ライフサイエンスコーパス: soma

1 xcitatory currents amplify when reaching the soma.

2 lization in germ cells or degradation in the soma.

3 bute to the formation of motile cilia in the soma.

4 n potential in the dendrites relative to the soma.

5 n compared with single large synapses at the soma.

6 late current originates predominantly in the soma.

7 information to be inherited from germline to soma.

8 detection more effectively than IKLT in the soma.

9 genesis at the synapse to degradation in the soma.

10 often hundreds of micrometers away from the soma.

11 c boutons during retrograde transport to the soma.

12 omical location of the retinal ganglion cell soma.

13 y and filtering of signals integrated at the soma.

14 solated after blocking GABAa receptor on the soma.

15 e on late endosomes for transport toward the soma.

16 mulation of unprocessed proforms in neuronal soma.

17 n germ cells when they are present in a male soma.

18 at apical dendrites, without inhibiting the soma.

19 uation and normalizing EPSP amplitude at the soma.

20 on, caused TH1-S31E accumulation in the cell soma.

21 orm amplitude of approximately 0.2 mV at the soma.

22 venation no matter how far they are from the soma.

23 d in the anterograde direction away from the soma.

24 he transport of signaling endosomes into the soma.

25 nuate excitatory signals passing to the cell soma.

26 nal Ca(2+) independently from actions at the soma.

27 eolytically active lysosomes enriched in the soma.

28 ns in nuclear migration and anchorage in the soma.

29 on potentials and few sodium channels in the soma.

30 K channel expression at the pyramidal neuron soma.

31 ndfeet hundreds of micrometers away from the soma.

32 A spikes or trains of EPSPs from dendrite to soma.

33 ed that microglia constantly survey neuronal soma.

34 same time efficiently connecting them to the soma.

35 dritic synaptic currents when they reach the soma.

36 sion of fluorescent proteins to the neuronal soma.

37 aracterized by strong attenuation toward the soma.

38 in two major settings: the germline and the soma.

39 lysosomal degradation of DAT are confined to soma.

40 an extended period following ablation of its soma.

41 the AIS, due to resistive coupling with the soma.

42 eriences energetic stress independent of the soma.

43 cantly higher in neurites as compared to the soma.

44 specific morphology in axons, dendrites and soma.

45 y to characterize interactions with neuronal somas.

46 ty over 3,000-fold higher than that on their somas.

47 an 26 mV) but are strongly attenuated at the soma (0.5-1 mV) and that the estimated neck resistance (

48 ing the action potential in mammalian neuron somas (-1.8 to 1.4 nm) and neurites (-0.7 to 0.9 nm), us

49 s of developmental arrest of the non-gonadal soma [1, 4, 5].

50 shold membrane potential fluctuations at the soma affect neurotransmitter release from synaptic bouto

51 nected pair, and synaptic distances from the soma along the axonal and dendritic paths, for more than

52 measurements of synaptic distances from the soma along the dendritic and axonal paths, which may aff

53 s are elongated and have a well-defined cell soma and a filopodia-like structure.

54 leading to its significant reduction in the soma and abnormal retention within late endosomes in dis

55 o facilitate retrograde communication to the soma and amplify neuronal responses, in a mechanism that

56 cerebellum, basket cells (BCs) innervate the soma and axon initial segment (AIS) of Purkinje cells (P

57 ntly, however, it has been proposed that RGC soma and axon size may be dynamic and change in response

58 Vesicles transport Nfasc186 to the soma and axon terminal where they fuse with the neuronal

59 itochondrial length in retinal ganglion cell soma and axon, but no degeneration.

60 nnervation pattern of D(1) R- and D(2) R-MSN soma and axonal initial segment (AIS) by GABAergic and c

61 nonical X dosage states that differ from the soma and between the sexes.

62 depletion inhibited BDNF trafficking to the soma and blocked downstream BDNF- and TrkB-dependent sig

63 PTP1B inactivation prevents TrkA exit from soma and causes receptor degradation, suggesting a "gate

64 rs follow a single dendrite mostly up to the soma and contact it at multiple (median 4) synaptic site

65 tic function are synthesized in the neuronal soma and conveyed via slow axonal transport.

