ライフサイエンスコーパス: sn

1 sn-1 acyltransferase activity in murine liver microsomes

2 Oleic acid occupied typically the sn-1/sn-3 positions but when together with FAs 20:1, 20:2, 18

3 lycerols rich in CLA, with a ratio of sn-1,3/sn-1,2 regioisomers of 21.8, compared to 2.3 for Novozym

4 muscle revealed that HSL KO mice accumulated sn-1,3 DAG and not sn-1,2 DAG.

5 ring channel activation by 1-oleoyl-1-acetyl-sn-glycerol (OAG), the membrane-permeable analog of diac

6 he diacylglycerol analogue 1-oleoyl-2-acetyl-sn-glycerol (OAG) reversed the inhibitory effect of cand

7 t both angiotensin II- and 1-oleoyl-2-acetyl-sn-glycerol-induced Ca(2+) entry in these cells, which w

8 acyl chains, and, in some cases, fatty acyl sn-position and relative abundances for isomeric fatty a

9 nds 1-(4-hydroxy-3-methoxy) cinnamoyl-2-acyl-sn-glycero-3-phosphocholine and 1-(4-hydroxy-3,5-dimetho

10 1-(4-hydroxy-3,5-dimethoxy) cinnamoyl-2-acyl-sn-glycero-3-phosphocholine exhibited excellent antioxid

11 pound 1-(4-hydroxy-3-methoxy) benzoyl-2-acyl-sn-glycero-3-phosphocholine exhibited good antifungal ac

12 ycerophospholipids as 1-O-alk-1'-enyl-2-acyl-sn-glycero-3-phosphoethanolamine or plasmenylethanolamin

13 ngly unsaturated PC bilayers (sn-1: 16:0 and sn-2: 18:1...22:6; or sn-1 and sn-2: 18:1...22:6).

14 ould cleave acyl chains at both the sn-1 and sn-2 positions of PC, and displayed substrate selectivit

15 the fatty acyl substituents at the sn-1 and sn-2 positions of the glycerol backbone.

16 ing unsaturated acyl chains in both sn-1 and sn-2.

17 n-1: 16:0 and sn-2: 18:1...22:6; or sn-1 and sn-2: 18:1...22:6).

18 of medium-chain fatty acids in the sn-2 and sn-3 positions of seed triacylglycerols (TAGs).

19 , DAG-sn-1 and DAG-sn-2, and both sn-1/3 and sn-2 positions in TAG.

20 tants, the esterification of both sn-1,3 and sn-2 positions of glycerol was impacted, and their cutin

21 through controlling both mRNA elongation and sn/snoRNA synthesis, the 7SK snRNP is a key regulator of

22 etail, their triacylglycerols identified and sn-2 positional arrangement of fatty acid constituents a

23 ative results of both lipid C=C location and sn-position isomers.

24 ty acyl chains, leaving the C=C location and sn-position unidentified.

25 regioselective preparation of sn-1 mono and sn-1,3 diacylglycerols rich in CLA, with a ratio of sn-1

26 apability of identifying C=C location(s) and sn-position(s) simultaneously.

27 lipid biomarkers (4alpha-methyl sterols and sn-2-hydroxyarchaeol, respectively), which were distinct

28 MCMCtreeR depends on the R packages ape, sn and stats4.

29 Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) and its derivatives

30 , the products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC) oxidation that contai

31 lipids (oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine [Ox-PAPC]) and proinflammato

32 ALE: Oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) generates a grou

33 ated phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-phosphocholine.

34 produce the endocannabinoid, 2-arachidonoyl-sn-glycerol (2-AG) upon antigen activation.

35 1, increased endocannabinoid (2-arachidonoyl-sn-glycerol (2-AG)) levels in the taste organ, and enhan

36 activates the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG), exert anxiolytic-like effects in rod

37 ation of the endocannabinoid, 2-arachidonoyl-sn-glycerol (2-AG), in the amygdala.

38 nzyme for the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG).

