a tumor su

85 C apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3alpha than nondiabetic kidneys.

86 Instead, triiodothyronine increased sirtuin-1, fibrillin-1, proliferator-activated receptor-

87 Sirtuin-1, Foxo3alpha, and catalase expression were sign

88 -570-3p rejuvenates cells via restoration of sirtuin-1, reducing many of the abnormalities associated

89 742, but not VEGF-A, was PPARbeta/delta- and sirtuin-1-dependent.

90 Furthermore, we identified that aging alters Sirtuin-1-hepatic nuclear factor 4alpha circuit in hepat

91 low AGE diets with increased adiponectin and sirtuin-1.

92 ignaling and drives senescence by inhibiting sirtuin-1.

93 nescence by restoring the antiaging molecule sirtuin-1.

94 signaling, plays a pivotal role in reducing sirtuin-1/6, and its inhibition with an antagomir result

95 heat shock proteins, antioxidant enzymes and sirtuin-1/PGC-1 signalling) are central to the protectiv

96 onsive E3 ubiquitin ligases targeting fungal sirtuin 2 (Sir2), an antioxidation regulator required fo

97 , we identified that the protein deacetylase sirtuin 2 (SIRT2) as a novel interactor of LMAN2.

98 rerequisite for its phosphorylation, whereas Sirtuin 2 (SIRT2) deacetylated MARCKS.

99 Derived from our previously reported human sirtuin 2 (SIRT2) inhibitors that were based on a 5-amin

100 Sirtuin 2 (SIRT2) is a protein lysine deacylase that has

101 Sirtuin 2 (SIRT2) is a sirtuin family deacetylase, which

102 cotinamide phosphoribosyltransferase (NAMPT)/sirtuin 2 (SIRT2) pathway.

103 munoblotting and kinase assays, we show that sirtuin 2 (SIRT2), a member of the NAD-dependent protein

104 Sirtuin 2 (SIRT2), one of the mammalian nicotinamide ade

105 dulators, NAD+ dependent histone deacetylase Sirtuin 2 (SIRT2), which upon infection translocate to t

106 esting of synthetic substrates of S. mansoni sirtuin 2 (SmSirt2) and kinetic experiments on a myristo

107 chanistic insight into the interplay between sirtuin 2 and alpha-synuclein, the major component of th

108 nstrating the potential therapeutic value of sirtuin 2 inhibition in synucleinopathies.

109 Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the leve

110 Sirtuin 2 was previously shown to modulate proteotoxicit

111 and that these residues are deacetylated by sirtuin 2.

112 and the NAD(+)-dependent tubulin deacetylase sirtuin-2 (SIRT2) play key roles in oligodendrocyte diff

113 cetylation was elevated because of decreased sirtuin-2 expression, thereby promoting loss of PCK1.

114 onal repression of mitochondrial deacetylase sirtuin 3 (SIRT3) by androgen receptor (AR) and its core

115 Sirtuin 3 (SIRT3) deacetylates and regulates many mitoch

116 Sirtuin 3 (SIRT3) detoxifies mitochondrial reactive oxyg

117 functional significance of the mitochondrial sirtuin 3 (SIRT3) in melanoma.

118 The mitochondrial sirtuin 3 (SIRT3) is involved in suppressing the onset o

119 The mitochondrial deacetylase sirtuin 3 (SIRT3) is thought to be one of the main contr

120 Sirtuin 3 (SIRT3) mediates histone protein post-translat

121 beta-oxidation, including sirtuin 1 (SIRT1), sirtuin 3 (SIRT3), and Nrf-1.

122 ly with oxidative phosphorylation Complex I, sirtuin 3 and succinate dehydrogenase.

