ライフサイエンスコーパス: small animal

1 od for early detection of intimal changes in small animals.

2 in 3D scaffolds subcutaneously implanted in small animals.

3 d function in complex and rapid movements of small animals.

4 a), with a highly diverse suite of large and small animals.

5 ce vocalizations with lower frequencies than small animals.

6 nuously recording large amounts of data from small animals.

7 arge animals and as a constant frequency for small animals.

8 noninvasive study of biological processes in small animals.

9 vers organelles, cells, tissues, organs, and small animals.

10 is widespread and is found in both large and small animals.

11 edictor for ejection fraction improvement in small animals.

12 ue types, which is not typically observed in small animals.

13 olution required to visualize the anatomy of small animals.

14 bot could be easily adapted for use in other small animals.

15 the early detection of disease outbreaks in small animals.

16 the behavioral monitoring of a wide range of small animals.

17 ivo and in vivo in exposed porcine liver and small animals.

18 demonstrated the feasibility of quantitative small-animal (18)F-FDG PET in rats by performing it repe

19 CLI) of in vivo radionuclide distribution in small animals, a method proven to be a high-throughput m

20 We study natural populations of this small animal and its relative, C. briggsae, and the viru

21 From 2009 to 2013, 60 small animals and 2250 mites were collected in the vicin

22 easuring antibody functionality of sera from small animals and nonhuman primates immunized with an ex

23 mBCs in large fish falls to ~1/3 of that of small animals, and intercellular spacing doubles.

24 Such measurements are challenging in small animals because of their small blood volume.

25 etail for meaningful comparison even in very small animals, but also that mu-CT can provide additiona

26 stingly, CSC therapy had a greater effect in small animals compared with large animals (P<0.001).

27 umin to the anatomic lung volume obtained by small-animal CT.

28 rovirus disease and representing a norovirus small animal disease model in wild-type mice.

29 automated tracking and proximity sensing of small animals, even in closed habitats, at high spatial

30 The island rule predicts that small animals evolve to become larger on islands, while

31 relates of protection and thereby provides a small animal experimental framework to guide the develop

32 areas of research, including organs-on-chip, small animal experiments, and neonatology.

33 or dead time was found to be unnecessary for small-animal experiments, whereas propagation delay and

34 lution optical imaging of the whole brain in small animals has been achieved ex vivo, the real-time a

35 While Haller's rule states that small animals have relatively larger brains, minute Tric

36 in culturing HuNoVs in the laboratory and a small animal host, studies of human viruses have inheren

37 ized animals using standard retinal or whole small animal imaging systems.

38 probes, such as GNPs, within the context of small animal imaging.

39 linear-array ultrasound systems designed for small-animal imaging provide high-frame-rate and Doppler

40 [(89)Zr]Zr-DFO-daratumumab PET/CT small-animal imaging was performed in severe combined im

41 meliorate disease is the lack of susceptible small animals in large numbers.

42 nal differences between and within large and small animals in the CSC therapy field.

43 precise 3D poses have not been addressed for small animals including the fly, Drosophila melanogaster

44 effective treatment together with a lack of small animal infection models has led to clinical trials

45 We employed a small animal irradiator to administer fractionated hindl

46 fast micrometer scale internal movements of small animals is a key challenge for functional anatomy,

47 parabiosis, heterochronic blood exchange in small animals is less invasive and enables better-contro

48 enon show organ protective effects mostly in small animal ischemia reperfusion injury models.

49 hile it demonstrated a strong correlation in small animals, its translation to primates remains in qu

50 composition strategies, such as having many small animals, may also be effective.

51 In a small animal model (chicken embryo), we achieved uniform

52 a protective passive vaccine antigen in this small animal model and merits further evaluation.

53 ing and in vivo PET imaging experiments in a small animal model demonstrated that (134)Ce (and its (1

54 ototype arenavirus, can serve as a surrogate small animal model for arenavirus hemorrhagic fevers.