39 vation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2AG), is tightly controlled by the cell's r

40 LPS and oxidized 1-palmitoyl-2-arachidonoyl-sn-phosphatidylcholine (oxPAPC) dependent pro-inflammato

41 process was not completely regiospecific at sn-1,3 positions, due to the spontaneous acyl migration

42 ro-3-phosphocholine, 1-palmitoyl-2-azelaoyl- sn-glycero-3-phosphocholine, O-1-O-palmitoyl-2-O-(5,8-di

43 ses in increasingly unsaturated PC bilayers (sn-1: 16:0 and sn-2: 18:1...22:6; or sn-1 and sn-2: 18:1

44 in PC-sn-2, DAG-sn-1 and DAG-sn-2, and both sn-1/3 and sn-2 positions in TAG.

45 o PCs having unsaturated acyl chains in both sn-1 and sn-2.

46 in these mutants, the esterification of both sn-1,3 and sn-2 positions of glycerol was impacted, and

47 nd re-esterification to the sn-2 position by sn-2 acyltransferase activity (i.e. the Lands cycle).

48 NAs), small nuclear, nucleolar, cytoplasmic (sn-, sno-, scRNAs, respectively), transfer (tRNAs), and

49 the levels of CPA increased in PC-sn-2, DAG-sn-1 and DAG-sn-2, and both sn-1/3 and sn-2 positions in

50 f CPA increased in PC-sn-2, DAG-sn-1 and DAG-sn-2, and both sn-1/3 and sn-2 positions in TAG.

51 noyl-lysophospholipids by acyl-CoA-dependent sn-1 acyltransferase(s).

52 On the other hand, (13)C-depleted sn-2-hydroxyarchaeol potentially derived from ANME-2 and

53 f diacylglycerol to form 3-acetyl-1,2-diacyl-sn-glycerol (acetyl-TAG).

54 in channel function in a thick 1,2-dierucoyl-sn-glycero-3-phosphocholine (DC(22:1)PC) but not in thin

55 ted the exchange of gA between 1,2-dierucoyl-sn-glycero-3-phosphocholine (DC22:1PC) or 1,2-dioleoyl-s

56 eased in the thickest bilayer (1,2-dierucoyl-sn-glycero-3-phosphocholine).

57 ng from fatty acid moieties having different sn-1/2 positions at the glycerol backbone, length of the

58 is approach is demonstrated to differentiate sn-positional and double-bond-positional isomers, such a

59 o-3-phosphocholine (DOPC)/1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC) membranes.

60 -glycero-2-phosphocholine and 1,2-dihexanoyl-sn-glycero-3-phosphocholine exhibit thermally reversible

61 hen using vesicles formed from 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), we measured the freq

62 Bilayers prepared using 1,2-dilauroyl-sn-glycero-3-phosphocholine, a lipid with 12 carbon acyl

63 t on the membrane surface in 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)/1,2-dimyristoyl-

64 3-phosphatidylcholine (DMPC)/1,2-dimyristoyl-sn-glycero-3-phosphatidylglycerol (DMPG) and 1-palmitoyl

65 -sn-glycero-3-phosphocholine/1,2-dimyristoyl-sn-glycero-3-phospho- (1'-rac-glycerol)/cholesterol lipi

66 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and its mixtures with

67 show that liquid crystalline 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and POPC/POPS 3:1 lip

68 composed of the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the saponin glycy

69 ptides melittin and MelP5 in 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) are repeated in POPC.

70 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposomes were the mo

71 ct tOmpA folding kinetics in 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposomes, suggesting

72 ree different phospholipids (1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dipalmitoyl-sn-g

73 itions in single bilayers of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)/1,2-dipalmitoyl-sn-gl

74 Conversely, in the 1,2-dimyristoyl-sn-glycero-3-phosphocholine bilayer, the overall hydroph

75 tions, isotopically distinct 1,2-dimyristoyl-sn-glycero-3-phosphocholine large unilamellar vesicle po

76 Using model membranes of 1,2-dimyristoyl-sn-glycero-3-phosphocholine lipids at pH > pHagg, we fou

77 Specifically, 1,2-dimyristoyl-sn-glycero-3-phosphocholine transfer and flip-flop kinet

78 melting of lipid domains in 1,2-dimyristoyl-sn-glycero-3-phosphocholine vesicles is observed to occu

79 -sn-glycero-3-phosphocholine/1,2-dimyristoyl-sn-glycero-3-phosphocholine vesicles was quantified from

80 obular actin-supported DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) bilayers, deposited via the

81 ion of synthetic redox DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) liposomes by single collisi

82 the phase behaviour of DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) multilamellar vesicles.