123 the NAD(+)-dependent deacetylase activity of sirtuin 3 to inhibit superoxide dismutase 2 (SOD2) activ

124 ALE: Clinical studies have shown that Sirt3 (Sirtuin 3) expression declines by 40% by 65 years of age

125 The mitochondrial deacetylase Sirt3 (Sirtuin 3) is critical in the regulation of metabolic an

126 SIRT3 (sirtuin 3) is the major deacetylase within the mitochond

127 rAT (carnitine acetyltransferase) and Sirt3 (sirtuin 3)-enzymes that oppose Kac by buffering the acet

128 vated protein kinase, sirtuin 1, PGC-1alpha, sirtuin 3, estrogen-related receptor-alpha, and Nrf-1; i

129 gnificantly induce mitochondrial deacetylase sirtuin-3 (SIRT3) activity, disrupted mitochondrial stru

130 We examined Sirtuin-3 (Sirt3) co-expressed gene sets extracted from

131 Sirtuin-3 (Sirt3) is a mitochondrial deacetylase that co

132 Here, we found that Sirtuin 4 (SIRT4) interacts with PTEN and regulates its

133 Sirtuin 5 (SIRT5) is a mitochondrial-localized NAD(+)-de

134 he discovery of the most potent inhibitor of sirtuin 5 (SIRT5) reported to date.

135 Sirtuin 5 (Sirt5), which localizes to both mitochondria

136 lysine succinylation, which is regulated by sirtuin 5 (SIRT5).

137 models and biochemical assays, we show that sirtuin 6 (SIRT6) deficiency plays a major role in aging

138 NAD + dependent Sirtuin 6 (SIRT6) is a glucose homeostasis regulator in

139 Sirtuin 6 (SIRT6) is a nuclear NAD(+)-dependent deacetyl

140 Sirtuin 6 (SIRT6) is a sirtuin family member involved in

141 Mammalian Sirtuin 6 (Sirt6) is an NAD(+)-dependent protein deacyla

142 The class III histone deacetylase sirtuin 6 (SIRT6) modulates numerous functions in the ce

143 The histone deacetylase sirtuin 6 (SIRT6) regulates numerous biological function

144 by the NAD(+)-dependent histone deacetylase Sirtuin 6 (SIRT6) that is critical for suppression of pa

145 Inhibition of sirtuin 6 (SIRT6), a histone deacetylase repressor of gl

146 SIRT6 (sirtuin 6) is a member of sirtuin family of deacetylases

147 SIRT6 (Sirtuin 6) is a nuclear deacetylase involved in DNA dama

148 Sirtuin 6, SIRT6, is critical for both glucose and lipid

149 oss of key antiaging molecules sirtuin-1 and sirtuin-6 may be important in acceleration of aging and

150 Sirtuin 7 (SIRT7), an NAD(+)-dependent deacetylase, play

151 Sirtuins, a family of protein deacetylases, promote cell

152 Although dietary sirtuin-activating compounds (dSTACs) including resverat

153 Research shows that resveratrol, a sirtuin activator in red wine, improves exercise enduran

154 ther dissect the regulation of both Gcn5 and sirtuin activities in vivo.

155 Our findings suggest that targeting sirtuin activities may offer an avenue in the developmen

156 Although multiple reports suggest that sirtuin activity is regulated by oxidative post-translat

157 ts oxidative damage, maintains mitochondrial sirtuin activity, and prevents metabolic stress-induced

158 erstanding of sirtuin targets, regulation of sirtuin activity, and the relationships between sirtuins

159 and hepatosteatosis by dioxin and increased sirtuin activity, providing a therapeutic approach for p

160 o increased poly(ADP-ribosyl) polymerase and sirtuin activity, suggesting an increased cellular deman

161 ied class of compounds capable of inhibiting sirtuin activity, which is thought to result in increase

162 m of the NAD+ salvage pathway due to reduced sirtuin activity.

163 The impact of sirtuin and PARP inhibition was also explored.

164 s, programmed cell death, synaptic function, sirtuins and aging, and insulin resistance, all processe

165 ng protein/p300 acetylated FUS, whereas both sirtuins and histone deacetylases families of lysine dea

166 a reduction in antiaging molecules, such as sirtuins and Klotho, which further accelerate the aging

167 dria approximate the Michaelis constants for sirtuins and PARPs in their respective compartments.

