ライフサイエンスコーパス: solvent-exposed

1 the binding to the collagen triple-helix are solvent exposed.

2 C-terminal 40 residues remain disordered and solvent exposed.

3 ion buffer where the peptides are completely solvent exposed.

4 th the N- and C-termini are unstructured and solvent exposed.

5 bserved for Fd, where the [Fe4S4] cluster is solvent exposed.

6 change data reveal that the center of TM3 is solvent exposed.

7 g conformations in which the nucleotides are solvent exposed.

8 rophobic pocket while the helix and loop are solvent-exposed.

9 (residues 141-149) become substantially less solvent-exposed.

10 he hydrophobic core while, in ReAz108W it is solvent-exposed.

11 polyglutamine (polyQ) segment disordered and solvent-exposed.

12 ent, while the hydrocarbon tail is partially solvent-exposed.

13 UNAG, and has the Cys115-terreic acid adduct solvent-exposed.

14 from the N terminus appear unstructured and solvent-exposed.

15 ironment while the edges are hydrophilic and solvent-exposed.

16 erminal portion of the fusion peptide can be solvent-exposed.

17 the subunit interface, moves from buried to solvent-exposed.

18 tacts with the enzyme, and the hydroxyls are solvent-exposed.

19 ally, the adenine ring is substantially more solvent-exposed, a result that could be explained by the

20 iking feature of the structure is an unusual solvent exposed acidic pocket formed between the peptide

21 A mutation in the solvent-exposed acidic domain of DSS1 compromises the ef

22 Glu69-containing molecule, revealed a unique solvent-exposed acidic pocket that includes betaGlu69 an

23 Helix 12 is displaced from the solvent-exposed active conformation and occupies the ort

24 ly polymerase, which has a more spacious and solvent-exposed active site than replicative and repair

25 is HisG has been solved and reveals a large, solvent-exposed active site with subsites for ATP and PR

26 ve NADP(H) and (hydroxy)ornithine bound in a solvent-exposed active site, providing structural eviden

27 er loop region in Mtb DsbF results in a more solvent-exposed active site.

28 rier (20.0 vs 15.0 kcal/mol) due to the more solvent-exposed active site.

29 r copper monooxygenases that function with a solvent-exposed active site.

30 hese molecular simulations revealed that the solvent-exposed active-site architecture results in lack

31 The presence of a solvent-exposed alanine residue stabilizes a helix by 0.

32 tates of the spin-label were resolved at the solvent-exposed alpha-helical site, at residue 28; these

33 -sheet content but also retain an element of solvent-exposed alpha-helix.

34 differential exchange rate constant for each solvent-exposed amide proton that is not hydrogen bonded

35 ange of peptide acidities observed for these solvent-exposed amides.

36 ethod relies on the irreversible labeling of solvent-exposed amino acid side chains by hydroxyl radic

37 sence of a native-like N() with a disordered solvent-exposed amino-terminal beta-strand.

38 Conversely, the THA group in fact remains solvent exposed and does not disrupt base stacking in RA

39 segment in alpha-synuclein, NAC(8-18), in a solvent exposed and extended conformation that can form

40 in the GRK2 large lobe whose side chains are solvent exposed and facing the membrane were targeted fo

41 shown to be critical for K1's function, are solvent exposed and located on a convex surface, opposit

42 ed the cryptic cysteine residues that became solvent exposed and redox regulated.

43 motif, whereas the C-terminal SUMO target is solvent exposed and situated in a typical consensus moti

44 , or an open conformation, with Gly-734 more solvent-exposed and accessible to the PFL-AE active site

45 ore, the structurally defined N-NO moiety is solvent-exposed and available to transfer NO to a partne

46 , the phosphoinositide head groups are fully solvent-exposed and complete the LBD fold by organizing

47 orylation, resulting in a more comprehensive solvent-exposed and conformationally dynamic enzyme.

