ライフサイエンスコーパス: small

1 However, the differences were small.

2 group of protein scaffolds characterized by small (1-10 kDa) size, stability, and versatility in dru

3 We find that, if capacity is small (~10 samples), it is optimal to draw one sample pe

4 Founding populations are small, a few colony-forming units, and infections are ra

5 LinearPartition also leads to a small accuracy improvement when used for downstream stru

6 brain structure, but might be achievable via small adjustments of neural circuitry in key brain areas

7 progressive condition of chronic bronchitis, small airway obstruction, and emphysema that represents

8 Interleukin-2 (IL-2) is a small alpha-helical cytokine that regulates immune cell

9 magnitude on average after directly adding a small amount (e.g., 2 mM) into TFA mobile phases without

10 surfaces are of widespread use for handling small amounts of matter, for harvesting energy, for manu

11 severity and relevant clinical factors, even small amounts of myocardial injury (e.g., troponin I >0.

12 Thus, in situ transient formation of small amounts of the Ru complex with N-oxide ligands can

13 otein is required to facilitate detection of small-amplitude vibrations essential for the perception

14 Thrombosis of small and mid-sized pulmonary arteries was found in vari

15 vidence has demonstrated that tau oligomers, small and soluble prefibrillar aggregates, are highly to

16 The small and transient actin structures regulating organell

17 TRPV1 activation induced only a small and transient increase in DAG levels, unlike the r

18 Small- and wide-angle X-ray scattering examines the pack

19 ined significant in the subgroup analysis of small aneurysms (width <= 3 mm) and when angles were exc

20 Small angle neutron scattering (SANS) provides a method

21 transmission electron microscopy and in-situ small angle neutron scattering.

22 We use small-angle X-ray scattering (SAXS) to characterize the

23 ns and a coexisting sponge phase observed by small-angle x-ray scattering.

24 Functional epitope mapping of these mAbs and small animal prophylaxis studies revealed a complex land

25 esions as shown in preclinical evaluation by small-animal PET studies, organ distribution, and a pati

26 meliorate disease is the lack of susceptible small animals in large numbers.

27 This critical behaviour is confined to a small area in the density-electric-field plane, and is a

28 sian model to estimate population numbers in small areas based on enumeration data from sample areas

29 Molecular features with m/z differences as small as 1.79 mDa were resolved and identified with high

30 n thin-film patterning with feature sizes as small as 180 nm and 1 mum line spacing was achieved, res

31 either a certain sequencing technology or a small assembly.

32 cture that realizes a giant atom by coupling small atoms to a waveguide at multiple, but well separat

33 itting effectively customizes the relatively small bandgap at the Fermi level, leading to an exotic p

34 time and with 39% less space and can answer small-batch queries at least five times faster.

35 ain how mass cell suicide can evolve, as any small benefit to surviving clonemates can lead to this r

36 osaurs) as well as morphologically disparate small-bodied coelurosaurs, including birds.

37 IS technique to address severe and extensive small bowel Crohn's disease presenting with 3 severely f

38 We examined the impact of upfront small bowel resection (USBR) for metastatic SB-NET compa

39 hould be regarded as a new standard for both small-bowel diagnosis and monitoring in inflammatory bow

40 We found that in small broiler flocks (<=16 birds/flock) the estimated pr

41 batch display what are often presumed to be small but possibly important differences in size, lattic

42 eral surgical approach was associated with a small but statistically significant increased risk of ma

43 ly the primary domestic cat host and related small cat species harbor a related endogenous virus in t

44 Although this paper considers a small catchment in Chernobyl, the conceptual model is sh

45 ion of platinum at the cellular level in non-small cell lung cancer (NSCLC) explant models after trea

46 ajority of miR-21-5p isolated from human non-small cell lung cancer (NSCLC) tissue possesses 3'-termi

47 ophages and monocytes from patients with non-small cell lung cancer (NSCLC) where c-MAF is overexpres

48 In non-small cell lung cancer (NSCLC), accumulation of anti-inf

49 iotherapy is an option for patients with non-small cell lung cancer (NSCLC), distinguishing between N

50 division of labor between YAP and TAZ in non-small cell lung cancer (NSCLC), the most common histolog

51 critical role for proline catabolism in non-small cell lung cancer (NSCLC).

