ライフサイエンスコーパス: sister chromatid

1 ls necessary for homologous pairing with the sister chromatid.

2 s length, with both effects independent of a sister chromatid.

3 tween chains, and entrap proximal strands of sister chromatids.

4 central core, which may physically separate sister chromatids.

5 and is required to promote bi-orientation of sister chromatids.

6 n and biases repair of DSBs to homologs over sister chromatids.

7 ndle during mitosis to capture and segregate sister chromatids.

8 on during mitosis depend on cohesion between sister chromatids.

9 lity for global recombination repair between sister chromatids.

10 hile maintaining close parallel alignment of sister chromatids.

11 lete replication and faithful segregation of sister chromatids.

12 d transcription take place in the context of sister chromatids.

13 mitotic recombination occurs solely between sister chromatids.

14 es generate mechanical forces that segregate sister chromatids.

15 mains that form separately within individual sister chromatids.

16 s that a single cohesin complex entraps both sister chromatids.

17 stablishes cohesion between newly replicated sister chromatids.

18 hes interactions between and along identical sister chromatids.

19 uires both compaction and disentanglement of sister chromatids.

20 iated with non-disjunction and catenation of sister chromatids.

21 genomic content between the loops formed on sister chromatids.

22 on through rampant unequal exchanges between sister chromatids.

23 hromosomes rather than the equally available sister chromatid, a bias that in Saccharomyces cerevisia

24 and Cyclin B, leading to the dissolution of sister chromatids and anaphase onset [1].

25 ngs containing the REC8 kleisin subunit bind sister chromatids and anchor chromosomes to the axis.

26 ein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate

27 e cohesin complex that regulates cohesion of sister chromatids and gene transcription.

28 t is associated with faithful segregation of sister chromatids and has been identified as dysfunction

29 histones are differentially incorporated by sister chromatids, and how epigenetically distinct siste

30 DSB repair occurs as replicated sister chromatids are connected to a polymerized axis.

31 Sister chromatids are held together by cohesin, a tripar

32 rom Separase-mediated cleavage ensuring that sister chromatids are kept together until their separati

33 Along arms, sister chromatids are less precisely aligned, with inter

34 e show that the structural axes of separated sister chromatids are linked by evenly spaced "mini-axis

35 In these cells, sister chromatids are not properly paired, and binding o

36 recombination during cell cycle phases when sister chromatids are present.

37 While sister chromatids are segregated from one another in mit

38 chromatids, and how epigenetically distinct sister chromatids are specifically recognized and segreg

39 During recombination, sister chromatids are tethered as loops to a polymerized

40 Sister chromatids are tethered together by the cohesin c

41 association of cohesins along the length of sister chromatid arms.

42 ntial enzyme that resolves catenanes between sister chromatids as well as supercoils associated with

43 factors in undamaged cells causes diminished sister chromatid association at centromeric sequences.

44 We find precise alignment of sister chromatids at centromeres.

45 attern in which both homologs separate their sister chromatids at meiosis I; detect selection for hig

46 egregation at meiosis I but also the fate of sister chromatids at meiosis II.

47 Human sister chromatids at metaphase are primarily linked by c

48 complex, which ensures proper segregation of sister chromatids at mitosis by mediating the interactio

49 al weak H3T3ph signals occur between cohered sister chromatids at prometaphase.

50 During mitosis, duplicated sister chromatids attach to microtubules emanating from

51 d asymmetric components, which ensure biased sister chromatid attachment and segregation during ACD o

52 Sister chromatid attachment during meiosis II (MII) is m

53 inking DSB repair pathway choice directly to sister chromatid availability.

54 ndant role for DNA ligase 1 in the fusion of sister chromatids bearing targeted double strand DNA bre

55 vents precocious DSB strand exchange between sister chromatids before homologs have completed pairing

56 's ability to ensure accurate segregation of sister chromatids, but, as in centromere localization, t

57 3 acetylation locks cohesin rings around the sister chromatids by counteracting an activity associate

58 has been implicated in the alignment of four sister chromatids by forming parallel guanine quadruplex

59 The tethering together of sister chromatids by the cohesin complex ensures their a

60 to template switches between homologs versus sister chromatids by using microhomology to prime DNA re

61 ucleate or multinucleate, and the replicated sister chromatids can remain attached and aligned, produ

62 ) is essential for mitosis since it resolves sister chromatid catenations.

