ライフサイエンスコーパス: skin biopsy

1 .3%) who had not received antibiotics before skin biopsy.

2 of melanoma diagnosed by means of results of skin biopsy.

3 p to 400 mg/kg in individual sections of the skin biopsy.

4 resent in 22 patients (78.6%) at the time of skin biopsy.

5 obial therapy, she was diagnosed with LCV by skin biopsy.

6 rom a variety of sources, including a simple skin biopsy.

7 ukocytosis, and a neutrophilic infiltrate on skin biopsy.

8 h dermatology referral patterns and rates of skin biopsies.

9 cy without increasing specialty referrals or skin biopsies.

10 s are limited by the need of large number of skin biopsies.

11 phorylated cyclin-dependent kinase (CDK1) in skin biopsies.

12 cells, but no laminin-332, were detected in skin biopsies.

13 s was based on the absence of laminin-332 in skin biopsies.

14 lysis of paired PP and nonlesional psoriatic skin biopsies.

15 d oxidized TRPV1 agonists in spinal cord and skin biopsies.

16 ficantly elevated in a subset of scleroderma skin biopsies.

17 phosphorylated ribosomal protein S6 (pS6) in skin biopsies.

18 n be used as biomarkers and a substitute for skin biopsies.

19 ells in the blood may eliminate the need for skin biopsies.

20 s underwent neurological examination and 3mm skin biopsies.

21 t electron microscopy was performed on human skin biopsies.

22 was significantly reduced in a subset of SSc skin biopsies.

23 h hand allografts presented in some of their skin biopsies an as yet unreported pathological finding

24 Skin biopsy analysis showed that compared with control s

25 specimens were reviewed, including 88 native skin biopsies and 126 specimens from the skin component

26 specimens were reviewed, including 88 native skin biopsies and 126 specimens from the skin component

27 he reprogramming of human somatic cells from skin biopsies and blood draws obtained from healthy dono

28 wing an extended length of time in hospital, skin biopsies and close monitoring of renal function and

29 We obtained skin biopsies and contemporaneous blood samples from pat

30 the protein expression of hBD2 in psoriatic skin biopsies and induced phospho-STAT6 protein.

31 h imatinib ameliorated cytokine release from skin biopsies and led to a correlative decrease in granu

32 ify CDK4 activity in melanoma cell extracts, skin biopsies and melanoma xenografts.

33 s gammaH2AX foci occurred in DNA-PKcs(3A/3A) skin biopsies and primary keratinocytes and that these f

34 ression of p300 was markedly elevated in SSc skin biopsies and was induced by TGF-beta in explanted n

35 Histological evaluation of a skin biopsy and analysis of inflammatory cytokines and m

36 A skin biopsy and chimerism study should be performed when

37 Skin biopsy and microneurography revealed an absence of

38 PXE diagnosis was confirmed by a positive skin biopsy and/or genetic testing.

39 erium fortuitum isolates (graywash ink and a skin biopsy) and 11 Mycobacterium abscessus isolates (5

40 , biologically (CRP values), histologically (skin biopsy), and morphologically (positron emission tom

41 ought to assess adiponectin signaling in SSc skin biopsies, and evaluate fibrosis in mice with adipon

42 ) finger prick blood, ii) venous blood, iii) skin biopsies, and in pools of mosquitoes that fed iv) o

43 in gene-related peptide release from hindpaw skin biopsies, and increased capsaicin-evoked inward cur

44 portion of dermatology referrals, subsequent skin biopsies, and PCP diagnostic accuracy for skin canc

45 tected by corneal confocal microscopy (CCM), skin biopsy, and neurophysiological tests in 86 recently

46 To determine the utility of skin biopsies as a biomarker of disease severity in subj

47 biopsies from patients with LN and evaluated skin biopsies as a potential source of diagnostic and pr

48 thermal injury determined by histology from skin biopsied at the camera trocar incision.

49 Nasal biopsies were obtained at 8 h and skin biopsies at 8 and 48 h after allergen and PPD chall

50 on demonstrated decreased expression in some skin biopsies at disease progression.

51 Pyrosequencing of bisulfite-treated DNA from skin biopsies at three DM loci confirmed earlier finding

52 dardized examinations, nerve conduction, and skin biopsy at 3 sites along the leg.

