ライフサイエンスコーパス: skeletal muscle mass

1 ation and synthesis is essential to preserve skeletal muscle mass.

2 s) through which mechanical stimuli regulate skeletal muscle mass.

3 developed diaphragm and a reduction in total skeletal muscle mass.

4 t are involved in the negative regulation of skeletal muscle mass.

5 er-family, is a potent negative regulator of skeletal muscle mass.

6 mouse muscle leads to profound increases in skeletal muscle mass.

7 myostatin (MSTN) normally functions to limit skeletal muscle mass.

8 investigated the role of TWEAK in regulating skeletal muscle mass.

9 lts in exencephaly and a marked reduction in skeletal muscle mass.

10 member that acts as a negative regulator of skeletal muscle mass.

11 rstanding the adaptive processes controlling skeletal muscle mass.

12 d body composition analysis revealed loss of skeletal muscle mass.

13 l inactivity, low energy intake, and loss of skeletal muscle mass.

14 8), that has an essential role in regulating skeletal muscle mass.

15 ary protein intake can attenuate the loss of skeletal muscle mass.

16 he age-related decline in total appendicular skeletal muscle mass.

17 and show a large and widespread increase in skeletal muscle mass.

18 uscle degeneration and dramatic reduction in skeletal muscle mass.

19 owever, ~35% of weight lost during CR+AT was skeletal muscle mass.

20 ly member that acts as a master regulator of skeletal muscle mass.

21 en by the LPD this may negatively affect the skeletal muscle mass.

22 over three orders of magnitude of mammalian skeletal muscle mass.

23 ) and its splice variant PGC1alpha4 increase skeletal muscle mass.

24 and GDF11 are potent negative regulators of skeletal muscle mass.

25 uperfamily member, and negative regulator of skeletal muscle mass.

26 epatic encephalopathy through an increase in skeletal muscle mass.

27 nterleukin-6 and MCP-1 levels, and decreased skeletal muscle mass.

28 d nitrogen excretion, reflecting the loss of skeletal muscle mass.

29 r beta superfamily that negatively regulates skeletal muscle mass (1).

30 iRNAs, die perinatally and display decreased skeletal muscle mass accompanied by abnormal myofiber mo

31 enotypes were observed: decreased accrual of skeletal muscle mass after weaning and reduced wheel-run

32 the fatigue resistance of muscle, increased skeletal muscle mass and ameliorated muscle injury in my

33 ressive body weight loss due to depletion of skeletal muscle mass and body fat.

34 PERK regulates skeletal muscle mass and contractile function in adult m

35 This was associated with reduced skeletal muscle mass and contractility in tumour-bearing

36 an body mass, improved grip strength, higher skeletal muscle mass and diameter, and an increase in ty

37 energy expenditure and elevated appendicular skeletal muscle mass and energy intake in Alzheimer dise

38 Loss of skeletal muscle mass and force is of critical importance

39 ostatin inhibition would improve recovery of skeletal muscle mass and function after cerebral ischemi

40 ed in assessments of sarcopenia, the loss of skeletal muscle mass and function associated with aging.

41 Sarcopenia is the accelerated loss of skeletal muscle mass and function commonly, but not excl

42 the UPR is essential for the maintenance of skeletal muscle mass and function in adult mice.

43 regulation after PoWeR that could influence skeletal muscle mass and function in aged mice.

44 Oxidative stress contributes to the loss of skeletal muscle mass and function in cancer cachexia.

45 e (PERK) arm of the UPR in the regulation of skeletal muscle mass and function in naive conditions an

46 drial metabolism in the pathological loss of skeletal muscle mass and function in older people.

47 RATIONALE: Loss of skeletal muscle mass and function is a common consequenc

48 Age-related loss of skeletal muscle mass and function is a key contributor t

49 Age-related loss of skeletal muscle mass and function is a major contributor

50 Sarcopenic obesity, the combination of skeletal muscle mass and function loss with an increase

51 During aging, a significant loss of skeletal muscle mass and function occurs that can have a

52 Loss of skeletal muscle mass and function occurs with increasing

53 lopment of therapeutic strategies to protect skeletal muscle mass and function of patients with chron

54 wever, the role of Fn14 in the regulation of skeletal muscle mass and function remains poorly underst

55 phenotype of accelerated age-related loss of skeletal muscle mass and function, although it is unclea

56 nockout (KO) mice lacking CTRP11 have normal skeletal muscle mass and function, and testosterone leve

57 Sarcopenia, the age-related loss of skeletal muscle mass and function, can dramatically impi

58 , a subtype of obesity, is marked by reduced skeletal muscle mass and function, or sarcopenia, and po

59 derlying sarcopenia, the age-related loss of skeletal muscle mass and function, remain unclear.