48 genetic cluster, on the other hand, occupies solvent-exposed and highly mobile regions.

49 The altered residues in the polymerase are solvent-exposed and lie in regions that are adjacent to

50 at in each Bak dimer the N-termini are fully solvent-exposed and mobile, the core is highly structure

51 A short helix, nHelix C, was fully solvent-exposed and nearly perpendicular to the bundle.

52 g the hypothesis that the thiol residues are solvent-exposed and not involved in disulfide bonds that

53 is domain, thereby leaving the cleavage site solvent-exposed and ready for cleavage.

54 ucture, whereas other portions of BID remain solvent-exposed and retain helical structure.

55 e it includes a poorly conserved sequence, a solvent-exposed and somewhat unstable helix and a mobile

56 he receptor, whereas its glutamate moiety is solvent-exposed and sticks out of the pocket entrance, a

57 Mutations that were solvent-exposed and therefore accessible to T-cell antig

58 ggesting that individual domains of hA3G are solvent-exposed and therefore may interact with other ma

59 EGCG, the Abeta(1-40) oligomers become less solvent exposed, and the beta-regions, which are involve

60 ever, the active site of PPIases is shallow, solvent-exposed, and well conserved between family membe

61 We previously identified a highly solvent-exposed apoA-I loop domain (Leu(159)-Leu(170)) i

62 Hydrophilic moieties, addressing the solvent-exposed area adjacent to hydrophilic region II,

63 d footprinting strategy was adopted to probe solvent-exposed aspartic and glutamic acid residues on t

64 vent-exposed surfaces of the FMO by labeling solvent-exposed aspartic and glutamic acid residues.

65 igand-binding sites is bonded to a different solvent-exposed Au atom, suggesting an associative mecha

66 module nor mutations altering access to the solvent-exposed axial copper coordination site significa

67 A solvent-exposed backbone on a beta-strand is thought of

68 interactions between the sidechains of these solvent-exposed basic residues and the graphene surface

69 The solvent-exposed beta- and gamma-phosphates of ATP are lo

70 we uncovered a point mutation (Y456T) on the solvent-exposed beta-sheet surface that allowed this dom

71 termining region 3 (CDR3H) that folds into a solvent-exposed beta-strand "stalk" fused to a disulfide

72 In contrast to deep, solvent-exposed binding pockets observed in other peptid

73 ending on whether the phenolic side chain is solvent-exposed, buried, or hydrogen-bonded.

74 e stronger ( approximately 4 Hz) than in the solvent exposed C-terminal AR ( approximately 2 Hz).

75 d in an intertau interface, from that of the solvent-exposed C terminus.

76 The more solvent exposed calcium can be easily displaced by mono-

77 he appearance of the first peroxidase with a solvent-exposed catalytic tryptophan to 194 +/- 70 Mya,

78 he appearance of secreted peroxidases with a solvent-exposed catalytic tryptophan.

79 tructural model, including the presence of a solvent-exposed cavity within its transmembrane region.

80 ER server that suggests that MurJ contains a solvent-exposed cavity within the plane of the membrane.

81 ica juncea) HMGCS binds hymeglusin in a more solvent-exposed cavity.

82 A solvent-exposed channel present in the SAM-forming enzym

83 with the displacement of iron atoms from the solvent-exposed cluster, suggesting that Cu(I) damages t

84 ed that Rpe employs a ferrous iron atom as a solvent-exposed cofactor and that H(2)O(2) rapidly oxidi

85 , the FAD of T. thermophilus PRODH is highly solvent-exposed compared with PutA due to a 4-A shift of

86 ally possible for Tyr106 to isomerize from a solvent exposed configuration to a buried rotameric stat

87 emplating base, the B[a]P moiety is in a non-solvent exposed conformation stacked within the DNA heli

88 In this solvent-exposed conformation, AdoCbl undergoes facile tr

89 xide (DMSO), the adduct is able to move to a solvent-exposed conformation, which enables error-prone

90 ase fold with the active site in the "open", solvent-exposed conformation.

