ライフサイエンスコーパス: six-membered ring

1 t for the formation of common delta-lactams (six-membered rings).

2 ved due to smaller hindrance for a five vs a six membered ring.

3 lar and a linear topology via an unsaturated six-membered ring.

4 ion with concomitant re-aromatization of the six-membered ring.

5 adjacent glycine residue to form an aromatic six-membered ring.

6 om to transform a former pyrrole ring into a six-membered ring.

7 mine nitrogen of doxorubicin into a five- or six-membered ring.

8 gs with heteroatoms in the 3-position of the six-membered ring.

9 bonds between the hydroxyl groups forming a six-membered ring.

10 d should be applicable to such motifs on any six-membered ring.

11 arbo[7]helicene units fused within a central six-membered ring.

12 cial for selectivity toward the five- or the six-membered ring.

13 planar hexagonal B36 cluster with a central six-membered ring.

14 p to Cgamma of the ligand giving a boat-like six-membered ring.

15 ene, thereby blocking cyclization to a third six-membered ring.

16 t of isolated open nickel(II) sites in their six-membered rings.

17 These sites are the T5/T6 sites in the six-membered rings.

18 stituted in pairs on opposite sides of these six-membered rings.

19 nine (ABA) and ten (ANA) consecutively fused six-membered rings.

20 nd length equalization in both the five- and six-membered rings.

21 talyst with P-tolerant Z(2)Cu(2)+ species in six-membered rings.

22 is of polycyclic natural products containing six-membered rings.

23 tions are mainly described to give five- and six-membered rings.

24 and their influence on the conformations of six-membered rings.

25 es that the final structure consists of only six-membered rings.

26 ynthetic transformations for the assembly of six-membered rings.

27 itions within sofa-type conformation for the six-membered rings.

28 substitution on the strength of C-H bonds in six-membered rings.

29 reochemistry: (1) conformational analysis of six-membered rings, (2) evaluation of stereoelectronic i

30 in (1)J(C-H) one-bond coupling constants in six-membered rings, (3) eclipsed conformation in cis-2-t

31 for the unusual thermal equilibration from a six-membered ring (3d) to a four-membered ring (4d) obse

32 Six-membered ring (6-MR) heteroaromatics with in-plane l

33 ross Si:Al ratios, the volumetric density of six-membered-rings (6MR) containing two Al (2Al sites) i

34 (2+) loaded onto paired anionic sites in the six-membered rings (6MRs) in the CHA cage are the primar

35 xylic acid (APCH), which is constrained by a six-membered ring across its Calpha-Cbeta bond.

36 MPO spin trap, leading to the formation of a six-membered ring adduct, occurs through a very favorabl

37 gned, synthesized, and evaluated a series of six-membered-ring analogs.

38 nucleophilic displacement reaction forming a six-membered ring and releasing a stable cationic report

39 ound to embed an extremely contorted central six-membered ring and two negative curvatures.

40 of two saturated carbon-carbon bonds of the six-membered ring and uses molecular oxygen as the hydro

41 in organic synthesis(2) for the formation of six-membered rings and are now well-established in biosy

42 yclic carbon scaffold comprising three fused six-membered rings and at least three quaternary centers

43 g currents flow diatropically in the stacked six-membered rings and in the helicene arms.

44 This versatile route converts five- to six-membered rings and provides a detailed view of high

45 ion can also be extended to the formation of six-membered rings and to N-homoallylindoles.

46 With approximately 10 eq of these monomeric six-membered rings and with heating, cyclic esters (MeCH

47 the terminal alkene dipolarophile leads to a six-membered ring), and most efficient is the formation

48 elective cycloisomerization to construct the six-membered ring, and a diastereoselective hydroxylativ

49 RCM reaction to close the congested central six-membered ring, and a hydroxy-directed epoxidation/ep

50 l rate is similar for formation of five- and six-membered rings, and a substantial KIE (k(H)/k(D)) is

51 The results show that in the six-membered ring antiperiplanar lone pairs provide a we

52 Carbo- and heterocycles of five- and six-membered rings are obtained in good yields.

53 Whereas six-membered rings are readily accessible from Diels-Ald

54 Cyclic imides within six-membered rings are shown to undergo efficient N-aryl

55 ch as the [4+2] Diels-Alder reaction to form six-membered rings, are among the most powerful and wide

56 ew reactions that yield benzo-fused five- or six-membered rings arising from conjugated ene-ene-yne p

57 s two alcohol molecules in a hydrogen bonded six-membered ring arrangement.

58 es, the same pattern of cyclization provided six-membered rings as an illustration of the reactivity

59 Introduction of nitrogen in the six-membered ring at the 2 position, to improve aqueous

60 re positioned adjacently within an aromatic, six-membered ring: azasilabenzenes.

