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1 ntially influence GAS pathophysiology during soft tissue infection.
2    Haemophilus influenzae is a rare cause of soft tissue infection.
3 d pathogenesis in a murine model of skin and soft tissue infection.
4 ced dermonecrosis, a key feature of skin and soft tissue infection.
5 y patterns was examined in a murine model of soft tissue infection.
6 cts of the care of patients with necrotizing soft tissue infection.
7 tants highly attenuated in a murine model of soft tissue infection.
8 ghly attenuated in the murine ulcer model of soft tissue infection.
9 anscriptome of GAS during experimental mouse soft tissue infection.
10 he pathogenesis of streptococcal necrotising soft tissue infection.
11 ted to have a minimal potential for invasive soft tissue infection.
12 lence factor for invasive disease, including soft tissue infection.
13 y and is mainly associated with subcutaneous soft tissue infection.
14 uronic acid capsule as a virulence factor in soft tissue infection.
15 sociated with enhanced virulence in skin and soft tissue infection.
16 (95% CI 23.6-40.5) have had a recent skin or soft tissue infection.
17 teomyelitis or septic arthritis, and skin or soft tissue infection.
18 dren with community-associated MRSA skin and soft tissue infection.
19 nsmission, a factor associated with skin and soft tissue infection.
20 s aureus and can be associated with skin and soft tissue infection.
21 lococcus aureus is a major cause of skin and soft tissue infection.
22 thogenesis of Staphylococcus aureus skin and soft tissue infection.
23 crotizing myositis, bacteremia, and skin and soft tissue infection.
24 ing fasciitis (NF) is a destructive skin and soft tissue infection.
25 ME mutants was assessed in a murine model of soft tissue infection.
26 a less invasive form of superficial skin and soft tissue infection.
27 elative to the odds of PVL-positive skin and soft-tissue infection.
28 tial therapeutic in SAg-mediated necrotizing soft-tissue infection.
29 l infection in a murine model of necrotizing soft-tissue infection.
30 s a role in pathogenesis in a mouse model of soft-tissue infection.
31  cause of community-onset S. aureus skin and soft-tissue infection.
32 sons with community-onset S. aureus skin and soft-tissue infection.
33 luenced by covR also was identified in mouse soft-tissue infection.
34  protein in a murine model of human invasive soft-tissue infection.
35  fasciitis is a rare, but potentially fatal, soft-tissue infection.
36 4.4 to 32.9 per 100 000 persons for skin and soft tissue infections.
37 ed for the traditional treatment of skin and soft tissue infections.
38 ng invasive disease, pneumonia, and skin and soft tissue infections.
39 hogen causing pulmonary disease and skin and soft tissue infections.
40 using an ongoing pandemic of mostly skin and soft tissue infections.
41 t of which (53%) were pneumonia and skin and soft tissue infections.
42 n the differential diagnosis of gingival and soft tissue infections.
43 ged as a frequent cause of purulent skin and soft tissue infections.
44  throat) and with invasive or "flesh-eating" soft tissue infections.
45 ysteine protease contributes to virulence in soft tissue infections.
46 ossible, probable, or definite cellulitis or soft tissue infections.
47 ureus is the most frequent cause of skin and soft tissue infections.
48 re pandemic consisting primarily of skin and soft tissue infections.
49 014 primarily reflected declines in skin and soft tissue infections.
50 s aureus (MRSA) is a major cause of skin and soft tissue infections.
51 s invasive disease, most frequently skin and soft tissue infections.
52 SA) causes invasive, drug-resistant skin and soft tissue infections.
53 fections and syndromes-most notably skin and soft tissue infections.
54  empirical treatment guidelines for skin and soft-tissue infections.
55 or patients presenting with serious skin and soft-tissue infections.
56 me a predominant cause of childhood skin and soft-tissue infections.
57 eus should be considered a cause of skin and soft-tissue infections.
58 nes, a common agent of pharyngeal, skin, and soft-tissue infections.
59 nes, a common agent of pharyngeal, skin, and soft-tissue infections.
60 itides, infective endocarditis, and skin and soft-tissue infections.
61 ylococcus aureus (SA), which causes skin and soft-tissue infections.
62  disease, osteomyelitis, and chronic skin or soft-tissue infections.
