ライフサイエンスコーパス: sophisticated

1 on and frequently prove to be among the most sophisticated.

2 used to analyze these data become ever more sophisticated.

3 gulated, and unreported fishing becomes more sophisticated.

4 is combination is driving the preparation of sophisticated 2D, 3D, and 4D materials at the nano-, mic

5 ot only enables the development of COFs with sophisticated 3D macrostructure but also facilitates the

6 Capabilities for controlled formation of sophisticated 3D micro/nanostructures in advanced materi

7 ake predictions via simple 2D images without sophisticated 3D-imaging equipment and with better than

8 Here we reveal how Yponomeuta moths acquire sophisticated acoustic protection despite being deaf the

9 ble to fix atmospheric nitrogen have evolved sophisticated adaptations to survive to long periods of

10 Bacteria and archaea have evolved sophisticated adaptive immune systems that rely on CRISP

11 Bacteria have evolved sophisticated adaptive immune systems, called CRISPR-Cas

12 We then discuss sophisticated adaptive strategies that bacteria have dev

13 Our results uncover a sophisticated algorithm implemented by the brain to adap

14 c communication network responsible for this sophisticated allosteric machinery.

15 Sophisticated analysis and simplified visualization are

16 be obtained through costly field studies or sophisticated analysis.

17 ated brain conditions become available, more sophisticated analytic approaches are needed to take ful

18 More sophisticated analytical approaches are needed to charac

19 he complexity of the glycosylation patterns, sophisticated analytical tools with high resolving power

20 Engineering mammalian cells to carry out sophisticated and customizable genetic programs requires

21 ent work serves as a starting point for more sophisticated and detailed studies of the history of che

22 Inflammasomes are highly sophisticated and effective orchestrators of innate immu

23 To be able to build sophisticated and efficient molecular machines for an in

24 cept of structural disorder in terms of more sophisticated and interrelated levels of chemical comple

25 Therefore, it is imperative to develop more sophisticated and more biomimetic preclinical cancer mod

26 nd time-dependent monitoring of samples very sophisticated and necessitates exploiting chemometric da

27 e indices have been hampered by the need for sophisticated and not easily reproducible processing ste

28 ale for future in vitro testing that is more sophisticated and reliable, leading to the generation of

29 ess of the trigged stimulus and represents a sophisticated and specialized manner of membrane-enzyme

30 Thus, Ae. aegypti employs a sophisticated antiviral mechanism that promotes viral pe

31 iral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell-intri

32 Furthermore, more sophisticated applications are also conceivable in, e.g.

33 ghlight the opportunities available for more sophisticated applications that could take full advantag

34 y of mental health and illness making such a sophisticated approach particularly suitable.

35 on and favourable printing speed, offering a sophisticated approach to fabricate bespoke medical devi

36 In addition, more sophisticated approaches applied to global protein-prote

37 As important as they are, even the most sophisticated approaches are unable to provide meaningfu

38 esulted in the emergence of novel and highly sophisticated approaches for studying hypothalamic neuro

39 support the design of MOFs with increasingly sophisticated architectures.

40 from preceding generations to engineer more sophisticated architectures.

41 Immune cells and epithelium form sophisticated barrier systems in symbiotic relationships

42 or, allowing the efficient implementation of sophisticated behavioral paradigms to study the mechanis

43 e largest brains, they also express the most sophisticated behaviors [17].

44 The emergence of new and increasingly sophisticated behaviors after birth is accompanied by dr

45 ire explanation: the tension between certain sophisticated beliefs about time, and certain phenomenol

46 equires the implementation and connection of sophisticated (bio)analytical methods.

47 uctures, such as tissues and organs, towards sophisticated biodevice personalization.

48 mains incompletely analyzed due to a lack of sophisticated bioinformatic tools and field-specific bio

49 nd disease categories requires appropriately sophisticated bioinformatics approaches and thorough val

50 However, the considerable size of many sophisticated biologging devices restricts their applica

51 potential to extremely enrich the design of sophisticated biological agents.