91 eptide bound in the protein core and a large solvent-exposed crevice for heme binding.

92 ein as EDTA-metal complexes by introducing a solvent-exposed cysteine residue using site-directed mut

93 human protein also contains three additional solvent-exposed cysteine residues (C95, C173, C188) that

94 eacted with a protein domain harboring three solvent-exposed cysteine residues, resulting in the in s

95 , the nanocapsid surface was modified with a solvent-exposed cysteine to conjugate monolayer protecte

96 d has a comparable pK(a) for the active-site solvent-exposed cysteine.

97 4Fe:4S](1+) state, our analysis identifies a solvent exposed, delocalized Fe(2.5+) pair and a buried

98 ost of which are located in proximity to the solvent-exposed edge of the FMN cofactor along with othe

99 Trp-specific fluorescence, indicating a more solvent-exposed environment for the Trp residues in the

100 ix 3, helix 4, and helix 11 that move from a solvent-exposed environment to one that interacts extens

101 tion in center layers and GT conformation in solvent-exposed exocyclic groups.

102 ydrophobic cavity upon ligand binding to the solvent exposed exterior of the LTP, facilitating proteo

103 on were overrepresented within the predicted solvent-exposed face of the LRR domain, although several

104 The solvent-exposed face of the third helix was found to con

105 n internal redox rearrangement such that the solvent-exposed Fe pair becomes reduced, thereby facilit

106 O,Ph), 1HHy(CO,Ph)), leading to an elongated solvent-exposed Fe-Fe bond.

107 -terminus of the peptide into both bound and solvent-exposed fractions.

108 water-network relaxation around the shallow, solvent-exposed function site.

109 lulose III(I), which increased the number of solvent-exposed glucan chain hydrogen bonds with water b

110 n of Z (but not OG) is strongly preferred at solvent-exposed guanine nucleobases at duplex ends.

111 mutant (GB1) with various amino acids at the solvent exposed guest position 53 in the internal strand

112 two distinct ring binding modes, buried and solvent-exposed, have been observed by X-ray structure a

113 hift analysis of the proton signals from the solvent-exposed headgroups of bound ligands suggests tha

114 ozyme, each containing a single p-AcPhe at a solvent-exposed helix site; the mutants were expressed i

115 in unphosphorylated Noxa, consistent with a solvent-exposed helix/loop, but strongly constrained in

116 In particular, the solvent-exposed heme is axially liganded by His75 and is

117 HigA does not cover the solvent-exposed HigB active site, suggesting that, in ge

118 Although solvent-exposed His and Tyr residues are more reactive w

119 this interaction, 13-HODE was docked to the solvent exposed histidines of a 15-hLO-2 homology model

120 where a beta-strand distortion results in a solvent-exposed hydrophobic amino acid at residue 5.

121 ate) phases], including the involvement of a solvent-exposed hydrophobic cluster and another delocali

122 protein reveals an SH3-like topology with a solvent-exposed hydrophobic ligand binding site.

123 Furthermore, an extended solvent-exposed hydrophobic loop, located between the Sy

124 A prominent solvent-exposed hydrophobic patch formed by residues Phe

125 eptide substrates is necessary to complete a solvent-exposed hydrophobic pocket to form the catalytic

126 The solvent-exposed hydrophobic residues (V619 and L623) the

127 dj3, as was the ability of ERdj3 to mask the solvent-exposed hydrophobic residues of CTA1.