83 g HA FP to TMD-reconstituted 1,2-dimyristoyl-sn-glycero-3-phosphocholine/1,2-dimyristoyl-sn-glycero-3

84 s of Abeta(1-40) interacting 1,2-dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG) bilayers.

85 Nanogels composed of dimyristoyl-sn-glycero-2-phosphocholine and 1,2-dihexanoyl-sn-glycer

86 Repeated addition of 1,2-dioctanoyl-sn-glycerol (DiC8) resulted in sustained plasma membrane

87 containing the fusogenic lipid 1,2-dioleoyl-sn-3-phosphoethanolamine (DOPE) in combination with DOTA

88 gated and the results show that 1,2-dioleoyl-sn-glycero-3-[phospho-L-serine] (DOPS) small unilamellar

89 -organic frameworks (MOFs) with 1,2-dioleoyl-sn-glycero-3-phosphate (DOPA) is presented.

90 osphatidic acid, whereby 300 nM 1,2-dioleoyl-sn-glycero-3-phosphate (DOPA), but not the control 1,2-d

91 Using 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) nanoliposomes, w

92 timulated 2-fold by liver PC or 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine lipids.

93 oyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycero-3-phosphochol ine with varying concentrations

94 ne (DC(22:1)PC) but not in thin 1,2-dioleoyl-sn-glycero-3-phosphocholine (DC(18:1)PC) lipid bilayer.

95 -3-phosphocholine (DC22:1PC) or 1,2-dioleoyl-sn-glycero-3-phosphocholine (DC18:1PC) lipid vesicles us

96 ptors that can efficiently bind 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in nonpolar solvents.

97 ation of nanoscale, fluid-phase 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes contacting

98 ncer, delivery of miR-630 using 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) nanoliposomes resulte

99 lycero-3-phosphocholine (DPPC), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and 1-palmitoyl-2-ol

100 ate (DOPA), but not the control 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), binds directly to S6

101 by unsaturated lipids, such as 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

102 model peptides in a bilayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

103 ro-3-phosphocholine (DPhPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dihexadecanoyl-sn

104 ave alamethicin (alm) pore in a 1,2-dioleoyl-sn-glycero-3-phosphocholine bilayer at 313 K indicates t

105 it is embedded show that in the 1,2-dioleoyl-sn-glycero-3-phosphocholine bilayer, charged residues of

106 Here we show, using supported 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid bilayers in different

107 act voltammetry with the aid of 1,2-dioleoyl-sn-glycero-3-phosphocholine liposomes.

108 at was composed of zwitterionic 1,2-dioleoyl-sn-glycero-3-phosphocholine, a model for cell membranes,

109 oyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycero-3-phosphocholine/cholesterol = 0.39/0.39/0.22

110 nd a supported lipid bilayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine/cholesterol = 0.8/0.2, we ob

111 with fusogenic properties such as 2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) are integrated i

112 ) and the zwitterionic liposome 1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine (DOPE) were tethered on

113 cently labeled lipid, NBD-DOPE [1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzox

114 ped with different PtdInsPs and 1,2-dioleoyl-sn-glycero-3-{[N-(5-amino-1-carboxypentyl)iminodiacetic

115 hosphatidylglycerol (DOPG), and 1,2-dioleoyl-sn-glycerol-3-phosphatidylcholine (DOPC) structurally st

116 mitoyl-2-oleoyl-sn-glycero- and 1,2-dioleoyl-sn-glycerophospholipids with phosphocholine (PC) or phos

117 icomponent lipid bilayers of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), 1,2-distearoyl-

118 are less permeable than pure 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine or DSPC bilayers.

