ライフサイエンスコーパス: small G-protein

1 complex B polypeptide, IFT27, is a Rab-like small G protein.

2 to both NF-kappaB and kappaB-Ras, a Ras-like small G protein.

3 down-stream effector of Cdc42, a Rho family small G-protein.

4 a specific effector for Cdc42, a Rho family small G-protein.

5 ke domain, which unexpectedly inhibits these small G proteins.

6 placement of the enzyme by heterotrimeric or small G proteins.

7 r that is specific for the RhoA subfamily of small G proteins.

8 totypic member of a subfamily of Ras-related small G proteins.

9 nction through the interaction with Rab-like small G proteins.

10 a2+ channel currents in the absence of these small G proteins.

11 d or I domain, has a fold similar to that of small G proteins.

12 Cdc42 is a member of the Rho family of small G proteins.

13 nits and members of the Rho GTPase family of small G proteins.

14 ntioxidative effects via inhibition of these small G proteins.

15 vating proteins (GAPs) for the Arf family of small G proteins.

16 king of GPCRs is linked to the Rab family of small G proteins.

17 se two domains govern their interaction with small G proteins.

18 coupled to extracellular signals via Brx and small G-proteins.

19 ionarily conserved subfamily of the Ras-like small G-proteins.

20 upply-based positive feedback acting through small G-proteins.

21 homology to other known exchange factors for small G-proteins.

22 Rho family small G proteins act synergistically with Raf-1 to stimu

23 ids, membrane curvature-modulating proteins, small G proteins, actin, and dynamin in endocytic pathwa

24 th protein kinase PKN, a fatty acid- and Rho small G protein-activated serine/threonine kinase with a

25 al mechanistic models have been proposed for small G protein activation of PI3K lipid kinases.

26 Rho family small G-protein activity is controlled by guanine nucleo

27 wo routes, one of which seems to involve the small G protein ADP-ribosylation factor (ARF) and its ph

28 The small G protein ADP-ribosylation factor 6 (Arf6) plays i

29 shown the adaptor protein complex, AP-4, and small G protein ADP-ribosylation factor-like GTPase 5b (

30 a guanine nucleotide exchange factor of the small G proteins ADP ribosylation factors (Arfs) 1 and 6

31 of small GTPases is a group of more than 150 small G proteins, all of which share some degree of homo

32 to adenosine diphosphate ribosylation of the small G protein alpha-subunit activating CFTR with conse

33 CR paracrine neoplasia, suggesting that this small G protein and its downstream effectors may represe

34 diphosphate ribosylation factor 6 (ARF6), a small G protein and upstream regulator of type I phospha

35 integrin pathway members, and regulators of small G proteins and CDC42.

36 While PAKs are usually activated by small G proteins and Ste20 binds Cdc42, the role of Cdc4

37 discuss the mechanisms of activation of the small G proteins and the downstream signaling pathways i

38 We examined the activation of Rho family small G proteins and the regulation of MAPKs through Rac

39 n-protein interactions such as those between small G proteins and their effector proteins control mos

40 ediate downstream effectors of the Rac/Cdc42 small G-proteins and implicated in promoting tumorigenes

41 Although receptor-mediated regulation of small G-proteins and the cytoskeleton is intensively stu

42 tutively linked to GIT1, a GAP of Arf family small G proteins, and that ARHGEF6 phosphorylation enabl

43 Small G proteins are an extensive family of proteins tha

44 Small G proteins are GTP-dependent molecular switches th

45 Members of the Arf family of small G proteins are involved in membrane traffic and or

46 Rho family small G proteins are key regulators of cytoskeletal orga

47 As other small G proteins are regulated in a similar manner, this

48 The activities of small G-proteins are in part regulated by their interact

49 Small G-proteins are key regulatory molecules that activ

50 VPS28, a component of ESCRT-I, and Cdc42, a small G protein, are associated with the M1 protein and

51 Rap1a and Rap1b, 2 highly homologous small G proteins, are both required for angiogenesis in

52 alpha subunits), as well as the Ras-related (small) G-proteins, are highly conserved.