63 a-analysis for Staphylococcus aureus skin or soft-tissue infections.
64 l, predominantly for abdominal, urinary, and soft-tissue infections.
65 tates and has caused an epidemic of skin and soft-tissue infections.
66  aureus, a common cause for serious skin and soft tissues infections.
67 h methicillin-susceptible S. aureus skin and soft-tissue infection (1%).
68  osteitis/osteomyelitis (27.9%), and distant soft tissue infections (3.0%).
69 ch 87.5% were catheter-associated), and skin/soft tissue infections (6.4%).
70 nd against isolates associated with skin and soft tissue infection (68%, compared to 85% susceptible
71 lated from 320 of 422 patients with skin and soft-tissue infections (76 percent).
72 awareness of fungi as a cause of necrotizing soft-tissue infections after a natural disaster is warra
73                      In a mouse model of GAS soft tissue infection, all DeltaptsI mutants exhibited a
74 ed USA300-0114, is a major cause of skin and soft tissue infections among persons in community settin
75 e most common identifiable cause of skin and soft-tissue infections among patients presenting to emer
76 Using an established mouse model of skin and soft tissue infection and a newly developed histopatholo
77 s streptococcal virulence in mouse models of soft tissue infection and bacteremia.
78  Cellulitis is a commonly occurring skin and soft tissue infection and one of the most frequently see
79 ations were infrequent (14, 6%) and included soft tissue infection and prominent scar.
80  for virulence in a murine model of invasive soft tissue infection and this attenuation is complement
81 frequent manifestation of S. aureus skin and soft tissue infections and are formed, in part, to conta
82 e opportunist pathogens that cause blood and soft tissue infections and are often resistant to antimi
83 ylococcus aureus is a leading cause of human soft tissue infections and bacterial sepsis.
84  We describe an HIV-infected patient with 24 soft tissue infections and multiple colonization events.
85 ble for severe, rapidly progressive skin and soft tissue infections and native valve endocarditis.
86 ase the risk of other bloodborne or skin and soft tissue infections and overdose.
87 le for a wide range of infections, including soft tissue infections and potentially fatal bacteremias
88 ection and plays an important role in severe soft tissue infections and systemic dissemination of GAS
89      Group A Streptococcus (GAS) necrotizing soft tissue infections and toxic shock syndrome remain h
90 view was conducted for estimates of skin and soft-tissue infection and endocarditis disease burden wi
91                                              Soft-tissue infection and osteomyelitis were the most co
92 lence in vivo using mouse models of invasive soft-tissue infection and septicemia.
93 A (SPEA), in the pathogenesis of necrotizing soft-tissue infection and toxic shock syndrome resulting
94 es are consistently associated with skin and soft-tissue infections and are comparatively rare in inv
95 nderstanding of the epidemiology of skin and soft-tissue infections and osteoarticular infections is
96 cation are changing the approach to skin and soft-tissue infections and osteoarticular infections.
97                 Ten cases (42%) had skin and soft tissue infection, and 2 cases had invasive disease.
98 aphylococcus aureus nasal carriage, skin and soft tissue infections, and bacterial sepsis.
99 ity from sequelae (overdose, severe skin and soft tissue infections, and endocarditis), costs, and in
100  wound infections, burn infections, skin and soft tissue infections, and meningitis.
101  children, NTM cause lymphadenitis, skin and soft tissue infections, and occasionally also lung disea
102  aureus is the most common cause of skin and soft tissue infections, and rapidly emerging antibiotic-
103 roup of patients presenting with necrotizing soft tissue infections, and, based on this analysis, pro
104 mutants were attenuated in a murine model of soft-tissue infection, and analysis of gene expression i
105 nfluenza, upper airway infection, pneumonia, soft-tissue infection, and genitourinary tract infection
106 ezolid in the setting of pneumonia, skin and soft-tissue infections, and infections due to vancomycin
107 ersons who inject drugs (PWID) with skin and soft-tissue infections annually in the United States.