128 ture of helix alpha1 is characterized by two solvent-exposed hydrophobic residues, F46 and L50, sugge

129 of factors V and VIII, some or all of these solvent-exposed hydrophobic residues, Trp26, Leu28, Phe3

130 targets alphaS(n) with sub-muM affinity via solvent-exposed hydrophobic sites, breaking the catalyti

131 Ca(2+)-bound CaBP7 NTD has a solvent-exposed hydrophobic surface that is more expansi

132 l change, which was featured by an increased solvent-exposed hydrophobicity, while MsESAT-6 showed li

133 revealing that one of the Fe(III) sites was solvent-exposed (i.e., at an edge, corner, or defect sit

134 all non-DeltaF508 structures but completely solvent exposed in all DeltaF508 structures.

135 side chain of this residue remains partially solvent exposed in both the lit and dark states.

136 side chain, which is glycosylated in E2 and solvent exposed in other complexes, is slightly buried u

137 ng that many phosphorylated residues are not solvent exposed in the unphosphorylated state opens seve

138 myristoyl group attached to FCaBP is indeed solvent-exposed in both the Ca(2+)-free and Ca(2+)-bound

139 This PH domain surface is not solvent-exposed in crystal structures of PLC-beta, neces

140 the phenylazido side chain was predominantly solvent-exposed in the bound conformation.

141 These include several residues that are solvent-exposed in the CPR crystal structure, indicating

142 as Asn-415 is buried by HCV1 and AP33, it is solvent-exposed in the HC33.1-E2(412-423) complex, such

143 d hydrophobic BP pyrenyl residue is entirely solvent-exposed in the major groove of the DNA.

144 in Abeta (residues 16-22 and 30-42) are more solvent-exposed in the more toxic Abeta oligomer.

145 hed myristoyl group at the N terminus may be solvent-exposed, in contrast to the highly sequestered m

146 f all xylose residues in the active site are solvent exposed, indicating that arabinose substituents

147 These singularities, called dehydrons, are solvent-exposed intramolecular hydrogen bonds that may b

148 it from the dynamic behavior of multi-option solvent-exposed ion pairs.

149 rge portion of the backbone amide groups are solvent-exposed leading to fast hydrogen exchange and ca

150 is closed, a region of the binding pocket is solvent-exposed, leading to the hypothesis that it may a

151 the enzyme active site but rather in a more solvent-exposed location.

152 and positions the isoaspartate residue in a solvent exposed loop that is stabilized by a MeLan ring.

153 ured N-terminus, a helical C-terminus, and a solvent-exposed loop containing Trp28 and Phe29.

154 ons in sequence at just three positions in a solvent-exposed loop greatly alter the extent of IB form

155 cid was extrapolated and incorporated into a solvent-exposed loop of a protein domain; the protein ex

156 domains have the ferredoxin-like fold and a solvent-exposed loop with a MXCXXC motif that can bind C

157 X(11)C(12)X(13)X(14)C(15) motif located in a solvent-exposed loop.

158 Two small solvent-exposed loops (loops A and B) located within TBD

159 ay library of Fn3 was created in which three solvent-exposed loops were diversified in terms of amino

160 t peptide with four disulfide bonds and four solvent-exposed loops, as a scaffold for engineering pep

161 We illustrate this new strategy by labeling solvent-exposed lysine residues with commercially availa

162 rough nonspecific modification of the mAb at solvent-exposed lysine residues.

163 Individual mutation of three solvent-exposed lysines in the villin headpiece subdomai

164 n peroxide-treated sample, in contrast, four solvent-exposed Met residues in the Fc portion were comp

165 o acids without explicit activation and that solvent-exposed methionine and tryptophan residues are l

166 dule forming a foothold on the virus and the solvent-exposed module able to adapt to bind to a variet

167 ding module containing domains 1 and 4 and a solvent-exposed module containing domains 2 and 3.

168 e cryo-electron microscopy to reveal how the solvent-exposed moiety of a BCL6-binding molecule contri

169 eading to locally enhanced chain dynamics of solvent-exposed monomers.

170 , where X1,2 not equal proline) in flexible, solvent-exposed motifs; however, several native glycopro

171 The solvent-exposed MPER tryptophan residue (Trp-680) was im

172 p predicted a mechanical intermediate with a solvent-exposed N terminus spanning the A and B beta-str

173 ic Abeta1-42 oligomers had more flexible and solvent-exposed N-termini than Abeta1-40 oligomers.

