ライフサイエンスコーパス: small T antigen

1 ive and transformation enhancing activity of small t antigen.

2 iscent of the role of simian virus 40 (SV40) small t antigen.

3 persistent expression of large T antigen and small T antigen.

4 y a mechanism mediated, at least in part, by small t antigen.

5 d throughout the infection and unaffected by small t antigen.

6 quires both the SV40 large T-antigen and the small t-antigen.

7 thin the common region shared by large T and small t antigens.

8 bryonic fibroblasts using the SV40 large and small T antigens.

9 and most tumors express the MCPyV large and small T antigens.

10 both the simian virus 40 (SV40) large-T and small-t antigens.

11 nd (iv) that this defines a new mechanism of small-t-antigen action to promote mitogenesis.

12 Sequences encoding large T antigen, small t antigen, agnoprotein, and the viral capsid prote

13 Small t antigen alters the activity of phosphatase pp2A

14 In contrast, small t antigen, an antagonist of PP2A-C, inhibited Dish

15 has a deletion that eliminates synthesis of small t antigen and a point mutation (E107K) that result

16 Merkel cell polyomavirus small T antigen and functional imitation of large T anti

17 en coupled with expression of SV40 Large and Small T antigen and oncogenic ras.

18 n of 4E-BP1 is specifically mediated by SV40 small t antigen and requires the protein phosphatase 2A

19 cell chromosomes of MCC tumors and expresses small T antigen and truncated large T antigen.

20 Small-t antigen and, to a lesser extent, large-T antigen

21 domain of human telomerase, large T antigen, small T antigen, and an oncogenic allele of H-ras to stu

22 ide some or all of the functions of the SV40 small T antigen, another well-characterized oncoprotein,

23 first 82 amino acids of large T antigen and small t antigen are identical, and genetic experiments s

24 transcriptase (hTERT) plus SV40 large T and small T antigens are transformed by either oncogenic Ras

25 somes to the TGN was established using SV-40 small t antigen as a diagnostic tool in vivo.

26 nhibited PP2A, and in HIRcB cells expressing small t antigen, beta-arrestin1 Ser-412 phosphorylation

27 Point mutations of small t antigen between residues 97-103 that reduced PP2

28 By binding YAP, small t antigen brings it together with protein phosphat

29 The two small T antigens can target different proteins for depho

30 )-terminal common domain of SV40 large T and small t antigens, can repress HER2/neu (also known as er

31 On its own, small t antigen controls cell survival and differentiati

32 ses of transgenic mice expressing T1-127 and small t antigen display acinar cell dysplasia at birth t

33 predicted to encode the large T antigen and small T antigen early proteins and the VP1, VP2, and VP3

34 rkat T cells, inhibition of PP2A activity by small t antigen enhanced activation of CREB-mediated tra

35 Verhaegen et al. report MCPyV small T-antigen-expressing transgenic mice that now prov

36 association with Grb2 were also elevated in small-t-antigen-expressing cells.

37 at this dissociation was inhibited by 65% in small-t-antigen-expressing cells.

38 ase kinase (MEK) activities were elevated in small-t-antigen-expressing cells.

39 Small t antigen expression blocked both stimulus-induced

40 plasms were extremely rare in the absence of small t antigen expression.

41 in; (iii) that growth factor stimulation, or small-t-antigen expression, causes dissociation of the P

42 uppression of protein phosphatase 2A by SV40 small t-antigen has been reported to be critical for the

43 Comparisons of polyoma and SV40 small T antigens implicate Abeta in the control of diffe

44 We report that small T antigen in complex with MYCL and the EP400 compl

45 henocopies an essential contribution of SV40 small T antigen in human cell transformation.

46 Small t antigen in trans supplied those activities.

47 ent of PP2A Abeta/Akt interaction by polyoma small T antigen increased turnover of Akt Ser-473 phosph

48 s thus suggest an important role of UNC5B in small-T antigen-induced mitotic catastrophe that also re

49 d indicate that the similar polyoma and SV40 small T-antigens influence PP2A to activate discrete cel

50 For small T antigens, interaction with PP2A is needed for ea

51 Polyomavirus small t antigen is a viral oncogene that cooperates with

52 Small t antigen is known to specifically inhibit PP2A by

53 s study, we show that a viral protein called small T antigen is one of the ways that the virus can pe

54 In addition, we provide evidence that small t antigen is unlikely to be required.

55 nic mice that express a fragment of the SV40 small t antigen known to inhibit protein phosphatase 2A

56 f Merkel cell polyomavirus (MCPyV) large and small T antigens (LT and ST).

