ライフサイエンスコーパス: spermatozoa

1 s (spermatid activation into actively motile spermatozoa).

2 ion and abnormal head morphologies in mature spermatozoa.

3 oximately 500-fold and is barely detected in spermatozoa.

4 ed expanding clones that gave rise to mature spermatozoa.

5 , however, did not impair the motility of WT spermatozoa.

6 erentiating daughter cells for production of spermatozoa.

7 effective but underused method to safeguard spermatozoa.

8 le others differentiate to eventually become spermatozoa.

9 enes potentially involved in the function of spermatozoa.

10 concentration, total volume, and motility of spermatozoa.

11 and terminal differentiation into functional spermatozoa.

12 is expressed in ciliated sensory neurons and spermatozoa.

13 s previously thought to be expressed only on spermatozoa.

14 flagellum between testicular and epididymal spermatozoa.

15 ractant concentration gradient detectable by spermatozoa.

16 e BTB and spermatocyte progression to mature spermatozoa.

17 A1-GFP fusion protein (57 kDa) in transgenic spermatozoa.

18 ifferentiation of the haploid spermatid into spermatozoa.

19 ne recombination of floxed alleles in ~2% of spermatozoa.

20 the superfluous cytoplasm of defective human spermatozoa.

21 and the induction of oxidative DNA damage in spermatozoa.

22 oxidase is expressed and functions in human spermatozoa.

23 studied in fish, aquatic invertebrates, and spermatozoa.

24 equired for optimal superoxide production by spermatozoa.

25 Seminal plasma is not just a carrier for spermatozoa.

26 MO acidification and formation of functional spermatozoa.

27 necessary for acrosomal exocytosis in mouse spermatozoa.

28 P1CC2 is the sole isoform found in mammalian spermatozoa.

29 ss associated with the development of mature spermatozoa.

30 form spermatids into fertilization-competent spermatozoa.

31 med in vitro fertilization cycle using fresh spermatozoa.

32 by antibodies alone are functional in mouse spermatozoa.

33 ing somatic gonad, giving rise to oocytes or spermatozoa.

34 n detected in the head or midpiece of mature spermatozoa.

35 to induce ion channel currents in the whole spermatozoa.

36 ding the egg is a potent stimulator of human spermatozoa.

37 seminiferous epithelium for development into spermatozoa.

38 intracellular alkalinization and activating spermatozoa.

39 a, spermatocytes, spermatids, and eventually spermatozoa.

40 ferentiation of round spermatids into mature spermatozoa.

41 competition is the cooperative behaviour of spermatozoa.

42 in germ cells ranging from spermatogonia to spermatozoa.

43 velope and cytoplasmic droplet of epididymal spermatozoa.

44 rial segment, neck and the midpiece of human spermatozoa.

45 ocalized to the centrioles of spermatids and spermatozoa.

46 eriments using motile Caenorhabditis elegans spermatozoa.

47 eteroduplex DNA at crossover sites in mature spermatozoa.

48 , which account for the steady production of spermatozoa.

49 nitor spermatogonia that develop into mature spermatozoa.

50 rvation of ejaculated, papain-treated alpaca spermatozoa.

51 nvironment for the maturation and storage of spermatozoa.

52 reactions) and fragmentation of DNA in human spermatozoa.

53 can be achieved after AI with papain-treated spermatozoa.

54 ither fresh, papain-treated or frozen-thawed spermatozoa.

55 spermatids elongate into chromatin-condensed spermatozoa.

56 inate with morphological transformation into spermatozoa.

57 ly diminished hyperactivation of capacitated spermatozoa.

58 erm-line stem cells, and ending with haploid spermatozoa.

59 ecific genes and histone retention in mature spermatozoa.

60 production in treated versus non-treated WT spermatozoa.

61 lize ova relies upon the swimming ability of spermatozoa.

62 by MJ33 on fertilization competence of mouse spermatozoa.

63 tion of spermatid elongation, and release of spermatozoa.

64 enrichment of the atypical centrioles in the spermatozoa.

65 for further development and maturation into spermatozoa.

66 e eye and on the inner acrosomal membrane of spermatozoa.

67 ticular morphology and comparable numbers of spermatozoa.

68 he calcium response to progesterone in human spermatozoa.

69 rrant miRNA profiles in Dicer and Drosha cKO spermatozoa.

70 ility and ultrastructural disorganization of spermatozoa.

71 Men with >15% of SPTRX3-positive spermatozoa, a cutoff value established by ROC analysis,

72 testis lacks elongated spermatids and mature spermatozoa, a phenotype similar to that of alpha-mannos

73 In spermatozoa, a small proportion of chromatin, which rang

74 Spermatozoa agglutinated head-to-head show contact-induc

75 tilization (IVF) that failed with epididymal spermatozoa alone.