52 capturing some of the essential features of sophisticated biological devices like skeletal muscles.

53 odules will enable the development of highly sophisticated biomachines that will make today's smartph

54 This represents a sophisticated but efficient immune evasion strategy to a

55 reasing number of artificial agents, display sophisticated capabilities to perceive and manipulate ob

56 fabrication of advanced delivery systems as sophisticated carriers for therapeutic agents.

57 tion induced mode switching does not rely on sophisticated cavity designs and is generic in a series

58 al response when appropriate is critical for sophisticated cell engineering using synthetic biology.

59 ling in eukaryotes that likely contribute to sophisticated cellular control mechanisms operating on v

60 These pathways constitute a highly sophisticated cellular control system in Bacteria and Ar

61 While we have an increasingly sophisticated cellular description of this journey, our

62 ded insights toward our understanding of how sophisticated cellular machineries shape such hierarchic

63 Instead, more sophisticated certification systems, that allow accurate

64 rom all fields is needed to address the many sophisticated challenges that remain, not the least of w

65 cial behaviours in termites are regulated by sophisticated chemical communication systems.

66 Sophisticated chemical processes widely observed in biol

67 that compare favourably to those of the most sophisticated clinical standards for non-resorbable devi

68 s to analyze their data without the need for sophisticated command-line skills.

69 As the electronic health record becomes more sophisticated, commensurate advances in cost accounting

70 dely adopted ontologies that together enable sophisticated computational analysis, mechanistic discov

71 ding specificities from these data, numerous sophisticated computational methods have been developed.

72 any researchers in this field have developed sophisticated computational models for application to sp

73 We used a sophisticated computational search of thousands of expre

74 with microfluidic interfaces has resulted in sophisticated conformal devices for biofluid sampling an

75 The adoption of a sophisticated, Coppice-with-Standards (CWS) management p

76 otor control in primates, alongside the more sophisticated corticospinal system.

77 he prototype (ii) improve and develop a more sophisticated cyber-physical system to sense and impose

78 n FT-ICR MS by developing and implementing a sophisticated data acquisition and data processing pipel

79 proach was analysed for the first time using sophisticated data-independent analysis by mass spectrom

80 Herein, we develop and test a sophisticated deep brain network (DeepBrainNet) using a

81 Preparation of sophisticated delivery systems for nanomedicine applicat

82 chanism of these long coherence lifetimes, a sophisticated description of interactions between the mo

83 , glassy carbon electrode, etc.) can undergo sophisticated design to detect chemicals/biologicals fro

84 Numerous sophisticated diagnostic techniques have been designed t

85 We show our approach is able to learn sophisticated drug-target topological features and outpe

86 nerating spatiotemporal beams with even more sophisticated dynamic properties.

87 r-order, and complex DNA objects, as well as sophisticated dynamic substrates for various application

88 synthesis techniques have led to a range of sophisticated electrocatalysts, mostly based on expensiv

89 ation of conjugated polymers for wafer-scale sophisticated electronics.

90 There is now a growing battery of sophisticated empirical and computational techniques tha

91 Thus, humans' sophisticated encoding of sensory stimuli that provides

92 eaction is sufficient, albeit supported by a sophisticated energy-coupling process termed flavin-base

93 el with the systematic consideration of more sophisticated ensemble approaches.

94 iae Although S. pneumoniae is known to use a sophisticated enzyme machinery to attack the human glyco

95 Virtual Pediatric Systems database allow for sophisticated epidemiologic studies of pediatric severe

96 gle-base discrimination without the need for sophisticated equipment, large volumes, or elaborate sam

97 gens and antibodies cost-effectively without sophisticated equipment; however, they are less sensitiv

98 l systems, and enables the implementation of sophisticated estimation techniques to quantify paramete

99 on from 3,4-DCNB by DcnAaAbAcAd represents a sophisticated evolution of the nitroarene dioxygenase th

100 time consuming, labor intensive and require sophisticated expensive instruments, thus not suitable f