60 ia, characterized by the progressive loss of skeletal muscle mass and function, represents a signific

61 mice blunts myogenesis and deteriorates aged skeletal muscle mass and function, which is associated w

62 n can initiate rapid and significant loss of skeletal muscle mass and function.

63 Sarcopenia is the age-related loss of skeletal muscle mass and function.

64 rized by progressive and generalized loss of skeletal muscle mass and function.

65 kine has now emerged as a major regulator of skeletal muscle mass and function.

66 h result in severe loss of motor ability and skeletal muscle mass and function.

67 ata show that targeting the ActRIIB improves skeletal muscle mass and functional strength in the mdx

68 Myostatin is a major negative regulator of skeletal muscle mass and initiates multiple metabolic ch

69 RP concentration and significantly increased skeletal muscle mass and lean body mass over time.

70 levels and no significant difference in both skeletal muscle mass and lean body mass.

71 A decline in skeletal muscle mass and low muscular strength are progn

72 on, 1 week of bed rest substantially reduces skeletal muscle mass and lowers whole-body insulin sensi

73 In contrast, reductions in both skeletal muscle mass and Mito(VD) have been reported fol

74 Loss of skeletal muscle mass and muscle weakness are common in a

75 strophic mdx(5Cv) mice for 2 weeks increased skeletal muscle mass and normalized plasma creatine kina

76 Reduced skeletal muscle mass and oxidative capacity coexist in p

77 HMB alone, or supplements containing HMB, on skeletal muscle mass and physical function in a variety

78 current RDA or twice the RDA (2RDA) affects skeletal muscle mass and physical function in elderly me

79 a better understanding of the maintenance of skeletal muscle mass and prevention of muscle atrophy by

80 we show that YAP positively regulates basal skeletal muscle mass and protein synthesis.

81 d UPR pathways are essential for maintaining skeletal muscle mass and strength and for protection aga

82 The causes of impaired skeletal muscle mass and strength during aging are well-

83 geted ablation of MyD88 inhibits the loss of skeletal muscle mass and strength in LLC tumor-bearing m

84 Loss of skeletal muscle mass and strength is a debilitating cons

85 The maintenance of skeletal muscle mass and strength throughout life is a k

86 ective strategies for preventing declines in skeletal muscle mass and strength with age.

87 There is a gradual loss of both skeletal muscle mass and strength with ageing (a process

88 isk factor for metabolic disease and loss of skeletal muscle mass and strength, a condition known as

89 Aging reduces skeletal muscle mass and strength, but the underlying mo

90 process, mammals lose up to a third of their skeletal muscle mass and strength.

91 e that contribute to the progressive loss of skeletal muscle mass and strength.

92 yndrome characterized by progressive loss of skeletal muscle mass and strength.

93 g hemodialysis experience a rapid decline in skeletal muscle mass and strength.

94 e characterized by an age-related decline in skeletal muscle mass and strength.

95 ty is sarcopenia, the age-associated loss of skeletal muscle mass and strength.

96 aim to clarify the relationship between low skeletal muscle mass and varying levels of adiposity and

97 clinical conditions characterized by loss of skeletal muscle mass and weakness.

98 sms underpinning this finding, such as a low skeletal muscle mass and/or fluid overload.

99 In 2-week-old mice, skeletal muscle masses and insulin responses were slight

100 insulin secretion increase adiposity, reduce skeletal muscle mass, and cause systemic inflammation.