55 cture similar to that in humans, is the only small animal model for congenital CMV infection and reca

56 The guinea pig is the only small animal model for congenital CMV infection.

57 These data support the D2.mdx as a superior small animal model for DMD, as compared to the B10.mdx m

58 The gold standard small animal model for JUNV infection is the guinea pig.

59 his study demonstrates the potential of this small animal model for studying BDBV and EBOV using wild

60 The lack of a small animal model for this infection impedes the develo

61 ymphomas in chickens and serves as a natural small animal model for virus-induced tumor formation.

62 Among these is the lack of a convenient small animal model in which to study antibody elicitatio

63 A small animal model of chronic CAVB that properly reflect

64 We developed a novel small animal model of co-infection in the humanized mous

65 tional profiling of LmnaH222P/H222P mouse, a small animal model of LMNA cardiomyopathy, suggested dec

66 gene targeting to develop a fully penetrant small animal model of this disease that recapitulates ma

67 representative encephalopathy of prematurity small animal model only dependent on preterm birth.

68 A small animal model that develops progressive pulmonary m

69 therapeutics have been hampered by lack of a small animal model that recapitulates key features of th

70 l, optimized NHP xenogeneic GVHD (xeno-GVHD) small animal model that recapitulates many aspects of NH

71 ease development; however, there is no valid small animal model that uses a human ehrlichial pathogen

72 tudied, likely due to the lack of a suitable small animal model.

73 tudies on this pathogen due to the lack of a small animal model.

74 ed protective effect against SARS-CoV-2 in a small animal model.

75 has hindered developing an immunocompetent, small animal model.

76 and there is a lack of a well-characterized small animal model.

77 articular importance, this is the only known small-animal model developed for Bundibugyo and the only

78 The guinea pig is a small-animal model for cCMV.

79 The guinea pig is the only small-animal model for cCMV.

80 infection of susceptible mice is a tractable small-animal model for encephalitis, and the virus cause

81 to -4A chimera-infected marmosets provide a small-animal model for evaluating novel antiviral drugs

82 system may provide a much-needed preclinical small-animal model for HCMV and VZV and, potentially, ot

83 d have been shown to cure mouse norovirus, a small-animal model for HNoVs.

84 ouse adenovirus type 1 was used to develop a small-animal model for oral replication-competent adenov

85 anized mice have raised the possibility of a small-animal model for preclinical testing of an HIV-1 v

86 flexneri pathogenesis and provides a unique small-animal model for research and development of thera

87 acle in ebolavirus research is the lack of a small-animal model for Sudan virus (SUDV), as well as ot

88 at humanized mice could be a highly relevant small-animal model for the study of dengue pathogenesis

89 and suggested that humice could be a useful small-animal model for the study of dengue pathogenesis

90 duced ultrasound-guided IUCT of hAEC using a small-animal model of a congenital metabolic disorder wi

91 A small-animal model of Ad14-induced lung infection was us

92 The lack of an appropriate small-animal model of dengue infection has greatly hinde

93 the disease, and the lack of an appropriate small-animal model of dengue infection has greatly incre

94 The development of a small-animal model of LASV infection that replicates hea

95 Murine gammaherpesvirus 68 (MHV68) is a small-animal model suitable for study of the human patho

96 The lack of a small-animal model that mimics systemic DEN disease with

97 mbating bacillary dysentery is the lack of a small-animal model that recapitulates the symptoms obser

98 sing murine gammaherpesvirus 68 (MHV68) as a small-animal model to define mechanisms of GHV pathogene

99 against SUDV is attributed to the lack of a small-animal model to screen promising compounds.

100 tributing to this situation is the lack of a small-animal model to screen promising drugs in an effic

101 nstrate that humanized mice can be used as a small-animal model to study the efficacy and mechanism o

102 he ferret model has emerged as the preferred small-animal model with which to study NiV disease, but

103 an efficient cell culture system and robust small-animal model, little is known about the innate hos

104 ossibility of studying HIV transmission in a small-animal model.