63 Along sister chromatids, cohesin results in the formation of l

64 3) heterodimeric ATPase, the kleisin subunit sister chromatid cohesion 1 (Scc1) that links the two AT

65 The sister chromatid cohesion 2 and 4 (Scc2-Scc4) complex lo

66 gulator of genome architecture with roles in sister chromatid cohesion and chromosome compaction.

67 gion of autosomes leads to premature loss of sister chromatid cohesion and chromosome missegregation,

68 Despite key roles in sister chromatid cohesion and chromosome organization, t

69 alleles are inviable and defective for both sister chromatid cohesion and condensation.

70 essential roles in chromosome condensation, sister chromatid cohesion and DNA repair.

71 n origins is important for establishing both sister chromatid cohesion and enhancer-promoter communic

72 or how SA and DNA replication help establish sister chromatid cohesion and facilitate enhancer-promot

73 topologically around chromosomes to mediate sister chromatid cohesion and facilitate long-range cont

74 n is a chromatin-bound complex that mediates sister chromatid cohesion and facilitates long-range int

75 hroughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin str

76 rates long-range DNA interactions to mediate sister chromatid cohesion and other aspects of chromosom

77 DNA replication, to promote establishment of sister chromatid cohesion and possibly other post-replic

78 topoisomerase and PARP inhibitors, defective sister chromatid cohesion and reduced DNA replication fo

79 NA helicase domain of DDX11 is essential for sister chromatid cohesion and resistance to G4 stabilize

80 xhibited defects in chromosomal congression, sister chromatid cohesion and spindle positioning, there

81 ng Smc3, but their relative contributions to sister chromatid cohesion are unknown.

82 cancer-associated SA2 mutation that supports sister chromatid cohesion but is unable to repress trans

83 t role for an lncRNA in the establishment of sister chromatid cohesion by modulating DDX11 enzymatic

84 c genome by extruding DNA loops and mediates sister chromatid cohesion by topologically entrapping DN

85 Sister chromatid cohesion conferred by entrapment of sis

86 Here, we show that Ctf18-RFC's role in sister chromatid cohesion correlates with PCNA loading b

87 Initiation of sister chromatid cohesion depends on a separate complex,

88 Cohesins establish sister chromatid cohesion during S phase and are removed

89 h modify cohesin's Smc3 subunit to establish sister chromatid cohesion during S phase, but differ in

90 In addition to mediating sister chromatid cohesion during the cell cycle, the coh

91 s suggest that Pds5's role in maintenance of sister chromatid cohesion during the mitotic prophase-an

92 Sister chromatid cohesion essential for mitotic chromoso

93 coordinates replication fork progression and sister chromatid cohesion establishment.

94 Timely resolution of sister chromatid cohesion in G2/M is essential for genom

95 USP13 was dispensable for sister chromatid cohesion in HCT116 and HeLa cells, wher

96 Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wi

97 ver, mtrm-null females are sterile [13], and sister chromatid cohesion is abolished on all chromosome

98 Sister chromatid cohesion is essential for tension-sensi

99 Sister chromatid cohesion is established during replicat

100 moters and transcriptional enhancers, or how sister chromatid cohesion is established.

101 Sister chromatid cohesion is intact in FACT-depleted cel

102 a decrease in securin that ultimately causes sister chromatid cohesion loss.

103 vering an unexpected link between stress and sister chromatid cohesion loss.