57 In contrast, neither E1a, small t antigen, nor mutants of large T antigen defectiv

58 When melanophores express the small t antigen of SV-40 virus, a specific inhibitor of

59 The separate effects of large-T and small-t antigens on these two inhibitors may explain the

60 e 2A (PP2A) activity by either expression of small t antigen or depletion of PP2A/C by RNA interferen

61 The introduction of SV40 small t antigen or the suppression of PP2A B56gamma subu

62 hospholipase D survival signals, either SV40 small t-antigen or pharmacological suppression of protei

63 ition of PP2A with okadaic acid, fostriecin, small T antigen, or PP2A knockdown abrogated rapamycin-i

64 or differences between SVST and polyomavirus small T antigen (POLST) in their effects on differentiat

65 This inhibition requires the small T-antigen PP2A-interacting domain.

66 We have utilized the murine polyomavirus small T antigen (PyST) as a tool to study UNC5B-mediated

67 In the present study, we report that polyoma small T antigen (PyST) associates with DBC1 in mammalian

68 Murine polyomavirus small t antigen (PyST) regulates cell cycle, cell surviv

69 ffinity and selective binding of the polyoma small T antigen (PyST) with the transcription cofactor T

70 Polyoma small T antigen (PyST), an early gene product of the pol

71 We show that Py small T-antigen (PyST) blocks ARF-mediated activation of

72 -antigen (PyLT), middle T-antigen (PyMT) and small T-antigen (PyST) will transform primary rodent cel

73 Interestingly, the polyoma small T-antigen (PyST), which shares with MTA both parti

74 e p53 and Rb-family of tumor suppressors and small T antigen's action on the pp2A phosphatase, are im

75 The simian virus 40 small t antigen (small-t) is required for optimal viral

76 t least three regions of the simian virus 40 small-t antigen (small-t) contribute to the protein's ab

77 Small t antigen specifically inhibited PP2A, and in HIRc

78 MCV-positive MCC expresses small T antigen (ST) and a truncated form of large T ant

79 The tumor antigens simian virus 40 small t antigen (ST) and polyomavirus small and medium T

80 Simian virus 40 (SV40) small t antigen (ST) binding to N-terminal HEAT repeats

81 The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A)

82 We recently demonstrated that polyomavirus small T antigen (ST) binds YAP, a major effector of Hipp

83 We have previously shown that SV40 small t antigen (st) cooperates with deregulated cyclin

84 ary was carried out with a bait of wild-type small T antigen (sT) fused N terminally to the DNA-bindi

85 SV40 small t antigen (ST) has been reported to be necessary a

86 Polyomavirus small t antigen (ST) impedes late features of retinoic a

87 can also be complemented for p53 override by small t antigen (st) in a manner independent of its J do

88 Simian virus 40 small t antigen (st) is required for optimal transformat

89 Merkel cell polyomavirus (MCV) small T antigen (sT) is the main oncoprotein for the dev

90 acement of regulatory B subunits by the SV40 Small T antigen (ST) or mutation/deletion of PP2A subuni

91 Coexpression of SV40 small t antigen (st), but not other tested oncogenes, ef

92 f the SV40 large T antigen (LT) and the SV40 small t antigen (ST).

93 the major transforming protein, to that from small T antigen (ST).

94 er some of the functions of the polyomavirus small T antigens (ST) are shared by the E6 and E7 oncopr

95 SV40 small t-antigen (ST) collaborates with SV40 large T-anti

96 ual SV40 oncogenes (large T antigen [LT] and small t antigen [st]) and human papillomavirus oncogenes

97 ls express putative polyomavirus oncoprotein small T antigen (sTAg) and truncated large T antigen.

98 In these studies, small t antigen stimulated cyclin D1 promoter activity 7

99 full-length T antigen, as well as wild-type small t antigen, stimulated the ATPase activity of hsc70

100 SV40 small T antigen (SVST) has received considerable attenti

101 ge T antigen (T antigen), and 174 amino acid small T antigen (t antigen), in transformation have been

102 pends on the region of T antigen shared with small-t antigen (T/t common region).

103 Polyomavirus small T antigen (tAg) plays important roles in regulatin

104 lpha (TGFalpha) or simian virus 40 large and small T antigen (TAg), each under the control of the pho

105 We also determined that the SV40 small t-antigen (tag) plays an important role in inducin

106 0) encodes two proteins, large T antigen and small t antigen that contribute to virus-induced tumorig

107 an inhibitor of PP2A, and is blocked by SV40 small T antigen that is known to disrupt B subunit bindi

108 s 2 transforming proteins, large T (Tag) and small t antigen, that produce neuroendocrine tumors in t

109 cooperated strongly with the simian virus 40 small t antigen to elicit aggressive anchorage-independe

110 gment (T1-127) expressed in conjunction with small t antigen under control of the rat elastase-1 (E1)

111 ormation induced by Merkel cell polyomavirus small T antigen viral oncoprotein.

112 the Ras/MAP kinase pathway, simian virus 40 small t antigen was expressed in Rat-1 fibroblasts which

113 ced levels of p21(WAF1), while expression of small-t antigen was required to decrease p27(KIP1).

114 a deletion that eliminated expression of the small t antigen were expressed in transgenic mice under

115 Rb tumor suppressors, respectively, and SV40 small t antigen were required to allow mutant K-Ras(12D)

116 CRE sites were sufficient for activation by small t antigen when linked to an heterologous promoter.

117 talized by it in the presence and absence of small t antigen, which can provide the T-common-region t

118 he transforming proteins large T-antigen and small t-antigen, which are involved in viral replication

119 The SV40 small T-antigen, which is similar to PyST in containing

120 This work shows how this association of small t antigen with YAP is important for its effects on

121 oncoproteins, by replacing SV40 large T and small T antigens with sh-p53, mutant CDK4 (CDK4(R24C)),

122 y cyclin A, cyclin E, or the simian virus 40 small-t antigen with no decrease in the levels of WAF1 p