ライフサイエンスコーパス: solid-phase peptide synthesis

1 ly available linkers (originally devised for solid-phase peptide synthesis).

2 hY(1)R-preferring ligand [F(7),P(34)]-NPY by solid phase peptide synthesis.

3 ethoxyaspartate, suitably protected for Fmoc solid phase peptide synthesis.

4 internalization and are compatible with Fmoc solid phase peptide synthesis.

5 synthesis and chemically incorporated using solid phase peptide synthesis.

6 JB3 was generated by solid phase peptide synthesis.

7 mmunoaffinity chromatography and prepared by solid phase peptide synthesis.

8 mino acid residues that are utilized in Fmoc solid phase peptide synthesis.

9 standard protected amino acids used in Fmoc-solid phase peptide synthesis.

10 orporated into the peptides by standard Fmoc solid phase peptide synthesis.

11 carboxylic acid as a building block for Fmoc solid phase peptide synthesis.

12 the preparation of derivatives suitable for solid phase peptide synthesis.

13 onto the N-terminus of a peptide segment by solid phase peptide synthesis.

14 ogenes as effectively as melittin created by solid phase peptide synthesis.

15 nd analogs were generated through Fmoc-based solid phase peptide synthesis.

16 ur peptide fragments, themselves prepared by solid phase peptide synthesis.

17 Methods: All inhibitors were synthesized by solid-phase peptide synthesis.

18 as incorporated into VM(11)VVQTK by standard solid-phase peptide synthesis.

19 hesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.

20 been recognized as a challenging target for solid-phase peptide synthesis.

21 ave been synthesized in a modular fashion by solid-phase peptide synthesis.

22 2 by 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis.

23 ptide on a solid support in conjunction with solid-phase peptide synthesis.

24 gue bearing N(alpha)-protection suitable for solid-phase peptide synthesis.

25 d particles and applied to reactions used in solid-phase peptide synthesis.

26 e prone to alpha-C epimerization during Fmoc solid-phase peptide synthesis.

27 ide by fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis.

28 used to cleave and deprotect peptides after solid-phase peptide synthesis.

29 trained substance P analogue with the use of solid-phase peptide synthesis.

30 in-3 variants were chemically synthesized by solid-phase peptide synthesis.

31 from influenza B was synthesized by standard solid-phase peptide synthesis.

32 -Arg-Thr-Pen]-Thr-NH(2), 1) were prepared by solid-phase peptide synthesis.

33 ral imaging spectrometer was used to monitor solid-phase peptide synthesis.

34 ragment of the atypically split CL intein by solid-phase peptide synthesis.

35 ability to join peptide segments prepared by solid-phase peptide synthesis.

36 Circular Aqueous Fmoc/t-Bu Solid-Phase Peptide Synthesis.

37 elaboration using 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis.

38 ing groups compatible with the conditions of solid-phase peptide synthesis.

39 ross-couplings, ring-closing metathesis, and solid-phase peptide synthesis.

40 f an unusually labile macrocyclic peptide by solid-phase peptide synthesis.

41 A) sequences were synthesized via Fmoc-based solid-phase peptide synthesis.

42 sing fluorenylmethyloxycarbonyl (Fmoc)-based solid-phase peptide synthesis.

43 corporated into a decapeptide using standard solid-phase peptide synthesis.

44 transmembrane-mimicking peptides produced by solid-phase peptide synthesis.

45 er construction and ring-closure assisted by solid-phase peptide synthesis.

46 11 fragments, all of which were prepared via solid-phase peptide synthesis.

47 1 chain (EM-1) and into model tripeptides by solid-phase peptide synthesis.

48 uilding block suitable for use in Fmoc-based solid-phase peptide synthesis.

49 ermini using specially adapted conditions of solid-phase peptide synthesis.

50 ral Fmoc-d-Hot horizontal lineTap-ketals for solid-phase peptide synthesis.