52 from real PET/CT scans of patients with non-small cell lung cancer served as model for three 3-dimen

53 ty, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phen

54 hat the inactive and active states differ by small changes in a regulatory region that extends up to

55 trate that the CCRA method is able to detect small changes in binding free energy with a sensitivity

56 ons suggest they have potential to encourage small changes in diet, which could be beneficial at the

57 n and promote a discrete population in which small changes in orientation control Ras' competence to

58 tical reporters are not capable of detecting small changes in potassium, in particular, in freely mov

59 Findings indicate, most strikingly, that small changes in the activity of PTP1B can cause large s

60 Our findings show that small changes outside of highly conserved DNA-binding re

61 llowed an improvement in the number of KT in small children with excellent results.

62 ne specialized transplant center, focused on small children, and cooperating with distant centers thr

63 Because small chromosomes would be at risk of missegregation if

64 ion, resulting in increased dissemination of small clusters compared to untreated control MCAs.

65 (multifidus and semispinalis cervicis) in a small cohort of participants with chronic whiplash assoc

66 Staphylococcus aureus small colony variants (SCVs) are frequently associated w

67 The mechanosensitive channel of small conductance (MscS) is the prototype of an evolutio

68 dicating coupling of ACh-mediated effects to small-conductance Ca(2+)-activated potassium (SKs) chann

69 Functional intermediate- and small-conductance K(+) (IK and SK) channels and endothel

70 applicable to proteins undergoing relatively small conformational changes upon target binding.

71 sensitivity OFF-RGCs that selectively encode small decrements, and (c) broad sensitivity OFF-RGCs tha

72 iveness in vitro within a specific subset of small-diameter nociceptors that bind isolectin B4.

73 of DAD2(N242I) and DAD2(D166A) revealed only small differences compared with the structure of the WT

74 Small differences in metabolic outcomes were apparent in

75 arge multiprotein complexes are connected by small diffusible electron carriers, the mobility of whic

76 These observations suggest that small disruptions of quaternary structure are sufficient

77 chitecture is that it allows for training on small domains and evaluation on arbitrarily-sized inputs

78 but the model overestimated inactivation by small-dose DUV on wet SS.

79 The temperature had a small effect on recovery, but significant differences we

80 a given disorder may be influenced by myriad small-effect noncoding variants and/or by rare but sever

81 Though common variants individually have small effects on disease risk, GWAS provide a powerful o

82 e number of genetic variants, each with very small effects, whose causal effects could not be individ

83 ebral blood flow (CBF; +10-20%) mediated via small elevations in arterial PCO2 and metabolism.

84 peding its migration into the patch, while a small fast-growing population can outcompete a large fas

85 on and spatial exclusion within the patch: a small fast-moving population can outcompete a large fast

86 respectively, the interplay of which allows small flakes to be utilized as stabilizers with an amphi

87 chronicles the progress made in the field of small fluorocarbon synthesis since their invention in th

88 ls were associated with a decreased risk for small-for-gestational-age (aOR = 0.622, 95% CI 0.458-0.8

89 s were associated with an increased risk for small-for-gestational-age (aOR = 1.955, 95% CI 1.465-2.5

90 poprotein cholesterol levels on the risk for small-for-gestational-age is larger.

91 ociations between maternal lipid profile and small-for-gestational-age neonates.

92 The detected 290 chemicals explained only a small fraction (<8%) of the measured effects.

93 nerally attributed to the late addition of a small fraction of hydrated materials, such as carbonaceo

94 fragmentation has been reported to impact a small fraction of the tRNA pool and thus presumed to not

95 although the vast majority of sequences were small fragments, which highlights the challenge of assem

96 le weighting, and there was some evidence of small gains in precision when using MRP, particularly fo

97 chnologies is limited in part by the lack of small genetic switches with wide dynamic ranges that con

98 ria rely on the genetic information in their small genome (mitochondrial DNA) and the nucleus.