53 The highly conserved small G protein Arf1 organizes Golgi trafficking.

54 The small G protein Arf1 regulates Golgi traffic and is acti

55 The small G protein Arf1 regulates the spatiotemporal recrui

56 s paper, we identify a positive role for the small G protein Arf6 in autophagosome formation.

57 rimeric G protein from the Gq family and the small G protein ARF6.

58 types of G proteins: heterotrimeric G(s) and small G protein Arf6.

59 f the adenosyl-ribosylation factor family of small G-proteins (ARFs) and the protein kinase D (PKD) f

60 The small G protein ARL-8 inhibits assembly by promoting dis

61 e report the characterization of an Arf-like small G protein, ARL-8, required during this process.

62 rkL in mediating Src signaling by activating small G proteins at focal adhesions.

63 Ran is a small G protein best known for its role in nuclear trans

64 on cellular signaling and activation through small G proteins, but mechanistic insight into the bioge

65 ese GEFs are often recruited to membranes by small G proteins, but the basis for specific recruitment

66 xins A and B depends on inactivation of host small G-proteins by glucosylation.

67 vated either by members of the Rho family of small G proteins, by proteolysis, or by interaction with

68 protein subunits, protein tyrosine kinases, small G proteins, Ca(2+), and phospholipids.

69 have Ras proteins, but they contain Rho-like small G proteins called RACs or ROPs that, like fungal a

70 The small G protein Cdc42 also functions in cell polarity an

71 novel interaction mediates activation of the small G protein Cdc42 by G(s)-coupled GPCRs, inducing cy

72 The small G protein Cdc42 is a key regulator of polarity in

73 activation of PAK1 by an active form of the small G protein Cdc42, suggesting that phosphorylation b

74 lin1 but are associated with activity of the small G protein Cdc42.

75 n 1 (TOCA1) is an effector of the Rho family small G protein Cdc42.

76 of cortical landmarks that converges on the small G protein Cdc42.

77 RasGAP activity and binds to the Rho family small G proteins Cdc42 and Rac1.

78 The small G proteins Cdc42, Rac1, and Rac2 regulate the rear

79 The Rho family small G-protein Cdc42 has been implicated in a diversity

80 The conserved small G-protein Cdc42 is a master regulator of eukaryoti

81 skeletal rearrangement via activation of the small G-protein Cdc42 is involved and that this activati

82 by the G-protein betagamma subunits and the small G-protein Cdc42.

83 Similar to most other small G proteins, Cdc42 binds to many downstream effecto

84 s are transmitted through Ras and Rho family small G-proteins coupled to mitogen-activated protein ki

85 Previously, we showed that small G protein Dexras1 is expressed by glucocorticoids

86 letal) cells activated RhoA GTPase, but this small G protein did not contribute to migration.

87 eotide exchange factors of HRas and isolated small G-protein dissociation stimulator (smgGDS), a guan

88 Although activating mutations in KRAS, a small G-protein downstream of EGFR, correlate with poor

89 Cross-talk between small G-protein families has an important role in signal

90 A member of the small G protein family, cdc42, was isolated from a scree

91 on each subunit; monomers adopted a typical small G protein fold.

92 rst evidence of an F-box protein targeting a small G protein for ubiquitination and degradation to mo

93 m for the need for tight cellular control of small G-protein function.

94 are phenocopied by ectopic expression of the small G protein Galpha13 but are independent of AKT sign

95 101A) and K-Ras (K-Ras-S17N) and also by the small G-protein GDP dissociation stimulator (SmgGDS).

96 el blocker, we overexpressed the ras-related small G-protein Gem in the heart by somatic gene transfe

97 ide exchange factor (GEF) that activates the small G protein (GTPase) Rac1 to control Rac1-dependent

98 The Ral family of small G proteins has been implicated in tumorigenesis, i

99 Here, we asked if small G proteins have other functions in photoreceptors.

100 with AlF4(-) and GDP complexed to G1alpha, a small G protein, heralded a new field of research into t

101 which is homologous to the GTPase eRF3, is a small G protein implicated in mRNA quality control.

102 y identified as a binding partner of ARL2, a small G-protein implicated as a regulator of microtubule

103 ed by actin polymerization and activation of small G proteins in a Rho-dependent manner.