119 into PSMs containing 2 mol % 1,2-dipalmitoyl-sn-glycero-3-phosphatidylinositol-4,5-bisphosphate and A

120 and mechanical properties of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayers using atomic

121 ify solute partitioning into 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipid vesicles as a f

122 ents with stiffer, gel-phase 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes verified th

123 pid vesicles having either a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or mixed-DPPC/cardiol

124 cero-3-phosphocholine (DMPC)/1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) phospholipid mixtures

125 of the three bilayer lipids, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dioleoyl-sn-glyc

126 nin on the phase behavior of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1-palmitoyl-2-oleoyl

127 ero-3-phosphocholine (DMPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and 1-palmitoyl-2-ol

128 (l(d)) bilayers derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC).

129 -plane phonon excitations in 1,2-dipalmitoyl-sn-glycero-3-phosphocholine above and below the main tra

130 glycero-3-phosphocholine and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine in the liquid-ordered (lo) a

131 okinetics of citric acid and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine was linear following intrape

132 ultilayers consisting of 1:1 1,2-dipalmitoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycero-3-ph

133 4,5-bisphosphate and Atto488-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine, and CGs were fluoresce

134 in antibodies for biotin-cap-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benz o

135 Chol (cholesterol) and Phos (1,2-dipalmitoyl-sn-glycerol-3-phospho-(1'rac-glycerol)) via disulfide bo

136 -sn-glycero-3-phosphocholine 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) and 1,2-dioleoyl-sn-

137 the self-assembly of stable 1,2-diphytanoyl-sn-glycero-3-phosphocholine 1,2-diphytanoyl-sn-glycero-3

138 The protein was dispersed in diphytanoyl-sn-glycero-3-phosphocholine lipid bilayers, and the spec

139 3-phosphatidylcholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphatidylcholine (DSPC), isostearyl isos

140 tionic liposomes composed of 1, 2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol and dime

141 well as incubating samples of 1,2-distearoyl-sn-glycero-3-phosphocholine at 60 degrees C for 24-72 h

142 preferences of GA dimers from 1,2-distearoyl-sn-glycero-3-phosphocholine bilayers were significantly

143 lamellar vesicles composed of 1,2-distearoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycero-3-ph

144 Gal-(1 --> 4)-beta-D-GlcNAc-1,2-di-O-dodecyl-sn-glycero (B2NGL) served as model protein-GL complexes

145 reveal both the acyl chain assignment (i.e., sn-position) and the site-specific location of double bo

146 Both LPEATs could acylate either sn position of ether analogs of LPC The data show that t

147 ids attached via ester bonds to enantiomeric sn-glycerol 3-phosphate.

148 We show here that the exolytic sn-glycerol-3-phosphodiesterase GlpQ can discriminate be

149 rect relationship between home-climate and g(sn) .

150 Nighttime stomatal conductance (g(sn) ) varies among plant functional types and species, b

151 enomenon of nighttime stomatal conductance g(sn) could lead to substantial water loss with no carbon

152 sessed higher SD, which resulted in higher g(sn) .

153 ould be the highest - generally had higher g(sn) .

154 Our results indicate that higher g(sn) may arise in genotypes from hotter climates via incr

155 Herbaceous species had higher g(sn) than woody species.

156 Across genotypes, higher g(sn) was associated with higher daytime stomatal conducta

157 Our results reveal the highest g(sn) rates in species from environments where neighboring

158 tion in shaping genetic differentiation in g(sn) .

159 Examinations of intraspecific variation in g(sn) as a function of climate and co-varying leaf traits

160 osely related species were more similar in g(sn) than expected by chance.

161 We measured g(sn) on a diverse suite of species (n = 73) across variou

162 sights into potential adaptive benefits of g(sn) .

163 ible role for the competitive advantage of g(sn) .

164 provide new insight into the evolution of g(sn) and its adaptive significance.

165 Given that studies of g(sn) have focused on controlled environments or small num

166 cies, but factors shaping the evolution of g(sn) remain unclear.

167 tic and biogeographic/climatic controls on g(sn) and further assessed the degree to which g(sn) co-va

168 ) and further assessed the degree to which g(sn) co-varied with leaf functional traits and daytime ga

169 a female-sterile allele of the singed gene (sn(X2)) on FM7c with a sequence from balanced chromosome

170 phocholine (POVPC), 1-palmitoyl-2-glutaroyl- sn-glycero-phosphocholine, lysophosphocholine, 1-palmito

171 ocholine (POVPC) and 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC), are two major oxidat

172 hocholine (POVPC) or 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine, two oxidized phospholipids

173 f the oxidized lipid, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC), and each of the thre

174 nsferase and mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase and an increase in serine

175 urified Vo sector with 1-palmitoyl-2-hydroxy-sn-glycero-3-[phospho-rac-(1-glycerol)] resulted in sele

176 r potassium channel in 1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol) (LPPG) micelles.