104 Sister chromatid cohesion mediated by the cohesin comple

105 The prevailing embrace model for sister chromatid cohesion posits that a single cohesin c

106 In vertebrates, sister chromatid cohesion requires the activity of the E

107 The cohesin protein complex mediates sister chromatid cohesion to ensure accurate chromosome

108 g S phase is accompanied by establishment of sister chromatid cohesion to ensure faithful chromosome

109 Thus, STAG1 and STAG2 support sister chromatid cohesion to redundantly ensure cell sur

110 In addition, defective sister chromatid cohesion was observed in five HNSCC cel

111 mediates DNA-DNA interactions both between (sister chromatid cohesion) and within chromosomes (DNA l

112 Failure to repair DNA damage or defective sister chromatid cohesion, a process essential for corre

113 Mitotic chromosome condensation, sister chromatid cohesion, and higher order folding of i

114 some metabolism modules, DNA replication and sister chromatid cohesion, and inactivated a third, the

115 omosome segregation, chromosome maintenance, sister chromatid cohesion, and mitotic chromosome compac

116 Pds5 is required for sister chromatid cohesion, and somewhat paradoxically, t

117 Cohesin mediates sister chromatid cohesion, but this is not always pertur

118 is a conserved protein complex required for sister chromatid cohesion, chromosome condensation, DNA

119 n chromosome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA

120 The cohesin complex regulates sister chromatid cohesion, chromosome organization, gene

121 component of the Smc5/6 complex, involved in sister chromatid cohesion, chromosome segregation, and D

122 chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptiona

123 in genome organization includes functions in sister chromatid cohesion, DNA repair, and transcription

124 multi-subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damag

125 mplex that regulates 3D genome organization, sister chromatid cohesion, gene expression, and DNA repa

126 In addition to its role in sister chromatid cohesion, genome stability and integrit

127 iotic prophase chromosome axis that mediates sister chromatid cohesion, homologous recombination and

128 s several major mitotic processes, including sister chromatid cohesion, kinetochore-microtubule attac

129 lls depleted of CONCR show severe defects in sister chromatid cohesion, suggesting an essential role

130 n proliferating cells, cohesin also mediates sister chromatid cohesion, which is essential for chromo

131 Sister chromatid cohesion, which is mediated by the cohe

132 e checkpoint activation and establishment of sister chromatid cohesion.

133 anochemistry may occur before dissolution of sister chromatid cohesion.

134 function as antagonists to regulate meiotic sister chromatid cohesion.

135 ith distinct sites on chromosomes to mediate sister chromatid cohesion.

136 ase activity, is required for Chl1's role in sister chromatid cohesion.

137 assembly, assembly, and the establishment of sister chromatid cohesion.

138 and helicase involved in DNA replication and sister chromatid cohesion.

139 ons in PDS5A or STAG2 resulted in inadequate sister chromatid cohesion.

140 acetylation of cohesin establishes enduring sister chromatid cohesion.

141 ion precedes the S-K entrapment required for sister chromatid cohesion.

142 cial for DNA replication but dispensable for sister chromatid cohesion.

143 and stalling, while simultaneously promoting sister chromatid cohesion.

144 nnected by the combination of crossovers and sister chromatid cohesion.

145 s known role in mediating DNA repair through sister chromatid cohesion.

146 on at the centromere region until release of sister-chromatid cohesion at the metaphase II/anaphase I

147 physically interacts with Naa50, rescues the sister-chromatid cohesion defects and the resulting mito

148 has previously been shown to play a role in sister-chromatid cohesion in metazoans.

149 they modify different effectors and regulate sister-chromatid cohesion in opposing ways.

150 Sister-chromatid cohesion is established by Eco1-mediate

151 ilitating the recruitment of kinetochore and sister-chromatid cohesion proteins, both required for co

152 During the cell cycle, sister-chromatid cohesion tethers sister chromatids toge

153 proteins SOLO, SUNN, and ORD is required for sister-chromatid cohesion, localizes to the centromeres

154 esins, which load during S phase and mediate sister-chromatid cohesion, usually occur as individual c

155 Kleisin-like protein and ORD is required for sister-chromatid cohesion, we tested the hypothesis that

156 favoring homologous recombination linked to sister-chromatid cohesion.

157 on, and a stable complex may be required for sister-chromatid cohesion.