51 acetate (TFA) is a strong anion byproduct of solid-phase peptide synthesis.

52 which can be readily used in subsequent Fmoc solid-phase peptide synthesis.

53 le, supports is an attractive alternative to solid-phase peptide synthesis.

54 ragments and have used them as units in Fmoc solid-phase peptide synthesis.

55 obtained compounds are suitable for standard solid-phase peptide synthesis.

56 ype primary sequence, themselves obtained by solid-phase peptide synthesis.

57 AM analogs were synthesized through solid-phase peptide synthesis.

58 blocks, fully compatible with standard Fmoc solid-phase peptide synthesis.

59 purified uPLB and pPLB standards produced by solid-phase peptide synthesis.

60 igopeptides site-specifically using standard solid-phase peptide synthesis.

61 amide bond is compatible with Fmoc-chemistry solid-phase peptide synthesis.

62 yl chloride resin by conventional Fmoc-based solid-phase peptide synthesis.

63 a suitably protected analogue for Fmoc-based solid-phase peptide synthesis.

64 rategy that is compatible with standard Fmoc solid-phase peptide synthesis.

65 H (1c) as ordinary amino acids in Fmoc-based solid-phase peptide synthesis.

66 y be incorporated into peptides via standard solid-phase peptide synthesis.

67 , we find that this fragment, synthesized by solid-phase peptide synthesis, also forms fibrillar stru

68 We have thus demonstrated that using solid phase peptide synthesis and chemical ligation it i

69 ully carboxylated Gla domain of Factor IX by solid phase peptide synthesis and crystallized Factor IX

70 re synthesized by a tandem combination using solid phase peptide synthesis and microwave-assisted rea

71 The protein is synthesized using Fmoc-based solid-phase peptide synthesis and assembled using combin

72 A new solid-phase peptide synthesis and bioprofiling of the an

73 he protein, a 22-mer peptide, is prepared by solid-phase peptide synthesis and contains the F(n)Y at

74 Methods: Peptides were synthesized by solid-phase peptide synthesis and labeled with (177)Lu.

75 and PLA2-(59-124) were prepared by stepwise solid-phase peptide synthesis and ligated to yield a pep

76 pHis analogues were successfully utilized in solid-phase peptide synthesis and semi-synthesis of hist

77 The target molecules were prepared using solid-phase peptide synthesis and subjected to extensive

78 ected peptide Lys-Met-Glu-(CpRu-Tyr)-Leu via solid-phase peptide synthesis and subsequent ruthenium-m

79 rated into a peptide sequence using standard solid-phase peptide synthesis and transformed on resin i

80 ic fragment LLELI[13C615N1]R was prepared by solid-phase peptide synthesis and was used as an interna

81 ated into peptides using Boc-chemistry-based solid-phase peptide synthesis, and in three of the four

82 ted into peptides using Fmoc-chemistry-based solid-phase peptide synthesis, and the resulting peptide

83 ith varying cation-pi binding energies using solid-phase peptide synthesis, and these analogues were

84 In this work, we prepared, via a solid phase peptide synthesis approach, a modular tripar

85 ng groups mostly adopted in the solution and solid-phase peptide synthesis, are compatible to the ado

86 Abeta(x-16), and Abeta(5-38(D23S)) by using solid phase peptide synthesis as internal standards for

87 reversible modification was found to improve solid-phase peptide synthesis as demonstrated in the che

88 pplications of this chemistry to reiterative solid-phase peptide synthesis as well as solid-phase fra

89 These approaches include solid-phase peptide synthesis based on an adaption of na

90 leration of the N-methylation process during solid-phase peptide synthesis but also offers a flexible

91 we synthesize DDMs using solution phase and solid phase peptide synthesis chemistry.

92 (Arg(11)) was synthesized using conventional solid-phase peptide synthesis chemistry and a rhenium cy

93 make our first-generation cross-linker using solid-phase peptide synthesis chemistry.