101 We consider a hierarchy of increasingly sophisticated experiments in which the minimal parameter

102 uillet et al. report a series of elegant and sophisticated experiments to quantitatively understand H

103 ricate microarchitectures typically requires sophisticated fabrication techniques such as flow lithog

104 ective and straightforward, does not require sophisticated facilities, and can be potentially employe

105 The method accounts properly for sophisticated features of gene segregation and recombina

106 id spermbots, can be engineered to integrate sophisticated features optimised for precision-targeting

107 e co-evolved to modify host plants to create sophisticated feeding cells and suppress plant defenses.

108 f the epidermis composes the skin barrier, a sophisticated filter constituted by layers of corneocyte

109 ia can process the remaining information, or sophisticated filtering policies that may not scale to t

110 Natural MAPs, however, show a more sophisticated functionality beyond lattice-diffusion.

111 cluding its entry into cells, its remarkably sophisticated gene expression and replication mechanisms

112 Sophisticated gene-regulatory mechanisms probably evolve

113 Importantly, Drosophila allow quick and sophisticated genetic manipulations, permit functional t

114 ecially for complex experimental designs and sophisticated genetic screens.

115 New studies that take advantage of sophisticated genetic tools for cell-type-specific ident

116 neic grafts in vivo Thus, when combined with sophisticated genetic tools, the ESC-GEMM platform enabl

117 the study of model organisms and the use of sophisticated genetic, biochemical and imaging tools.

118 omises to expedite development of additional sophisticated genetic/genomic tools in Drosophila.

119 convection avoids the use of the complex and sophisticated hardware that is required for precise main

120 enable a clinical diagnostic capability to a sophisticated head injury model, such as facilitating he

121 the origin of criminal law is a cognitively sophisticated human nature.

122 in Sri Lanka that demonstrates specialized, sophisticated hunting of semi-arboreal and arboreal monk

123 0 images of dried blood droplets, developing sophisticated image processing analysis routines and opt

124 t0819/FIG1F1fig1The age of big data includes sophisticated imaging datasets.

125 The introduction of sophisticated immunomodulatory therapies has given renew

126 nt mechanisms of action suggesting that such sophisticated in vitro approaches may facilitate improve

127 we find that shape perception also involves sophisticated inferences that parse shapes into features

128 scussion: 'Integration could also allow more sophisticated information processing, for example as sho

129 With its sophisticated infrastructure and a large selection of fl

130 nventional MTB DNA detection methods require sophisticated infrastructure and well-trained personnel,

131 global population due to the requirements of sophisticated instrumentation and trained personnel.

132 ical analytical tools without requirement of sophisticated instrumentation have become attractive, al

133 s either entail low-throughput analysis with sophisticated instrumentation, or offer the potential fo

134 ood and environmental samples often required sophisticated instrumentation, which restrains the acces

135 y, a technique which is applicable with less sophisticated instrumentation.

136 t strategies for GSH detection often require sophisticated instruments that may not be available in l

137 tion at the ppt level in milk normally needs sophisticated instruments, a larger amount of sample, an

138 R while real-time PCR requires expensive and sophisticated instruments.

139 Understanding the sophisticated interactions among arthropod vectors, micr

140 all-inducing insects and nematodes engage in sophisticated interactions with their host plants.

141 Autophagy, a sophisticated intracellular process first described for

142 ercome these difficulties, we present here a sophisticated inverted RDE (iRDE) cell design.

143 r head-fixation, of awake rodents allows for sophisticated investigation of neural circuits in vivo,

144 ular biology techniques and does not require sophisticated laboratory equipment.