105 irus due to the lack of a well-characterized small-animal model.

106 However, questions remain whether small animal models accurately predict efficacy in human

107 Our work demonstrates that small animal models are valuable screening tools for the

108 observed in rodent brain, and whether other small animal models capture this aspect of human brain d

109 The lack of immunocompetent small animal models for hepatitis C virus (HCV) has grea

110 Additionally, the lack of small animal models for these infections hinders the in

111 Experimental work in small animal models has revealed many details of the inf

112 scular diseases like diabetic retinopathy in small animal models is often complicated by their failur

113 Small animal models of chronic obstructive pulmonary dis

114 Small animal models of JUNV infection are limited becaus

115 human livers offer a valuable alternative as small animal models of liver stage human malaria.

116 benefit greatly from in vivo studies, using small animal models such as Caenorhabditis elegans for h

117 c interfacing with fine peripheral nerves in small animal models that begins to meet these constraint

118 Small animal models that recapitulate SARS-CoV-2 disease

119 logical complexities in C. elegans and other small animal models used to investigate human disease an

120 erapies is hampered by a lack of appropriate small animal models with autologous human tumor and immu

121 Similar studies in small animal models, such as Caenorhabditis elegans (C.

122 lopment have been hampered by the absence of small animal models.

123 vo applications, e.g., for the bioimaging of small animal models.

124 e magnitude of effect in large compared with small animal models.

125 flows at high spatial and time resolution in small animal models.

126 ysiology of AKI, mainly through the study of small animal models.

127 OVID-19 disease would benefit from validated small animal models.

128 a biomarker of pancreatic beta-cell death in small animal models.

129 l molecule histone methylation modulators in small animal models.

130 ensitive tracking of biological processes in small animal models.

131 FV have been limited due to lack of suitable small animal models.

132 th minimal toxicity as shown in vitro and in small animal models.

133 hepacivirus) have been stymied by a lack of small animal models.

134 CHF has been limited by the lack of suitable small animal models.

135 has been difficult to study due to a lack of small animal models.

136 ly understood because of a lack of tractable small- animal models.

137 fficiently elicit neutralizing antibodies in small-animal models and primates.

138 oritize vaccine candidates more efficiently, small-animal models are needed.

139 ingle deficient hepatic enzyme, and multiple small-animal models exist for preclinical testing.

140 r of cardiac fibrosis, and its inhibition in small-animal models has been shown to be an effective an

141 The lack of small-animal models has impeded studies of antiviral imm

142 troduction of analogous Scn5a mutations into small-animal models has not recapitulated alterations in

143 Small-animal models have been developed for several Filo

144 There is a need for small-animal models of MERS, but mice are not susceptibl

145 proved neutralizing responses induced in two small-animal models of MV immunogenicity.

146 Here we show, using established small-animal models of MV infection, that fusion-inhibit

147 s herein the advantages and disadvantages of small-animal models that have been developed to replicat

148 cancer-specific imaging agents and effective small-animal models to test them.

149 disease have been difficult to achieve, and small-animal models traditionally used to investigate vi

150 emodeling following myocardial infarction in small-animal models.

151 the effects of chemical compounds in living small-animal models.

152 ntrast, and specificity were achieved in the small-animal models.

153 both binding and neutralizing antibodies in small-animal models.

154 ty to infect, cause disease, and transmit in small-animal models.

155 ple in the form of a multimodal CT scan of a small animal (mouse, ex vivo).

156 lled a custom-fabricated PET insert into our small-animal MRI instrument and used PET/MRI hybrid imag

157 sed in the BioSpec 70/20 and 94/20 series of small-animal MRI systems, the insert can easily be insta

158 Furthermore, through small-animal MRI, we analyzed edema and vascular leakage

159 perienced in marmoset care and handling, and small-animal neurosurgery; an assistant for monitoring t

160 Small-animal nuclear imaging modalities have become esse

161 r eukaryotes (protists, >0.8 micrometers) to small animals of a few millimeters.

