ライフサイエンスコーパス: skeletal muscle fiber

1 renal epithelial cells) and Cav-3 null mice (skeletal muscle fibers).

2 external Cl-free challenge, for an isolated skeletal muscle fiber.

3 C on the myosin lever arm in a permeabilized skeletal muscle fiber.

4 o decrease RyR1 Ca(2+) leak in human skinned skeletal muscle fibers.

5 we could achieve acute suppression of JPs in skeletal muscle fibers.

6 s region (R3614-3643) on Ca2+ sparks in frog skeletal muscle fibers.

7 e nucleus to the cytoplasm in cultured adult skeletal muscle fibers.

8 clear aggregates and TUNEL-stained nuclei in skeletal muscle fibers.

9 ng of tubular filaments within the nuclei of skeletal muscle fibers.

10 mitochondrial Ca2+ dynamics in permeabilized skeletal muscle fibers.

11 sses predominantly in cardiac cells and slow skeletal muscle fibers.

12 tiffness and aberrant mechanotransduction in skeletal muscle fibers.

13 tion in calsarcin-1 showed an excess of slow skeletal muscle fibers.

14 ease properties of RYR in permeabilized frog skeletal muscle fibers.

15 t exerts both short and long term effects on skeletal muscle fibers.

16 pecifically inhibits the contraction of fast skeletal muscle fibers.

17 bone marrow can give rise to differentiated skeletal muscle fibers.

18 oponin C (TnC) was measured in permeabilized skeletal muscle fibers.

19 charge movement and intracellular Ca(2+) in skeletal muscle fibers.

20 tes, while E-Tmod is found in heart and slow skeletal muscle fibers.

21 nants of JPH1 recruitment at triads in adult skeletal muscle fibers.

22 similar to those reported in adult amphibian skeletal muscle fibers.

23 wo rhodamine probes bound to myosin heads in skeletal muscle fibers.

24 howed significant Evans blue accumulation in skeletal muscle fibers.

25 of newly synthesized JPHs at triads in adult skeletal muscle fibers.

26 echanisms that regulate energy metabolism in skeletal muscle fibers.

27 but not keratin, were all expressed in fish skeletal muscle fibers.

28 development after photorelease of Ca(2+) in skeletal muscle fibers.

29 suitability as rapid Ca2+ indicators in frog skeletal muscle fibers.

30 were examined in slow soleus and fast psoas skeletal muscle fibers.

31 tput from fully contracting segments of frog skeletal muscle fibers.

32 x(4cv) mouse hearts with up to 15% rescue in skeletal muscle fibers.

33 otypes with increasingly severe RyR1 leak in skeletal muscle fibers.

34 uscular junction (NMJ) from motor neurons to skeletal muscle fibers.

35 s aimed at restoring dysferlin expression in skeletal muscle fibers.

36 properties associated with HIIT in diabetic skeletal muscle fibers.

37 o track the movement of each Ca(V)1.1 VSD in skeletal muscle fibers.

38 of endogenous GLUT4 translocation in primary skeletal muscle fibers.

39 ths, and actomyosin crossbridge formation in skeletal muscle fibers.

40 of influenza A viruses to replicate in avian skeletal muscle fibers.

41 probes on the myosin motor domain in relaxed skeletal muscle fibers.

42 compartment model of Ca(2+) dynamics in frog skeletal muscle fibers.

43 voltage dependent calcium signaling in frog skeletal muscle fibers.

44 rgo fusion events to share matrix content in skeletal muscle fibers.

45 of dysferlin during membrane repair in adult skeletal muscle fibers.

46 tudies of excitation contraction coupling in skeletal muscle fibers.

47 and accessory structures typical of striated skeletal muscle fibers.

48 enriched in the t-tubule membrane of mature skeletal muscle fibers.

49 heterodimeric bZIP transcription factors in skeletal muscle fibers.

50 rotein content across the continuum of human skeletal muscle fibers.

51 essential light chain (ELC) in permeabilized skeletal muscle fibers.

52 activating transcription factor 4 (ATF4) in skeletal muscle fibers.

53 e nucleotide turnovers in relaxed, permeable skeletal muscle fibers.

54 aligned and highly differentiated cardiac or skeletal muscle fibers.

55 arms in the thick filaments of permeabilized skeletal muscle fibers.

56 androgen receptor (AR) exclusively in their skeletal muscle fibers.

57 perimental and computational studies suggest skeletal muscle fiber activation is greatly augmented by

58 ulum for an AP, the physiological signal for skeletal muscle fiber activation.