61 ered rings are less pronounced than those on six-membered rings because of the difference in bond ang

62 h R(2)NH and R(2)NH(2)(+) groups on the same six-membered ring, behaving both as an electron donor an

63 tack at the armchair edge and formation of a six-membered ring by peri-attack at the zigzag edge clea

64 lpha-bisallylaldehydes rearrange to generate six-membered rings by a mechanism triggered by aldehyde

65 ols with four- (C(4)-1), five- (C(5)-1), and six-membered rings (C(6)-1).

66 ion reactions of alpha-halogenated five- and six-membered rings can be highly stereoselective.

67 henylmaleimide is isolated for the five- and six-membered ring cases.

68 eveal that the conformational preferences of six-membered-ring cations depend significantly upon the

69 electivity arises through the formation of a six-membered ring chelate.

70 about the linking bond, stable nonracemizing six-membered ring chelates can be formed.

71 ly unreported autochelates contain two fused six-membered rings, cis-proline, chiral boron, and -NH(2

72 minal amino group of lysine 66 to form a new six-membered ring, cleaving the polypeptide backbone at

73 es are close to 0 degrees , but in five- and six-membered ring compounds and in open-chain compounds

74 d portion of the catalytic domain, such as a six-membered ring, confer selectivity for HKs.

75 The six-membered ring conferred increased RARbeta specificit

76 s only indole oxidation was observed for the six-membered ring congener.

77 ctions with the enzyme and a solvent exposed six-membered ring, consistent with its poor repair susce

78 The proteolipid subunits form a six-membered ring containing single copies of subunits c

79 erent heteroatoms, thus leading to five- and six-membered rings containing adjacent heteroatoms.

80 ring, containing two double bonds, or into a six-membered ring, containing two double bonds and a six

81 Unlike many reactions of their six-membered-ring counterparts, the reactions of chiral

82 Zeolites with double six-membered rings (D6MRs) that orient 6MRs into the cag

83 units (net-cBUs), 12-connected (12-c) double six-membered ring (d6R) building units.

84 t is the first time that RE-MOFs with double six-membered ring (d6R) secondary building units are iso

85 ansitive nets with a vertex figure as double six-membered-ring (d6R) building unit, namely the (4,12)

86 eogenic center, lying at the junction of two six-membered rings, defines the conformation of the subs

87 ch the cyclization delivered either five- or six-membered rings depending on the temperature of the e

88 e by a factor of ~4 going from the five- and six-membered ring derivatives to the eight-membered ones

89 e unit of the 3-sila-1,2,4-trioxepane yields six-membered ring diisopropylsilylene acetals.

90 (m-aniline)s with 9 and 13 collinearly fused six-membered rings employed Pd-catalyzed aminations and

91 ich respectively possess two and three fused six-membered rings, exhibit a similar trend, with the fo

92 A key finding is that the five- to six-membered ring expansion process is not a viable reac

93 etals preferentially bind the substrate as a six-membered ring, exposing the exact same sites to the

94 have investigated the formation of five- and six-membered rings for the other two new ring sizes.

95 Moreover, while the pyranose (six-membered ring) form of ribose is more stable than th

96 peri-position versus a topologically similar six-membered ring formation at the armchair edge reveals

97 aldol and Michael cycloreductions, five- and six-membered ring formation occurs in good yield with hi

98 Where six-membered ring formation operates, cyclization can be

99 inones were synthesized intramolecularly via six-membered ring formation with high regio- and diaster

100 eri-attack at the zigzag edge clearly favors six-membered ring formation.

101 er hand the systems with fused benzene and a six-membered ring formed atropisomers separated by a bar

102 Two of the six-membered rings formed by the diphosphine ligands and

103 For 6b, all four six-membered rings formed upon coordination of the dipho

104 In contrast, if the six-membered ring-fusion is across the C(2)-C(3) cyclope

105 tivity is strongly ring size dependent, with six-membered rings giving exclusively alpha-benzyl pente

106 e isomer of 1H-benz[f]indene, with separated six-membered rings, has an electron affinity of -0.07 eV

107 irculene consisting of alternating five- and six-membered rings, have been generated by reduction wit

108 nsecutive aza-Michael additions assemble the six-membered ring heterocycle, while in the second domin

109 d borylation to cyano-substituted, five- and six-membered ring heterocycles is also reported.

110 ns undergo ring contraction, giving five- or six-membered ring heterocycles.

111 ver, this approach provides direct access to six-membered ring heterocyclic systems bearing all-carbo

112 etries revealed that the syn isomer favors a six-membered ring hydrogen bond to nitrogen and the anti

113 and trialkoxyphenyl-substituted alkynes into six-membered rings, i.e., tetrahydropyridines, was devel

114 bonds of the five-membered ring in 15 or the six-membered ring in 12b are discussed, and the conseque

115 A heptaene that contains a six-membered ring in the central unit also was prepared

116 trong intramolecular hydrogen bonds within a six-membered ring in the enones and the enols.

