ライフサイエンスコーパス: somatotroph

1 hibiting growth hormone release in pituitary somatotrophs.

2 , including via a direct effect on pituitary somatotrophs.

3 triggered secretion only in lactotrophs and somatotrophs.

4 mixed pituitary cells and in highly purified somatotrophs.

5 (ET) receptors were studied in rat pituitary somatotrophs.

6 annels in mixed pituitary cells and purified somatotrophs.

7 ncluding 28 corticotroph, 27 gonadotroph, 24 somatotroph, 17 lactotroph, 5 null-cell and 6 plurihormo

8 These results indicate that in somatotrophs a cyclic nucleotide-controlled plasma membr

9 2 and SSTR5 are involved in GH regulation in somatotroph adenoma cells, whereas SSTR5 exclusively reg

10 a somatostatin receptor ligand that targets somatotroph adenoma GH secretion in patients with acrome

11 These results elucidating somatotroph adenoma pathophysiology identify pathways fo

12 STAT3 and GH expression were concordant in a somatotroph adenoma tissue array.

13 In primary human somatotroph adenoma-derived cell cultures, STAT3 suppres

14 Somatotroph adenomas from patients with or without AIP m

15 Somatotroph adenomas from pituitary-specific Aip-knockou

16 Pituitary somatotroph adenomas result in dysregulated growth hormo

17 ed DNA damage, aneuploidy, and senescence in somatotroph adenomas, we studied links between cAMP sign

18 a potential therapeutic target for pituitary somatotroph adenomas.

19 s in growth hormone-secreting (GH-secreting) somatotroph adenomas.

20 x 1 (POU1F1) as well as severe disruption of somatotroph and thyrotroph differentiation.

21 summary, GHRH-R is specifically expressed in somatotrophs and GH-producing adenomas, suggesting that

22 Rat somatotrophs and lactotrophs exhibit spontaneous burstin

23 rization comparable with signals observed in somatotrophs and lactotrophs.

24 lar to this receptor's actions in the normal somatotrophs and may be involved in the growth of GH-sec

25 e proliferation and maintenance of pituitary somatotrophs and other cell types of the anterior pituit

26 iginating from late-born precursors, such as somatotrophs and POU1F1-dependent thyrotrophs, were seve

27 ence in electrical activity between bursting somatotrophs and spiking gonadotrophs is due to the pres

28 pes, Asic2 in gonadotrophs, thyrotrophs, and somatotrophs, and Asic4 in lactotrophs.

29 although rat anterior pituitary lactotrophs, somatotrophs, and gonadotrophs exhibited spontaneous and

30 p185(c-neu) protein expression in GH3 lacto-somatotroph but not in adrenocorticotropic hormone-secre

31 large conductance potassium (BK) channels on somatotrophs but not on gonadotrophs.

32 e (GH) gene expression in anterior pituitary somatotrophs by binding to the GHRH receptor, a G-protei

33 IGF-1 somatotroph regulation using the MtT/S somatotroph cell line.

34 nous GH mRNA, GH content, pituitary size and somatotroph cell number were also reduced significantly

35 GHRH-R was specifically localized in somatotroph cells in the normal pituitary.

36 ecretion inhibitor (TSI) targeting pituitary somatotroph cells to suppress growth hormone (GH) secret

37 by promoting the proliferation of pituitary somatotroph cells.

38 As somatotroph differentiation and GH secretion are depende

39 mote calcium influx, whereas lactotrophs and somatotrophs fired plateau-bursting action potentials th

40 pathways have been implicated in regulating somatotroph function, the physiological relevance of thi

41 Here we show that rat pituitary somatotrophs generate spontaneous [Ca(2+)](i) oscillatio

42 Blocking BK channels in bursting lacto-somatotroph GH4C1 cells changes their firing activity to

43 th heregulin, the ErbB3 ligand, in rat lacto-somatotroph (GH4C1) tumor cells specifically induced pro

44 Our results suggest that pituitary somatotrophs have the ability to undergo continuous exoc

45 gy did not uncover any pituitary adenomas or somatotroph hyperplasia in either group.

46 cally reduces the numbers of lactotrophs and somatotrophs in the pituitary.

47 n essential role in the specification of the somatotroph, lactotroph and thyrotroph lineages and in t

48 scription factor required for development of somatotroph, lactotroph, and thyrotroph cell lineages an

49 NA and protein were detected in GH3 and MMQ (somatotroph-lactotroph lineages) and TtT/GF cells, and e

50 L gene expression, and reversed EGF-mediated somatotroph-lactotroph phenotype switching.

51 < 0.05), excluding dysfunction of pituitary somatotrophs or GHRH neurons as a cause for the absent G

52 We conclude that cAMP, which induces somatotroph proliferation and GH secretion, may concomit

53 cifically targeting GH secretion rather than somatotroph proliferation may be an advantage in the med

54 that BK channel activation in rat pituitary somatotrophs prolongs membrane depolarization, leading t

55 ET(A) receptors to the G(i)/G(o) pathway in somatotrophs provides an effective mechanism to change t

56 stigate the role of CBP as a target of IGF-1 somatotroph regulation using the MtT/S somatotroph cell

57 alysis implicated FOXO and RUNX1 regulation, somatotroph signaling, and height-related pathways.

58 ic mice expressing the intact hGH locus in a somatotroph-specific manner were generated.

59 In somatotrophs treated with pertussis toxin overnight, the

60 provide evidence that STAT3 directly induces somatotroph tumor cell GH.

61 sitive feedback loop between STAT3 and GH in somatotroph tumor cells.

62 In addition, S3I-201 attenuated somatotroph tumor growth and GH secretion in a rat xenog

63 -interacting protein (AIP) mutations lead to somatotroph tumorigenesis in mice and humans.

64 Somatotroph tumors invaded the medial wall much more oft

65 y complex which is frequently accompanied by somatotroph tumors.

66 owth and PRL secretion in experimental lacto-somatotroph tumors.

67 exocytosis and endocytosis in rat pituitary somatotrophs using patch-clamp capacitance, FM1-43 fluor

68 numbers of corticotrophs, gonadotrophs, and somatotrophs were equally decreased in Pact(-/-) mice wi

69 The RET receptor, uniquely co-expressed in somatotrophs with PIT1, induces apoptosis when unligande