101 r LBM (beta = -0.75; P = 0.03), appendicular skeletal muscle mass, and grip strength than did control

102 ssential for mechanically induced changes in skeletal muscle mass, and previous studies have suggeste

103 skeletal muscle index (SMI), a surrogate of skeletal muscle mass, and to evaluate the skeletal muscl

104 The ability to maintain skeletal muscle mass appears to be impaired in insulin-r

105 Bone and skeletal muscle mass are highly correlated in mammals, s

106 cle wasting, there were significant gains in skeletal muscle mass, as represented by dual X-ray absor

107 Although appendicular skeletal muscle mass (ASM) and handgrip strength (HGS) a

108 ment failed to prevent age-dependent loss of skeletal muscle mass associated with myofiber atrophy or

109 drome characterized by a progressive loss of skeletal muscle mass associated with significant functio

110 ound that TRB3 has the potential to regulate skeletal muscle mass at the basal state.

111 demonstrate that there was no difference in skeletal muscle mass between control and muscle-specific

112 cal health (i.e., cardiorespiratory fitness, skeletal muscle mass, body fat mass, and visceral fat).

113 s with bimagrumab treatment safely increased skeletal muscle mass but did not improve functional capa

114 The adipose tissue expansion and reduced skeletal muscle mass, but not the systemic inflammation

115 generate a mechanically induced increase in skeletal muscle mass, but the mechanism(s) through which

116 other catabolic conditions, induces loss of skeletal muscle mass by promoting fiber atrophy.

117 Skeletal muscle mass can be measured noninvasively with

118 experienced reductions in adipose tissue and skeletal muscle mass compared to the control group.

119 mutants also exhibit a dramatic reduction in skeletal muscle mass, consistent with a defect in expans

120 ndurance or strength characteristics enhance skeletal muscle mass content and/or oxidative capacity,

121 During the later adult years, skeletal muscle mass decreases and body fat becomes cent

122 Skeletal muscle mass decreases in end-stage heart failur

123 a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber numbe

124 has been proposed to bind key regulators of skeletal muscle mass development, including the ligands

125 The skeletal muscle mass did not change significantly.

126 eding, total subcutaneous adipose tissue and skeletal muscle mass did not differ significantly betwee

127 openia was defined based on the appendicular skeletal muscle mass divided by body mass index (ASM/BMI

128 ence that pericytes effectively rehabilitate skeletal muscle mass following disuse atrophy.

129 Skeletal muscle mass, function, and repair capacity all

130 signaling has been shown to be required for skeletal muscle mass gains in some models of hypertrophy

131 though it is unknown whether this represents skeletal muscle mass gains.

132 ABSTRACT: Significant skeletal muscle mass guarantees functional wellbeing and

133 A decrease in skeletal muscle mass has been shown to increase hospital

134 ers of a genetic model that harbours reduced skeletal muscle mass have yet to be analysed.

135 OS) in skeletal muscle is a key regulator of skeletal muscle mass; however, it is unclear whether nNO

136 eriod has been associated with reduced adult skeletal muscle mass; however, the mechanisms responsibl

137 kout mice exhibit a progressive reduction in skeletal muscle mass, impairment of motor function and s

138 o known as GDF-8) as a critical regulator of skeletal muscle mass in 1997, there has been an extensiv

139 essential for the growth and maintenance of skeletal muscle mass in adult mice.

140 Precise and accurate determinations of skeletal muscle mass in clinical settings are often chal

141 trauterine growth restriction (IUGR) reduces skeletal muscle mass in fetuses and offspring.

142 TRB3 regulates skeletal muscle mass in food deprivation-induced atrophy

143 aneous AT, visceral AT (VAT), and total-body skeletal muscle mass in healthy sedentary African Americ

144 al-body skeletal muscle mass (TBMM) and limb skeletal muscle mass in hemodialysis patients.

145 (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals.

146 ction has been shown to underlie the loss of skeletal muscle mass in many acquired and genetic muscle

147 s that is essential for proper regulation of skeletal muscle mass in mice.

148 e role of ER stress and UPR in regulation of skeletal muscle mass in naive conditions and during canc

149 inversely associated with total appendicular skeletal muscle mass in older men (r = -0.43; slope: -0.

150 offset the age-related loss of appendicular skeletal muscle mass in older men.

151 ture research directives designed to protect skeletal muscle mass in physically active, normal-weight

152 Mechanistically, the better recovery of skeletal muscle mass in PINTA745-MCAO mice involved an i

153 the complex molecular mechanisms controlling skeletal muscle mass in response to increased physical a

154 ABSTRACT: Reduced skeletal muscle mass in the fetus with intrauterine grow

155 s reported here, we investigated the role of skeletal muscle mass in the regulation of liver:body mas

156 is (TWEAK)-Fn14 system are key regulators of skeletal muscle mass in various catabolic states.