99 We tested whether (1) small group size, (2) early age of allocation to a group

100 d that, after 5 complete weeks' gestation, a small GS and a large YS reliably predicted pregnancy los

101 ediated through the inhibition of Rac family small GTPase 1 and cell division cycle 42 activation, as

102 hing motility is under the dependence of the small GTPase MglA, but the underlying molecular mechanis

103 fy systemically the changes in expression of small GTPase proteins in cells upon genetic ablation of

104 Rab6, a small GTPase that regulates a number of endosomal traffi

105 ses, but unsuccessful attempts to target the small GTPases directly have resulted in them being class

106 trafficking, activity of the Rab3 and Rab27 small GTPases, tumour necrosis factor-alpha (TNF-alpha)-

107 the MRM quantification results for selected small GTPases.

108 High metabolic rates combined with small hatching size in ammonoids as opposed to lower met

109 Small heat-shock proteins (sHsps) compose the most wides

110 The nuclear receptor small heterodimer partner (Shp) plays a complex role in

111 Higher-order many-body errors are small in both SCAN and self-interaction-corrected SCAN.

112 including single-nucleotide variants (SNVs), small insertions and deletions (indels), copy-number var

113 sal nature of single-nucleotide variants and small insertions and deletions in exomes has been unders

114 aterials at the level of single molecules or small interacting complexes of molecules.

115 h these composite electrolytes demonstrate a small interfacial resistance with good cycling performan

116 of Ash1l, Ezh2, Kdm5b, and Kdm6b by specific small interfering RNA and Vivo-Morpholino, as well as in

117 expression of these genes is ablated by p63 small interfering RNA as well.

118 RNA interference (RNAi) by topically applied small interfering RNA has potential applications for pla

119 tem for the potential use of allele-specific small interfering RNA in treating KID syndrome and other

120 Small interfering RNA knockdown of KAT2A or H3K9ac inhib

121 r-Cas9-mediated deletion of Mm47, as well as small interfering RNA studies in mice primary macrophage

122 Notably, allele-specific small interfering RNA treatment caused only low-level of

123 processed by DICER-LIKE3 into 24-nucleotide small interfering RNAs (siRNAs) that guide RNA-directed

124 f bacteria or bacterial products through the small intestinal epithelium.

125 Moreover, we observed increased small intestinal inflammation and apoptosis after hepati

126 ability characteristics of human and porcine small intestinal mucus secretions to sub-micron sized pa

127 n polymerase chain reaction and RNAscope) of small intestinal organoids incubated with the Notch inhi

128 PTMs in >1 million single cells derived from small intestinal organoids reveals cell-type- and cell-s

129 ients we found along the length of the mouse small intestine and in tumours contrast with previous re

130 ells collected from the proximal half of the small intestine of Hnf4alphagamma(DKO) and control mice.

131 Moreover, the small intestine of treated animals show reduced hypoxic

132 . might be prevented from spreading from the small intestine to the large intestine.

133 eracts with the developing microbiome of the small intestine, the major site for nutrient metabolism

134 The data reveal small intrinsic barriers for electron transfer proximate

135 s containing polyatomic species ranging from small ions to nanocrystals and large protein complexes.

136 Further, it is demonstrated that, despite small isobaric interferences, results obtained at low ma

137 ization like waste of reproductive effort in small isolated populations may be more problematic.

138 0-layer graphene electrodes displayed only a small kinetic difference with respect to SLG, suggesting

139 y of using DL to enhance spatial detail from small-matrix MRI acquisitions and evaluate its performan

140 Researchers frequently employ definitions of small, medium, and large that were proposed by Jacob Coh

141 Among them, Magnets are small modules engineered from the Neurospora crassa phot

142 n this review, we briefly update the current small molecular drugs that could synergize with immunoth

143 f the novel NMR-based machine learning tool "Small Molecule Accurate Recognition Technology" (SMART 2

144 rmacologically activating PKM2 via ML-265, a small molecule activator of PKM2, during acute outer ret

145 monstrate that targeting FPR1 by a selective small molecule antagonist, such as ICT12035, can provide

146 nd the "geometric packing parameter" dictate small molecule compatibility with 3HM's alkyl tail core.

