ライフサイエンスコーパス: skeletal muscle differentiation

1 C2C12 myoblasts, a tissue culture model for skeletal muscle differentiation.

2 novel mTOR signaling mechanism essential for skeletal muscle differentiation.

3 ellular syncytial formation is a hallmark of skeletal muscle differentiation.

4 form normal ribs and sternum, and extent of skeletal muscle differentiation.

5 inesterase (AChE) expression observed during skeletal muscle differentiation.

6 redox homeostasis which is downregulated in skeletal muscle differentiation.

7 MyoD and the expression of a late marker of skeletal muscle differentiation.

8 subunits and activation of MAPKs to repress skeletal muscle differentiation.

9 he MAPKs during the early and late stages of skeletal muscle differentiation.

10 implicated in the control of cell growth and skeletal muscle differentiation.

11 s as an E3 ubiquitin ligase to repress human skeletal muscle differentiation.

12 played opposing roles in cardiac muscle and skeletal muscle differentiation.

13 ed if Cbx1, PurB and Sp3 similarly regulated skeletal muscle differentiation.

14 ains with undefined functional importance in skeletal muscle differentiation.

15 is required for myogenic gene expression and skeletal muscle differentiation.

16 miR-675-5p, both of which are induced during skeletal muscle differentiation.

17 ors, we investigated the function of AUF1 in skeletal muscle differentiation.

18 ion activity and function as an inhibitor of skeletal muscle differentiation.

19 um (K(+)) channels is a pivotal event during skeletal muscle differentiation.

20 sion and activity and consequently inhibited skeletal muscle differentiation.

21 esents a key molecular link between O(2) and skeletal muscle differentiation.

22 that negatively regulates mTOR activity and skeletal muscle differentiation.

23 represses slow fiber gene expression during skeletal muscle differentiation.

24 omoting slow fiber type specification during skeletal muscle differentiation.

25 cancer, which arrested during the process of skeletal muscle differentiation.

26 f the important signaling pathways linked to skeletal muscle differentiation.

27 tin cytoskeleton is a critical early step in skeletal muscle differentiation.

28 es gene expression throughout the program of skeletal muscle differentiation.

29 neoplasm of primitive mesenchyme exhibiting skeletal muscle differentiation.

30 thway that regulates myogenin expression and skeletal muscle differentiation.

31 NF-kappaB functions in myoblasts to modulate skeletal muscle differentiation.

32 s miRNAs that repress gene expression during skeletal muscle differentiation.

33 activation of genes involved in cardiac and skeletal muscle differentiation.

34 and MyoD, a critical lineage determinant for skeletal muscle differentiation.

35 m C2C12 myoblasts by RNA interference blocks skeletal muscle differentiation.

36 e regulator of cardiomyocyte hypertrophy and skeletal muscle differentiation.

37 mily in myoblasts and that Mirk is active in skeletal muscle differentiation.

38 is an aggressive pediatric cancer exhibiting skeletal-muscle differentiation.

39 iptional activation of Fbxl2 is required for skeletal muscle differentiation, a process that is inter

40 n of a dominant-negative Set7 mutant impairs skeletal muscle differentiation, accompanied by a decrea

41 nstrate that Map4k4 is a novel suppressor of skeletal muscle differentiation, acting through a Myf5-d

42 x and ER exit sites takes place early during skeletal muscle differentiation and completely remodels

43 transcription factors are upregulated during skeletal muscle differentiation and cooperate with the M

44 Mesoangioblasts have the ability to undergo skeletal muscle differentiation and cross the blood vess

45 e integral in cardiac hypertrophy as well as skeletal muscle differentiation and fiber-type specifica

46 heart valve formation, vascular development, skeletal muscle differentiation and fiber-type switching

47 ors and a cell cycle inhibitor essential for skeletal muscle differentiation and for survival.

48 muscle cluster expressed genes that mediate skeletal muscle differentiation and function.

49 nstrate a novel role for EGLN3 in regulating skeletal muscle differentiation and gene expression.