177 ore deeply inserted in 1-myristoyl-2-hydroxy-sn-glycero-3-phospho-1'-rac-glycerol (LMPG, anionic) tha

178 (LMPG, anionic) than in 1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine (LLPC, zwitterionic) micelle

179 Radiolabeling identified sn-2 monoacylglycerol as an initial glycerolipid interme

180 ss ordered in unsaturated PCs having 16:0 in sn-1, as compared to PCs having unsaturated acyl chains

181 aration of lipid isomer standards, including sn backbone isomers, acyl chain isomers, and double-bond

182 loomington Drosophila Stock Center have lost sn(X2) by this mechanism on a historical timescale.

183 ydroxyeicosatetraenoic acid (HETE) ether-LPC sn-1 esterification is markedly activated by thrombin tr

184 26 cells, the LPA3 agonist 1-oleoyl-2-methyl-sn-glycero-3-phosphothionate (2S-OMPT) promoted erythrop

185 saturated acyl-CoA selectivity of microsomal sn-1 acyltransferase(s) and reveal its participation in

186 l (C16:0) groups specifically at the middle (sn-2 or beta) position on the glycerol backbone, and the

187 op a constrained matrix factorization model, sn-spMF, to learn patterns of tissue-sharing and apply i

188 sphocholine, 1-palmitoyl-2-(9-oxo-nonanoyl)- sn-glycero-3-phosphocholine, 1-palmitoyl-2-azelaoyl- sn-

189 t HSL KO mice accumulated sn-1,3 DAG and not sn-1,2 DAG.

190 omplexes (RNPs), spliceosomal small nuclear (sn), and small CB-specific (sca)RNPs.

191 The U1 small nuclear (sn)RNA (U1) is a multifunctional ncRNA, known for its pi

192 Spliceosomes comprise small nuclear (sn)RNAs and proteins.

193 n distinguishing the fates of small nuclear (sn)RNAs of the spliceosome from unstable genome-encoded

194 hree regioisomers of 1,2-di(9Z-octadecenoyl)-sn-glycero-3-[phosphoinositol-x,y-bisphosphate] (PI(3,4)

195 One interesting by-product (18% of sn-2 monoacylglyceride of DHA) remained at the end of th

196 skeletal muscle and that the accumulation of sn-1,3 DAG originating from lipolysis does not inhibit i

197 (TAG) by the acyl-CoA-dependent acylation of sn-1,2-diacylglycerol catalyzed by diacylglycerol acyltr

198 alibration curves and the sum of ACN + DB of sn-2 fatty acids.

199 nt was attributed to decreased expression of sn-1,2 diacylglycerol acyltransferase and mitochondrial

200 ransmembrane helices observed as increase of sn-1 chain order, while thicker bilayers were compressed

201 We further showed that after incubation of sn-2-[(14)C]acyl-PC, formation of [(14)C]TAG was only po

202 sn-glycerol-3-phosphate, and LTA is made of sn-glycerol-1-phosphate.

203 ey are enantiomeric polymers: WTA is made of sn-glycerol-3-phosphate, and LTA is made of sn-glycerol-

204 on of a phospholipid to the sn-3-position of sn-1,2-diacylglyerol, thus forming triacylglycerol and a

205 rth an optimal regioselective preparation of sn-1 mono and sn-1,3 diacylglycerols rich in CLA, with a

206 thirty-fold faster compared to the rates of sn-2 cleavage and isomerization, respectively.

207 diacylglycerols rich in CLA, with a ratio of sn-1,3/sn-1,2 regioisomers of 21.8, compared to 2.3 for

208 monstrated the unanticipated significance of sn-1 hydrolysis of arachidonoyl-containing choline and e

209 lycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glycero- 3-phosphoglycerol bilayer.