59 Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous

60 ereas beta 1A could not be detected in adult skeletal muscle fibers and cardiomyocytes by immunofluor

61 lt dissociated flexor digitorum brevis (FDB) skeletal muscle fibers and human embryonic kidney (HEK)

62 ite cells reside beneath the basal lamina of skeletal muscle fibers and include cells that act as pre

63 ue interface between lower motor neurons and skeletal muscle fibers and is indispensable for muscle f

64 apse type that forms between motoneurons and skeletal muscle fibers and that exhibits a high degree o

65 racellular [Ca(2+)] simultaneously in mature skeletal muscle fibers and that the voltage distribution

66 sion is up-regulated and observed throughout skeletal muscle fibers and within satellite cells.

67 t or greatly reduced in dystrophin-deficient skeletal muscle fibers, and are thought to undergo degra

68 endothelia, adipocytes, smooth muscle cells, skeletal muscle fibers, and cardiac myocytes.

69 (NMJ) is a synapse between motor neurons and skeletal muscle fibers, and is critical for control of m

70 ive capacity, including the heart and type I skeletal muscle fibers, and is regulated by the MyoD fam

71 rvated muscle fibers (SIFs), similar to most skeletal muscle fibers, and multiply innervated muscle f

72 ated reduced locomotion, reduced diameter of skeletal muscle fibers, and reduced expression of muscle

73 Although extrafusal skeletal muscle fibers appeared normal, Egr3-deficient a

74 nd wild-type mtDNA molecules within the same skeletal muscle fiber are consistent with the "maintenan

75 Nuclei in multinucleated skeletal muscle fibers are capable of expressing differe

76 ese results provide convincing evidence that skeletal muscle fibers are capable of mounting a robust

77 Our findings highlight that avian skeletal muscle fibers are capable of productive influen

78 Skeletal muscle fibers are defined by patterned covariat

79 These results show for the first time that skeletal muscle fibers are directly responsive to space

80 The thick filaments of mammalian and avian skeletal muscle fibers are disordered at low temperature

81 Transport distances in skeletal muscle fibers are mitigated by these cells havi

82 Skeletal muscle fibers are multinucleated cellular giant

83 Due to their high energetic profile, skeletal muscle fibers are prone to damage by endogenous

84 etermine fast- and slow-twitch phenotypes of skeletal muscle fibers are thought to stem from depolari

85 of tension development in bundles of skinned skeletal muscle fibers as a function of the level of Ca(

86 ite cells (the myogenic stem cells of mature skeletal muscle fibers) as a model system, we elucidated

87 ectional signaling between motor neurons and skeletal muscle fibers at neuromuscular synapses.

88 activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a-m

89 Skeletal muscle fiber atrophy develops in response to se

90 Skeletal muscle fiber atrophy was induced (P < 0.05) by

91 er atrophy and required for Gadd45a-mediated skeletal muscle fiber atrophy.

92 ssion, which is necessary and sufficient for skeletal muscle fiber atrophy.

93 eased levels of holo betaAPP751 and Abeta in skeletal muscle fibers became significantly weaker with

94 ng slow fiber type electrical stimulation of skeletal muscle fibers because of activation of the Ca(2

95 to act as a soluble relaxing factor in fast skeletal muscle fibers by acting as a delayed Ca(2+) sin

96 r system network (SSTN) has been detected in skeletal muscle fibers by confocal imaging after the rem

97 issue types and (ii) its localization within skeletal muscle fibers by immunofluorescence microscopy

98 yoplasmic proteins in frog (Rana temporaria) skeletal muscle fibers by using single Sephadex beads as

99 Adult skeletal muscle fibers can be categorized into fast and

100 ed by membrane depolarization in single frog skeletal muscle fibers can be terminated prematurely by

101 Myoblasts, the precursors of skeletal muscle fibers, can be induced to withdraw from

102 n (alpha-tropomyosin-slow) expressed in slow skeletal muscle fibers cause nemaline myopathy.

103 contribution of thick and thin filaments to skeletal muscle fiber compliance has been shown to be si

104 bryogenesis and early postnatal development, skeletal muscle fibers contain a previously unknown form

105 Vertebrate skeletal muscle fibers contain hundreds of nuclei, of wh

106 Skeletal muscle fibers contain hundreds of nuclei, which

107 -related reductions of the levels of Numb in skeletal muscle fibers contribute to loss of muscle stre

108 myloid-beta (Abeta) peptide within selective skeletal muscle fibers contributes to the degenerative p

109 active MMP-9 protein significantly increased skeletal muscle fiber cross-section area, levels of cont

110 tive correlation between NOX4 expression and skeletal muscle fiber cross-sectional area in pancreatic

111 Two-dimensional (2D) human skeletal muscle fiber cultures are ill-equipped to suppo

112 himeras protected them from both cardiac and skeletal muscle fiber damage.