50 gest that K(v)7.4 plays a permissive role in skeletal muscle differentiation and highlight REST as a

51 regulatory regions of genes expressed during skeletal muscle differentiation and initiates chromatin

52 Depletion of 4.1R impairs skeletal muscle differentiation and is accompanied by a

53 anscription factor, is a potent repressor of skeletal muscle differentiation and is dysregulated in m

54 miR-26a is induced during skeletal muscle differentiation and is predicted to targ

55 The role of SMYD3 in the regulation of skeletal muscle differentiation and myotube formation, p

56 SRF is an essential regulator of skeletal muscle differentiation and numerous components

57 e up-regulated genes were mainly involved in skeletal muscle differentiation and proliferation, inclu

58 r suppressor protein (pRb) family both block skeletal muscle differentiation and promote cell cycle p

59 evidence for the requirement of miR-26a for skeletal muscle differentiation and regeneration in vivo

60 has a critical trans-regulatory function in skeletal muscle differentiation and regeneration that is

61 Thus, we examined the role of the H19 RNA in skeletal muscle differentiation and regeneration.

62 e we illustrate how these transcripts affect skeletal muscle differentiation and related disorders.

63 , we have identified a novel role for Sp3 in skeletal muscle differentiation and through the applicat

64 hat ectopic expression of cyclin D1 inhibits skeletal muscle differentiation and, conversely, that ex

65 For example, Myod drives skeletal muscle differentiation, and Hand2 potentiates c

66 sion of utrophin (Utrn) is suppressed during skeletal muscle differentiation, and it is replaced at t

67 myogenin and that correct sternum formation, skeletal muscle differentiation, and viability each requ

68 nts that modulate chromatin structure during skeletal muscle differentiation are still poorly underst

69 uggesting intracellular responses regulating skeletal muscle differentiation are transduced by activa

70 ine methyltransferase Prmt5 was required for skeletal muscle differentiation at the early stages of m

71 letal Tmod (Sk-Tmod), expressed late in fast skeletal muscle differentiation, bind on overlapping sit

72 Overexpression of c-Ski/SnoN also induces skeletal muscle differentiation, but how c-Ski/SnoN func

73 tor-beta (TGF-beta) is a potent inhibitor of skeletal muscle differentiation, but the molecular mecha

74 ong been implicated in regulating vertebrate skeletal muscle differentiation, but their precise role(

75 These are known to inhibit skeletal muscle differentiation by binding and blocking

76 ative cis-regulatory modules (CRMs) in human skeletal muscle differentiation by combining myogenic TF

77 vertebrate MEF2 transcriptional function in skeletal muscle differentiation by depleting individual

78 Thus, it appears that regulation of skeletal muscle differentiation by FGFs requires only ac

79 p38-gamma puts the brakes on skeletal muscle differentiation by promoting the associa

80 expressed SMYD3, revealed that SMYD3 impacts skeletal muscle differentiation by targeting the key mus

81 cyclin-cdk activity blocks the initiation of skeletal muscle differentiation by two distinct mechanis

82 In a C2C12 model of skeletal muscle differentiation, Cbx1 and PurB knockdown

83 During skeletal muscle differentiation, Cn activates the nuclea

84 The mechanisms that regulate skeletal muscle differentiation, fiber type diversity an

85 nsferases are employed at different times of skeletal muscle differentiation for the purpose of facil

86 f hematologic cancer cell lines and promoted skeletal muscle differentiation from C2C12 myoblasts.

87 During skeletal muscle differentiation, GRIP-1 is localized to

88 Mechanical stimulation can regulate skeletal muscle differentiation, growth and metabolism;

89 annel and regulates PI3K-AKT-mTOR signaling, skeletal muscle differentiation, growth, and systemic gl

90 Skeletal muscle differentiation has been shown to be dep

91 iptional regulation during the initiation of skeletal muscle differentiation; however, there is less

92 Thus, MyoD gene transfer can induce skeletal muscle differentiation in healing heart lesions

93 olin, and the GSK3beta inhibitor BIO induced skeletal muscle differentiation in human induced pluripo

94 p-regulates MYOD signature genes and induces skeletal muscle differentiation in normal myoblasts and

95 dicate that cyclin D-cdk4 activity represses skeletal muscle differentiation in proliferating cells b

96 that N-cadherin- mediated adhesion enhances skeletal muscle differentiation in three-dimensional cel

97 OR signaling in skeletal muscle to influence skeletal muscle differentiation in vitro and skeletal my

98 ammalian SMYD3 methyltransferase coordinates skeletal muscle differentiation in vitro.