145 Controlling gene expression with sophisticated logic gates has been and remains one of th

146 Lately, sophisticated machine learning techniques are applied in

147 speech recognition (ASR) systems, which use sophisticated machine-learning algorithms to convert spo

148 During the exit step, the virus hijacks the sophisticated machineries that host cells employ to corr

149 the evolution of conventional computers into sophisticated machines, there are many classes of proble

150 t activation of innate immune responses in a sophisticated manner.IMPORTANCE BK polyomavirus can caus

151 While most research in this field uses sophisticated masks implemented using spatial light modu

152 teric disulfides are firmly established as a sophisticated means by which a protein's shape and funct

153 Sophisticated mechanically interlocked molecules (MIMs)

154 Together, our results reveal a sophisticated mechanism by which ABA receptors are targe

155 Consequently, the existence of sophisticated mechanisms that tightly regulate the speci

156 nd behavior, animals and humans have evolved sophisticated mechanisms to detect temperature changes.

157 Eukaryotic cells have developed sophisticated mechanisms to ensure the integrity of the

158 We conclude that gaze cueing is a sophisticated mental phenomenon: It is not merely driven

159 grams provide the most compelling account of sophisticated mental representations.

160 This sophisticated metal-dependent dynamic equilibrium may ap

161 exciting advances, coupled with increasingly sophisticated methods for generating radiopharmaceutical

162 outlined, which currently represent the most sophisticated methods for modeling nanoparticle dynamics

163 Increasingly sophisticated methods have been used to identify gaps in

164 Sophisticated methods of tracking, sensing, and stimulat

165 We show that even sophisticated methods, applied to unlimited data from ev

166 nhibitory and excitatory neurons, which form sophisticated microcircuits for processing and transmitt

167 an be easily adopted in laboratories lacking sophisticated microinjection equipment, and can be imple

168 as expanded the possibilities of fabricating sophisticated microvascular systems by enabling precise

169 The data deluge can leverage sophisticated ML techniques for functionally annotating

170 Here we report a sophisticated mode of regulation by a tRNA-cleaving toxi

171 have generated a TRPA1 KO rat to enable more sophisticated modeling of pain, itch, and asthma.

172 results of this work emphasise the need for sophisticated models in order to explain subtle differen

173 s to cellular dynamics and will lead to more sophisticated models in the future.

174 parasite, Plasmodium falciparum, to acquire sophisticated molecular mechanisms to ensure its surviva

175 he LegK7-MOB1A complex, our study unravels a sophisticated molecular mimicry strategy that is used by

176 reening with network information can uncover sophisticated molecular response programs.

177 Sophisticated MRI techniques provide high-resolution ima

178 Together, we provided a novel sophisticated multi-assay screening platform to test pre

179 ple assessment of tumor location and size to sophisticated multimodality exploration of molecular, ph

180 Here, we apply mass spectrometry to a sophisticated multiorgan human-on-a-chip system for the

181 Contractile injection systems are sophisticated multiprotein nanomachines that puncture ta

182 res many hundreds of proteins acting through sophisticated multistep mechanisms.

183 gies for compositionally and architecturally sophisticated nanocrystals.

184 evelopment of more efficient, selective, and sophisticated nanopore-based nanofluidic devices.

185 immune response against difficult pathogens, sophisticated nanovaccine technologies are under investi

186 Animals and humans evolved sophisticated nervous systems that endowed them with the

187 Vertebrates have evolved the most sophisticated nervous systems we know.

188 pread throughout the country, constituting a sophisticated network of "people as sensors" that provid

189 ctions that explicitly take into account the sophisticated network of chemical interactions regulatin

190 Copper is controlled by a sophisticated network of transport and storage proteins

191 ing the effects of habituation in other more sophisticated neural systems.

192 ion-based navigation in Cataglyphis requires sophisticated neuronal networks to process the broad rep

193 ll and spatial transcriptomics, has fostered sophisticated new methods to reconstruct lineage relatio

194 (2020) use sophisticated Notch- based genetic tools to uncover high

195 of these complex cell configurations require sophisticated numerical calculation.

196 Aside from the precise control in sophisticated on-surface synthesis, this work proposes a

197 le amplification (RCA) are restricted by the sophisticated operation steps and unsatisfactory picomol

198 plex genetic systems and circuits to perform sophisticated operations in living cells.