66 tty acid synthesis (FAS), is produced in the soma and delivered through gap junctions to the germline

67 ith impaired GTPase activity, ER networks in soma and dendrite branch points are reduced and replaced

68 In PVD soma and dendrite branch points, ER tubules connect to f

69 w dynamic coupling between the input region (soma and dendrite) and the spike-generating output regio

70 s were found to be unevenly clustered on the soma and dendrites of dopamine neurons within the substa

71 is, we performed patch-clamp recordings from soma and dendrites of rat hippocampal pyramidal neurons,

72 SPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell ty

73 so develops substantially more slowly in the soma and dendrites than the development of the 1D MPS in

74 CD63-GFP(+) ILVs are primarily localized in soma and dendrites, but not in axonal terminals in vitro

75 icroscopy recently revealed that, unlike the soma and dendrites, the axon membrane skeleton is struct

76 cluster at inhibitory synapses mainly on the soma and dendritic shafts.

77 ng reduction in astrocyte free Ca(2+) in the soma and endfeet.

78 of varying the AIS position relative to the soma and found that AIS distal relocation of both Nav an

79 nel mutants that reduce coupling between the soma and germ cells in the Caenorhabditis elegans gonad.

80 The KoRV-A gammaretrovirus infects the soma and germline and is sweeping through wild koalas by

81 is achieved both at nerve terminals and the soma and is independent of membrane hyperpolarization an

82 remendously long distances from the neuronal soma and make use of localized mRNA translation to rapid

83 ng sex chromosome dosage compensation in the soma and meiotic sex chromosome inactivation in the germ

84 nt, TH1-S31E, was distributed throughout the soma and neurites.

85 he tangential axis and make contact with the soma and processes of NPCs dividing at the ventricle for

86 pond to mechanical stimulations close to the soma and produce up to three spikes with increasing stim

87 Kv2.1 serves a major structural role in the soma and proximal dendrites of mammalian brain neurons,

88 e synapses were localized exclusively on the soma and proximal dendrites, placing them in a good loca

89 thod and restricting channelrhodopsin to the soma and proximal dendrites, we are able to reliably evo

90 eled putative Renshaw cell synapses on their soma and proximal dendrites.

91 es revealed pvBC axons innervating their own soma and proximal dendrites.

92 Axonal autophagosomes enter the soma and remain confined within the somatodendritic doma

93 rase dUTP nick end labeling (TUNEL)-positive soma and the eventual loss of 5HT neurons in the DRif an

94 radiation, a genotoxic stress affecting the soma and the germ line, and tested how fast the soma rec

95 stance, denoting the path length between the soma and the start of the AIS, and to produce invariant

96 he trafficking of axonal retromer toward the soma and thus enhances protease transport to lysosomes,

97 A custom microscope allowed us to image the soma and up to 300 mum of contiguous dendrite at 15 Hz,

98 eted siRNA led to striking protection of RGC somas and axons from hypertension-induced damage.

99 Immunostaining of the somas and peripheral axons of corneal neurons responding

100 Microglia displayed larger somas and shorter processes.

101 segment (AIS), controls retrograde (axon-to-soma) and anterograde (soma-to-axon) traffic of Tau.

102 nes expressing this sensor of MAPK activity (SOMA) and performed live-cell imaging experiments using

103 is a postzygotic mutation that occurs in the soma, and it may occur at any developmental stage or in

104 nically isolate radial glia endfeet from the soma, and we use photoconvertible proteins to demonstrat

105 Transcriptomes in axons and soma are distinct, but the mechanisms governing the comp

106 ontrast, autophagosomes generated within the soma are less mobile and tend to cluster.

107 e found that genes normally expressed in the soma are mis-expressed in germ cells.

108 In Tetrahymena, the germline and soma are partitioned into two different nuclei within a

109 by increasing the number of neurites and the soma area.

110 r; and (iii) using organelle motility inside somas as an intrinsic contrast agent.