113 Immunolocalization of caveolin-3 in skeletal muscle fibers demonstrates that caveolin-3 is l

114 es beta-fodrin (betaII) at the sarcolemma as skeletal muscle fibers develop.

115 Oxidative and glycolytic skeletal muscle fibers differ in their contractile abili

116 down of Tid1 by short hairpin RNA (shRNA) in skeletal muscle fibers dispersed synaptic AChR clusters

117 The G93A skeletal muscle fibers display localized loss of mitocho

118 kd amyloid-beta and the carboxyl-terminus in skeletal muscle fibers during aging.

119 c enhancer in the somite myotomes and in all skeletal muscle fibers during embryogenesis and adulthoo

120 cium from the sarcoplasmic reticulum (SR) of skeletal muscle fibers during excitation-contraction (e-

121 ow angle x-ray diffraction pattern of rabbit skeletal muscle fibers during ramp stretch compared to t

122 to undertake in the context of intact, live skeletal muscle fibers during real time physiological tw

123 At the plasma membrane of skeletal muscle fibers, dystrophin associates with a mul

124 potent activators of Ca2+ release via RyR in skeletal muscle fibers (e.g. Ca2+ sparks) and potent mod

125 Here, we find that unstimulated adult skeletal muscle fibers exhibit a previously unanticipate

126 Skeletal muscle fibers express distinct gene programs du

127 Human skeletal muscle fibers express five highly conserved typ

128 Skeletal muscle fibers express members of the myosin hea

129 ocal expression of a growth factor in mature skeletal muscle fibers extends replicative life span of

130 e isoform that is normally expressed in fast skeletal muscle fibers (fast muscle-specific MLC2).

131 Multinucleated skeletal muscle fibers form through the fusion of myobla

132 confirmed by those obtained ex vivo on adult skeletal muscle fibers from a biopsy from a pseudomyoton

133 Using patch clamp methods on isolated skeletal muscle fibers from adult zebrafish, we show her

134 , are present in enzymatically isolated fast skeletal muscle fibers from adult zebrafish.

135 of ryanodine receptors uncoupled to DHPRs in skeletal muscle fibers from aging mammals.

136 In this work we tested the hypothesis that skeletal muscle fibers from aging mice exhibit a signifi

137 Interestingly, skeletal muscle fibers from Cav-3 (-/-) knock-out mice s

138 taining sarcolemmal integrity and protecting skeletal muscle fibers from damage.

139 rther protect laminin alpha2 chain-deficient skeletal muscle fibers from degeneration.

140 ->A)] were expressed in cultured adult mouse skeletal muscle fibers from flexor digitorum brevis (pre

141 Our results indicate that skeletal muscle fibers from male Cav-1(-/-) and Cav-2(-/

142 alpha-dystroglycan, and alpha-sarcoglycan in skeletal muscle fibers from mdx mice.

143 on patterns of single membrane-permeabilized skeletal muscle fibers from mice lacking Tmod1.

144 properties of the Ca(2+)-release process in skeletal muscle fibers from normal and mdx fibers were d

145 Skeletal muscle fibers from the flexor digitorum brevis

146 dynamics, and mitophagy were analyzed in the skeletal muscle fibers from the red gastrocnemius.

147 orce development was studied in skinned fast skeletal muscle fibers from wildtype (WT) and nebulin de

148 und that, by forming a complex with MEKK4 in skeletal muscle fibers, Gadd45a increases MEKK4 protein

149 t extracellular matrix remnants from injured skeletal muscle fibers, "ghost fibers," govern muscle st

150 Here, we show that segments of human skeletal muscle fibers harboring two pathogenic mtDNA mu

151 erologously expressed in HEK293 cells and in skeletal muscle fibers, hClC-4 localizes to the endoplas

152 ications for designing experiments to assess skeletal muscle fiber heterogeneity and its role in heal

153 ctivity at neuromuscular junctions (NMJs) of skeletal muscle fibers in adult mice.

154 ecular weight diazo dye, does not cross into skeletal muscle fibers in normal mice.