147 Development of small molecule compounds that target several cancer driv

148 Importantly, we also identify a small molecule dicarboxylate that acts as an essential c

149 es, initiating the downstream release of the small molecule drug by a retro DA reaction.

150 e imaged and quantified the flow and flux of small molecule drugs through the layers and structures o

151 ined the effects of oral administration of a small molecule inhibitor for CCR2, CCR2i, which blocks C

152 , NLRP3, or IL18 and in mice given MCC950, a small molecule inhibitor of the NLRP3-inflammasome.

153 ciated with increased sensitivity to the OGT small molecule inhibitor OSMI-1.

154 DNA-encoded small molecule libraries (DELs) have enabled discovery o

155 in the presence of the capsid destabilising small molecule PF-74 also induced a cGAS-dependent IFN r

156 Leupeptin is a bacterial small molecule that is used worldwide as a protease inhi

157 oclonal antibodies (mAb) with the potency of small molecule therapeutics, are one of the fastest grow

158 s that are normally difficult to target with small molecule therapies.

159 protein (TSPO), the reported target for this small molecule, and instead were driven by a metabolic s

160 A chromene-based small molecule, CXL146, selectively eliminates cancer ce

161 on was investigated using a newly identified small molecule, soticlestat (TAK-935/OV935).

162 could be quickly degraded upon addition of a small molecule.

163 tial to participate in tandem or cooperative small-molecule activation and catalysis.

164 trated that both adiponectin and AdipoRon, a small-molecule adiponectin receptor agonist, suppress co

165 that this can be achieved in the context of small-molecule catalysts has had sizable impact on the f

166 e designed a series of novel monophosphonate small-molecule CD73 inhibitors.

167 y that we previously reported, we identified small-molecule compounds that modulate the skeletal musc

168 l and pain management, effective targets for small-molecule drugs.

169 ed N/S HNST, and targeted treatment with the small-molecule ERBB inhibitor lapatinib led to prolonged

170 drug target in cancer and inflammation, and small-molecule ERK5 kinase inhibitors have been develope

171 This was further confirmed using a small-molecule inhibitor of ferroptosis that prevents CZ

172 aiming to destabilize MYCN protein, such as small-molecule inhibitors of Aurora A and mTOR, are curr

173 This study aimed to discover small-molecule inhibitors targeting RANKL trimer formati

174 These small-molecule inhibitors, collectively termed JAK inhib

175 hiro-Inositol ribophostin is the most potent small-molecule Ins(1,4,5)P(3) receptor agonist without a

176 Small-molecule kinase inhibitors have the potential for

177 hibitor has entered clinical trial; however, small-molecule orally available antiviral drugs have yet

178 acy of previously published state-of-the-art small-molecule relative binding affinity calculations, w

179 ranslation inhibitors from a high-throughput small-molecule screen for fragile X tremor ataxia syndro

180 duce tau burden in human neurons and, from a small-molecule screen, identify the mTOR inhibitors OSI-

181 Small-molecule targeted RNA degradation will thus provid

182 y harbor pockets that are only accessible to small molecules and constitutes a rich subset of binding

183 ized protocol to eliminate interference from small molecules and degraded proteins.

184 g activity (that is, reacting diversely with small molecules at one extreme or selectively with prote

185 Small molecules have been classically developed to inhib

186 Furthermore, less than a dozen small molecules have been incorporated and approved for

187 emical synthesis to predict and then produce small molecules inspired by biosynthetic gene clusters.

188 ibody, sGC or PDE activity and the effect of small molecules modulating their function can be studied

189 d in the synthesis of densely functionalized small molecules suitable for fragment-based drug discove

190 oped a machine-learning approach to identify small molecules that broadly correct gene networks dysre

191 bit enzyme activity; however, new classes of small molecules that endow new functions to enzymes via

192 Small molecules that selectively kill senescent cells (S

193 challenging because of the inability of most small molecules to accumulate inside GN bacteria.

194 lso may permit the cell-specific delivery of small molecules to improve the post-MI healing process.