53 In conclusion, CCM and skin biopsy both detect nerve fiber loss in recently dia

54 es were examined in the sera by ELISA and in skin biopsies by immunohistochemistry and in situ RNA hy

55 in peripheral blood by flow cytometry and in skin biopsies by immunohistochemistry.

56 Cutaneous involvement is near universal, and skin biopsy can be used to diagnose the majority of pati

57 ulture, and IHC plus PCR from full thickness skin biopsy can lead to improved diagnosis of M. marinum

58 imidazolones (P = 0.049), an AGE measured in skin biopsy collagen, in DCCT.

59 condary outcome measures were obtained and a skin biopsy collected.

60 Prussian blue staining of skin biopsies confirmed iron-laden cells in the inflamed

61 A skin biopsy confirmed a diagnosis of GEH.

62 A skin biopsy confirmed mycosis fungoides (MF).

63 Skin biopsy, corneal confocal microscopy, laser-evoked p

64 ve sensory testing (QST), electrophysiology, skin biopsy, corneal sensitivity, and CCM at baseline an

65 e compared analyte levels in both plasma and skin biopsies (cross-sectional area same as the micropro

66 EM, 28 of whom were confirmed to have LB by skin biopsy culture (N=18), seroconversion (N=2) or both

67 Findings from the skin biopsy demonstrated a deep dermal lymphocytic infil

68 Skin biopsy demonstrated an altered cellular distributio

69 Skin biopsy-derived RNAs from 14 early systemic sclerosi

70 ed for surveillance of rejection (i.e. punch skin biopsies, DSA and conventional vascular imaging stu

71 anin index, reflectance spectroscopy, and/or skin biopsy evaluated by a blinded dermatopathologist.

72 In this study, we utilized PPR skin biopsy explants to integrate both differentially ex

73 matory cells and some surrounding tissues in skin biopsies expressed PTHrP.

74 on-Gottron's DM lesions and Gottron's papule skin biopsies for C4S, CD44 variant 7 (CD44v7), a chondr

75 ensory testing, nerve conduction studies and skin biopsy for intraepidermal nerve fibre assessment.

76 ributions (n = 16 per group) underwent: 1) a skin biopsy for vascular immunohistochemistry, gene expr

77 , we analyzed miRNA expression in diagnostic skin biopsies from 154 Danish patients with early-stage

78 drug susceptibility testing was performed on skin biopsies from 24 leprosy patients from Guinea-Conak

79 th quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodu

80 e real-time PCR and in situ hybridization in skin biopsies from 40 healthy donors, 13 actinic keratos

81 that IL-17-expressing cells were present in skin biopsies from acne patients but not from normal don

82 Electron microscopy of skin biopsies from affected individuals revealed that th

83 To address this issue, we collected lesional skin biopsies from aGVHD (n = 25), clGVHD (n = 17), and

84 The histology of skin biopsies from all patients was consistent with EV.

85 demonstrated that reduction of PMP22 mRNA in skin biopsies from ASO-treated rats is a suitable biomar

86 ing activation, and are enriched in lesional skin biopsies from atopic patients.

87 wly established a human in vitro model using skin biopsies from ChAc patients to generate disease-spe

88 rt omalizumab's effect on gene expression in skin biopsies from CSU patients enrolled in a double-bli

89 2 millimeter) and deep (>3 millimeter) punch skin biopsies from each thigh on days 1 and 14.

90 ng to the Ligurian subpopulation, collecting skin biopsies from free-ranging specimens.

91 Additionally, examination of plantar skin biopsies from individuals with PC confirmed the pre

92 examined protein expression of IL-25 in the skin biopsies from normal subjects (n=10), ADEH- (n=18),

93 show that TRPV3 and PAR2 were upregulated in skin biopsies from patients and mice with atopic dermati

94 ast cells, and the epidermis in the lesional skin biopsies from patients with AD, but not in the skin

95 ificantly increased numbers of mast cells in skin biopsies from patients with cutaneous T-cell lympho

96 We also confirmed the increase of TAZ/YAP in skin biopsies from patients with diffuse SSc.

97 Skin biopsies from patients with neuropathic pain often

98 he cellular infiltrates and transcriptome of skin biopsies from patients with NOMID (n = 14) before t

99 gether with cultured Schwann cells (SCs) and skin biopsies from patients with type 2 diabetes (T2DM),

100 Microarray analysis of skin biopsies from psoriasis patients revealed increased

101 Lesional skin biopsies from SAM syndrome patients (n = 7) reveale

102 mal nerve fiber densities were quantified in skin biopsies from six subjects.