168 otide (NAD(+)) is an essential substrate for sirtuins and poly(adenosine diphosphate-ribose) polymera

169 tivity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases.

170 NAD-dependent signaling (e.g., by sirtuins and poly-adenosine diphosphate [ADP] ribose pol

171 The development of monoclonal antibodies, sirtuins, and cyclopropovir may provide new treatment op

172 enzymes (e.g. poly(ADP-ribose) polymerases, sirtuins, and others).

173 Sirtuins are class III histone deacylases that use NAD(+

174 expression is highest in the heart and that sirtuins are commonly stress-response proteins, we used

175 Modulators of sirtuins are considered promising therapeutic targets fo

176 Gcn5 and sirtuins are highly conserved histone acetyltransferase

177 Sirtuins are important regulators of lysine acylation, w

178 rapamycin, AMP-activated protein kinase and sirtuins are key regulators of autophagy.

179 Sirtuins are NAD(+) dependent protein deacetylases, whic

180 Sirtuins are NAD(+)-dependent enzymes universally presen

181 Sirtuins are NAD(+)-dependent lysine deacylases, regulat

182 Sirtuins are NAD(+)-dependent protein deacylases that cl

183 Sirtuins are protein deacylases regulating metabolism an

184 These enzymes, along with the sirtuins, are collectively responsible for reversing lys

185 vo These data suggest a re-evaluation of the sirtuins as direct sensors of the NAD(+)/NADH ratio.

186 Several studies have described the sirtuins as sensors of the NAD(+)/NADH ratio, but it has

187 foundation for future studies investigating sirtuin-based therapies.

188 sttranslational modifications, and show that sirtuins can act as erasers of HibK modified proteins.

189 l significance of lysine fatty acylation and sirtuin-catalyzed protein lysine defatty-acylation.

190 on-redox NAD(+)-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases.

191 This makes the sirtuin class of enzymes interesting targets for develop

192 nt work indicates that SIRT1 and orthologous sirtuins coactivate the oestrogen receptor/ER and the wo

193 Different sirtuins control similar cellular processes, suggesting

194 ematic comparative study of potential direct sirtuin cysteine oxidative modifications has been perfor

195 discrepancies involving effects of sir-2.1 (sirtuin deacetylase) on ageing, and show that in a fln-2

196 Although early studies showed that sirtuins deacetylated lysines in a reaction that consume

197 ARP-enzymes (mono/poly-ADP-ribosylation) and sirtuins (deacetylation).

198 All tested sirtuin deacylase activities showed sensitivity to NADH

199 We report 1) modulation of a bacterial sirtuin deacylase activity by acetylation, 2) that the G

200 s in an NAD(+)-dependent manner, and loss of sirtuin deacylase activity correlates with the developme

201 we report that, in Salmonella enterica, the sirtuin deacylase CobB long isoform (CobB(L)) is N-termi

202 ied CoA ligases were under NAD(+) -dependent sirtuin deacylase reversible lysine (de)acetylation cont

203 Here, we investigated the role of the sirtuin deacylase Sirt5 in MCT metabolism by feeding Sir

204 Sirtuins (e.g. human Sirt1-7) catalyze the removal of ac

205 results thus provide a structural basis for Sirtuin effects of quercetin-related compounds and helpf

206 The sirtuin enzymes are important regulatory deacylases in a

207 nzymatic activity of the histone deacetylase sirtuin family (SIRT1, SIRT2, SIRT3, SIRT5 and SIRT6) us

208 roto member of the proteins in the mammalian sirtuin family and plays multiple roles in aging and dis

209 Sirtuin 2 (SIRT2) is a sirtuin family deacetylase, which maintains genome integ

210 ial cross-regulatory interactions within the sirtuin family is still limited.