162 Data acquired with our small-animal OT system were highly repeatable and reprod

163 We used a commercial small-animal OT system.

164 due to technological limitations of tracking small animals over large areas.

165 is was significantly higher in studies using small animals (p < 0.0001) and in peritonitis models (p

166 Small animal PET and biodistribution studies were perfor

167 cose ([F]FDG) and N-labeled ammonia ([N]NH3) small animal PET imaging in a well-established murine ca

168 over a 2-week period using a high-resolution small animal PET scanner.

169 Both organ distribution and small animal PET studies revealed limited brain uptake o

170 In vivo, small animal PET studies were conducted in nude mice bea

171 Small animal PET studies with [(76)Br]5 demonstrated goo

172 Dynamic (18)F-FDG PET using a dedicated small animal PET system was performed under hyperinsulin

173 Biodistribution and small animal PET/CT studies in the mouse DBT model of gl

174 k, each rat underwent (18)F-FDG quantitative small-animal PET 6 times.

175 ries in Abeta mouse models examined by Abeta small-animal PET and tested if such asymmetries have an

176 kilogram (n = 5 each) and underwent dynamic small-animal PET beforehand and afterward to estimate le

177 oradiographic findings confirmed the in vivo small-animal PET data.

178 The small-animal PET experiments did not show any significan

179 Small-animal PET experiments were performed in athymic n

180 In vivo small-animal PET experiments were performed on tumor-bea

181 In the small-animal PET experiments, LNCaP tumors were clearly

182 here was a high positive correlation between small-animal PET findings of microglial activation with

183 unohistochemical analyses confirmed the TSPO small-animal PET findings.

184 Rat small-animal PET images showed (11)C-metformin uptake in

185 On small-animal PET images, the tumor was clearly delineate

186 Depending on their in vitro performance, small-animal PET imaging and biodistribution studies wer

187 utoradiography and in living rats by in vivo small-animal PET imaging and ex vivo autoradiography.

188 Small-animal PET imaging demonstrated high tumor uptake

189 However, small-animal PET imaging is limited by coarse spatial re

190 Finally, small-animal PET imaging of an LNCaP tumor-bearing mouse

191 The in vivo biodistribution and dynamic small-animal PET imaging studies were investigated in BA

192 Biodistribution and small-animal PET imaging studies were performed in CB17

193 9)Zr-AMG 110 can be clearly visualized using small-animal PET imaging up to 72 h after injection.

194 In vivo biodistribution and small-animal PET imaging were performed in mice bearing

195 amyloid-beta pathology were obtained through small-animal PET imaging with (18)F-FDG, (18)F-periphera

196 Longitudinal quantitative small-animal PET imaging with an arterial input function

197 ed its utility to increase the throughput of small-animal PET imaging without considerable loss of im

198 to (18)F-fluorination, autoradiography, and small-animal PET imaging.

199 In this first triple-tracer small-animal PET in a well-established AD mouse model, w

200 Tumor xenografts were clearly detectable by small-animal PET in all cases.

201 ng candidates were additionally evaluated by small-animal PET in healthy rats using PSMA-positive per

202 Amyloid imaging by small-animal PET in models of Alzheimer disease (AD) off

203 The small-animal PET measurements showed high tumor-to-backg

204 A small-animal PET scan of a rhesus monkey revealed modera

205 Small-animal PET scans of Wistar rats revealed moderate

206 Dynamic small-animal PET showed binding of (11)C-JNJ-54173717 in

207 iary excretion of [(18)F]FGlc-FAPI; however, small-animal PET studies in HT1080hFAP xenografts showed

208 In vivo small-animal PET studies in Sprague-Dawley rats were per

209 Biodistribution studies and in vivo small-animal PET studies of [(18)F]FGlc-FAPI compared wi

210 ings, we completed 12 (18)F-FDG quantitative small-animal PET studies on 2 rats.