158 mosomes to promote chromosome compaction and sister-chromatid cohesion.

159 icated DNA, fully replicated and intertwined sister chromatids--commonly referred to as DNA catenatio

160 llows study of the complex interplay between sister chromatid compaction and their segregation during

161 d pairs inside TADs and is required to focus sister-chromatid contacts at TAD boundaries.

162 n DNA sequence, making recombination between sister chromatids difficult to detect.

163 ls, where they are the consequence of failed sister chromatid disentanglement during chromosome compa

164 lexes ensure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mit

165 Separases are large proteins that mediate sister chromatid disjunction in all eukaryotes.

166 indle assembly checkpoint (SAC) ensures that sister chromatids do not separate until all chromosomes

167 al role in the dissolution of cohesion among sister chromatids during chromosome segregation.

168 x subunit SMC3 to regulate the separation of sister chromatids during mitosis and meiosis.

169 To separate replicated sister chromatids during mitosis, eukaryotes and prokary

170 ts are essential for faithful segregation of sister chromatids during mitosis.

171 nt (SAC) ensures the accurate segregation of sister chromatids during mitosis.

172 sis for partitioning epigenetically distinct sister chromatids during stem cell ACDs, which opens new

173 he symmetric tethering of plasmid sisters to sister chromatids embodies the replication-dependent com

174 studies demonstrate that H3T3P distinguishes sister chromatids enriched with distinct pools of H3 in

175 ir at endogenous genomic loci by combining a sister chromatid exchange (SCE) assay with fluorescent i

176 , called Strand-seq, that can be used to map sister chromatid exchange (SCE) events genome-wide in si

177 the simultaneous high-resolution mapping of sister chromatid exchange (SCE), facilitating the study

178 At bulky adducts, PrimPol promotes sister chromatid exchange and genetic recombination.

179 centromeric CO-FISH patterns consistent with sister chromatid exchange at the frequency of 5% in prim

180 mutagenic but causes DNA breaks and elevates sister chromatid exchange in mammalian cells.

181 easured interhomolog recombination and intra/sister chromatid exchange in the CUP1 locus.

182 fications, TERRA expression levels, telomere sister chromatid exchange or telomere length.

183 BLM, telomeric circle formation and telomere sister chromatid exchange, both arising out of nucleolyt

184 on can be induced display elevated levels of sister chromatid exchange, gross chromosomal aberrations

185 s can occur by replication slippage, unequal sister chromatid exchange, homologous recombination, and

186 ary Pml(C62A/C65A) cells exhibited increased sister-chromatid exchange and chromosome abnormalities.

187 n of oncogenic selection and fine mapping of sister-chromatid-exchange events.

188 cytic leukemia (PML) bodies (APBs), telomere sister chromatid exchanges (T-SCEs), and extrachromosoma

189 c mitotic recombination, a high frequency of sister chromatid exchanges and double strand DNA breaks,

190 RECQ5 is significant in suppressing sister chromatid exchanges during homologous recombinati

191 Sister chromatid exchanges, a surrogate measure of iHR,

192 d Strand-seq data, to enable fine-mapping of sister chromatid exchanges, germline inversion and to su

193 cause in its absence cells display increased sister chromatid exchanges, replication origin firing an

194 DNA damage signaling, telomere fragility and sister chromatid exchanges.

195 elayed and reduced RAD51 response, and fewer sister chromatid exchanges.

196 hugoshin) mutants during meiosis II when the sister chromatids exhibit random distribution.

197 Cohesin stably holds together the sister chromatids from S phase until mitosis.

198 ocalized genomic recombinations initiated by sister chromatid fusion are predominantly mediated by al

199 te cells(3-7), but the identical sequence of sister chromatids has made it difficult to determine how

200 nd exchange with the homolog rather than the sister chromatid (homolog bias).

201 owing the reproducibility of banding between sister chromatids, homologue pairs and from one metaphas

202 lexes are thought to bind by encircling both sister chromatids in a topological embrace.

203 also provide crucial links between pairs of sister chromatids in eukaryotic meiosis.