155 Permeabilized skeletal muscle fibers in rigor were labeled with a fluo

156 rapidly restore contractile function to DMD skeletal muscle fibers in vitro.

157 ng domain of ATF4 (the bZIP domain) in mouse skeletal muscle fibers in vivo Interestingly, we found t

158 with Gadd45a as it induces atrophy in mouse skeletal muscle fibers in vivo We found that Gadd45a int

159 n internal vesicular membrane compartment in skeletal muscle fibers in vivo.

160 ned the kinetic properties of rabbit skinned skeletal muscle fibers in which the endogenous myosin re

161 Gadd45a interacts with multiple proteins in skeletal muscle fibers, including, most prominently, MEK

162 At birth, each mammalian skeletal muscle fiber is innervated by multiple motor ne

163 that nuclear factor-kappaB signaling within skeletal muscle fibers is a key pathway leading to diaph

164 stering of acetylcholine receptors (AChR) on skeletal muscle fibers is an early event in the formatio

165 The Golgi complex of skeletal muscle fibers is made of thousands of dispersed

166 nitric oxide synthase (nNOS) in fast-twitch skeletal muscle fibers is primarily particulate in contr

167 Gene expression in skeletal muscle fibers is regulated by innervation and i

168 at overexpression of wild-type caveolin-3 in skeletal muscle fibers is sufficient to induce a Duchenn

169 In summary, the restoration of dysferlin in skeletal muscle fibers is sufficient to rescue the MD in

170 rom multiple to single axonal innervation of skeletal muscle fibers is the most accessible example of

171 Skeletal muscle fibers isolated from TDP-43 transgenic m

172 been associated with aging, particularly in skeletal muscle fibers; its mechanism has remained uncle

173 xchange of signals between motor neurons and skeletal muscle fibers, leading to the accumulation of p

174 e distribution; Sk-Tmod predominates in fast skeletal muscle fibers, lens, and erythrocytes, while E-

175 In adult skeletal muscle fibers, levels of Syne-1 are highest in

176 In healthy adult skeletal muscle fibers microtubules form a three-dimensi

177 to promote clearance of Abeta from affected skeletal muscle fibers mitigates the IBM-like myopatholo

178 In skeletal muscle fibers, mitochondria are densely packed

179 n difference, hyperemic calf blood flow, and skeletal muscle fiber morphometry, oxidative enzyme acti

180 ge secrete exosomes, it is not known whether skeletal muscle fibers (myofibers) release exosomes.

181 tween the nerve terminals and multinucleated skeletal muscle fibers (myofibers).

182 We previously showed that, in mouse skeletal muscle fibers, Numb is localized to sarcomeres

183 function measures were all markedly lower in skeletal muscle fibers obtained from patients with HFpEF

184 nuclei isolated from flexor digitorum brevis skeletal muscle fibers of adult mice.

185 Our results indicate that avian skeletal muscle fibers of chicken and duck could be sign

186 muscle fiber size and increased fibrosis in skeletal muscle fibers of D2-mdx mice compared with B10-

187 UDP-glucose (UDP-Glc) and glycogen levels in skeletal muscle fibers of defined fiber type were measur

188 ally, mRNA for both clc and clf was found in skeletal muscle fibers of embryonic mice during the moto

189 the organization of the membrane skeleton of skeletal muscle fibers of mdx mice, which lack dystrophi

190 In single isolated skeletal muscle fibers of the frog, we studied (i) the r

191 SERCA1 isoform, which is essential for fast skeletal muscle fiber phenotype.

192 c oxide modulate the contractile function of skeletal muscle fibers, possibly via direct interaction

193 ight chain phosphorylation in skinned rabbit skeletal muscle fibers (potentiation of force developmen

194 cellularly applied tubular system markers in skeletal muscle fiber preparations with a combination of

195 Understanding how skeletal muscle fiber proportions are regulated is vital

196 In intact single adult skeletal muscle fibers, real time twitch contractile dat

197 infection rescues macrophage homeostasis and skeletal muscle fiber regeneration, showing that Tregs c

198 Skeletal muscle fibers regulate surrounding endothelial

199 These findings demonstrate that skeletal muscle fibers release exosomes which can exert

200 It was shown previously that skeletal muscle fibers require merosin for survival and

201 repolarizing pre-pulse to a depolarized frog skeletal muscle fiber restores a small fraction of the t

202 hannels causes a prolonged depolarization of skeletal muscle fibers, resulting in membrane inexcitabi

203 als, the TnC biosensor incorporated into the skeletal muscle fiber sarcomeres by stoichiometric repla