174 a3-40/42 had significantly more flexible and solvent-exposed N-termini than Abeta1-40/42 conformation

175 ny open questions regarding the hydration of solvent-exposed non-polar tracts and pockets in proteins

176 lass A beta-lactamases and is located in the solvent-exposed Omega-loop of KPC-2.

177 ns suggest that the thiol groups present are solvent-exposed on a single protein surface and are too

178 tures include elongated beta-sheets that are solvent-exposed on both faces and the lack of a canonica

179 lation of cryptic cysteine residues that are solvent exposed only upon changes in protein conformatio

180 ntacts also place the NAC(8-18) segment in a solvent exposed orientation, a finding in contrast to th

181 , AlkD captures the extrahelical lesion in a solvent-exposed orientation, providing an illustration f

182 The flavin cofactor of PhzS is in the solvent exposed out orientation typically seen in unliga

183 esponding to the dimer interface became more solvent exposed over time at 3 degrees C; unexpectedly,

184 The N-terminal region formed a solvent-exposed patch located on the opposite side of th

185 These residues form a solvent-exposed patch on the surface of the chaperone-bo

186 We found two solvent-exposed patches of extraordinarily conserved sit

187 s and that fibrillization is promoted by two solvent-exposed patches, which are also involved in reco

188 AFUDG contains a large solvent-exposed peptide region containing an alpha helix

189 ains pack within a shallow depression at the solvent-exposed periphery of the interface.

190 a novel peptide-binding motif centered on a solvent-exposed phosphate anchor.

191 as associated with closure of a neighboring, solvent-exposed pocket between the extracellular poles o

192 morphinan ligand binds deeply within a large solvent-exposed pocket.

193 eeply buried position in the dark state to a solvent-exposed position in the light excited state.

194 ups that are gradually pulled from a distal, solvent-exposed position into the flat, bowl-shaped S2'

195 te and involved Ala and Gly substitutions of solvent exposed positions in the RT loop.

196 result in semiconservative substitutions at solvent-exposed positions in the folded conformation and

197 esigned with randomized amino acids at seven solvent-exposed positions was developed from 1.6 x 10(9)

198 examined alpha --> beta substitution at four solvent-exposed positions, Asn19, Trp23, Gln26 and Lys30

199 2 of the V(H) exhibited frequent mutation in solvent-exposed positions, but conservation of common st

200 In lead optimization, open, solvent-exposed protein pockets are often disregarded as

201 S-sulphenylation is favored at solvent-exposed protein surfaces and is associated with

202 DXMS identifies solvent-exposed protein surfaces; docking is used to cre

203 Molecular dynamics simulations show that solvent-exposed proteins (S15 and S17) tend to adopt mor

204 the glucosyltransferase, appears as a large solvent-exposed protrusion.

205 an incompletely formed substrate channel and solvent-exposed pyridoxal 5'-phosphate cofactor and prov

206 The CDK-bound form of CR8 has a solvent-exposed pyridyl moiety that induces the formatio

207 en the coupling constants for the buried and solvent-exposed radical are primarily caused by variatio

208 e compared to those of a previously studied, solvent-exposed radical at position 108 to identify sign

209 ed by approximately 7 cm(-1) relative to the solvent-exposed radical, and large changes in intensity

210 tease target is dictated by its flexible and solvent exposed reactive centre loop (RCL), which forms

211 pins, a protease cleaves a peptide bond in a solvent-exposed reactive center loop (RCL) of the serpin

212 tch, near the Chi recognition domain, on the solvent-exposed RecC surface.