104 Thus, the involvement of small G proteins in hypertrophy has become an area of si

105 this review is a role for the Rab family of small G proteins in regulating subcellular protein traff

106 he regulation of MAPK (ERK1/2) activation by small G proteins in the CNS by using different patterns

107 Small G proteins in the Rho family are known to regulate

108 talytic activity or response to PKCalpha and small G proteins in vitro, although the phosphorylated f

109 RhoGEFs are central controllers of small G-proteins in cells and are regulated by several m

110 implicate RAB25, and thus the RAB family of small G proteins, in aggressiveness of epithelial cancer

111 rectly with cytoskeletal, cell adhesion, and small G proteins, including Rac1.

112 lasma membrane via regulation of a series of small G proteins, including RalA and Rab10.

113 lt, Trk receptor signaling activates several small G proteins, including Ras, Rap-1, and the Cdc-42-R

114 s been shown to inhibit the farnesylation of small G-proteins, including Ras, up-regulate the mannose

115 Each small G protein interacts with several effectors, some s

116 anine nucleotide exchange factor for Rap1, a small G protein involved in many cellular functions, inc

117 vated in Src-transformed cells and that this small G protein is a critical component of the pathway c

118 Geranylgeranylation of RhoA small G-protein is essential for its localization to cel

119 Cellular signaling by small G-proteins is down-regulated by GTPase-activating

120 Activation of the RAS family of small G-proteins is essential for follicle stimulating h

121 ational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeleta

122 IFT27, a small G protein, is one of a growing number of flagellar

123 We show that MglA, a Ras-like small G-protein, is an integral part of this machinery.

124 We recently identified the small G protein K-ras as an alcohol-regulated gene in th

125 Expression of the small G protein K-ras was differentially regulated follo

126 cts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional

127 The small G-protein KRAS is crucial for mediating gonadotrop

128 Dexras1, a small G-protein localized predominantly to the brain, is

129 se to methylmalonyl-CoA mutase is gated by a small G protein, MeaB.

130 component that transduces CaMKII activity to small G protein-mediated spine enlargement, AMPA recepto

131 ls, is stimulated by signaling of Dexras1, a small G protein member of the Ras family.

132 ethylation reactions, specific inhibitors of small G-protein methylation or prenylation had no effect

133 ce deficient for a RhoGAP suggests that this small G protein might also regulate the growth of animal

134 w the agonist-stimulated receptor recruits a small G protein necessary for the endocytic process and

135 Arabidopsis gene that encodes Rop (RHO-like small G protein of plants) guanosine triphosphatase (GTP

136 Dexras1 is a small G protein of the Ras family discovered on the basi

137 production is greatly amplified by Rab5A, a small G protein of the Ras GTPase superfamily.

138 urification method to identify effectors for small G proteins of the Arf family.

139 in revealed a G-protein fold most related to small G proteins of the Rab and Arf families.

140 Human cells contain more than 60 small G proteins of the Rab family, which are localized

141 ents is regulated by sequential signaling of small G proteins of the Rab5 and Rab7 families.

142 e nucleotide exchange factors (GEFs) against small G proteins of the Rab5 family.

143 Like other small G proteins of the Ras superfamily, Rap1 is activat

144 ypertrophic process is mediated, in part, by small G proteins of the Rho family.

145 Small G-proteins of the ADP-ribosylation-factor-like (Ar

146 Small G-proteins of the Ras superfamily control the temp

147 e activated by receptor tyrosine kinases and small G-proteins of the Ras superfamily that stimulate s

148 ptosome activator by mediating the effect of small G-proteins on glucocorticoid-regulated genes.

149 Defects in the RAS small G protein or its associated network of regulatory

150 e binding sites for IQGAP1 and RhoGAP on the small G proteins overlap only partially.

151 aling through a common pathway involving the small G protein p21(ras).