76 spermatids that cannot activate to crawling spermatozoa, although spermatids from mutant males activ

77 hin the periacrosomal region of mature mouse spermatozoa and are thus well positioned to regulate the

78 0 nt was extracted from sonicated (SS) mouse spermatozoa and detergent demembranated sucrose gradient

79 substantial remodeling of the glycocalyx of spermatozoa and epididymal epithelial cells by endogenou

80 nic acid residues was detected in epididymal spermatozoa and epithelial cells using combined laser mi

81 Many microorganisms, including spermatozoa and forms of bacteria, oscillate or twist a

82 e KLOTHO is expressed in both germ cells and spermatozoa and forms with FGFR1 a specific receptor for

83 Here we show that in intact spermatozoa and in a heterologous expression system, the

84 that NOX5 is a major source of ROS in human spermatozoa and indicate a role for NOX5-dependent ROS g

85 evel of Atp6v0a2 is required for the fertile spermatozoa and its decreased level in spermatozoa could

86 tnatal period is essential for production of spermatozoa and male fertility.

87 required for the hyperactivated motility of spermatozoa and male fertility.

88 ivation of Spata6 in mice leads to acephalic spermatozoa and male sterility.

89 cell viability compared with wild type (WT) spermatozoa and often were detected in large agglutinate

90 Their concentration of spermatozoa and percentage of morphologically normal spe

91 issues linked to immediate removal of excess spermatozoa and preparation of the uterus for implantati

92 proved motility, fertilizing capacity of cat spermatozoa and prevented acrosomal exocytosis in vitro.

93 number, an increased proportion of abnormal spermatozoa and reduced fertility.

94 ces in metabolism to 3-chlorolactaldehyde in spermatozoa and somatic cells.

95 roxidation, target the mitochondria of human spermatozoa and stimulate mitochondrial superoxide gener

96 her alterations of the sialome of epididymal spermatozoa and surrounding epithelial cells occur durin

97 en without any apparent cytotoxic effects on spermatozoa and that these structures change along the l

98 fusion pores during the acrosome reaction in spermatozoa and the mobilization of calcium from the acr

99 in the mouse results in a binding defect in spermatozoa and their inability to pass through the uter

100 ons, contributes to the prodigious output of spermatozoa and to the elaborate organization of spermat

101 Progesterone induces Ca(2+) influx into spermatozoa and triggers multiple Ca(2+)-dependent physi

102 were also expressed in human germ cells and spermatozoa, and FGF23 treatment augmented the calcium r

103 living single cells (e.g. bacteria, archaea, spermatozoa, and protozoa).

104 nt motile and percent morphologically normal spermatozoa, and testis size.

105 indeed the principal Ca(2+) channel of human spermatozoa, and that it is strongly potentiated by prog

106 the AR in sperm from WT but not alpha7-null spermatozoa, and the induced AR was inhibited by alpha7

107 In the distal epididymis, these spermatozoa appear to lack calcium-dependent association

108 The remaining spermatozoa are abnormal with impaired motility and fert

109 ed that significantly demonstrated that boar spermatozoa are attracted by a progesterone gradient.

110 Eutherian spermatozoa are dependent on the environment of the prox

111 evelopment in Drosophila ensures that mature spermatozoa are devoid of DNA.

112 pment and increases gradually to a peak when spermatozoa are ejaculated.

113 ored whether steroid hormones to which human spermatozoa are exposed in the male and female genital t

114 Human spermatozoa are quiescent in the male reproductive syste

115 Mature mammalian spermatozoa are quiescent in the male reproductive tract

116 ygous male mice present with massive loss of spermatozoa as a consequence of meiotic failure.

117 nalyses on the testis squash preparation and spermatozoa at a subcellular level indicated that the pr

118 liosides in the plasma membrane of live boar spermatozoa before and after cholesterol reduction.

119 Human fertilization begins when spermatozoa bind to the extracellular matrix coating of

120 At fertilization, spermatozoa bind to the zona pellucida (ZP1, ZP2, ZP3) s

121 We show that ABHD2 is highly expressed in spermatozoa, binds progesterone, and acts as a progester

122 ntial for the function of the epididymis and spermatozoa, but ATP release in the epididymis remains u

123 Proteasomes are present in human and boar spermatozoa, but little is known about the interactions

124 expression of Smed-TTBK-d results in loss of spermatozoa, but not spermatids.

125 ially in membranes of the retina, brain, and spermatozoa, but the functional significance of this lar

126 non-genomic action of progesterone on human spermatozoa by identifying the Ca(2+) channel activated

127 action of Hv1 and CatSper channels in human spermatozoa can induce elevation of both intracellular p

128 sence of RNAs in transcriptionally quiescent spermatozoa can only be derived from transcription that

129 matogenesis to occur, and that production of spermatozoa capable of fertilization in vivo can take pl

130 In spermatozoa, capacitation, hyperactivation of motility a

131 hat the ultrastructure of the matured sperm (spermatozoa) centrioles is modified dramatically and tha

132 alysis revealed morphological defects in the spermatozoa collected from the cauda epididymis of Ncoa5

133 activity and reduced these parameters in WT spermatozoa compared with controls (p </= 0.05).