204 sess the resection needed for repair between sister chromatids in G-2 arrested cells of random, radia

205 hich condensin complexes compact and resolve sister chromatids in mitosis and by which cohesin genera

206 oint system prevents premature separation of sister chromatids in mitosis and thus ensures the fideli

207 oint system prevents premature separation of sister chromatids in mitosis and thus ensures the fideli

208 that, despite a loss in centromere cohesion, sister chromatids in STAG2 mutant tumor cells maintain c

209 al genome fails to condense and resolve into sister chromatids in synchrony with the maternal genome.

210 This may reflect that cohesin-mediated sister chromatid interactions are sufficient for double-

211 These mitotic sister chromatid intertwines (SCIs) can be found as; sho

212 Sister chromatid intertwines (SCIs), or catenanes, are t

213 l regions as circular "loop outs" to convert sister chromatid intertwines into catenated circles.

214 ompanied by drastic changes in the degree of sister chromatid intertwines.

215 the S and G2 phases of the cell cycle when a sister chromatid is present(2).

216 The establishment of tension between sister chromatids is essential for quenching a checkpoin

217 Formation of individualized sister chromatids is essential for their accurate segreg

218 Homologous recombination involving sister chromatids is the most accurate, and thus most fr

219 ior to pairing, the homolog, rather than the sister chromatid, is used as repair partner for crossing

220 ge effect." During meiosis, cohesion between sister chromatids keeps recombinant homologs physically

221 he SAC coordinates the correct attachment of sister chromatid kinetochores to the mitotic spindle wit

222 mmonly referred to as DNA catenation--and as sister chromatid linkages generated by homologous recomb

223 mechanism to enable formation of asymmetric sister-chromatid loops.

224 This requires that sister chromatids maintain cohesion at the centromere as

225 ous DNA displacement loops (D-loops) between sister chromatids, Mph1(FANCM) ensures high levels of cr

226 All physical connections between sister chromatids must be broken before cells can divide

227 During mitosis, sister chromatids must be faithfully segregated to ensur

228 nd ensures it persists during anaphase, when sister chromatids must transit into daughter cells unint

229 ICRF-193-treated PICH(-/-) cells undergo sister chromatid non-disjunction in anaphase, and freque

230 g bacterial cells, the process of separating sister chromatids occurs concomitantly with ongoing tran

231 During hermaphrodite spermatogenesis, the sister chromatids of the X chromosomes separate during m

232 the formation of DNA intermediates, in which sister chromatids or homologous chromosomes are covalent

233 olliday junctions (HJs) that physically link sister chromatids or homologous chromosomes are formed a

234 Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad2

235 eiotic-specific cohesin member, required for sister chromatid pairing and for preventing telomere sho

236 t (SAC) delays mitotic progression until all sister chromatid pairs achieve bi-orientation, and while

237 ng chromosomes once each cell cycle produces sister chromatid pairs, which separate accurately at ana

238 loading of a dynamic cohesin pool separates sister-chromatid pairs inside TADs and is required to fo

239 mation maps of human chromosomes reveal that sister-chromatid pairs interact most frequently at the b

240 ility of ESCO2 to establish cohesion between sister chromatids precisely as they are born during DNA

241 and meiosis II, and premature separation of sister chromatids (PSSC) and reverse segregation (RS) in

242 otes high-fidelity homologous recombination, sister chromatid recombination (SCR), and break-induced

243 inating the extended repair synthesis during sister chromatid recombination (SCR).

244 ite DNA sequences at metaphase and increased sister chromatid recombination events leading to rampant

245 The rate of intra/sister chromatid recombination exceeded the rate of inte

246 ation in rate of both interhomolog and intra/sister chromatid recombination in the CUP1 array; recomb

247 Despite its importance, sister chromatid recombination is not easily studied bec

248 und centromeres is protected by shugoshin-2, sister chromatids remain attached through centromeric/pe

249 Sister chromatid resolution during mitosis required the

250 omologs segregate to opposite poles; and (3) sister chromatids segregate to opposite poles.