211 ings, we completed 12 (18)F-FDG quantitative small-animal PET studies on 2 rats.

212 Dynamic small-animal PET studies were performed in rats and a rh

213 Dynamic small-animal PET studies were performed in vector-inject

214 esions as shown in preclinical evaluation by small-animal PET studies, organ distribution, and a pati

215 steadily before and after the 6 quantitative small-animal PET studies.

216 sively imaging the PD-L1 status of tumors by small-animal PET studies.

217 prostate cancer imaging was demonstrated by small-animal PET studies.

218 prostate cancer imaging was demonstrated by small-animal PET studies.

219 8)Ga]6 and [(68)Ga]8 and specific binding in small-animal PET studies.

220 o AD pathology, we undertook a triple-tracer small-animal PET study to assess microglial activation a

221 s x 30 s, 20 frames x 60 s) with a dedicated small-animal PET system and postmortem tissue counting i

222 mages obtained with the SiPM-based MiniPET-3 small-animal PET system are similar in quality to those

223 We recently completed construction of a small-animal PET system-the MiniPET-3-that uses state-of

224 bits were studied with (18)F-LMI1195 using a small-animal PET system.

225 In the present study, we used small-animal PET to characterize the expression of molec

226 Therefore, we used dual-tracer small-animal PET to examine directly the link between ne

227 Performing quantitative small-animal PET with an arterial input function has bee

228 locator protein (TSPO) ((18)F-GE180; n = 58) small-animal PET, with volume-of-interest and voxelwise

229 d-type mice of various ages were examined by small-animal PET.

230 mine for (89)Zr radiolabeling and subsequent small-animal PET/CT acquisition and ex vivo biodistribut

231 vein and noninvasively imaged by optical and small-animal PET/CT at different time points.

232 graft tumors (BxPC-3) and investigated using small-animal PET/CT imaging 1, 2, and 4 h after injectio

233 f tumors, we performed in vitro and in vivo (small-animal PET/CT imaging and autoradiography) experim

234 cantly increased (18)F-FDG uptake at 24 h on small-animal PET/CT imaging and autoradiography.

235 ografts grown in female athymic nude mice by small-animal PET/CT imaging and tissue biodistribution u

236 A considerable limitation of current small-animal PET/CT imaging is the low throughput of acq

237 Small-animal PET/CT imaging of 5F7 Nanobody labeled usin

238 Based on Lindmo analysis and small-animal PET/CT imaging, (89)Zr-DFO-trastuzumab rema

239 enously injected, followed by imaging with a small-animal PET/CT scanner and autoradiography.

240 he performance of a novel mobile human brain/small-animal PET/CT system.

241 Methods: Tumor-bearing mice were imaged with small-animal PET/CT to evaluate the whole-body distribut

242 fter inoculation, all mice were scanned with small-animal PET/CT using two new uPAR PET ligands ((64)

243 0 and imaged longitudinally over 4-5 d using small-animal PET/CT.

244 ng mobilization of CD11b(+) myeloid cells by small-animal PET/CT.

245 tapir uptake in the 5xFAD brain by dedicated small-animal PET/MRI and PET/CT to validate the quantita

246 Development of small-animal PET/MRI enables tracking of brain region-sp

247 Longitudinal amyloid small animal positron emission tomography demonstrates a

248 ke was measured in tumor xenografts by using small-animal positron emission tomographic/computed tomo

249 PR biodistribution and imaging in mice using small-animal positron emission tomography (PET).

250 Small animals possess intriguing morphological and behav

251 Functional epitope mapping of these mAbs and small animal prophylaxis studies revealed a complex land

252 irradiated (IR) to the marked area using the Small Animal Radiation Research Platform (SARRP).