94 ng that it can be manipulated under standard solid-phase peptide synthesis conditions.

95 -ReCCMSH-Asp-OH (10), were synthesized using solid phase peptide synthesis followed by rhenium cycliz

96 While lipovelutibol D was prepared using solid-phase peptide synthesis followed by an O-N acyl mi

97 These building blocks are compatible with solid-phase peptide synthesis following the 9-fluorenylm

98 acids showed that they could be utilized in solid phase peptide synthesis for the preparation of a b

99 s bearing amide carbonyl derivatives rely on solid-phase peptide synthesis for amide functionalizatio

100 Here, we introduce metallaphotocatalysis in solid-phase peptide synthesis for the on-resin orthogona

101 Solid-phase peptide synthesis has been an attractive met

102 Solid-phase peptide synthesis has been applied to the pr

103 OphMA, intein-mediated protein ligation and solid-phase peptide synthesis have allowed us to demonst

104 otection/Peptide Resin Cleavage in Fmoc/t-Bu Solid-Phase Peptide Synthesis: HCl/FeCl(3) and AcOH/FeCl

105 d psoriasin of 100 amino acid residues using solid phase peptide synthesis in combination with native

106 can be used as the detection method for the solid-phase peptide synthesis in combinatorial chemistry

107 acid building blocks, suitably protected for solid-phase peptide synthesis, in 2-3 steps starting fro

108 The application of microwave irradiation to solid-phase peptide synthesis increases product purity a

109 hese redox modules were incorporated through solid-phase peptide synthesis into a 13-residue helical

110 containing glyco-amino acids for downstream solid-phase peptide synthesis is challenging.

111 acids appropriately protected for Fmoc-based solid-phase peptide synthesis is described.

112 hniques, including the Fmoc/tBu strategy for solid phase peptide synthesis, is stable under mild acid

113 perform many different reactions, including solid-phase peptide synthesis, iterative cross-coupling

114 PNA synthesis employs protocols derived from solid-phase peptide synthesis, making the methodology st

115 s been meticulously synthesized via the Fmoc-solid phase peptide synthesis methodology on Wang resin.

116 A solid-phase peptide synthesis methodology that allows fo

117 Cys)n-NH2, n = 2-6) have been synthesized by solid-phase peptide synthesis methods and characterized

118 Using solid-phase peptide synthesis methods, two units of the

119 denotes N-isobutylglycine), were prepared by solid-phase peptide synthesis methods.

120 describe five of the main techniques, namely solid phase peptide synthesis, native chemical ligation,

121 The heterogeneous reaction medium in solid-phase peptide synthesis necessitates the use of la

122 We show here the first full stepwise solid phase peptide synthesis of mambalgin-1 and confirm

123 lar beta-sheets" are synthesized by standard solid-phase peptide synthesis of a linear precursor foll

124 nd identification of the products during the solid-phase peptide synthesis of glycine, alanine, and v

125 1 linker is applied in the manual Fmoc-based solid-phase peptide synthesis of Leu-enkephalin and in m

126 Solid-phase peptide synthesis of several flavopeptin spe

127 The fusion of metallaphotocatalysis with solid-phase peptide synthesis opens new perspectives in

128 ation step can be carried out as part of the solid-phase peptide synthesis, or it can be undertaken i

129 ating that residue into peptides by standard solid-phase peptide synthesis procedures.

130 zation/epimerization, and compatibility with solid-phase peptide synthesis protocol make it highly ad

131 both in solution and as part of conventional solid-phase peptide synthesis protocols.

132 h can be seamlessly integrated into existing solid-phase peptide synthesis protocols.