108                The mortality for necrotizing soft-tissue infections appears to be decreasing, possibl
109 sful management of patients with necrotizing soft tissue infection are early recognition and complete
110  (MyD88) deficiency, staphylococcal skin and soft tissue infections are a leading and potentially lif
111                                     Skin and soft tissue infections are common reasons for medical ca
112                        PVL-positive skin and soft-tissue infections are more likely to be treated sur
113                                  Necrotizing soft-tissue infection-associated in-hospital mortality.
114  injection drug use who were readmitted with soft tissue infections at new sites (16.8% of readmissio
115  that are critical for fitness during murine soft-tissue infection at both 24 h and 48 h postinfectio
116 ism to explain the development of severe GAS soft-tissue infections at the sites of prior minor muscl
117 nt of streptococcal sore throat and invasive soft-tissue infections, attaches to human pharyngeal or
118 ribe an outbreak of Nocardia cyriacigeorgica soft-tissue infections attributable to unlicensed cosmet
119  aureus (CA-MRSA), a major cause of skin and soft tissue infections, became successful so quickly, ov
120 cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and ho
121  is an opportunistic pathogen that can cause soft tissue infections but is also a frequent cause of f
122 trains are strongly associated with skin and soft-tissue infections, but are comparatively rare in pn
123      We report the first case of complicated soft tissue infection caused by P. lilacinus in an immun
124  We present the first case of human skin and soft tissue infection caused by this species in a patien
125 increasing in frequency is serious bacterial soft tissue infections caused by group A streptococci.
126                               Human invasive soft-tissue infections caused by group A Streptococcus a
127 idence of infections, such as RTIs; skin and soft-tissue infections; chronic comorbid conditions, inc
128 oft tissue infection (NSTI) in adults with a soft tissue infection clinically concerning for NSTI.
129 y is indicated for the treatment of skin and soft-tissue infections, clinicians should consider obtai
130                                  We report a soft tissue infection containing multiple pathogens, inc
131                         Complicated skin and soft tissue infections (cSSTIs) are among the most rapid
132 commendations regarding complicated skin and soft tissue infections (cSSTIs).
133 ients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlati
134 n immunocompromised patient with an invasive soft tissue infection due to Scedosporium apiospermum wa
135 tered three patients with severe necrotising soft tissue infections due to beta-haemolytic group G st
136 egative cocco-bacillus often associated with soft tissue infections due to dog and cat bites.
137                                          For soft tissue infections due to molds characterized by thi
138                     Community-onset skin and soft-tissue infection due to S. aureus was identified in
139 itive and most were associated with skin and soft tissue infections (especially abscesses).
140 nt of streptococcal sore throat and invasive soft tissue infections, evades internalization and intra
141 e differential diagnosis of chronic skin and soft tissue infections following bee venom acupuncture.
142 occus aureus are the major cause of skin and soft tissue infection in the United States.
143                                      In vivo soft tissue infection in wild-type mice demonstrated tha
144 ngal pathogen, causing a variety of skin and soft tissue infections in healthy people and more virule
145 s also identified among humans with skin and soft tissue infections in Saudi Arabia, France and Germa
146  cause of as much as 98% of CA-MRSA skin and soft tissue infections in the United States.
147 and has become the leading cause of skin and soft tissue infections in the United States.
148     (68)Ga-NOTA-UBI could diagnose bone- and soft-tissue infection in 3 of 3 patients.
149                       We defined a case as a soft-tissue infection in a person injured during the tor
150 ccus aureus (MRSA) causes S. aureus skin and soft-tissue infection in selected populations.
151 o-associated Mycobacterium chelonae skin and soft-tissue infections in Rochester, New York.
152 sis of patients with necrotizing S. pyogenes soft tissue infection indicates that a STING genotype as
153                                  Necrotizing soft tissue infection is a severe illness that is associ
154           The early diagnosis of necrotizing soft tissue infection is challenging, but the keys to su
155 rgan transplant recipients, localized fungal soft tissue infection is infrequent, with only 35 cases
156  during septic cardiomyopathy or necrotizing soft tissue infections is mediated by several protein fa
157 ezolid has approved indications for skin and soft tissue infections; lower respiratory tract infectio
158 r as adjuncts to antibiotic therapy, for GAS soft tissue infection may contribute to worse outcomes.