199 The sophisticated optics of the lens and its gradient of ref

200 ew possibilities for generating structurally sophisticated out-of-equilibrium species.

201 tect epistasis will be a key for discovering sophisticated pathogenesis, which is especially importan

202 set the stage for the advent of increasingly sophisticated pathways operating under catalytic control

203 omarkers of cardiovascular disease, applying sophisticated, pattern-revealing technologies to growing

204 eneralize over the proto-lexicon to generate sophisticated phonotactic knowledge, which lets them eva

205 Herein, we synthesize a sophisticated porphyrin nanocage that is further functio

206 tein components, should enable the design of sophisticated posttranslational control logic over a wid

207 tabolomics techniques, NMR spectroscopy is a sophisticated, powerful, and generally applicable spectr

208 no clinically relevant improvement when more sophisticated prediction models were used.

209 el information and the application of a more sophisticated predictive model, a well-parametrized supp

210 of bacterial stress responding sigma(S) is a sophisticated process and mediated by multiple interacti

211 lipid membrane though a stepwise and highly sophisticated process.

212 fashion are ubiquitous in nature and govern sophisticated processes such as development and differen

213 ases has greatly improved, resulting in more sophisticated prognostic models and multiple patient-rel

214 Many genes are subject to sophisticated programs of transcriptional regulation, me

215 Sophisticated properties of gold complexes with Au...Au

216 Biological systems exhibit strikingly sophisticated properties, including adaptability, direct

217 er molecules, which were studied by means of sophisticated quantum chemical investigations.

218 work independently and together to generate sophisticated rapid motor responses that integrate plann

219 This finding indicates the need for sophisticated reader training emphasizing known pitfalls

220 autonomous experimentation have become more sophisticated recently, allowing for multi-dimensional p

221 ge which is perfectly consistent with a more sophisticated regression analysis technique based on Tay

222 These provide sophisticated regulation of neuronal excitability and sy

223 and pathological conditions, suggesting that sophisticated regulatory mechanisms to coordinate and pr

224 Cells use sophisticated repair machineries to detect and heal DSBs

225 ent findings and current perspectives on the sophisticated repertoire of cellular and molecular featu

226 f using high-resolution regional models with sophisticated representations of land-atmosphere feedbac

227 In eukaryotes, initiation is sophisticated, requiring dozens of protein factors and 2

228 Finally, through sophisticated research methods, they clarify the results

229 ful to apprise the research community of the sophisticated research tools currently available for cha

230 Sophisticated risk stratification for children with RMS

231 Recently, more sophisticated RL algorithms have been proposed to better

232 interacting and collaborating with socially sophisticated robots.

233 trate a design paradigm that circumvents the sophisticated routing and size limitations intrinsic to

234 ing are commonly used techniques but require sophisticated sample preparation and long incubation tim

235 front-end with download functionality offers sophisticated search functionalities and tracks the orig

236 Sophisticated sentimentalists should take note of this w

237 is not only an inspiring technique to create sophisticated shapes, but also a surprisingly powerful m

238 the probes that can be partially overcome by sophisticated signal amplification methods.

239 radation stations, lysosomes have emerged as sophisticated signalling centres that govern cell growth

240 It permits highly sophisticated simulations to be set up with little codin

241 , and increasingly, these analyses depend on sophisticated simulations.

242 have led to robots endowed with increasingly sophisticated social abilities.

243 petitors to field-monitoring instruments and sophisticated spectrophotometers.

244 short light pulses and to the development of sophisticated spectroscopic techniques, which greatly in

245 Here, we used sophisticated statistical and phylogenetic methods to an

246 takes many hours to complete involving many sophisticated steps.