210 ar headgroup size using 1-palmitoyl-2-oleoyl-sn-glycero- and 1,2-dioleoyl-sn-glycerophospholipids wit

211 idylglycerol (DMPG) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC)/1-palmitoyl-2-ol

212 sphatidylcholine (POPC)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG), as expected, w

213 of 18:1 cardiolipin and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (POPG) mediated b

214 lycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) membranes compare

215 osphocholine (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS) 3:1 mol/mole and at

216 pp), between Cu(2+) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (POPS), a negatively charg

217 branes with 20 mol % of 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-rac-glycerol in the outer leaflet o

218 n membranes composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-ole

219 nce on the structure of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membranes.

220 rosecond simulations in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) of hexamers of these

221 sphocholine (DPPC), and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)), and the average GM1

222 -phosphocholine (DPPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), and cholesterol lipi

223 we show that the ApoA1-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)-based particles are d

224 size and composition of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)-containing PDs at neu

225 exchangeable mimics of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-sn-glyce

226 ution in both symmetric 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and asymmetric 1-palmitoyl-2

227 ion between pHLIP and a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine bilayer.

228 In a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine lipid bilayer and a plasma m

229 sins were inserted into 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine lipid nanodiscs and the kine

230 ased on solid-supported 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine membranes doped with differe

231 n nanodiscs formed with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine or cholesterol, phosphatidyl

232 an its association with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, in bilayers with equal acyl

233 ocholine and asymmetric 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1,2-dimyristoyl-sn-glycero-3

234 of local environment in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glyc

235 res in a fully hydrated 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glyc

236 e lipid polymorphism of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), using different

237 nfection-derived lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and 1-palmitoyl-2-ol

238 layers (sn-1: 16:0 and sn-2: 18:1...22:6; or sn-1 and sn-2: 18:1...22:6).

239 selectivity towards sn-2-ricinoleoyl-PC over sn-2-oleoyl-PC.

240 ral products [1-palmitoyl-2-(5-oxovaleroyl)- sn-glycero-phosphocholine (POVPC), 1-palmitoyl-2-glutaro

241 phospholipids, 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC) and 1-palmitoyl-2-gl

242 on addition of 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC) or 1-palmitoyl-2-glu

243 -(4-hydroxy-3-methoxy) cinnamoyl-2-palmitoyl-sn-glycero-3-phosphocholine exhibited good antibacterial

244 hydroxy-3,5-dimethoxy) cinnamoyl-2-palmitoyl-sn-glycero-3-phosphocholine exhibited good antioxidant a

245 e level of C18:1 substrate at PC-sn-1 and PC-sn-2 (i.e. the sites of CPA synthesis), while the levels

246 y reduced the level of C18:1 substrate at PC-sn-1 and PC-sn-2 (i.e. the sites of CPA synthesis), whil

247 is), while the levels of CPA increased in PC-sn-2, DAG-sn-1 and DAG-sn-2, and both sn-1/3 and sn-2 po

248 the sn-2 position generating polyunsaturated sn-2-acyl lysophospholipids.

249 the spontaneous acyl migration from position sn-2 to sn-1,3.

250 ase domain containing 8 (PNPLA8)), possesses sn-1 specificity, with polyunsaturated fatty acids at th

251 to interesterify ePL utilizing Lipozyme(R): sn-1,3 specific lipase.

252 genes and U small nuclear or nucleolar RNA (sn/snoRNA) loci that form intra- and inter-chromosomal c

253 phospholipid synthesis comprising sequential sn-1 hydrolysis by a phospholipase A(1) (e.g. by patatin

254 acid, saturated fatty acids beta-sitosterol, sn-1 and 3 diglyceride values.

255 hibits RNAPII recruitment to RNAPII-specific sn/snoRNA genes, and reduces nascent snRNA and snoRNA sy

256 mponents of the 7SK snRNP on RNAPII-specific sn/snoRNA genes.

257 10:0 fatty acids in the Camelina sativa TAG sn-2 position, indicating a 10:0 CoA specificity that ha

258 currence of saturated fatty acids in the TAG sn-2 position is infrequent in seed oils.

259 ith FAs 10:0, 12:0, 14:0, 20:1 and 20:2, the sn-2 preference of 16:0 was less clear.