159                    Osteomyelitis and distant soft tissue infection may occur less frequently when BCG
160                    Osteomyelitis and distant soft tissue infection may occur less frequently when BCG
161                 Here we developed a skin and soft tissue infection model in rabbits to test the hypot
162  and 24 h after bacterial challenge in a rat soft tissue infection model resulted in a significant de
163 creased lesion size and severity in a murine soft tissue infection model when compared with parental
164 d with HlaH35L and challenged via a skin and soft tissue infection model, HlaH35L immunization led to
165                   However, in a rat skin and soft tissue infection model, the abscesses on rats infec
166 rvival in human serum, and survival in a rat soft tissue infection model.
167 c spyCEP mutant derivative strain in a mouse soft tissue infection model.
168 beta and was attenuated in a murine skin and soft tissue infection model.
169 B307.27 was significantly decreased in a rat soft-tissue infection model (P<.001) and a rat pneumonia
170       Next we tested the hypothesis that the soft-tissue infection model could be used to discriminat
171 hly paralleled their growth/clearance in the soft-tissue infection model in vivo.
172  drug-resistant Acinetobacter baumannii in a soft-tissue infection model through light-triggered NO d
173  were subsequently used for challenge in the soft-tissue infection model to determine if the disrupte
174              Lastly we hypothesized that the soft-tissue infection model would serve as an efficient
175 ble to demonstrate growth of 307-0294 in the soft-tissue infection model.
176 gnificantly attenuated in the bacteremia and soft tissue infection models, and the mutant strain lack
177 ed the hypothesis that the rat pneumonia and soft-tissue infection models that our laboratory had pre
178 ically significant, with bacteremia (n = 5), soft tissue infections (n = 3) osteomyelitis (n = 2), in
179 in (PVL) are associated with severe skin and soft tissue infections, necrotizing pneumonia, and eye i
180                            In mouse invasive soft-tissue infection, neither SLO or SLS expression sig
181 ortunistic pathogen associated with skin and soft tissue infections, nosocomial pneumonia and sepsis.
182 ive infections, such as necrotizing skin and soft tissue infections (NSSTI).
183 s (LRINEC) score in diagnosis of necrotizing soft tissue infection (NSTI) in adults with a soft tissu
184  immunocompromised patients with necrotizing soft-tissue infection (NSTI).
185                                  Necrotizing soft-tissue infections (NSTI) are life-threatening condi
186                                  Necrotizing soft-tissue infections (NSTI) have high morbidity and mo
187                                  Necrotizing soft tissue infections (NSTIs) are severe life- and limb
188                                  Necrotizing soft tissue infections (NSTIs) caused by group A Strepto
189 ) patients, including sepsis and necrotizing soft tissue infections (NSTIs).
190                        BACKGROUNDNecrotizing soft-tissue infections (NSTIs) are rapidly progressing i
191 cci are frequently implicated in necrotizing soft-tissue infections (NSTIs).
192 cci are frequently implicated in necrotizing soft-tissue infections (NSTIs).
193                      Of the 10 MRSA skin and soft tissue infections observed in this study, all occur
194 ervous System Infections, Ocular Infections, Soft Tissue Infections of the Head and Neck, Upper Respi
195 ervous System Infections, Ocular Infections, Soft Tissue Infections of the Head and Neck, Upper Respi
196 ns, eight (15.7%) had postoperative skin and soft tissue infections of the neck, and eight (15.7%) ha
197  not a critical virulence factor in invasive soft-tissue infection or bacteraemia caused by S. pyogen
198 CrI 1.96-8.20), and report interval skin and soft tissue infection (OR 1.32, CrI 1.07-1.64).
199  colonization, primary or recurrent skin and soft tissue infection, or invasive disease.