247 otein micro/nanopatterning has long provided sophisticated strategies for a wide range of application

248 ess can be incredibly complex, necessitating sophisticated strategies that are difficult to translate

249 To counter this, some viruses have evolved sophisticated strategies to circumvent immune cell recog

250 HSV1 has evolved highly sophisticated strategies to evade host immunosurveillanc

251 Our results provide evidence that people use sophisticated strategies to explore complex, real-world

252 acterial vector-borne pathogens have evolved sophisticated strategies to interact with their hemipter

253 ry low CO(2) states, Chlamydomonas induces a sophisticated strategy known as a CO(2) -concentrating m

254 e that even without physical purification, a sophisticated strategy of differential filtering, correl

255 sk mitigation and prompt treatment rely on a sophisticated strategy to address the contributing facto

256 Sophisticated structural elucidation studies identified

257 troma has always been a challenge due to its sophisticated structure and keratocyte-fibroblast transf

258 amolecular cages/vesicles in biology display sophisticated structures and functions by utilizing a fe

259 y amines, allow the formation of complex and sophisticated structures through a trial-and-error mecha

260 this Opinion piece we highlight a series of sophisticated studies describing the identification of u

261 nabled this humanized mouse model for highly sophisticated studies involving cell type-specific trans

262 ible protein analysis for these increasingly sophisticated studies.

263 d provide a new approach to construct highly sophisticated supramolecular architectures.

264 While sometimes a sophisticated synthesis route can address this issue, of

265 rosstalk is a major challenge to engineering sophisticated synthetic gene networks.

266 genome description of strain WSUCF1 suggests sophisticated systems for its adaptation under thermophi

267 circuits are promising tools for developing sophisticated systems for medical, industrial, and envir

268 excitability, and enabled the development of sophisticated systems for rapid and long-range signaling

269 Sophisticated systems-level control mechanisms involving

270 oncentrations was set up and monitored using sophisticated targeted elementary and metabolite analysi

271 se to therapy has called for the use of more sophisticated techniques, such as whole-body low-dose co

272 pling campaigns need to be considerably more sophisticated than at present to capture the full deep-s

273 mbryophytes possessed stomata that were more sophisticated than previously envisioned and that the st

274 d assays to measure immunogenicity were less sophisticated than today.

275 y, and treatment duration have become highly sophisticated, the challenge of widespread application o

276 anced EES systems are becoming more and more sophisticated, the methodologies to reliably evaluate th

277 The relative scarcity of sophisticated theoretical models that include sufficient

278 We also consider the more sophisticated therapeutic strategies under active invest

279 Fruit have evolved a sophisticated tissue and cellular architecture to secure

280 Taken together, these results elucidate the sophisticated, tissue-dependent role of the circadian cl

281 nome annotation server MITOS to an even more sophisticated tool for fully automatic annotation of met

282 Biosensors became the most sophisticated tool for the detection of glucose and insu

283 s the presented ATR module into an even more sophisticated tool.

284 ethods, providing gold standard networks and sophisticated tools for on-the-fly comparative analyses

285 In parallel, sophisticated tools have been developed to process, visu

286 logistic regression perform as well as more sophisticated tools.

287 Eukaryotes evolved a sophisticated trafficking system which allows proteins t

288 Contemporary semantics has uncovered a sophisticated typology of linguistic inferences, charact

289 However, despite our sophisticated understanding of how conflict shapes socia

290 One example is the progressively sophisticated understanding of how extinction underlies

291 othesis in light of the field's increasingly sophisticated understanding of neuronal circuits.

292 findings will be a starting point for a more sophisticated understanding of piezo2 roles in light-tou

293 e North American Pacific Northwest reveals a sophisticated use of iron oxide produced by the biominer

294 re difficult to use for even technologically sophisticated users.

295 (phages), are no exception and have evolved sophisticated ways to control essential biosynthetic mac

296 ver, to harness their therapeutic potential, sophisticated ways to manipulate MiT factor activity saf

297 diaza-benzo[a]fluorene derivatives has been sophisticated, which includes oxygen and AcOH-induced ox

298 polysomnography because they do not require sophisticated wiring.

299 tive capacities central to TTOM also support sophisticated yet remarkably early-emerging inferences a

300 ize require that these pathogens must employ sophisticated, yet parsimonious mechanisms to effectivel