251 roteolysis of cyclin B and securin initiates sister chromatid segregation and anaphase.

252 itotic defects in apc8-1, including abnormal sister chromatid segregation and microtubule morphology.

253 icrotubules of the mitotic spindle, enabling sister chromatid segregation in mitosis.

254 es that link centromeres to microtubules for sister chromatid segregation in mitosis.

255 APC/C, controlling sister chromatid segregation, cytokinesis, and the estab

256 microtubule activities results in randomized sister chromatid segregation.

257 rt of a response mechanism ensuring accurate sister chromatid segregation.

258 Here we describe sister-chromatid-sensitive Hi-C (scsHi-C), which is base

259 ts and H2AThr133ph on maize lines containing sister chromatids separate precociously in anaphase I re

260 he PAR, its chromosome axes elongate and the sister chromatids separate.

261 is followed by equational meiosis II, where sister chromatids separate.

262 er-sister kinetochore distance and premature sister chromatid separation (PSCS), suggesting aberrant

263 s induced bone marrow aplasia with premature sister chromatid separation and revealed an absolute req

264 Hos1 depletion significantly delayed sister chromatid separation and segregation.

265 Removal of cohesin is necessary for sister chromatid separation during anaphase, and this is

266 Precise control of sister chromatid separation during mitosis is pivotal to

267 proteins) is critically important for proper sister chromatid separation during mitosis.

268 Crucially, sister chromatid separation must be delayed until all th

269 SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are at

270 Coupling sister chromatid separation with subsequent exit from mi

271 Timely sister chromatid separation, promoted by separase, is es

272 omologous chromosome segregation followed by sister chromatid separation; cells then underwent additi

273 spindle microtubules and prevents precocious sister-chromatid separation and aneuploidy.

274 gulation through its prevention of premature sister-chromatid separation and the formation of DNA loo

275 the relative involvement of these ligases in sister chromatid telomere fusion through a precise genet

276 required both for the tethering together of sister chromatids (termed cohesion) and subsequent conde

277 Sister chromatids that arrested with a lateral attachmen

278 ggesting that it controls the segregation of sister chromatids through heterochromatin modification.

279 points in the cell cycle when the lack of a sister chromatid to serve as a homologous template preve

280 to a bipolar spindle, which moves one set of sister chromatids to each nascent daughter cell.

281 taphase facilitates the equal segregation of sister chromatids to each of the nascent daughter cells.

282 ose 53BP1 function, routing only DSBs within sister chromatids to HR.

283 forms a ring-shaped structure that embraces sister chromatids to promote their cohesion.

284 plexes that mediate the physical coupling of sister chromatids to spindle microtubule bundles (called

285 The ability of cohesin to tether sister chromatids together depends on acetylation of its

286 ell cycle, sister-chromatid cohesion tethers sister chromatids together from S phase to the metaphase

287 The cohesin ring holds newly replicated sister chromatids together until their separation at ana

288 rase-mediated cleavage, in order to maintain sister chromatids together until their separation in mei

289 oval of cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I

290 identified through its major role in holding sister chromatids together.

291 ecruitment of high levels of cohesin to link sister chromatids together.

292 The rich pattern of sister-chromatid topologies and our scsHi-C technology w

293 tantly, symmetric incorporation of CENP-A on sister chromatids via HASPIN knockdown or overexpression

294 ated dimerization, but recombination between sister chromatids was largely unaffected.

295 Finally, an abnormal separation of sister chromatids was observed upon INO80 downregulation

296 mitosis requires the physical separation of sister chromatids which depends on correct position of m

297 The unpaired X precociously separates into sister chromatids, which co-segregate with the autosome

298 chromatin that connects oppositely attached sister chromatids, which may then act as a mechanical si

299 Cohesin complex mediates cohesion between sister chromatids, which promotes high-fidelity chromoso

300 mitotic fidelity as evidenced by unresolved sister chromatids with marked accumulation of H1S/T18ph

301 e not consistent with cohesin embracing both sister chromatids within silent chromatin domains.