200 eraemia, musculoskeletal infection, skin and soft-tissue infection, or colonisation published before
201 Infections, Genital Infections, and Skin and Soft Tissue Infections; or into etiologic agent groups,
202 Infections, Genital Infections, and Skin and Soft Tissue Infections; or into etiologic agent groups,
203                         We report a skin and soft-tissue infection outbreak among football team membe
204  bacteremia, meningitis, pneumonia, skin and soft tissue infections, peritonitis, and urinary tract i
205 tients with invasive infections, noninvasive soft tissue infections, pharyngitis, and rheumatic fever
206 tients with invasive infections, noninvasive soft tissue infections, pharyngitis, and rheumatic fever
207 adult patients with acute, purulent skin and soft-tissue infections presenting to 11 university-affil
208 uced and (2) many strains of MSSA that cause soft-tissue infections produce higher levels of PVL than
209 for infective endocarditis (IE) and skin and soft-tissue infections related to IDU in the United Stat
210 and emergency department visits for skin and soft-tissue infections related to IDU yielded a crude es
211 mplications, including sepsis or necrotizing soft-tissue infection, renal damage and rheumatic heart
212                                  Necrotizing soft tissue infections represent a group of highly letha
213           Care for patients with necrotizing soft tissue infection requires a team approach with expe
214 istant Staphylococcus aureus (MRSA) skin and soft tissue infection requires an understanding of facto
215 roup G streptococcus can produce necrotising soft tissue infections resembling those produced by grou
216 0DeltasaeR/S) in murine models of sepsis and soft-tissue infection revealed that this sensory system
217 RR = 1.44, 95% CI: 1.22, 1.72), and skin and soft tissue infections (RR = 1.20, 95% CI: 1.03, 1.39) i
218 injecting-related infections (i.e., skin and soft-tissue infection, sepsis/bacteremia, endocarditis,
219 s, meningitis or encephalitis, cellulitis or soft tissue infection, septic arthritis or osteomyelitis
220  smaller series of patients with necrotizing soft tissue infections, similar analyses of risk factors
221 reatment efficacy of GmPcides using skin and soft tissue infection (SSTI) and biofilm formation model
222 olonization of cases and subsequent skin and soft tissue infection (SSTI) in cases and household cont
223 pproach to decolonization decreases skin and soft tissue infection (SSTI) incidence, though this is b
224 fense against Staphylococcus aureus skin and soft tissue infection (SSTI) is dependent on both estrog
225 dia databases for suggestion of AIT skin and soft tissue infection (SSTI) risk and compare this risk
226 rrent infection, in which S. aureus skin and soft tissue infection (SSTI) strongly protected against
227      In a murine model of S. aureus skin and soft tissue infection (SSTI), local SLIT2 levels fall in
228       lukF-PV was present in 36% of skin and soft tissue infection (SSTI)-derived methicillin-suscept
229 ogical agents of community-acquired skin and soft tissue infection (SSTI).
230  CA-MRSA strain in a mouse model of skin and soft tissue infection (SSTI).
231 istant Staphylococcus aureus (MRSA) skin and soft tissue infection (SSTI).
232 ant Staphylococcus aureus (CO-MRSA) skin and soft tissue infections (SSTI) are associated with SCCmec
233 tained from pediatric patients with skin and soft tissue infections (SSTI) from Taipei did not carry
234 MRSA) is currently a major cause of skin and soft tissue infections (SSTI) in the United States.
235 s (CA-MRSA) is a prevalent cause of skin and soft tissue infections (SSTI), but the association betwe
236 has been associated previously with skin and soft-tissue infection (SSTI) and with carriage of staphy
237 s (MRSA) after community-onset MRSA skin and soft-tissue infection (SSTI) remain unclear.
238 t (ED) visit or hospitalization for skin and soft-tissue infection (SSTI), respiratory infection, int
239  aureus frequently causes recurrent skin and soft-tissue infection (SSTI).
240 as emerged as an important cause of skin and soft-tissue infections (SSTI).
241  subtropics with S. aureus-positive skin and soft tissue infections (SSTIs) and 124 control patients
242 RSA) lineage causes the majority of skin and soft tissue infections (SSTIs) and is highly associated
243 ccus aureus is the leading cause of skin and soft tissue infections (SSTIs) and mounting antibiotic r
244 n which we identified patients with skin and soft tissue infections (SSTIs) and randomized them to re
245     Recurrent Staphylococcus aureus skin and soft tissue infections (SSTIs) are common despite detect
246                                Most skin and soft tissue infections (SSTIs) are managed in the outpat
247  other nontuberculous mycobacterial skin and soft tissue infections (SSTIs) associated with handling
248 ions (UTIs) and Staphylococcus aureus skin & soft tissue infections (SSTIs) captured by a northern Au
249 empirical therapy for patients with skin and soft tissue infections (SSTIs) caused by molecularly and
250                                 All skin and soft tissue infections (SSTIs) cultured in the Cook Coun
251                                     Skin and soft tissue infections (SSTIs) disproportionately impact
252                    The incidence of skin and soft tissue infections (SSTIs) has increased dramaticall
253  is causing an increasing number of skin and soft tissue infections (SSTIs) in Denmark and other Euro
254 illin-susceptible, has been causing skin and soft tissue infections (SSTIs) in epidemic proportions a
255 istant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) in high-risk community se
256 age responsible for the epidemic of skin and soft tissue infections (SSTIs) in humans.