111 e idea that the germline is prioritized over soma, at least, within the ejaculate.

112 ction potentials (APs) initiate close to the soma, at the axonal initial segment.

113 Dual soma-axon patch-clamp recordings combined with axonal Na

114 Close to their soma, axons almost exclusively targeted inhibitory inter

115 ries substantial information that reveals GC somas, axons, and other retinal neurons and permits thei

116 L7 is part of a local feedback loop with the soma because it regulates cumulus cell replication.

117 cell types are always recorded first at the soma before backpropagating into the dendrites while und

118 evidence for TMEM16B actions not only in the soma but also in the presynaptic nerve terminals of GABA

119 d endoplasmic reticulum were abundant in the soma but minimally present in MFB axons, suggesting that

120 -morbidities related to an aging and damaged soma can hinder achievement of ACM benefit.

121 zed rule: for all nerve pathway origins, the soma cluster centroids in closest proximity are those wh

122 f malonyl-CoA may be a strategy by which the soma communicates nutritional status to the germline.

123 ing spermatid differentiation, and germ cell-soma communication.

124 P amplitude increased with distance from the soma, compensating for dendritic attenuation and normali

125 ore, support the idea that both germline and soma components of the ejaculate contribute to male repr

126 We find that at steady state, the cell soma contains populations of autophagosomes derived from

127 (SGC), which completely envelop the neuronal soma, contribute to nerve regeneration remains unexplore

128 cal neurons, mitochondrial distance from the soma correlates with increased mitochondrial protein dam

129 trong soma-to-axon coupling and weak axon-to-soma coupling enables spikes to be generated efficiently

130 dels with weak soma-to-axon and weak axon-to-soma coupling, IKLT in the axon enhances coincidence det

131 s regulated differently from the non-gonadal soma: daf-18/PTEN acts non-autonomously within the somat

132 sulin as a model drug, demonstrated that the SOMA delivers active pharmaceutical ingredient plasma le

133 g to determine the signaling patterns in CA1 soma, dendrites, and axons associated with place field f

134 reticulum (ER) that elaborate throughout the soma, dendrites, axon and presynaptic terminal.

135 cted in the axon initial segment, changes in soma-dendritic compartments may also be involved.

136 The membrane properties, soma-dendritic shape, and intrastriatal and extrastriata

137 Here we report that soma depth and dendritic path lengths within each cortic

138 mmed genome rearrangement during germline to soma differentiation.

139 % of the outer stratifying cells) have their soma displaced to the inner nuclear layer.

140 Here we characterise a major germline-soma dissimilarity caused by a germline-restricted chrom

141 The origin of the germline-soma distinction is a fundamental unsolved question.

142 We use dendrite-soma dual patch-clamp recordings to show that the strong

143 ent work suggests possible remobilization of soma during maturation (a "capital" source).

144 Inner stratifying cells have their soma exclusively in the ganglion cell layer and include

145 ation of specific mRNAs transported from the soma, exposing new mechanistic layers within stem cells

146 lastocyst, acquire capacity for germline and soma formation, and then undergo lineage priming.

147 gans synMuv B proteins are important for the soma/germline fate decision and mutants demonstrate ecto

148 evelopmentally arrested neurons with a small soma, heterochromatin-rich nucleus, and unbranched axon

149 ully integrated with synapses, dendrites and soma, implemented using scalable memristor devices.

150 eters of tyrosine hydroxylase immunoreactive soma in cave Astyanax in the olfactory bulb, basal telen

151 cytes (ILA) in the cerebral cortex possess a soma in layer I and extend an interlaminar process that

152 EPSPs from the distal apical dendrite to the soma in pyramidal neurons in the ACC, which was signific

153 ariations in AIS length or distance from the soma in rat substantia nigra pars compacta dopaminergic

154 otentials to antidromically propagate to the soma in retrograde signaling.