211 Sirtuin 6 (SIRT6) is a sirtuin family member involved in a wide range of physio

212 Here we show that the sirtuin family member SIRT7 participates in the epigenet

213 SIRT6 (sirtuin 6) is a member of sirtuin family of deacetylases involved in diverse proce

214 trated that SIRT6, a member of the mammalian sirtuin family of enzymes, can remove the fatty acyl mod

215 ls and highlights how SIRT7, a member of the sirtuin family of protein deacylases and mono-ADP ribosy

216 The sirtuin family of proteins catalyze the NAD(+)-dependent

217 In particular, we review the biology of the sirtuin family of proteins, the insulin/insulin-like gro

218 SIRT6 is a chromatin-bound member of the sirtuin family, implicated in regulating many cellular p

219 Targeting sirtuins for cancer treatment has been a topic of debate

220 Sirtuin genes have been associated with aging and are kn

221 Sirtuins have been shown to possess NAD(+)-dependent des

222 3 are robust deacetylases, whereas the other sirtuins have preferences for longer acyl chains.

223 association between class I, II, or IV (non-sirtuin) HDACs and linker histones has been reported.

224 However, the pivotal targets for sirtuins in cancer are mainly unknown.

225 rescent probe (EGFP-K85AcK) that responds to sirtuins in living cells.

226 tify novel nonhistone substrates of Gcn5 and sirtuins in yeast and found a shared target consensus se

227 that the probe can respond to various human sirtuins, including SIRT1, SIRT2, SIRT3 and SIRT5.

228 s may causatively link nuclear and cytosolic sirtuin inhibition to aging-related inflammatory disease

229 e developed a mitochondrial-targeted class I sirtuin inhibitor, YC8-02, which phenocopied the effects

230 siRNA or treated with nicotinamide (NAM), a sirtuin inhibitor.

231 Due to the strong effects of human sirtuin inhibitors on parasite survival and reproduction

232 nowledge of HDACi (both class I/II HDACi and sirtuin inhibitors) targeted to the main human parasitic

233 This work reveals sirtuin interactions with numerous functional modules wi

234 ding and activity effects on Sirt6 and other Sirtuin isoforms and solved crystal structures of compou

235 ut showing any significant increase in other sirtuin isoforms.

236 on to the well established activities of the sirtuins, "long chain" acyllysine modifications were als

237 rapies that regulate NAD+ and thereby target sirtuins may be beneficial in human diabetic sensory pol

238 olism through histone hyper-acetylation, and Sirtuin-mediated silencing of starvation-induced subtelo

239 an also be added by other enzymes, including sirtuins or bacterial toxins.

240 inhibition was not caused by suppression of sirtuins or PARP1, and 4) phosphorylation of several pro

241 The sirtuin pathway may represent a target for intervention

242 and poly(ADP-ribose) polymerase also reduce sirtuin, PGC-1alpha, and AMP-activated protein kinase ac

243 ivated) by the NAD(+) -dependent (class III) sirtuin protein deacetylase (hereafter SaCobB).

244 on proteomics to elucidate the mitochondrial sirtuin protein interaction landscape.

245 together, our results uncover a link between sirtuin proteins and direct control over cellular iron h

246 he combination of the unique features of the sirtuin rearranging ligands (SirReals) as highly potent

247 The sirtuin rearranging ligands (SirReals) have recently bee

248 ty of sirtuins with a focus on how different sirtuins recognize distinct substrates and thus carry ou

249 tuin activity, and the relationships between sirtuins remains a key challenge in mitochondrial physio

250 Moreover, other Sirtuins share some DSB-binding capacity and DDR activat

251 es that use exploitative mimicry to modulate sirtuin signalling through steroid receptors.

252 gly, resveratrol non-monotonically modulates sirtuin signalling, suggesting that it may induce hormes

253 arkedly changes histone acetylation, and the sirtuin Sir2/SIRT1 that deacetylates histones and transc

254 preserving the NAD(+)-dependent deacetylase sirtuin (Sirt) 1 in human macrophages.

255 malian cells, histone deacetylase (HDAC) and Sirtuin (SIRT) are two families responsible for removing

256 One such factor is the sirtuin (SIRT) family of nicotinamide adenine dinucleoti

257 Acetylation of NAT1 was enhanced by the sirtuin (SIRT) inhibitor nicotinamide but not by the his

258 ivation of the class III histone deacetylase sirtuin (SIRT)-1.