117 ons at the VHL ligand included a constrained six-membered ring in the peptidic scaffold and the addit

118 five-membered ring is more aromatic than the six-membered rings in 3a and 3b.

119 n more extended conjugated system with seven six-membered rings in a row (Qu-BEt) is obtained by bory

120 reaction and gave the respective trans-fused six-membered rings in good yields (68-98%).

121 own to be quite general for the formation of six-membered rings in good yields and was tolerant of a

122 the (S)-cis configuration of the two central six-membered rings in protoberberine BIA compounds.

123 esis of spiro compounds featuring seven- and six-membered rings in the spirobicyclic motif is success

124 on occurs, and Pt(2+) ions are stabilized at six-membered rings in the zeolite that contain paired al

125 y planar with a central B atom and an AlB(5) six membered ring, in contrast to that of B(7)(-), which

126 The reactions of three-, four-, five-, and six-membered rings incorporating the S-Se bond with HS-

127 binding affinities of those having three- to six-membered rings increase incrementally with ring size

128 single or multiple hydrophilic moieties on a six-membered ring inhibited the Hh pathway in both Hh-de

129 plexes of neuraminidase with known five- and six-membered ring inhibitors revealed that potent inhibi

130 t as effectively as those of the established six-membered ring inhibitors such as DANA (2), zanamivir

131 By low-temperature NMR spectroscopy the six-membered-ring interconversion could be frozen at 103

132 t FLPs can adsorb an N(2) molecule to form a six-membered ring intermediate, which enables the cleava

133 iimide-based coupling reagent DIC leads to a six-membered-ring intermediate acting as a versatile pre

134 A union of five- and six-membered ring intermediates by an efficient pi-allyl

135 veral syn-pentane interactions which force a six-membered ring into a twist-boat conformation.

136 In the bicyclic six-five series, the six-membered ring is accommodated in the cation, but it

137 les with a high level of substitution on the six-membered ring is described.

138 ure for one of the complexes showed that the six-membered ring is very distorted and the thiophene ri

139 ketopiperazine at both the five-membered and six-membered rings is described.

140 The formation of five- and six-membered rings is possible using this methodology.

141 controlled while an "expected" product with six-membered rings is thermodynamically more favored.

142 zation through the N- and B-termini, forming six-membered rings, is a common occurrence at neutral pH

143 lative to the previously published five- and six-membered ring ketone-based inhibitor series.

144 le N-methylamide function into a more stable six-membered ring lactam 4, resulting in increased stabi

145 Five- and six-membered ring lactams bearing aromatic, heteroaromat

146 be a hydrogen-bonded OH-HONO(2) complex in a six-membered ring-like configuration.

147 d acetoacetyl fluoride is characterized by a six-membered ring-like structure containing an intramole

148 henomenon in the conformational chemistry of six-membered ring molecules.

149 pX subunits (Mr 46, 000) associate to form a six-membered ring (Mr approximately 280, 000) that is st

150 ally dealing with the synthesis of five- and six-membered ring nitrogen containing heterocycles, then

151 ere found to cyclize to give either five- or six-membered ring nitrogen heterocycles.

152 Both the six-membered ring nitroxides and substituted five-member

153 For six-membered ring nitroxides, the compounds exhibiting t

154 epared and further elaborated into the final six-membered ring nucleosides via nucleobase incorporati

155 cyclization to a phenyl-substituted five- or six-membered-ring occurs.

156 hosphate and through pi-pi stacking with the six-membered ring of adenine.

157 le saturation of adjacent C=C bonds within a six-membered ring of C60.

158 ropenyl-like electronic structure within the six-membered ring of the 1,3,5-benzene triradical.

159 dless of whether the site is on the five- or six-membered ring of the purine.

160 tion of the alcohol at the 3 position of the six-membered ring of the spiroketal subunit, the configu

161 ease with the fraction of H(+) sites sharing six-membered rings of chabazite (CHA) zeolites.

162 een the seven-membered rings of ClpP and the six-membered rings of ClpX.

163 tion, resulting in weaker aromaticity of the six-membered rings of the buckybowl skeleton.

164 wo adjacent carbon atoms located between two six-membered rings of the C60 cage affects the orientati

165 ridge and the centroids of three of the four six-membered rings of the pyrene system of a neighboring

166 reaction is effective for forming five- and six-membered rings of widely divergent structure.

167 cal modeling suggest that 7 was formed via a six-membered ring oxathiaphosphenine intermediate rather

168 ons of trimethylsilyl cyanide with five- and six-membered ring oxocarbenium ions are attributed to th

169 y as compared to that of reactions involving six-membered-ring oxocarbenium ions.