155 Control lines expressing a version of SOMA in which the phosphosite was mutated to an alanine

156 M1-like cells typically had somas in the ganglion cell layer, with 23% displaced to

157 tochondrial degradation and mitophagy in RGC somas in vitro, it does not affect transport dynamics an

158 We perform morphometry on GC layer somas, including projection of GCs onto photoreceptors a

159 at single action potentials generated at the soma increase calcium concentration in the somatic cytos

160 r how low sodium channel availability in the soma influenced the temporal precision of action potenti

161 tionally, glial ensheathment of the neuronal soma influences dendritic regeneration after injury.

162 ith neuronal cell bodies) to understand glia-soma interactions.

163 Taken together, our results suggest that SOMA is able to dynamically report MAPK activity in livi

164 annose-6-phosphate receptors (CI-MPR) in the soma is disrupted in mutant hAPP neurons, causing defect

165 Transport from the axon to the soma is driven by the molecular motor cytoplasmic dynein

166 i-dependent functions occur in the mammalian soma is unclear.

167 arply in the dendrite with distance from the soma (length constant, 53.6 mum), but their attenuation

168 kinin1 and Pet1 (Tac1-Pet1 neurons), mapping soma localization to the caudal medulla primarily and ax

169 1 shows all L4B neurons, regardless of their soma location in blob or interblob columns, as projectin

170 ifying cells cover the retina independent of soma location.

171 germ cells and growth and maintenance of the soma may explain the deterioration of the soma over time

172 revealed the channel to be localized at the soma membrane, axon, axon terminals, and the nodes of Ra

173 nearly all found to express Kv3.1b in their soma membranes.

174 ns and co-localizes with lysosome markers in soma, neurites and synaptic boutons.

175 e sections Nrg3 protein was localized to the soma, neurites, and to the Golgi apparatus, where it is

176 bitory responses at synapses proximal to the soma of CA1 neurons.

177 ts produce a 5- to 6-fold larger EPSP at the soma of CA2 compared with CA1 PNs, which is sufficient t

178 an unusually strong excitatory drive at the soma of CA2 pyramidal neurons, with EPSPs that are 5-6 t

179 actin-capping protein, in the dendrites and soma of cultured hippocampal neurons at different develo

180 Pum2 is restricted to the soma of developing neurons, and Pum2 knockdown or blocki

181 d Tc-Ago3, are also expressed throughout the soma of early embryos.

182 xpressed sex-specifically in the non-gonadal soma of hermaphrodites.

183 cell recordings from the apical dendrite and soma of layer 5 (L5) pyramidal neurons in the anterior c

184 null mutant, TH1-S31A, was restricted to the soma of neuroblastoma cells, with decreased association

185 enance, was dynamically repositioning in the soma of newborn cells during this initial integration st

186 lar transcriptomes of neural projections and soma of primary mouse cortical neurons and two neuronal

187 ric alphaSyn were injected directly into the soma of pyramidal neurons in mouse neocortical brain sli

188 much higher number of L-type channels in the soma of SNc DA neurons, as well as a smaller single-chan

189 The dorsal root ganglia (DRG) contain the somas of first-order sensory neurons critical for somato

190 Here we show that the individual somas of neurons within the retinal ganglion cell (RGC)

191 ase of GluA2 AMPAR subunit expression in the somas of parvalbumin-positive interneurons was identifie

192 age compensation states between germline and soma offer unique perspectives on sex chromosome inferti

193 showing a spatial specificity to either the soma or the axon.

194 interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is dete

195 he soma may explain the deterioration of the soma over time.

196 s that transmit signals between synapses and soma, play a critical role in processing functions, such

197 s are found in subsets of primaries based on soma position and predominantly in secondary fast-twitch

198 We found that neuronal number and soma position are highly conserved.

199 rve to innervate the labrum, indicating that soma position was independent of function and target are

200 morphology to individual neuron types, where soma position, dendritic architecture, and axonal projec

201 severe attenuation as they propagate to the soma, potentially reducing the influence of distal input

202 The absence of natural unicellular, soma-producing species previously prevented these hypoth

203 Slow off-rate modified aptamer (SOMA) protein-binding technology was used to quantify 13

204 ls, the acquisition of the germline from the soma provides the germline with an essential challenge:

205 ace and by simultaneously recording from the soma, proximal and distal dendrites of neocortical pyram

206 ted by a sperm-sensing pathway acting on the soma rather than by fertilization.