157 y in cellular models, has a direct impact on skeletal muscle mass in vivo.

158 tion mutations are associated with increased skeletal-muscle mass in mice, cattle, and humans.

159 Stair climbing correlates included skeletal muscle mass (in kilograms) and its change, pain

160 We aimed to determine whether skeletal muscle mass increases early during LVAD support

161 body mass index < 20 kg/m(2) or appendicular skeletal muscle mass index <= 7.25 [men] and <= 5.67 [wo

162 e and associated factors of low appendicular skeletal muscle mass index (ASMI) in older adults.

163 Body composition [appendicular skeletal muscle mass index (ASMI), visceral fat, and tot

164 definitions - %Skeletal Muscle Mass (%SMM), Skeletal Muscle Mass Index (SMI) and European Working Gr

165 Low muscle mass (MM) was defined as low skeletal muscle mass index (SMI) using dual-energy X-ray

166 we calculated body fat percentage (%BF) and skeletal muscle mass index (SMI).

167 We also assessed associations between skeletal muscle mass index (SMMI) and CRF.

168 ne inactivation prevented the severe loss of skeletal muscle mass induced in mice engrafted with Lewi

169 Maintenance of skeletal muscle mass is contingent upon the dynamic equi

170 The maintenance of skeletal muscle mass is critical for sustaining health;

171 Skeletal muscle mass is determined predominantly by feed

172 ABSTRACT: The maintenance of skeletal muscle mass is essential for health and quality

173 uals because attenuating the extent to which skeletal muscle mass is lost during energy deficit could

174 result in cases when a prominent portion of skeletal muscle mass is lost, for example, following tra

175 Skeletal muscle mass is regulated by the coordinated act

176 Skeletal muscle mass is regulated through coordinated ac

177 Sarcopenia was defined as appendicular skeletal muscle mass (kg)/height2 (m2) being less than t

178 In stroke patients, loss of skeletal muscle mass leads to prolonged weakness and les

179 Ten percent of women had skeletal muscle mass levels less than a proposed cutpoin

180 rhomocysteinemia (HHcy) and obesity with low skeletal muscle mass (LMM) has not been established.

181 Skeletal muscle mass loss and dysfunction have been link

182 whether CTSS participates in stress-related skeletal muscle mass loss and dysfunction, focusing on p

183 ammation is associated with cachexia-induced skeletal muscle mass loss in cancer.

184 Skeletal muscle-mass loss with age has severe health con

185 y weight loss as a high proportion of fat to skeletal muscle mass lost.

186 The relationship between bone and skeletal muscle mass may be affected by physical trainin

187 results in a progressive loss of functional skeletal muscle mass (MM) and replacement with fibrofatt

188 rmation even though the largest increases in skeletal muscle mass occur after birth.

189 Loss of skeletal muscle mass occurs during aging (sarcopenia), d

190 We also conducted a GWAS on hindlimb skeletal muscle mass of 1,867 mice from an advanced inte

191 7, 95% CI [1.01, 1.13], p = 0.016) and lower skeletal muscle mass (OR = 0.88, 95% CI [0.78, 0.99], p

192 free mass (1.7-kg gain, P < 0.001), relative skeletal muscle mass (P = 0.009), android distribution o

193 urthermore, an effect of age on appendicular skeletal muscle mass persisted after standing height and

194 An effect of age on appendicular skeletal muscle mass persisted after standing height and

195 found that PGC1beta progressively decreases skeletal muscle mass predominantly associated with loss

196 s indicate that TRB3 plays a pivotal role in skeletal muscle mass regulation under food deprivation-i

197 light the autonomous role the VDR has within skeletal muscle mass regulation.

198 ividual arms of the UPR in the regulation of skeletal muscle mass remain largely unknown.

199 role and mechanisms by which TAK1 regulates skeletal muscle mass remain less understood.

200 lation of TAK1 activity in the regulation of skeletal muscle mass remain unknown.