152 As well as small G proteins, PAK interacts with the Cdc42/Rac excha

153 ntly, many studies have examined the role of small G proteins, particularly the Ras family of G prote

154 Aberrant activity of Rho small G-proteins, particularly Rac1 and their regulators

155 These results support a role of Rap small-G-protein pathway in E6-mediated oncogenesis.

156 2, a member of the Rho family of Ras-related small G-proteins, plays key roles in the regulation of c

157 ly arrestin-independent phase, requiring the small G protein RAC family small GTPase 1 (RAC1) and pro

158 In this issue, Shuai et al. find that the small G protein Rac may function as a switch for remembe

159 The small G protein Rac regulates cytoskeletal protein dynam

160 n and phagocytosis through activation of the small G protein Rac.

161 ) in nucleotide release and binding with the small G protein rac.

162 recently been shown to act downstream of the small G proteins Rac and Arf.

163 at is activated by binding to the Rho family small G proteins Rac and Cdc42hs.

164 of GTPase activating proteins (GAPs) for the small G-protein Rac that have gained recent attention du

165 family of GTPase activating proteins for the small G-protein Rac, have been implicated in development

166 embranes, leading to the inactivation of the small G-protein Rac.

167 ctin filaments, a process dependent upon the small G-protein Rac.

168 closely related Abr negatively regulate the small G-protein Rac: loss of their combined function in

169 PI3 kinase can stimulate the small G protein, Rac, a direct activator of Pak, as well

170 A reduction in migration and activation of a small G protein, Rac, was observed in mast cells derived

171 nvasive activities through activation of the small G protein, Rac.

172 Epinephrine promoted activation of the small G protein Rac1 and also led to the activation of p

173 CR transformation requires activation of the small G protein Rac1 and its effector, the p21-activated

174 We find that inhibition of the small G protein Rac1 by the Rac GTPase-activating protei

175 Taken together, our data establish that the small G protein Rac1 is a key regulator of beta(3)AR sig

176 cells (NFAT), through the activation of the small G protein Rac1.

177 t arsenic trioxide induces activation of the small G-protein Rac1 and the alpha and beta isoforms of

178 Our data also demonstrate that the small G-protein Rac1 is activated by RA and functions as

179 l transduction under ND, suggesting that the small G-protein Rac1 is required.

180 The small G-protein Rac1 plays a key role in platelets and w

181 tem with LAD constructs that can recruit the small G-protein Rac1 to the plasma membrane and induce t

182 ch effects correlated with activation of the small G-proteins Rac1/Cdc42 and downstream engagement of

183 Recent studies identified the small G protein, Rac1, as a key player in the Drosophila

184 ells deficient in the hematopoietic-specific small G protein, Rac2.

185 ly shown to be dependent upon binding of the small G protein, Ral, to Sec5, a central component of th

186 The small G proteins RalA/B have a crucial function in the r

187 We find that the Ras-like small G protein, RalB, is localized to nascent autophago

188 The asymmetric distribution of the small G protein Ran across the nuclear envelope regulate

189 Using mass spectrometry, we identified the small G protein Ran and Ran binding protein 2 (RanBP2) a

190 similar to that seen in the structure of the small G protein Ran bound to GDP.

191 cleus to the cytoplasm by associating with a small G-protein Ran (RAs-related nuclear protein), in th

192 The formation of an activity gradient of the small G-protein Ran around chromatin depends on the diff

193 d guanine nucleotide exchange factor for the small G protein Rap.

194 ediated activation of the geranylgeranylated small G protein Rap1 and the Rap1 association with Pyk2.

195 ons of cAMP and stimulates migration via the small G protein Rap1 but inhibits collagen synthesis in

196 The small G protein Rap1 can mediate "inside-out signaling"

197 In mammalian cells, the small G protein Rap1 has been proposed to couple RTKs to

198 ential for the NGF-induced activation of the small G protein Rap1 in PC12 cells.

199 Thus, the small G protein Rap1 is an intermediary signaling molecu

200 We show that the small G protein Rap1 is regulated in the opposite manner

201 Raf-1 is also thought to be recruited to the small G protein Rap1 upon GTP loading of Rap1.

202 of the MAP kinase cascade is mediated by the small G protein Rap1.

203 cbl protooncogene product, CrkL adapter, and small G protein Rap1.