207 how abnormalities predominantly within their soma, rather than the apical dendrite.

208 a and the germ line, and tested how fast the soma recovered following partial fin ablation.

209 nimise genetic conflict between germline and soma, relevant to antagonistic pleiotropy, an evolutiona

210 Transgenic cell labeling showed Tac1-Pet1 soma resident largely in the caudal medulla.

211 in that interacts with UNC79 and overcomes a soma-retention signal to achieve dendritic localization.

212 important for axon integrity and for axon-to-soma retrograde signaling, a process critical for axon d

213 depletion of endogenous DAF-15/Raptor in the soma revealed that TORC1 is required at each stage of th

214 quires fully functional germline (sperm) and soma (seminal fluid) components.

215 uire activity at the site of injury, axon-to-soma signaling, and transcription.

216 or Gp130/JAK/STAT3, but not DLK/JNK, axon-to-soma signaling.

217 rating the ratio of dendritic field size vs. soma size (r(d/s) ).

218 rites with increased autophagy, shrinkage of soma size and axonal pathology even in the pons region.

219 multipolar glycinergic cells were smaller in soma size and dendritic area, but over ten-fold more num

220 TOR in the VTA had no significant effects on soma size and dendritic morphology of VTA neurons but si

221 hese four GABAergic subtypes differ in their soma size and distribution among IC subdivisions.

222 TORC1 hyperactivation and increased neuronal soma size and misplacement in a dose-dependent manner.

223 we used cluster analyses based on changes in soma size and roundness to yield novel insights into the

224 M5 ipRGCs can only be distinguished based on soma size and the number of dendritic branch points in c

225 different developmental changes in neuronal soma size and volume of distinct layers in different sub

226 A sex difference in neuronal soma size favoring males was also evident, but only on t

227 dent increases of dendritic arborization and soma size in both mouse and human cultures as measured 7

228 led significantly altered neurite length and soma size in CS patients.

229 Neuronal soma size increased transiently at 6 months of age and d

230 and evaluated the dendritic arbor extent and soma size of each cell according to its specific retinot

231 unbiased stereology was used to compare the soma size of typical pyramidal neurons (n = 2,238) acros

232 ys produced a complete restoration of neuron soma size, and also reversed the significant loss of neu

233 provide estimates of neuron number, neuronal soma size, and volume of the different layers and subdiv

234 A higher microglial soma size-to-process length ratio was observed in the fr

235 mice with corresponding decrease in neuronal soma size.

236 nuclear PTEN alone is sufficient to regulate soma size.

237 s have typically been limited to measures of soma size.

238 the nucleus partially restores regulation of soma size.

239 In the soma, Smed-TTBK-d RNAi impaired the function of multicil

240 Reproductive division of labor (e.g. germ-soma specialization) is a hallmark of the evolution of m

241 Moreover, loss of the soma-specific (CSP-3) and germline-specific (CSP-2) casp

242 creased locomotion at midlife, however, only soma-specific knockdown of nsun-1 extended lifespan.

243 Moreover, soma-specific knockdown of nsun-1 reduced body size and

244 n addition, we find that germline-active and soma-specific promoters have distinct features.

245 Local soma stimulations with micrometer-sized beads evoke tran

246 tion in promoting lysosome biogenesis in the soma, suggesting a potential approach for rescuing lysos

247 verted to the germline at the expense of the soma, suggesting differential impacts of aging on sperm

248 f TRA-1 expression in the entire non-gonadal soma, suggesting that somatic sexual differentiation may

249 s to cell bodies, where they are inserted on soma surfaces and promote phosphorylation of resident na

250 ne immortality comes at the cost of an aging soma [T.