253 Measurements of brain amyloid burden in small animals require laborious post-mortem histological

254 We developed a new small animal research tool called "Diffuse in vivo Flow

255 cine MRI sequence was implemented on a 9.4T small animal scanner.

256 T scans in rhesus monkeys were obtained on a small-animal scanner to assess the pharmacokinetic and i

257 stom firmware to enable measurements next to small-animal scanners.

258 Recent observations of feeding dynamics in small animals showed feeding patterns of bursts and paus

259 In rodents and other small animals, slow oscillations of local field potentia

260 barrier to infection for other nonpermissive small-animal species, namely, ferret, guinea pig, and ha

261 tumor colonies could be visualized with both small-animal SPECT and fluorescence imaging from the fir

262 ith (99m)Tc-TCP-1 or control peptide using a small-animal SPECT imager: Group I (n=5) received no blo

263 Small-animal SPECT images and optical images were acquir

264 cked with CT, echocardiography, MMP-targeted small-animal SPECT imaging using (99m)Tc-RP805, and hist

265 nsplantation in a rat model with a dedicated small-animal SPECT scanner by targeting the glucagonlike

266 was manufactured and mounted in a stationary small-animal SPECT system.

267 ginase was performed in C57BL/6 mice by both small-animal SPECT/CT and ex vivo biodistribution studie

268 On in vivo small-animal SPECT/CT and ex vivo planar images, the MMP

269 MMP activation was imaged by in vivo small-animal SPECT/CT followed by ex vivo planar imaging

270 In vivo (99m)Tc-RYM1 small-animal SPECT/CT images showed higher uptake of the

271 Biodistribution and small-animal SPECT/CT imaging (18.5 +/- 2.6 MBq) with 25

272 Methods: Here we have used noninvasive small-animal SPECT/CT imaging and ex vivo biodistributio

273 Biodistribution and small-animal SPECT/CT imaging studies were performed to

274 uno-PET imaging with (64)Cu-cetuximab and of small-animal SPECT/CT imaging with (177)Lu-cetuximab, in

275 nfused apoE(-/-) (n = 16) mice were used for small-animal SPECT/CT imaging.

276 Small-animal SPECT/CT-based MMP-targeted imaging of the

277 There was a significant correlation between small-animal SPECT/CT-derived MMP signal and CD68 expres

278 B-DAR4-MMAE could clearly be visualized with small-animal SPECT/CT.

279 ios (4-6) allowed for high image contrast in small-animal SPECT/CT.

280 ce were used for biodistribution studies and small-animal SPECT/CT.

281 However, our recent small animal studies found large numbers of recipient st

282 Minor publication bias was observed in small animal studies.

283 ing and analyzing the locomotion behavior of small animals such as Drosophila larvae or C. elegans wo

284 reliably and reproducibly track movement of small animals such as rodents or insects, and quantify p

285 Small animals such as the roundworm C. elegans are excel

286 Small animals, such as rabbits, are used to evaluate pro

287 Small animals support a wide range of pathological pheno

288 can be implemented by researchers skilled in small-animal surgery but lacking embryo-handling skills.

289 Small-animal surgery experience is required to successfu

290 ulate guilds help to suppress populations of small animals that act as agricultural pests and disease

291 ructures post considerable challenges to use small animals to model ASD and to translate experimental

292 The small animal tumor model is the most versatile and effec

293 Most of these strategies were from small animal tumor models which are our primary tool for

294 Small animals typically localize sound sources by means

295 eeks of age were imaged by using a dedicated small-animal US system after intravenous injection of 5

296 Drugs can be released remotely inside the small animals using pre-implanted, novel vertically alig

297 The fundamental challenge for small animals using vibrational communication is to move

298 icroscopy, flow cytometry, and the flexiVent small-animal ventilator.Measurements and Main Results: T

299 solution to low oxygen availability in this small animal with no respiratory structures or pigment.

300 suited for cardiac imaging, particularly in small animals with rapid heart rates.