103 The comparison of skin biopsies from SSc patients to skin lesions of patie

104 Skin biopsies from STAT6VT transgenic mice, which develo

105 ssed at baseline and on Day 85 compared with skin biopsies from the same area of 10 untreated healthy

106 Whole skin biopsies from the same subjects were evaluated conc

107 lysis of nerve morphology and morphometry in skin biopsies from the third digit fingertip.

108 presence of extravascular parasites in human skin biopsies from undiagnosed individuals.

109 e, we determined 11beta-HSD1 levels in human skin biopsies from young and older volunteers and examin

110 ome sequence of M. lepromatosis present in a skin biopsy from a Mexican patient, and compared it with

111 We performed a clinical case note review and skin biopsy from affected sites in 4 HIV-infected adoles

112 Histological analysis of a skin biopsy from an individual homozygous for the varian

113 Subjects underwent skin biopsy from proximal (ie, cervical) and distal (ie,

114 Skin biopsy gene expression was analyzed by DNA microarr

115 The diagnosis of PXE was based on skin biopsy, genetic analysis or both.

116 Only 1 subject with a positive skin biopsy had elevated ACE, lymphopenia, and bihilar l

117 epidermal cells, whole psoriatic and healthy skin biopsies, human keratinocytes and Langerhans cells

118 Ultra-deep sequencing of two healthy-looking skin biopsies identified five somatic nonsynonymous muta

119 Immunohistochemistry on ACD skin biopsies identified PU.1+ CD3+ and PU.1+ CD4+ cells

120 of non-professional phagocytosis in healthy skin biopsies immediately after resection.

121 2 mRNA in dermal nerves were performed using skin biopsies in human clinical trials for CMT1A, but th

122 Skin biopsies in patients with HFpEF showed rarefaction

123 CCM generally correlates with outcomes of skin biopsies in patients with small fiber pathology.

124 Skin biopsies in purpura fulminans lesions revealed thro

125 In contrast, skin biopsies in the same participants showed that the i

126 rs that may increase the diagnostic yield of skin biopsy in clinical practice.

127 mimicking acute GVHD highlights the need for skin biopsy in patients who have undergone a stem cell t

128 netic results from environmental samples and skin biopsies indicated that 2 Mycobacterium fortuitum i

129 Evaluation of human melanoma skin biopsies indicates that expression of WISP-1 is sig

130 ing automated, high-throughput conversion of skin biopsies into iPSCs and differentiated cells with m

131 sification of individual cycle stages within skin biopsies is clinically important and essential for

132 e, we found that Evi expression in psoriatic skin biopsies is down-regulated, suggesting that Evi-def

133 animal model-derived potential biomarkers in skin biopsy mRNA extracts.

134 Emmonsia sp. was cultured from skin biopsy (n = 20/28), mycobacterial/fungal and aerobi

135 We discovered that skin biopsies obtained during asymptomatic human HSV-2 r

136 Skin biopsies obtained from pegylated IFN-alpha-associat

137 ing was used to assess donor LC-chimerism in skin biopsies obtained on days 28, 56, and 84 after tran

138 CuV DNA was detected in skin biopsies of 4/25 (16.0%) CTCL and 4/136 (2.9%) tran

139 ative real-time polymerase chain reaction on skin biopsies of 45 patients with CMT1A, obtained at stu

140 tudy this we generated fibroblast lines from skin biopsies of five patients with Gaucher disease and

141 ee independent fibroblast lines derived from skin biopsies of patients harbouring nonsense mutations

142 e, we found a massive accumulation of VWF in skin biopsies of patients suffering from immune complex

143 expression of B7-H6 was observed in lesional skin biopsies of patients with atopic dermatitis, and in

144 llagen I and IV, laminin, and fibronectin-in skin biopsies of patients with SS reveal that the baseme

145 a meta-analysis of gene expression data from skin biopsies of patients with systemic sclerosis treate

146 heral nerves, which were further verified in skin biopsies of patients with T2DM.

147 cells isolated from lesional and unaffected skin biopsies of psoriasis patients.