259 NR prevents and reverts NAFLD by inducing a sirtuin (SIRT)1- and SIRT3-dependent mitochondrial unfol

260 , transcription factor A, mitochondrial, and Sirtuin (Sirt)3 and Sirt1 expression in whole lungs and

261 p300/CBP in situ and is deacetylated by the sirtuins SIRT1 and 2.

262 We show that the primarily nuclear sirtuins Sirt1 and Sirt6, as well as the primarily cytos

263 Small molecule activators for the human sirtuins Sirt1-7 are sought as chemical tools and potent

264 Sirtuins (SIRT1-7) are NAD-dependent proteins with the e

265 Humans encode seven sirtuins (Sirt1-7), and recent studies have suggested th

266 , ADP-ribosyl cyclases (CD38 and CD157), and sirtuins (SIRT1-7).

267 Sirtuins (Sirt1-Sirt7) are NAD(+)-dependent protein deac

268 The best-studied sirtuin, SIRT1, counteracts aging- and obesity-related d

269 te kinase (PKM2) as a critical target of the sirtuin SIRT2 implicated in cancer.

270 nd Sirt6, as well as the primarily cytosolic sirtuin Sirt2, are modified and inhibited by cysteine S-

271 Surprisingly, the mitochondrial sirtuins Sirt3 and Sirt5 were resistant to inhibition by

272 Mitochondrial sirtuins, SIRT3-5, are NAD(+)-dependent deacylases and A

273 In mitochondria, the sirtuin SIRT5 is an NAD(+)-dependent protein deacylase t

274 hts into regulation of the tumor suppressive sirtuin SIRT6 and its implications for the development o

275 riggers degradation of the tumor-suppressive sirtuin SIRT6 in hepatocellular carcinoma.

276 The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activit

277 The enzymatic activity of the mammalian sirtuin SIRT7 targets acetylated lysine in the N-termina

278 Sirtuins (Sirts) are implicated in regulating a myriad o

279 Sirtuins (SIRTs) are NAD(+)-dependent deacylases that pl

280 Sirtuins (SIRTs) are NAD-dependent deacylases, known to

281 eacetylases (HDACs) and the NAD(+) dependent sirtuins (SIRTs) in the DNA damage response (DDR).

282 Sirtuins (SIRTs), central regulators of the aging proces

283 hat several histone deacetylases (HDACs) and sirtuins (SIRTs), including HDACs 2, 7, 8, and 11 and SI

284 ch as CD38, poly-ADP-ribose polymerases, and sirtuins (SIRTs).

285 d 9, and Silent information regulator genes (sirtuins [SIRTs]) 6 and 7 were significantly high in HBE

286 However, other reported sirtuin substrate proteins such as cyclophilin D, supero

287 protein structure is a major determinant of sirtuin substrate specificity.

288 es within mitochondria, identifies candidate sirtuin substrates, and uncovers a fundamental role for

289 However, a comprehensive understanding of sirtuin targets, regulation of sirtuin activity, and the

290 SIRT2 is a cytoplasmic sirtuin that plays a role in various cellular processes,

291 d uncovered the unexpected contribution of a sirtuin to heterochromatin dynamics.

292 lly mimic gonadal steroid hormones, enabling sirtuins to transduce the cognate signals through a cons

293 roach can be used to examine the activity of sirtuins toward additional lysyl posttranslational modif

294 ld not be removed by the histone deacetylase sirtuin type 1.

295 erring the silencing and show it to encode a sirtuin-type histone deacetylase.

296 The activity of mitochondrial sirtuins was reduced in livers of the KO mice.

297 asite survival and reproduction, Schistosoma sirtuins were postulated as potential therapeutic target

298 SIRT6, a sirtuin with established tumor suppressor function, regu

299 ure, chemistry, and substrate specificity of sirtuins with a focus on how different sirtuins recogniz

300 underlie the distinct roles of the different sirtuins within a given organism.

301 lated with Zn(2+) release from the conserved sirtuin Zn(2+)-tetrathiolate and a loss of alpha-helical