251 In the visual cortex, we use soma-targeted ASAP3 to illustrate cell-type-dependent su

252 Combining a soma-targeted ASAP3 variant and ULoVE, we show single-tr

253 One-photon imaging of soma-targeted GCaMP in dense neural circuits reported fe

254 We designed a high-efficacy soma-targeted opsin, finding that fusing the N-terminal

255 , but only a negligible fraction of putative soma-targeting (parvalbumin-expressing) interneurons, sh

256 inputs as dendrite-targeting excitation and soma-targeting inhibition (the latter contributes non-di

257 xplain how dendrite-targeting excitation and soma-targeting inhibition generate these field potential

258 Thus, soma-targeting of fluorescent calcium indicators facilit

259 Most circuit models postulate that soma-targeting parvalbumin-positive GABAergic neurons ar

260 ificantly more alpha(1) -GABA(A) Rs on their soma than D(1) R-MSN.

261 igher mutation rate in the early segregating soma than in germline, as seen in some animals.

262 ulthood, with greater FMRP reductions in the soma than in the neurite, despite several-fold elevation

263 self-orienting millimeter-scale applicator (SOMA) that autonomously positions itself to engage with

264 Conversely, far from the soma the targets were mostly other excitatory neurons, a

265 Kv 3.1b is restricted to the soma, the primary neurite and the axon branch.

266 molecules are studied on the surface of the soma: the voltage-gated potassium and sodium channels Kv

267 The disposable soma theory is a central tenet of the biology of aging w

268 ories of senescence, such as the 'disposable soma' theory, propose that natural selection trades late

269 BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta production.

270 terograde neuropeptide distribution from the soma to axon terminals, suggesting that the generation o

271 newly synthesized synaptic proteins from the soma to distal synapses, raising the fundamental questio

272 h a polarised microtubule network within the soma to guide growing microtubules towards the axon; whi

273 decrease in a distance-dependent manner from soma to tuft.

274 studied, but how glia interact with neuronal somas to regulate their activity is unclear.

275 For instance, in models with weak soma-to-axon and weak axon-to-soma coupling, IKLT in the

276 rmore, the feedforward combination of strong soma-to-axon coupling and weak axon-to-soma coupling ena

277 We show that strong soma-to-axon coupling promotes the negative feedback eff

278 By using a minimal model of soma-to-axon coupling, we connect structure, dynamics, a

279 d nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathet

280 s retrograde (axon-to-soma) and anterograde (soma-to-axon) traffic of Tau.

281 omosome-regulatory functions contribute to a soma-to-germline model for cancer, in which activation o

282 d semi-simultaneously GCaMP6s signals in the soma, trunk and distal tuft dendrites of layer 5 pyramid

283 al phases of neuron differentiation, such as soma ventral translocation and axonal targeting.

284 fy GFAP-immunoreactive astrocyte density and soma volume in layers I, III, and V of the prefrontal an

285 ders; and unbiased stereology to compare the soma volume of layer V pyramidal and gigantopyramidal ne

286 treatment on the total number, density, and soma volume of septal cholinergic cells, which were visu

287 inin (~8.6 million in number, all of similar soma volume), very few WMICs containing parvalbumin, and

288 million in number, with both small and large soma volumes), calretinin (~8.6 million in number, all o

289 tion (pre/post-zygotic), and site of action (soma vs. germen).

290 the distance of activated synapses from the soma, was dendritic in origin, and involved SK-dependent

291 addition, weakly labeled cells with a large soma were identified as parasol ganglion cells.

292 Ca(2+) transients in the otherwise silent soma were secondary to this peripheral hyperactivity tha

293 reduced alpha-synuclein aggregation in cell somas when axonal terminals were exposed to alpha-synucl

294 beta protein and subsequent transport to the soma, where it can impact axonal growth.

295 antly in the retrograde direction toward the soma, where mature lysosomes are mainly located.

296 vacuoles (AVs) from distal axons toward the soma, where mature lysosomes are mainly located.

297 l detection of action potentials at neuronal soma with sensitivity exceeding genetically encoded volt

298 ut retromer is mislocalized from neuropil to soma with the Rab7 GTPase.

299 ess blocked the CUS-induced decreases in 5HT soma within the DRif and its projections to the mPFC.

300 the normalization of dendritic EPSPs at the soma would increase the importance of input timing versu