204 Interestingly, beta(2)AR activates both the small G proteins Rap1 and Ras, but only Rap1 is capable

205 unded-up Dictyostelium discoideum cells, the small G-protein Rap1 is activated uniformly at the cell

206 with C3G, a guanine exchange factor for the small G-protein Rap1, which was also rapidly activated i

207 ls have uncovered multiple functions for the small G protein, Rap1 (Ras-proximate-1).

208 ated with the constitutive activation of the small G protein, Rap1, and the lack of Ras-dependent act

209 hrough PKA, PI3K, p70S6k and the Ras-related small G protein, Rap1.

210 PKA-dependent activation of the Ras-related small G-protein, Rap1, and subsequent stimulation of the

211 link neuronal calcium influx to ERKs via the small G-protein, Rap1, and the neuronal Raf isoform, B-R

212 ing of developing dendrites by targeting the small G protein Rap2.

213 receptor tyrosine kinase (RTK) activates the small G protein Ras (D-Ras1) and the protein kinase Raf

214 -T cell receptor (pre-TCR) or the TCR to the small G protein Ras before emerging as functional T lymp

215 Activation of the small G protein Ras is required for thymocyte differenti

216 The small G protein Ras regulates proliferation through acti

217 Comparison of Galpha with the small G protein Ras reveals how the evolution of short s

218 leotide exchange factors (GEFs), through the small G protein Ras, to the three-tiered Raf-MAPK/ERK ki

219 Structural studies identify a small G protein Ras-association domain in the ASPP2 N te

220 s the MAPK pathway through activation of the small G protein Ras.

221 meric G protein Galpha(12) and activates the small G protein Ras/mitogen-activated protein kinase sig

222 ignaling to ERKs via distinct actions on the small G proteins Ras and Rap1.

223 osphatase 1B, protein kinase Calpha, and the small G-protein ras as substrates for S-thiolation durin

224 showed that NMDA-mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway ac

225 The intracellular pathway leading from the small G-protein Ras to the extracellular regulated kinas

226 differ in their requirements for Ca(2+) and small G proteins (Ras versus Rap1).

227 nd characterized the Aplysia homologs of the small G proteins, Ras and Rap1 (ApRas and ApRap, respect

228 Two small G proteins, Ras and Rap1 have been proposed to med

229 Two small G proteins, Ras and Rap1, have been proposed to me

230 ed the role of Src in the stimulation of two small G proteins, Ras and Rap1, that have been implicate

231 ons of MAPKs are dependent upon two distinct small G-proteins, Ras and Rap1, that link the growth fac

232 In Candida albicans, a fungal pathogen, the small G-protein Ras1 regulates many important behaviors

233 nine protein kinase regulated by Ras-related small G proteins, regulates sinoatrial node (SAN) ion ch

234 In animal and yeast cells some of the small G-proteins relay signals from receptors to MAPK pa

235 ich receptors control the activation of this small G protein remain, however, largely unknown.

236 The Rho and Rab family small G-proteins require addition of these isoprenyl moi

237 -activating domain (GAP) for Rabs, which are small G proteins required for membrane trafficking.

238 oprenylation of members of the Rho family of small G-proteins, resulting in the functional inactivati

239 Reversal is initiated by a small G-protein reversal switch; a pulse of frzE approxi

240 We show that the small G protein Rheb (Ras homolog enriched in brain) is

241 g protein) activity specifically towards the small G protein Rheb and inhibits its ability to stimula

242 ted signaling downstream of the farnesylated small G protein Rheb and synergistically enhanced etopos

243 disease may reflect the striatally selective small G protein Rhes binding to mHtt and enhancing its n

244 We recently reported that the small G-protein Rhes has the properties of a SUMO-E3 lig

245 and cell migration through the activation of small G protein Rho and its downstream effectors.

246 e by which a GDP-bound form of the conserved small G protein Rho GTPase directly activates mTORC2 in

247 ve previously shown that the function of the small G protein Rho is required for vascular smooth musc

248 hat links G12 signaling to activation of the small G protein Rho.