133 do-5-hydroxylysine derivative can be used in solid-phase peptide synthesis, providing access to prote

134 The conjugates were synthesized by solid-phase peptide synthesis, purified by reversed-phas

135 moc-K(2M) derivative can be used directly in solid phase peptide synthesis, rendering bPNA+ convenien

136 ed amino acid building blocks, followed by a solid-phase peptide synthesis sequence, featuring two re

137 To prove the usefulness of this strategy in solid-phase peptide synthesis, several bioactive peptide

138 urdles due to the limitations of traditional Solid Phase Peptide Synthesis (SPPS) and Liquid Phase Pe

139 The superior robustness of this scaffold for solid phase peptide synthesis (SPPS) applications when c

140 alpha-Azido acids have been used in solid phase peptide synthesis (SPPS) for almost 20 years

141 4S)-methyldecanoic acid) required to support solid phase peptide synthesis (SPPS) for structure-activ

142 hieved using direct attachment of biotin and solid phase peptide synthesis (SPPS) of histidine (His)-

143 We present a process for solid phase peptide synthesis (SPPS) that completely eli

144 GlcNAc-Asn building blocks during automated solid phase peptide synthesis (SPPS), followed by orthog

145 In solid phase peptide synthesis (SPPS), the most common ph

146 orm for convenient use as building blocks in solid phase peptide synthesis (SPPS).

147 cial building block, ready for direct use in solid phase peptide synthesis (SPPS).

148 native chemical ligation (NCL) reaction with solid phase peptide synthesis (SPPS).

149 On average, solid-phase peptide synthesis (SPPS) (PMI ~ 13,000) does

150 are reported by a combination of Fmoc-based solid-phase peptide synthesis (SPPS) and beta-hydroxyasp

151 Solid-phase peptide synthesis (SPPS) and native chemical

152 Key was the development of a solid-phase peptide synthesis (SPPS) approach to generat

153 lysine residues, which are incompatible with solid-phase peptide synthesis (SPPS) due to the intrinsi

154 Universal Fmoc/t-Bu solid-phase peptide synthesis (SPPS) has long been inter

155 Solid-phase peptide synthesis (SPPS) is a widely used te

156 The semisynthetic approach relies on the solid-phase peptide synthesis (SPPS) of N-terminal thioe

157 They are prepared by solid-phase peptide synthesis (SPPS) or biosynthetically

158 and proteins can be either synthesized using solid-phase peptide synthesis (SPPS) or by applying a co

159 a-Ile-Asp-Tyr-Ile-Asn-Gly-OH), following the solid-phase peptide synthesis (SPPS) protocol and Amyloi

160 The use of solid-phase peptide synthesis (SPPS) to prepare four suc

161 three complementary strategies: linear Fmoc solid-phase peptide synthesis (SPPS) using several advan

162 Solid-phase peptide synthesis (SPPS) using tert-butyloxy

163 fluorophores are directly incorporated after solid-phase peptide synthesis (SPPS) via on-resin deriva

164 lows this chelator to be incorporated during solid-phase peptide synthesis (SPPS) with total site spe

165 classical solution peptide synthesis (CSPS), solid-phase peptide synthesis (SPPS), and liquid-phase p

166 ted to linear thiopeptide cores prepared via solid-phase peptide synthesis (SPPS), giving an efficien

167 Gla), appropriately protected for Fmoc-based solid-phase peptide synthesis (SPPS), is described.

168 r, peptide manufacturing is often limited to solid-phase peptide synthesis (SPPS), liquid phase pepti

169 Since the advent of automated solid-phase peptide synthesis (SPPS), many commercial pl

170 mma-glutamate 20, suitable for Fmoc-strategy solid-phase peptide synthesis (SPPS), was achieved in fo

171 ically to KTag, available via semi-automated solid-phase peptide synthesis (SPPS), while equipping th

172 Here we describe a simple and efficient Fmoc solid-phase peptide synthesis (SPPS)-based method for sy

173 irable side reaction that occurs during Fmoc solid-phase peptide synthesis (SPPS).

174 dard N(alpha)-fluorenylmethoxycarbonyl-based solid-phase peptide synthesis (SPPS).

175 used to protect the alpha-amino function in Solid-Phase Peptide Synthesis (SPPS).