195 otein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradatio

196 Inhibition of TRPCs by small molecules was shown to be promising in treating re

197 Ynamides are fascinating small molecules with complementary reactivities under ra

198 receptors targeting radiopharmaceuticals are small molecules with fast blood clearance and urinary ex

199 This is demonstrated for small molecules, peptides, and proteins up to 66 kDa on

200 ing a broad range of single analytes such as small molecules, proteins, nanoparticles, exosomes, and

201 biotechnology for the synthesis of drugs or small molecules.

202 dynamics of the actin cytoskeleton, and the small, monomeric GTPases Rac and Rho are important regul

203 s support that oligomerization of PrPSc into small multimeric assemblies appears to be a critical bio

204 , dynamics and biophysical properties of two small nanodiscs, MSP1D1DeltaH5 and DeltaH4H5.

205 Our results indicate that small networks of marine reserves yield previously unrec

206 MicroRNA-27a/b are small non-coding RNAs which are reported to regulate inf

207 The U2 small nuclear ribonucleoprotein (snRNP) has an essential

208 he U12-type spliceosomes, large complexes of small nuclear ribonucleoprotein particles and associated

209 ting urgent screening for Ebola virus, and a small number developed persistent arthralgia.

210 ation and distance of migration all map to a small number of genomic regions that do not overlap with

211 However, only a small number of individual RV strains have been recovere

212 ly infer model parameters using a relatively small number of measurements.

213 A small number of procedures account for a disproportionat

214 mixtures", with quantification limited to a small number of resolvable components and/or total obser

215 Because of the small number of results from well designed, large-scale,

216 ft from greater energetic investment in many small offspring towards investing less total energy into

217 Women with small or large for gestational age offspring are at incr

218 y microinjecting the probe into the lumen of small or large intestine fragments, robust phosphorescen

219 the 20 ribosomal protein genes of either the small or large ribosomal subunit.

220 c theory of epithelial shells which resemble small-organoid morphologies.

221 Metal centers in X-ray structures of small organometallic or coordination complexes are often

222 A previously unreported subset of small peptide-coding transcripts was identified from the

223 has developed robust methods that integrate small-peptide units into designed scaffolds.

224 Here we design small peptidic inhibitors based on the atomic structure

225 In 3D, a substantially larger number of small plaques were observed than that indicated by the 2

226 fication of a gene family encoding for three small plastidial proteins of the envelope membrane that

227 ahigh-throughput bioanalysis of metformin, a small polar substrate commonly used in high-throughput i

228 flowers with long styles, short anthers, and small pollen grains, S-morph individuals have flowers wi

229 The small population of neutrophils in the lymph node can ac

230 These results highlight that small primary sequence differences between the two mamma

231 forage species simply because the limit is a small proportion of the species' standing biomass may no

232 e study's main limitations included a rather small proportion of women included, the open label desig

233 Cytokines are small proteins secreted by cells in innate and adaptive

234 or more after the first colonoscopy (HR for small proximal SPs 2.6; 95% CI, 1.7-3.9 and HR for large

235 spatial scale of a study site, the losses of small-ranged species reduce biome-scale (gamma) diversit

236 Our platform uses small reagent volumes and inexpensive equipment, paving

237 We also observed a small reduction in activity magnitude during the bimanua

238 tent to which CodY exerts its effect through small regulatory RNAs (sRNAs).

239 , identification of all particles present in small representative areas of the filter by micro-Raman

240 Small RNAs (sRNAs) regulate gene expression, play import

241 loading of the nuclear Argonaute NRDE-3 with small RNAs that normally effect maternal piRNAs, which p

242 The natural ability of plants to exchange small RNAs with invading eukaryotic organisms can be exp

243 nore non-coding but functional elements e.g. small RNAs, long antisense RNAs or untranslated regions

244 nto RNA-dependent RNA polymerase 6-dependent small RNAs, resulting in their continued turnover likely

245 Desmoplastic small round cell tumor (DSRCT), a rare sarcoma of adoles

246 OCT B-scans show SLG as small, round, hyporeflective structures with a character

247 raised the need to reliably identify BSE in small ruminants.

248 Post hoc analysis, small sample size, and examination of only patients with

249 because of its restricted geographic scope, small sample size, and possible recall bias, which are t

250 confounded by indications for surgery or has small sample size.