249 landin F(2alpha) (PGF(2alpha)) activates the small G-protein Rho, leading to morphological changes co

250 anized with major signal transducers, c-Src, small G-protein (Rho A), and focal adhesion kinase (FAK)

251 Moreover, by using constitutively active Rho small G-protein (Rho QL) as well as its inhibitor, C3 to

252 grity signaling pathway that consists of the small G-protein Rho1, protein kinase C (Pkc1), and a mit

253 ed by the Ca2+-independent activation of the small G protein RhoA and a downstream target, Rho-kinase

254 The small G protein RhoA and its GDP/GTP exchange factors (G

255 The small G protein RhoA increases ENaC activity by increasi

256 lular permeability through inhibition of the small G protein RhoA.

257 present evidence that transactivation of the small G-protein RhoA is required for phospholipase D act

258 The small G-protein RhoA regulates the actin cytoskeleton, a

259 cent studies have identified the Ras-related small G-protein, Rit, as a central regulator of a p38-MK

260 at suggested for the activation of the plant small G protein Rop4 by RopGEF8.

261 osolic TorC2, encountering locally activated small G protein(s) at the leading edge of the cell, beco

262 change factor responsible for activating the small G protein Sar1.

263 Small G proteins serve as critical control points in sig

264 ed in part by extra centrosomes, which alter small G protein signaling and activate LATS2 kinase.

265 es and demonstrates how GRAF1 can coordinate small G protein signaling and membrane remodeling to fac

266 s also cloned by others and referred to as a small G protein signaling modulators.

267 man disease associated with abnormalities of small G protein signaling pathways.

268 The outcomes of small G-protein signaling can both potentiate and antago

269 nity and further expand on the complexity of small G-protein signaling in DCs.

270 he possibility that HPV E6 may alter the Rap small-G-protein signaling pathway.

271 hanisms of exocytosis particularly involving small G proteins, SNARE proteins and chaperone molecules

272 hanisms of exocytosis particularly involving small G proteins, soluble N-ethylmaleimide-sensitive fac

273 cipate in several signaling pathways through small G proteins such as Ras (rat sarcoma).

274 ated formins, is activated by the binding of small G-proteins such as RhoA.

275 Because small G proteins (such as Rho) can play a role in BMVEC

276 e" G proteins comprising three subunits and "small" G proteins, such as the proto-oncogene product RA

277 The small G-protein superfamily is an evolutionarily conserv

278 (21 kDa) guanine nucleotide-binding protein (small G protein) superfamily comprises 5 subfamilies (Ra

279 This oscillator, in turn, drives MglAB, a small G-protein switch, to oscillate between its GTP- an

280 The small G protein Tem1p is critical in promoting mitotic e

281 Mitotic exit is controlled by the small G protein Tem1p.

282 h signal transducers (Src family kinases and small G-proteins), tetraspanins, growth factor receptors

283 th the ubiquitin-E3-ligase Siah1 and Rheb, a small G protein that activates mTOR.

284 Cdc42 is a Rho-family small G protein that has been widely studied for its rol

285 ssed in mouse hearts prototypical Rab1a, the small G protein that regulates vesicle transport from en

286 pathway involving the activation of RhoA, a small G protein that relays signals to the cytoskeleton.

287 Small G proteins that cannot displace 14-3-3 fail to rec

288 elated GTPases of plants) are plant-specific small G proteins that function as molecular switches wit

289 ghly homologous members of the Rho family of small G proteins that interact with several downstream e

290 calcium channel blockers inspired by Rem, a small G-protein that constitutively inhibits CaV1/CaV2 c

291 RhoA a small G-protein that has an established role in cell gro

292 S1/RASD1, a member of the Ras superfamily of small G-proteins that often promotes cell growth and tum

293 However, the ability of small G-proteins to interact with nucleation factors on

294 plicated signaling pathways that may involve small G-proteins, ubiquitin-mediated protein degradation

295 The majority of small G-proteins undergo posttranslational modifications

296 d by binding to members of the Rho family of small G proteins via a Rho binding motif known as an HR1

297 ion of the ARHI gene, encoding a RAS-related small G-protein, were strongly predictive of good surviv

298 adhesion induces activation of Cdc42 and Rac small G proteins, which eventually enhances the formatio

299 TPase-activating proteins (GAPs) for the Ras small G proteins, yet it has no RasGAP activity and bind

300 tutions for this residue in Ras and related (small) G-proteins yield nucleotide-depleted, dominant-ne