176 a solid support using a similar approach to solid-phase peptide synthesis (SPPS).

177 ocols provide products in a form amenable to solid-phase peptide synthesis (SPPS).

178 yclic thioether peptide BMS-986189 utilizing solid-phase peptide synthesis (SPPS).

179 ell as full compatibility with standard Fmoc solid-phase peptide synthesis (SPPS).

180 osphopeptides from the crude preparations of solid-phase peptide synthesis step.

181 tep procedure which is fully integrated with solid-phase peptide synthesis strategy and usually takes

182 synthesis has been developed on the basis of solid-phase peptide synthesis techniques and is accompli

183 ently incorporated into peptides by standard solid-phase peptide synthesis techniques.

184 oresis (SDS-PAGE) with peptides produced via solid-phase peptide synthesis that correspond to the TM

185 Standard solid-phase peptide synthesis then resulted in the desir

186 and can be incorporated into peptides during solid-phase peptide synthesis through reductive aminatio

187 ogues with a lactam linkage were prepared by solid phase peptide synthesis to explore possible biolog

188 deoxygalactosyl-carborane building blocks in solid phase peptide synthesis to produce selective boron

189 lable starting materials and was employed in solid-phase peptide synthesis to afford the desired cycl

190 and tyrosine building blocks for Fmoc-based solid-phase peptide synthesis to allow convenient incorp

191 the theoretical methods, taking advantage of solid-phase peptide synthesis to incorporate approximate

192 Peptides are synthesized by standard solid-phase peptide synthesis to incorporate Fmoc-hydrox

193 the alpha-hemolysin (alphaHL) pore by using solid-phase peptide synthesis to make the central segmen

194 e used Fmoc (N-(9-fluorenyl)methoxycarbonyl) solid-phase peptide synthesis to prepare alpha-amino-n-b

195 elective molecular recognition, we have used solid-phase peptide synthesis to prepare individual ring

196 tically replaced with diaminopimelate during solid-phase peptide synthesis to produce several analogu

197 onding to histone N termini were prepared by solid phase peptide synthesis using an acid labile Boc/H

198 The method is based on solid-phase peptide synthesis using 2-chlorotrityl resin

199 d a bicyclic analogue by ultrasound-assisted solid-phase peptide synthesis using a green approach.

200 for introducing an N-Me group during regular solid-phase peptide synthesis using Boc protection.

201 /chymotrypsin proteolysis was synthesized by solid-phase peptide synthesis using known mixtures of na

202 We recently showed that solid-phase peptide synthesis using racemic amino acids

203 ublished and conjugated to bombesin(7-14) by solid-phase peptide synthesis using standard Fmoc chemis

204 Novo29 and epi-Novo29 were then prepared by solid-phase peptide synthesis using these building block

205 ini has been challenging in the past because solid-phase peptide synthesis usually starts from the C-

206 lipopeptide antibiotic paenibacterin by Fmoc solid-phase peptide synthesis via a new and very efficie

207 A preselected synthetic sequence via solid phase peptide synthesis was designed to produce 2,

208 Fmoc-protected DOTAla suitable for solid phase peptide synthesis was synthesized and integr

209 Solid-phase peptide synthesis was employed to elaborate

210 beled ADM analogues synthesized by Fmoc/t-Bu solid phase peptide synthesis were used to analyze their

211 g residues 354-375 of R2 was generated using solid-phase peptide synthesis where 354, a serine in the

212 problems persist in key applications (i.e., solid phase peptide synthesis) where reagent excess can

213 m were found fully compatible with Fmoc/ tBu solid-phase peptide synthesis, which allowed for the lab

214 was accomplished through the combination of solid-phase peptide synthesis with detailed liquid chrom

215 These peptides were prepared using solid-phase peptide synthesis with Fmoc alpha-amino prot

216 Results: Solid-phase peptide synthesis yielded 9%-15% purified la