148 Skin biopsies of the challenge site were taken 2 weeks p

149 ed three different T cell populations from a skin biopsy of a patient suffering from acute graft-vers

150 Skin biopsy of an erythematous plaque on the thigh demon

151 Two weeks after BCG challenge, skin biopsy of the challenge site was performed.

152 Skin biopsy of the erythematous lesions showed dense neu

153 lidocaine, a local anesthetic used for human skin biopsy, on B. burgdorferi presence was measured.

154 resumptive skin cancer or actinic keratoses, skin biopsies, or PCP diagnostic accuracy with the excep

155 ted with the disability grade at the time of skin biopsy (p = 0.004), and was positively correlated w

156 tion of PMP22 levels in CMT1A versus control skin biopsies, particularly after normalization to SC-sp

157 Skin biopsies performed before and after treatment showe

158 Results from skin biopsies performed on 5 patients showed that the me

159 We performed a retrospective study of 34 skin biopsies performed over 430 d for rejection surveil

160 Serial mid-forearm skin biopsies, performed before and after treatment, wer

161 nostic performance of the standard method of skin biopsy processing with the practice of EVD with DD.

162 nostic performance of the standard method of skin biopsy processing with the practice of EVD with DD.

163 Skin biopsies promote our understanding of atopic dermat

164 15, 17, 20, 24, 36, and 38 association with skin biopsy proven cSCC.

165 patients with painful SFN were evaluated by skin biopsy, quantitative sensory testing, nerve conduct

166 s to identify small fibre neuropathy include skin biopsy, quantitative sensory, and autonomic testing

167 Skin biopsy results confirmed a clinical diagnosis of de

168 heir physician by telephone to receive their skin biopsy results, followed by a distant second choice

169 Skin biopsies revealed a predominantly small-vessel thro

170 Skin biopsies revealed dense lymphocytic infiltrates wit

171 Skin biopsies revealed reduced DSTYK protein levels alon

172 Skin biopsies revealed that cryolipolysis decreased epid

173 Skin biopsy revealed acanthosis and focal lymphocytes wi

174 tensity in the corticomedullary junction and skin biopsy revealed intranuclear inclusions suggestive

175 ntion of gadolinium in the human organism, a skin biopsy sample from a suspected NSF patient was inve

176 ronatin is significantly up-regulated in the skin biopsy sample of LD patients having mutations in bo

177 Although skin biopsy samples can be used to directly measure topi

178 have been used to identify features in human skin biopsy samples diagnosed for basal cell carcinoma (

179 Lesional skin biopsy samples from 81 patients with moderate-to-se

180 of EDGE to a non-model organism, we examine skin biopsy samples from a cheetah (Acinonyx jubatus) an

181 Skin biopsy samples from patients with AD show greater E

182 wn-regulated in vitiligo cell line PIG3V and skin biopsy samples from vitiligo patients, whereas its

183 orearms, and epidermal repair was studied in skin biopsy samples obtained at precise times during the

184 ound that Sp1 was significantly decreased in skin biopsy samples obtained from patients with atopic d

185 ze the global transcriptional alterations in skin biopsy samples of EM lesions from untreated adult p

186 heir unaffected relatives were recruited and skin biopsy samples taken.

187 Skin biopsy samples were evaluated by immunohistochemist

188 Lesional skin biopsy samples were taken from this patient and 2 o

189 Levels of tenascin-C are elevated in SSc skin biopsy samples, and serum and SSc fibroblasts, and

190 y the results of histopathologic analysis of skin biopsy samples.

191 Immunomodulatory effects were examined in skin biopsies, serum samples, and immune cells of the pe

192 Skin biopsies showed a perivascular mononuclear cell inf

193 An analysis of human psoriatic skin biopsies showed a rich infiltrate of IL-22(+)CD4(+)

194 Protocol skin biopsies showed absent or minimal perivascular cell

195 Serial skin biopsies showed consistent and non-progressing gene

196 Skin biopsies showed epidermal atrophy, basal cell vacuo

197 Skin biopsies showed histopathological findings consiste

198 sensory and motor nerve conduction; however, skin biopsy showed a significant decrease in intraepider