204 Skeletal muscle fibers show a high level of constitutive

205 anges, as well as increases in the number of skeletal muscle fibers showing mitochondrial enzyme abno

206 Furthermore, repletion of vitamin D improved skeletal muscle fiber size and in vivo muscle function,

207 In Nedd4 mutant embryos, skeletal muscle fiber sizes and motoneuron numbers are s

208 oll receptor adapter protein, Myd88, only in skeletal muscle fibers (skmMyd88KO), and followed male a

209 ovide mechanistic insight into regulation of skeletal muscle fiber-specification that is of relevance

210 In voltage-clamp studies of single frog skeletal muscle fibers stained with the potentiometric i

211 insulin receptor substrate (IRS)-1 in human skeletal muscle fiber strips in vitro.

212 Ca(2+) release and Ca(2+) currents in adult skeletal muscle fibers subjected to voltage-clamp and on

213 scribe a method to isolate nuclei from adult skeletal muscle fibers that are suitable for electrophys

214 Finally, in skeletal muscle fibers that coexpress both Sk- and E-Tmo

215 is a synapse formed between motoneurons and skeletal muscle fibers that is covered by Schwann cells

216 Within skeletal muscle fibers, the ATF4-C/EBPbeta heterodimer i

217 hanism underlying the diversity of mammalian skeletal muscle fibers, the elementary steps of the cros

218 The first skeletal muscle fibers to form in vertebrate embryos app

219 and population differences in the ability of skeletal muscle fibers to function in the presence of TT

220 atrix LDH is strategically positioned within skeletal muscle fibers to functionally interact with mit

221 mote inflammation and muscle necrosis and in skeletal muscle fibers to limit regeneration through the

222 While alpha-MNs innervate extrafusal skeletal muscle fibers to mediate muscle contraction, ga

223 w in exercising muscle by diffusing from the skeletal muscle fibers to the nearby microvessels where

224 iously appreciated that the determination of skeletal muscle fiber type (fast or slow) could be regul

225 ion, these mice provide unique insights into skeletal muscle fiber type composition.

226 hat the influence of motor nerve activity on skeletal muscle fiber type is transduced to the relevant

227 an increasingly common method for describing skeletal muscle fiber type proportions.

228 proach establish a reliable method for human skeletal muscle fiber type specific protein analysis.

229 These results indicate that Fnip1 controls skeletal muscle fiber type specification and warrant fur

230 ignaling plays a critical role in regulating skeletal muscle fiber type switching but not hypertrophy

231 NFATc1, NFAT2) may contribute to slow-twitch skeletal muscle fiber type-specific gene expression.

232 owth, bone development, and specification of skeletal muscle fiber type.

233 C1alpha) coordinates the exercise-stimulated skeletal muscle fiber-type switch from glycolytic fast-t

234 We compared the percent distribution of skeletal muscle fiber types, cross-sectional areas, and

235 al fashion throughout the continuum of human skeletal muscle fiber types, further highlighting the ne

236 g the voltage sensor-is demonstrated in frog skeletal muscle fibers under voltage clamp.

237 Labeled RLC was reconstituted into skeletal muscle fibers using a modified method that resu

238 calcium release events in permeabilized frog skeletal muscle fibers, using laser scanning confocal mi

239 Up-regulation of class I MHC in skeletal muscle fibers was an early and consistent featu

240 Activation in skinned skeletal muscle fibers was enhanced with all TnI mutants

241 ese mutated proteins to TnC-depleted skinned skeletal muscle fibers was investigated as well as the r

242 ases 1 and 2 (ERK1/2) in slow-twitch, type 1 skeletal muscle fibers, we studied the soleus muscle in

243 re highly expressed in innervated regions of skeletal muscle fibers, where it is externalized and att

244 function is poorly understood, especially in skeletal muscle fibers, which are among the largest cell

245 rce and relaxation were performed in skinned skeletal muscle fibers whose endogenous TnI (along with

246 trophic, necrotic, and immature/regenerating skeletal muscle fibers with characteristic central nucle

247 Autoantibodies targeting TRIM72 lead to skeletal muscle fibers with compromised membrane barrier

248 g expression of GFP-JPH1 deletion mutants in skeletal muscle fibers with in vitro biochemical experim

249 CK is expressed predominantly in fast-twitch skeletal muscle fibers with insignificant amounts in hea

250 ss endogenous GLUT4 translocation in primary skeletal muscle fibers without the need for overexpresse