213 the structure also reveals the presence of a solvent-exposed redox-sensitive disulphide bridge, uniqu

214 ion of the morpholine ring engaging the mTOR solvent exposed region led to the discovery of PQR626 (8

215 to engineer structural modifications in the solvent-exposed region of the ATP-binding site that sign

216 sters, we explored the chemical space in the solvent-exposed region of the enzyme catalytic binding p

217 differences are clustered in peripheral and solvent exposed regions when compared with Escherichia c

218 s: while sequons were positively selected in solvent exposed regions, they were almost completely eli

219 located within or near to the interdomain or solvent-exposed regions in the antibody structure.

220 The interaction specifically involved solvent-exposed regions in the hsp90beta M domain that a

221 Q-like motifs are more frequently located in solvent-exposed regions of proteins, and that the positi

222 proteins tend to be clustered in buried and solvent-exposed regions, respectively.

223 n compared with C3b, revealing more dynamic, solvent-exposed regions.

224 Phenylalanine-427 (F427), a solvent-exposed residue in the lumen of the pore, was id

225 Moreover, solvent exposed residues have amide I bands with >20 cm(

226 inetic effect of mutating both interface and solvent exposed residues in pKID.

227 8 mutants of the SARS-CoV nsp1, targeting 62 solvent exposed residues out of the 180 amino acid prote

228 xtensive hydrogen-bonding network with three solvent exposed residues, linking the catalytic Fe(II) t

229 Solvent-exposed residues along the alpha-helices of the

230 asis for the role of R242 and other critical solvent-exposed residues at the GRTH/PKA interface (E165

231 quantify the number of lipid-correlated and solvent-exposed residues by amino acid type, which furth

232 Indeed, the CBD helix and the solvent-exposed residues in the dimeric CREB bZip coiled

233 Val-131, Leu-132, and Leu-135) interact with solvent-exposed residues in the Frq1 C-terminal pocket (

234 -160, Val-161, Met-165, and Met-167) contact solvent-exposed residues in the Frq1 N-terminal pocket (

235 ine GRK1 as a guide, we generated mutants of solvent-exposed residues in the GRK1 kinase domain that

236 osine-glutamine-phenylalanine (YQF) triad of solvent-exposed residues that are displayed on the beta-

237 26 mutants wherein clusters of 1-5 putative solvent-exposed residues were changed to alanine, ultima

238 InsA14-20 shares two solvent-exposed residues with previously identified AI4

239 rface, featuring key charged and hydrophobic solvent-exposed residues, at the membrane-distal tip of

240 integrated alleles that target conserved and solvent-exposed residues, we identified surfaces on p35/

241 ording to CLEANEX experiments, reflected the solvent-exposed residues.

242 xal-5'-phosphate (PLP), apparently without a solvent-exposed Schiff base.

243 structural distortions occur: distortions in solvent-exposed seed and 3'-end regions are less likely

244 reased sequence coverage and localization of solvent-exposed segments for mass-analyzed solution-phas

245 tify multiple structural features within the solvent-exposed SF region of apoA-I of nascent HDL essen

246 5 unit, respectively, than commonly seen for solvent-exposed side chains in water-soluble proteins, i

247 4 side chains move to interact with the more solvent-exposed side chains of D88 and E100'.

248 Localization of the oxidative label to solvent-exposed side chains was determined by high-resol

249 strand, shows the presence of three distinct solvent-exposed side-chain rotamers.

250 lts highlight how a single substitution at a solvent-exposed site can affect the mechanism of aggrega

251 Glycans were introduced at seven solvent exposed sites within the Im7 sequence and the ki

252 latter two phenotypes lie in two overlapping solvent-exposed sites adjacent to the sugar-binding clef

253 redicted by existing methods, even when only solvent-exposed sites are targeted.

254 These solvent-exposed sites featured an axial ZFS of 0.21 cm(-

255 and are generally considered as prototypical solvent-exposed sites on the surfaces of alpha-helices.