170 amine sugar, one compound with a nonaromatic six-membered ring (pirarubicin) in place of the 4'-OH, a

171 tive reaction to form unprecedented five- or six-membered rings possessing a geometrically defined en

172 coupling introduces an aromatic ring as the six-membered ring precursor, and a gold(I)-catalyzed Con

173 o give a pair of diastereomeric heterocyclic six-membered ring products due to the newly formed sulfu

174 s, a ruthenium-based system that affords the six-membered ring products was also developed.

175 Five- and six-membered ring products were obtained in good to exce

176 to a methyl-aryl or isopropyl carbon to form six-membered ring products.

177 bis(enone) substrates afford both five- and six-membered ring products.

178 lectron-deficient alkenes and imines to form six-membered-ring products diastereoselectively.

179 constrained by four-, five-, and rigidified six-membered rings, providing rapid access to sp(3)-rich

180 s undergo SN2 reactions, while the five- and six-membered rings react via the addition-elimination pa

181 tion/combination with cyclopropane to form a six-membered ring reference compound.

182 ioxirane (DO) has been estimated relative to six-membered ring reference compounds by dimerization of

183 i(2+): forming a five-membered ring versus a six-membered ring, respectively, thus exposing different

184 proton acceptor is located in the five- and six-membered rings, respectively.

185 uble bond-localization within the connecting six-membered ring resulted in reduced antiaromaticity of

186 e displays a boat conformation for its Ge-Se six-membered ring ("six-ring"), while the previously kno

187 s of two intermolecular H bonds by forming a six-membered ring structure with a calculated dissociati

188 ields primarily high-energy dications with a six-membered-ring structure.

189 a pyribenzihexaphyrin macrocycles containing six-membered rings such as pyridine and p-phenylene alon

190 unique ring expansion reaction to provide a six-membered ring suitably functionalized for introducti

191 Formation of a six-membered ring supports the hypothesis that epoxy est

192 group abilities already established for the six-membered ring system (NHBn >> OH > NBn2), an N,N-dib

193 ere found to be consistently higher with the six-membered ring system than its cycloheptane counterpa

194 ntramolecular alkene hydroaminations forming six-membered ring systems are rare, especially for syste

195 The functionalized five- and six-membered ring systems obtained by these novel cycliz

196 h 1,3,5-triazinanes, leading to the five- or six-membered ring systems under mild conditions in yield

197 The method employs a six-membered ring template to control the relative stere

198 le access to biaryl sultams annulated into a six-membered ring that are otherwise difficult to obtain

199 in the enamine-iminium complex by forming a six-membered ring that favors one helicity of the electr

200 are found with many of the oxygen-containing six-membered rings that were investigated.

201 For the five- and six-membered rings, the reaction proceeds via the additi

202 was easily achieved, ultimate closure of the six-membered ring to form ring D remains an unsolved pro

203 ivity, suggesting a strict requirement for a six-membered ring to maintain potency.

204 However, annelation of a six-membered ring to the conformationally mobile D'-pipe

205 the C-C single bonds connecting the central six-membered rings to the helicene arms.

206 ens of the pinacol group was observed in the six-membered ring transition structure toward the alleny

207 the formation of an energetically favorable six-membered-ring transition structure with neighboring

208 and N-acyl-oxazolidinones bearing five- and six-membered rings using Pd(II)-NHC and Pd-phosphine sys

209 ree carbo[7]helicenes fused within a central six-membered ring was described.

210 y, electron density suggestive of a puckered six-membered ring was discovered at a site structurally

211 ontal lineNH and cis-1,3-butadiene to form a six-membered ring was examined by quantum calculations.

212 synthesis of N-arylated cyclic imides having six-membered rings was restricted largely to strongly he

213 '-(3''-piperidone-1''-yl)doxorubicin (with a six-membered ring) were tested in vitro, the former bein

214 ues 21, 22, 46, and 54, comprising four- and six-membered rings, were synthesized using two different

215 of the methyl groups, to close a [LiOCCZnC] six-membered ring; whereas 8 displays an open structure

216 nd "closed." The gp61 structure is clearly a six-membered ring, which may be a trimer of dimers or a

217 The complex forms a distorted, six-membered ring with the water unit acting as both a h

218 ns leads to selective formation of four- and six-membered rings with 2pai E(2)C(2) and 4pai E(2)C(4)

219 -H bonds leads to the formation of five- and six-membered rings, with an all-carbon quaternary stereo

220 nounced reactivity and strain of the central six-membered ring within the [3]phenylene subunit.

221 of disubstituted alkenes to form seven- and six-membered rings without requiring substrate-embedded

222 clidine derivative salts with fused five and six-membered rings (X-ray) were obtained via modificatio