201 in gene (Mstn) have a widespread increase in skeletal muscle mass resulting from a combination of mus

202 eight (body-mass index [BMI] <20 kg/m(2)) or skeletal muscle mass (sarcopenia).

203 perative discrimination of patients with low skeletal muscle mass (sarcopenic patients) using compute

204 intake, restore energy balance, and maintain skeletal muscle mass should be a future area of investig

205 n of Ihh in chicken embryo hindlimbs reduced skeletal muscle mass similar to that seen in Ihh(-/-) mo

206 al muscle aging results in a gradual loss of skeletal muscle mass, skeletal muscle function and regen

207 prediction equations to quantify whole-body skeletal muscle mass (SM) in adults.

208 Percentages of body fat (BF) and skeletal muscle mass (SM) were calculated using validate

209 mposition method is estimation of total-body skeletal muscle mass (SM, in kg) from 24-h urinary creat

210 or supplements containing HMB, on increasing skeletal muscle mass (SMD = 0.25; 95% CI: -0.00, 0.50; z

211 Three established sarcopenia definitions - %Skeletal Muscle Mass (%SMM), Skeletal Muscle Mass Index

212 to reduced exercise tolerance and decreased skeletal muscle mass, specific force, increased overall

213 study aims were to characterize deficits in skeletal muscle mass, strength and physical performance,

214 targeted inducible deletion of PERK reduces skeletal muscle mass, strength, and force production dur

215 ned as a progressive and generalized loss of skeletal muscle mass, strength, and function.

216 ned as a progressive and generalized loss of skeletal muscle mass, strength, and function.

217 s in myostatin exhibit dramatic increases in skeletal muscle mass, suggesting that myostatin normally

218 though low levels of TAK1 activation improve skeletal muscle mass, sustained hyperactivation of TAK1

219 tracellular volume (ICV) to model total-body skeletal muscle mass (TBMM) and limb skeletal muscle mas

220 -week-old 2ND mice exhibited higher body and skeletal muscle mass than other strains.

221 lation (particularly hepatic fat), and lower skeletal muscle mass than white people of a similar age

222 indicate that TP53INP2 negatively regulates skeletal muscle mass through activation of autophagy.

223 not yet been explored whether TRB3 regulates skeletal muscle mass under atrophic conditions.

224 Our results suggest that PDK1 regulates skeletal muscle mass under the static condition and that

225 f PI3K signaling pathway, manifest a reduced skeletal muscle mass under the static condition as well

226 A rapid and early loss of skeletal muscle mass underlies the physical disability c

227 We measured body fat and skeletal muscle mass using whole-body dual X-ray absorpt

228 e decile values of fat mass and appendicular skeletal muscle mass utilizing the LMS statistical proce

229 At all ages examined the loss of skeletal muscle mass was accompanied by a loss of myobla

230 sition was determined anthropometrically and skeletal muscle mass was determined as the creatinine-he

231 Total appendicular skeletal muscle mass was determined by dual-energy X-ray

232 ometric equation for predicting appendicular skeletal muscle mass was developed from a random subsamp

233 was assessed with a handgrip dynamometer and skeletal muscle mass was estimated using bioelectrical i

234 s, liver weights were preserved and instead, skeletal muscle mass was reduced in GCN2(-/-) mice fed a

235 of myostatin, a master negative regulator of skeletal muscle mass, was strongly increased in skeletal

236 d body composition (lean mass and total body skeletal muscle mass), weight, and walking capacity.

237 Participants' LBM and appendicular skeletal muscle mass were measured using dual energy x-r

238 racterized by a continuous loss of locomotor skeletal muscle mass, which causes profound muscle weakn

239 F11, and activins are negative regulators of skeletal muscle mass, which have been reported to primar

240 that predominantly results from the loss of skeletal muscle mass, which is in part associated with a

241 ed muscle contraction secondary to a reduced skeletal muscle mass, which may be related to pulmonary

242 trics, spinal cord motor neuron numbers, and skeletal muscle mass, while at the second time point, th

243 ibuted to greater gains in fat-free mass and skeletal muscle mass with RT in older men than did an LO

244 We investigated the relationship between skeletal muscle mass (with dual-energy x-ray absorptiome

245 orial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass)

246 We hypothesized that loss of skeletal muscle mass would include inspiratory muscles a