199 Any remaining BCG was quantified in a skin biopsy specimen obtained 2 weeks after challenge an

200 R and Western blotting) and in normal and AE skin biopsy specimens (immunofluorescence).

201 Skin biopsy specimens (n = 16), serum (n = 114), blister

202 nducible nitric oxide synthase (P = 0.02) in skin biopsy specimens 48 hours after experimental sunbur

203 Skin biopsy specimens and blood samples were collected o

204 Lesional skin biopsy specimens and peripheral blood lymphocyte ph

205 alyzed by using RT-PCR and immunostaining in skin biopsy specimens and primary human keratinocytes fr

206 Skin biopsy specimens are often obtained from these lesi

207 Encoded proteins were investigated in skin biopsy specimens by means of immunohistochemistry.

208 BCG load was quantified from skin biopsy specimens by polymerase chain reaction (PCR)

209 Analysis of lesional and nonlesional skin biopsy specimens demonstrated decreases in epiderma

210 by laser microdissection from human genital skin biopsy specimens during the clinically quiescent pe

211 compares the diagnostic performance in 6526 skin biopsy specimens examined from 2008 to 2010 with a

212 compares the diagnostic performance in 6526 skin biopsy specimens examined from 2008 to 2010 with a

213 Uninvolved skin biopsy specimens from 26 pediatric patients with AD

214 We performed single-cell RNA sequencing on skin biopsy specimens from 5 patients with AD (4 lesiona

215 We conducted a study of blood and skin biopsy specimens from 57 patients with a clinical d

216 microscopy (EM) with immunogold labeling on skin biopsy specimens from 7 patients with SSc and 3 hea

217 RNA) expression of candidate immune genes in skin biopsy specimens from 85 individuals with leprosy.

218 nsity in 1-mm basal layers was determined in skin biopsy specimens from all lesions stained with hema

219 , histologic analysis and gene expression in skin biopsy specimens from guselkumab-treated patients w

220 ue-stage FMF was made by a blinded review of skin biopsy specimens from patients presenting with plaq

221 G7 expression was significantly increased in skin biopsy specimens from patients with AD compared wit

222 Skin biopsy specimens from patients with dcSSc (n = 14)

223 c analyses of pretreatment and posttreatment skin biopsy specimens from patients with moderate-to-sev

224 ression of Wnt-10b was increased in lesional skin biopsy specimens from patients with SSc and in thos

225 nd mRNA levels were selectively increased in skin biopsy specimens from persons with recurrent HSV-2,

226 pression of Wnt antagonists DKK2 and WIF1 in skin biopsy specimens from subsets of patients with diff

227 Skin biopsy specimens from the distal leg from 96 type 2

228 Skin biopsy specimens obtained at baseline and weeks 1,

229 2 reactivation in situ in sequential genital skin biopsy specimens obtained from HSV-2-seropositive s

230 ed to profile genome-wide gene expression of skin biopsy specimens obtained from patients with GPP, P

231 regulation of immune system-related genes in skin biopsy specimens of chronic AD lesions.

232 To investigate this hypothesis, skin biopsy specimens of positive patch-test sites from

233 zed a panel of macrophage surface markers in skin biopsy specimens of pustules obtained from experime

234 BCG-vaccinated individuals, PCR analysis of skin biopsy specimens reflected a degree of mycobacteria

235 Skin biopsy specimens revealed extensive hemorrhage and

236 Skin biopsy specimens revealed panniculitis (n = 5), wit

237 Polymerase chain reaction testing of skin biopsy specimens should be performed more systemati

238 A subgroup analysis on cases whose skin biopsy specimens showed a pattern of inflammation t

239 Immunofluorescence microscopy on skin biopsy specimens showed that reduction of CCR7(+) c

240 une histology and transcriptomic analyses on skin biopsy specimens taken from the challenge site in y

241 skin of a patient with HCDD, we examined her skin biopsy specimens under light and electron microscop

242 ty of pathogens from infected and uninfected skin biopsy specimens using current molecular techniques

243 n of Wnt signaling pathway components in SSc skin biopsy specimens was analyzed.

244 Skin biopsy specimens were collected after intradermal a

245 Skin biopsy specimens were collected from 4 patients wit

246 Peripheral blood and skin biopsy specimens were collected from control subjec

247 A total of 15110 skin biopsy specimens were included.

248 Skin biopsy specimens were performed at baseline, day 15

249 ical records from 2010 to 2015 and available skin biopsy specimens were retrospectively reviewed.