256 n bonding interactions with the enzyme and a solvent exposed six-membered ring, consistent with its p

257 lar-pseudolamellar organization, and (3) the solvent-exposed Solar Flare loops, proposed sites of int

258 Of interest, ESR spectra of GB1 domain with solvent-exposed spin label can be accurately reproduced

259 th in silico docking calculations identified solvent-exposed STAS residues involved in nucleotide bin

260 onment in closed buried hydrophobic and open solvent-exposed states.

261 The more solvent exposed structure of intermediate oligomers in t

262 e compounds can be modulated by variation of solvent-exposed substituents.

263 trained TCR docking mode, an optimal peptide solvent exposed surface leading to an optimal complement

264 mino acid substitutions introduced along the solvent exposed surface of the inhibitory helix.

265 f nine individual sites, each located on the solvent exposed surface of the protein where structural

266 The plot of free energy against the apparent solvent-exposed surface area is given for linear alkanes

267 to each other, differing primarily in their solvent-exposed surface areas in a manner accounting for

268 Modeling of solvent-exposed surface electrostatic potentials showed

269 of hydroxyl radicals to covalently label the solvent-exposed surface of proteins has been shown to be

270 transformation, we designed mutations on the solvent-exposed surface of TAg.

271 dues ( approximately 75%) are located on the solvent-exposed surface of the complex, a number of buri

272 residues (81%) are located on the oxygenated solvent-exposed surface of the complex, several residues

273 ns have been introduced incrementally on the solvent-exposed surface of the main alpha-helix (residue

274 tal structure of ATX suggests a role for the solvent-exposed surface of the N-terminal tandem somatom

275 by the presence of the olefinic chain on the solvent-exposed surface of the peptide.

276 syndrome missense mutations map to a common solvent-exposed surface that is not expected to alter en

277 sidues were predicted to cluster on a common solvent-exposed surface, suggesting a model in which the

278 ense negative external and positive internal solvent exposed surfaces.

279 distributions of hydrophobic residues on the solvent-exposed surfaces of native proteins.

280 ionizable amino acid residues present on the solvent-exposed surfaces of proteins, the protein charge

281 a mass spectrometry-based method that probes solvent-exposed surfaces of the FMO by labeling solvent-

282 the chemical equivalence of the protons of a solvent-exposed tert-butyl group from Tby, the singlet r

283 irst, the central region of (CAG)(8) is more solvent-exposed than single-stranded DNA, which suggests

284 ince this strategy leaves the alkylated base solvent exposed, the means to achieve enzymatic cleavage

285 When the cyanylated cysteine side chain is solvent-exposed throughout the structural transition, it

286 shifted compared to native PNP, suggesting a solvent-exposed Trp residue.

287 ctivity of hSOD1 causes oxidation of its own solvent-exposed Trp(32) residue.

288 action strongly depends on the presence of a solvent-exposed tryptophan residue (Trp-164).

289 d changes in its tertiary structure and more solvent-exposed tryptophan residues.

290 in docking of the short helix III remaining solvent-exposed until after the rate-limiting transition

291 These residues also become more solvent-exposed upon binding of FABP1 with the endogenou

292 s show that the ClpP N-terminus becomes more solvent-exposed upon interaction with ClpA.

293 mably because the hydrophobic inner sheet is solvent-exposed upon tetramer disassembly.

294 Finally, a solvent-exposed vector was defined from the pyridazinone

295 nd is anchored at both of its ends, with the solvent-exposed Watson-Crick edges of stacked bases 2 to

296 riments showed that the 2F5 epitope was more solvent exposed, whereas the 4E10 epitope was immersed i

297 s reveal that the distal NPXY motif is fully solvent-exposed, whereas the proximal one is not.

298 vicinity of the loop, the bases become more solvent exposed, which suggests that the instability ass

299 (AppA1-126) reveals that Trp104 is partially solvent exposed while a BLUF domain containing a slightl

300 Mutation of the solvent-exposed Y127, positioned on the beta-platform su