251 stical power for this was low because of the small sample size.

252 e matter (WM) microstructure in 22q11DS, but small samples and variable methods have led to contradic

253 We propose this represents a shift from small-scale biological control to large-scale oceanograp

254 Our analysis demonstrates how small-scale experimental data can be leveraged to derive

255 anostructures have converged in the field of small-scale swimmers.

256 ammonia synthesis under milder conditions in small-scale, distributed, and on-site electrolysis cells

257 conferring more tolerance to drought such as small sclerophyllous leaves and lower percent loss of hy

258 ed to large numbers of ions with arbitrarily small separation and is a step toward realizing strongly

259 Models were built from small sets of randomly-selected core genes after removin

260 ardiac surgery literature consists mostly of small, single-center studies, and the epidemiology of fr

261 features of this synaptic network due to the small size and dense packing of its elements.

262 ese lack an annotated sgl, mainly due to the small size, lack of sequence similarity, and embedded na

263 en representation of important cell types in small sketches, in contrast with prior sketching methods

264 Neurogliaform cells had small somata and numerous short dendrites that formed a

265 Following the rapid decay (0.6 ns) of a small spectral side band, the broad emission line shape

266 under the assumption that visual percepts of small spots of light produced with electrical stimulatio

267 Small structural changes in the axial coordinating linke

268 An increasing number of small studies describing aspergillosis in COVID-19 patie

269 In this small study in children and adolescents perinatally infe

270 Cancer stem cells (CSCs) are a small subpopulation of quiescent cells with the potentia

271 (BCMA) is expressed only on plasma cells, a small subset of B cells and MM cells, which makes it a s

272 Only a small subset of biallelic deletions were predicted to re

273 CreERT2) transgenic mouse line, we labeled a small subset of itch-sensing neurons that express multip

274 ency can be achieved by simply introducing a small substituent into the 2-position of AOPCP without t

275 Small subunit 18S rRNA gene sequencing and accessory pig

276 housekeeping genes such as that encoding the small subunit ribosomal RNA has revealed the extensive d

277 ubunit and prevents its association with the small subunit.

278 were produced that lacked cognate Se Rubisco small subunits (SSU) and expressed the Se LSU in place o

279 ASOs are small synthetic single-stranded chains of nucleic acids

280 large systems tend to shift more slowly than small systems but disproportionately faster.

281 ndom and tended to assemble in large T gene, small T gene and viral protein 2 gene.

282 lt by several copies of a large (TerL) and a small (TerS) terminase subunit.

283 gh energy density (0.23 Wh cm(-3)), an ultra-small time constant (0.01 ms), outstanding specific capa

284 the pore openings of both materials are too small to admit either guest, signalling the importance o

285 levant precursors and early cancers were too small to be detected.Keywords: Genital/Reproductive, Ult

286 on the surface of pure water droplets is too small to host the whole process.

287 in a wide variety of population sizes, from small towns to huge megacities.

288 Small ubiquitin-like modifier (SUMO1-3) conjugation (SUM

289 ition of neddylation, the conjugation of the small ubiquitin-like protein NEDD8 to lysine residues, i

290 manipulation resulted in the capture of many small vesicles (30 nm diameter) at the mitochondrial sur

291 ns in older adults with and without cerebral small vessel disease in vivo.

292 se (i.e. atherosclerosis) and/or of cerebral small vessel disease or worse multiple sclerosis patholo

293 a 57% (95% CI = 29-91%) increase in risk for small vessel ischemic stroke, a 197% increase (95% CI =

294 on is to assess the presence and severity of small-vessel arteriopathy.

295 luable technique for assessing the degree of small-vessel disease and postoperative outcome after PEA

296 oup of disorders involving severe, systemic, small-vessel vasculitis and are characterized by the dev

297 Maya civilization was gradual, assuming that small villages began to emerge during the Middle Preclas

298 omate the movement of magnetic beads between small volumes of reagents commonly employed for NA extra

299 CXCL13(+) follicular reticular cells form a small-world network of guidance structures, with compute

300 content; particularly the latter results in small, yet, noticeable differences in VNC attenuation.