257  USA300 has led to a high burden of skin and soft tissue infections (SSTIs) in the United States, yet
258 A-MRSA) has become a major cause of skin and soft tissue infections (SSTIs) in the US.
259  mellitus frequently develop severe skin and soft tissue infections (SSTIs) that are recalcitrant to
260 ncreasingly important as a cause of skin and soft tissue infections (SSTIs), particularly abscesses,
261 tive bacteria cause the majority of skin and soft tissue infections (SSTIs), resulting in the most co
262  aureus is the most common cause of skin and soft tissue infections (SSTIs), yet sex bias in suscepti
263 005 guidelines for the treatment of skin and soft tissue infections (SSTIs).
264 aphylococcus aureus strains causing skin and soft tissue infections (SSTIs).
265                                     Skin and soft-tissue infections (SSTIs) are an important cause of
266                                     Skin and soft-tissue infections (SSTIs) caused by community-assoc
267 tion coding system, epidemiology of skin and soft-tissue infections (SSTIs) has conflated abscess wit
268                    The incidence of skin and soft-tissue infections (SSTIs), for which human immunode
269 ave increased the overall number of skin and soft-tissue infections (SSTIs), increasing the overall d
270 nds and 136 non-IFI wounds (63 with skin and soft tissue infections [SSTIs] and 73 without) were exam
271                                              Soft tissue infection (STI) was based on negative bone c
272 solates from infective endocarditis (IE) and soft tissue infections (STIs), we sought to (1) validate
273 nearly twice as common in community skin and soft tissue infections than in nosocomial bloodstream in
274 itoneal necrotizing fasciitis is an uncommon soft tissue infection that is often fatal.
275 n 1750 developed nonlethal necrotic skin and soft tissue infections that healed spontaneously after 1
276 ) is a rapidly progressive, life-threatening soft-tissue infection that is traditionally caused by gr
277                  Among patients with skin or soft-tissue infections, therapy to which the infecting s
278 re known to make it more likely for skin and soft tissue infection to occur in association with atopi
279  Clinical manifestations range from skin and soft tissue infection to pneumonia with sepsis.
280 de spectrum of disease ranging from skin and soft tissue infections to life-threatening pneumonia and
281 uman disease ranging from localized skin and soft tissue infections to potentially lethal systemic in
282 ecutive patients with documented necrotizing soft tissue infections, treated at a single institution
283 l infection rates and rates of RTI, skin and soft-tissue infection, urinary tract infection, and bloo
284                                     Skin and soft tissue infection was present in 50%, sepsis/bactere
285    The proportion of operations for skin and soft tissue infections was highest during natural disast
286   However, the frequency of serious skin and soft tissue infections was increased in anti-TNF-treated
287    In contrast, the rate of serious skin and soft tissue infections was increased, suggesting an impo
288                      The presence of skin or soft-tissue infection was predictive for CA-MRSA, and th
289 pically similar virulence defect in skin and soft tissue infection, we sought to determine the relati
290                 Most procedures for skin and soft tissue infections were minor (76%), whereas most op
291                                     Skin and soft tissue infections were more common among community-
292                      Operations for skin and soft tissue infections were the most common (64%), follo
293           Patients with a stoma, fistula, or soft-tissue infection were excluded.
294                                    For other soft tissue infections, when antibiotic susceptibility d
295 ssue biopsies from patients with necrotizing soft tissue infections, where GAS biofilms are common.
296 of the isolates were recovered from skin and soft tissue infections, whereas the remaining isolates (
297 ivity, and the presence of pneumonia or skin/soft tissue infection with increased mortality.
298 hil deployment protected mice against lethal soft tissue infection with Streptococcus pyogenes and pr
299 er respiratory tract infections and skin and soft tissue infections with local pharmacists.
300 er respiratory tract infections and skin and soft tissue infections with local pharmacists.
301                   The risk for MRSA skin and soft tissue infection within 3 months after documented c

 
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