99 achexia and has been demonstrated to inhibit skeletal muscle differentiation in vitro.

100 ein expression increase substantially during skeletal muscle differentiation, independently of their

101 Skeletal muscle differentiation is a complex, highly coo

102 Skeletal muscle differentiation is controlled by associa

103 Skeletal muscle differentiation is controlled by interac

104 utations has been identified in which normal skeletal muscle differentiation is followed by a tissue-

105 Skeletal muscle differentiation is initiated by the tran

106 The complex process of skeletal muscle differentiation is organized by the myog

107 Skeletal muscle differentiation is regulated by the basi

108 myosarcoma, a malignancy showing features of skeletal muscle differentiation, is the most common soft

109 ly expressed in muscle cells and serves as a skeletal muscle differentiation marker.

110 t pRb is required for the expression of late skeletal muscle differentiation markers and for the inhi

111 Skeletal muscle differentiation, maturation, and regener

112 Skeletal muscle differentiation, maturation, and regener

113 Here we use both a skeletal muscle differentiation model and normal diploid

114 ugh a few research groups have used them for skeletal muscle differentiation, most were based on gene

115 the sternum developed normally and extensive skeletal muscle differentiation occurred.

116 f constitutive proteasomes, are critical for skeletal muscle differentiation of mouse C2C12 cells.

117 Thus, we conclude that skeletal muscle differentiation of patient cells causes

118 nrecognized role for Myocd in repressing the skeletal muscle differentiation program and suggest that

119 on induces transcriptional activation of the skeletal muscle differentiation program associated with

120 blasts lacking pRb, MyoD induces an aberrant skeletal muscle differentiation program characterized by

121 ive in proliferating cells, can suppress the skeletal muscle differentiation program in proliferating

122 , MITR has minimal inhibitory effects on the skeletal muscle differentiation program.

123 f5, myogenin, and MRF4-can each activate the skeletal muscle-differentiation program in transfection

124 the genes that are central to the process of skeletal muscle differentiation remain in a transcriptio

125 rations, stress hormones may be important in skeletal muscle differentiation, repair and regeneration

126 Skeletal muscle differentiation requires a cascade of tr

127 Skeletal muscle differentiation requires precisely coord

128 Skeletal muscle differentiation requires the coordinated

129 dramatically up-regulated during smooth and skeletal muscle differentiation, respectively, and p40 c

130 MyoD regulates skeletal muscle differentiation (SMD) and is essential f

131 ighted a maturation trajectory suggestive of skeletal-muscle differentiation, some striated structure

132 y studies, bioartificial muscle engineering, skeletal muscle differentiation studies and for better u

133 the level of beta-catenin failed to promote skeletal muscle differentiation suggesting an adhesion-c

134 During skeletal muscle differentiation, the activation of some

135 During skeletal muscle differentiation, the actomyosin motor is

136 During skeletal muscle differentiation, the Akt2 but not Akt1 e

137 During skeletal muscle differentiation, the Golgi complex (GC)

138 l molecular axis, which functionally acts in skeletal muscle differentiation through the modulation o

139 e alternative splicing regulator nPTB during skeletal muscle differentiation to control a potential n

140 (HSPGs) are implicated in FGF signaling and skeletal muscle differentiation, we examined the express

141 ture system with reporters of early and late skeletal muscle differentiation, we examined the influen

142 To identify genes regulated during skeletal muscle differentiation, we have infected mouse

143 rly transcriptional targets of MyoD prior to skeletal muscle differentiation, we have undertaken a tr

144 s for microRNAs (miRNAs) that participate in skeletal muscle differentiation were among the most diff

145 tory element of MyoD, a central regulator of skeletal muscle differentiation, where they induce repre

146 ranscriptional repressor of Myog, inhibiting skeletal muscle differentiation while activating SMC-spe