250 Two hundred fourteen swine skin biopsy specimens were reviewed, including 88 native

251 214 swine skin biopsy specimens were reviewed, including 88 native

252 Skin biopsy specimens were taken from the infected site

253 Psoriatic skin biopsy specimens, as well as normal human skin, blo

254 alpox, and R. parkeri rickettsiosis by using skin biopsy specimens.

255 merase chain reaction and silver staining of skin biopsy specimens.

256 rom formalin-fixed, paraffin-embedded (FFPE) skin biopsy specimens.

257 alidated by immunofluorescence microscopy on skin biopsy specimens.

258 ical Wnt signaling was hyperactivated in SSc skin biopsy specimens.

259 h the patients, histopathological testing of skin-biopsy specimens, acid-fast bacilli smears, and mic

260 Skin-biopsy specimens, obtained from 17 patients, showed

261 asis pathophysiology is largely derived from skin biopsy studies that cause scarring and may be impra

262 bserved, further diagnostics were performed (skin biopsy, subcutaneous provocation, clinical/laborato

263 Comparing cultured fibroblasts to skin biopsies suggested that culturing might boost the a

264 Analysis of longitudinal skin biopsies suggests that a patient's subset assignmen

265 od for precise evaluation of PMP22 levels in skin biopsies that can discriminate CMT1A patients from

266 eted proteomics results using infected mouse skin biopsies that facilitate detection of this pathogen

267 igenetic changes in immune cells or in total skin biopsies that include stromal-associated changes.

268 y controls underwent 3 mm distal thigh punch skin biopsies to create an intracutaneous excision axoto

269 Regrowth can be monitored by serial skin biopsies to determine intraepidermal nerve fiber de

270 cence staining, and RT-PCR were performed on skin biopsies to evaluate the epithelial barrier.

271 orrelated with the interval from the time of skin biopsy to the time of wheelchair usage (p = 0.029).

272 s, or Fabry disease) can be evaluated with a skin biopsy to visualize pathologically decreased densit

273 s for rejection has routinely involved punch skin biopsies, vascular imaging and graft appearance.

274 Findings from skin biopsy, viral culture for varicella-zoster virus, a

275 urvival in filaggrin-deficient (ft/ft) mouse skin biopsies was determined based on Keratin 5 staining

276 Skin biopsy was consistent with borderline tuberculoid l

277 contrast agent in the aqueous extract of the skin biopsy was found to be 1.76 nmol/L.

278 t perivascular inflammatory infiltrate while skin biopsy was normal.

279 In seven cases, a skin biopsy was obtained from positive skin tests and po

280 Skin biopsy was performed in 11 subjects (positive in 8)

281 Skin biopsy was performed in all eight affected members

282 inans were recruited for blood sampling, and skin biopsy was performed in deceased patients.

283 When cutaneous reaction was detected, a skin biopsy was performed.

284 f 45 patients with CMT1A, from whom a second skin biopsy was taken after 2-3 years, the cutaneous mRN

285 A skin biopsy was taken from a median nerve innervated are

286 n (TCRbeta) genotyping on sequential genital skin biopsies, we show that CD8alphaalpha(+) T cells are

287 and tryptase immunohistochemical staining in skin biopsies were also assessed in some patients with a

288 Skin biopsies were also done when tissue rejection was s

289 Lesional and nonlesional AD skin biopsies were collected for analysis of morphology

290 Lesional and nonlesional skin biopsies were collected from the same area of conse

291 IFN-responsive biomarkers in whole blood and skin biopsies were measured.

292 Adult human skin biopsies were obtained from volunteers at the Alzhe

293 ils, and mucous membranes was performed, and skin biopsies were performed if needed.

294 Skin biopsies were performed in patients and carriers to

295 Skin biopsies were performed on 5 patients, both in heal

296 Skin biopsies were performed on the distal leg of FAP pa

297 ed immunological players and pathways, human skin biopsies were taken at 0, 2, 48, and 96 hours after

298 has been confirmed by genetic testing and/or skin biopsy were studied from March 1, 2013, through Feb

299 ash tattoo ink, 2 from tap water, and 4 from skin biopsies) were indistinguishable.

300 with a complete dermatologic examination and skin biopsy when indicated.