260 s linking the fatty acyl substituents at the sn-1 and sn-2 positions of the glycerol backbone.

261 sulted in increased occupation of HFA at the sn-1/3 positions of TAG as well as small but insignifica

262 to triacylglycerol (TAG), especially at the sn-1/3 positions of TAG.

263 In particular, occurrence at the sn-2 position allows optimal intestinal absorption condi

264 ity, with polyunsaturated fatty acids at the sn-2 position generating polyunsaturated sn-2-acyl lysop

265 ances the probability that DHA chains at the sn-2 position in SDPC rise up to the bilayer surface, wh

266 in transferring acyl groups modified at the sn-2 position of PC to the sn-1 position of this molecul

267 -valuable polyunsaturated fatty acids at the sn-2 position) could be very attractive for food industr

268 B expression generated TAGs with 14:0 at the sn-2 position, but not 10:0.

269 f concentrated fatty acids esterified at the sn-2 position.

270 AT-PLA) could cleave acyl chains at both the sn-1 and sn-2 positions of PC, and displayed substrate s

271 orated into the sn-2 position of PC, but the sn-1 position of de novo DAG and indicated similar rates

272 the transfer of a fatty acyl moiety from the sn-2 position of a phospholipid to the sn-3-position of

273 th increasing fatty acid chain length in the sn-1(3) position.

274 acylation of medium-chain fatty acids in the sn-2 and sn-3 positions of seed triacylglycerols (TAGs).

275 trate, CrDGTT1 preferred C16 over C18 in the sn-2 position of the glycerol backbone, but CrDGTT2 and

276 se TAGs contained up to 40 mol % 10:0 in the sn-2 position, nearly double the amounts obtained from c

277 C18 FAs, palmitic acid was typically in the sn-2 position.

278 ds were preferentially incorporated into the sn-2 position of PC, but the sn-1 position of de novo DA

279 incorporation of fatty acyl chains into the sn-2 site of phosphatidylcholine, play important roles i

280 of nascent and elongated acyl-CoAs into the sn-3 position of TAG.

281 we demonstrated the high selectivity of the sn-1 acyltransferase activity for saturated acyl-CoA spe

282 function in proteoliposomes composed of the sn-1 chain perdeuterated lipids 14:0d27-14:1-PC, 16:0d31

283 nsferase (Lnt) catalyzes the transfer of the sn-1-acyl chain of phosphatidylethanolamine to this N-te

284 The estimated rate of the sn-1/3 hydrolysis was around two- to thirty-fold faster

285 curve and the number of double bonds of the sn-2 fatty acids.

286 ransferase (LPAT) catalyzes acylation of the sn-2 position on lysophosphatidic acid by an acyl CoA su

287 ck by the substrate alpha-amino group on the sn-2 ester to form a cyclic tetrahedral intermediate tha

288 s modified at the sn-2 position of PC to the sn-1 position of this molecule in plant cells).

289 synthetase(s), and re-esterification to the sn-2 position by sn-2 acyltransferase activity (i.e. the

290 er of an acetyl group from acetyl-CoA to the sn-3 position of diacylglycerol to form 3-acetyl-1,2-dia

291 m the sn-2 position of a phospholipid to the sn-3-position of sn-1,2-diacylglyerol, thus forming tria

292 We observed that Lit transfers the sn-2 ester-linked lipid from the diacylglycerol moiety t

293 Oleic acid occupied typically the sn-1/sn-3 positions but when together with FAs 20:1, 20:

294 taneous acyl migration from position sn-2 to sn-1,3.

295 isoprenoid chains linked via ether bonds to sn-glycerol 1-phosphate (G1P), whereas bacteria and euka

296 ypically hydrolyze glycerophosphodiesters to sn-glycerol 3-phosphate (Gro3P) and their corresponding

297 and displayed substrate selectivity towards sn-2-ricinoleoyl-PC over sn-2-oleoyl-PC.

298 clusters and suppresses the expression of U sn/snoRNA and histone genes.

299 The accumulated DAG was sn-1,3 DAG, which is known not to activate PKC, and insu

300 on of triacylglycerol composition along with sn-2 positional identification of the fatty acids consti