134 sence leads to impaired peristalsis, reduced spermatozoa concentration in the semen, and, eventually,

135 ges are influenced by seminal fluid, the non-spermatozoa-containing component of semen, we injected q

136 rtile spermatozoa and its decreased level in spermatozoa could be used to predict male infertility.

137 igh percentage of decapitated and decaudated spermatozoa (DDS), whose semen contains abnormal spermat

138 ility of the mitochondrial capsule of mature spermatozoa depends on the moonlighting function of Gpx4

139 Mammalian oocytes and spermatozoa derive from fetal cells shared by the sexes.

140 tment with these inhibitors also resulted in spermatozoa displaying reduced acrosome reaction potenti

141 Third, we evaluated ROS in zebrafish spermatozoa during cryopreservation and its effect on vi

142 2) = 0.89) in untreated populations of human spermatozoa emphasized the pathophysiological significan

143 le germ cells differentiate to become mature spermatozoa, entails dramatic morphological and biochemi

144 Furthermore,Cul4b(Vasa)spermatozoa exhibited defective arrangement of axonemal

145 Functionally, spermatozoa exposed to calcium ionophore, phorbol ester,

146 Mouse spermatozoa express a pH-dependent K(+) current (KSper)

147 tic subcellular reorganizations that lead to spermatozoa formation common to a wide range of animals.

148 ered with spermatogenesis proceeding through spermatozoa formation in 13% to 17% of the seminiferous

149 ord, maternal, and paternal blood as well as spermatozoa from 39 families in Crete, Greece, and the U

150 p6v0a2 protein (P<0.05) and mRNA (P<0.05) in spermatozoa from infertile men were significantly lower

151 Furthermore, spermatozoa from L68Q mice exhibited reduced cell viabil

152 Examination of the epididymal fluid and spermatozoa from L68Q mice showed increased levels and d

153 In vitro studies showed that epididymal spermatozoa from L68Q mice were unable to fertilize oocy

154 Spermatozoa from Nhe8(-/-) mice completely lacked acroso

155 Spermatozoa from older knockout mice showed a lower perc

156 swim-up failed to remove all SPTRX3-positive spermatozoa from semen prepared for ART.

157 ce lacking alpha4 are completely sterile and spermatozoa from these mice are unable of fertilizing eg

158 Mammalian spermatozoa gain competence to fertilize an oocyte as th

159 testes, and its absence resulted in reduced spermatozoa generation, lower actin levels in testes, an

160 The percentage of SPTRX3-positive spermatozoa had predictive value for pregnancy after ART

161 Regulation of ion balance in spermatozoa has been shown to be essential for sperm mot

162 Instead, we find that mouse spermatozoa have a cation-nonselective current in the mi

163 te the loss of ATP-gated current, P2rx2(-/-) spermatozoa have normal progressive motility, hyperactiv

164 r identity of the potassium channel of human spermatozoa (hKSper) is unknown.

165 spe-45 mutant spermatozoa, however, could not complete gamete fusion,

166 conversion of sessile spermatids into motile spermatozoa, implicating PI(3,4,5)P3 signaling in nemato

167 Development of spermatozoa in adult mammalian testis during spermatogen

168 ior to any surgical procedure to try to find spermatozoa in an azoospermic man.

169 emonstrated in capacitated and uncapacitated spermatozoa in low- and high-viscosity media.

170 S during in vitro capacitation of fresh boar spermatozoa in relation to changes in sperm proteome.

171 Together, we reveal that fertilizing mouse spermatozoa in situ are characterized by intact CatSper

172 ted in decreased motility and progression of spermatozoa in the cauda epididymis, leading to infertil

173 utinations in the efferent ducts and lack of spermatozoa in the epididymis (azoospermia).

174 in sperm number and the presence of abnormal spermatozoa in the epididymis.

175 Spermatids subsequently give rise to spermatozoa in the final phase of spermatogenesis, calle

176 but occasionally spermatids and rarely a few spermatozoa in the semen were observed.

177 o expression and Orco-mediated activation of spermatozoa in the yellow fever mosquito, Aedes aegypti.

178 The migratory abilities of motile human spermatozoa in vivo are essential for natural fertility,

179 the respiratory burst, in pH regulation, in spermatozoa, in apoptosis, and in cancer metastasis.

180 cell viability and motility compared with WT spermatozoa incubated in epididymal fluid from WT mice.

181 Mammalian spermatozoa indeed undergo complex adaptations within th

182 Physiological and pathological processes in spermatozoa involve the production of reactive oxygen sp

183 ocalization of TRP-3/SPE-41 in spe-38 mutant spermatozoa, ionomycin or thapsigargin induced influx of

184 in the site of fertilization in the knockout spermatozoa is associated with a gradual loss of ADAM3 a

185 Producing mature spermatozoa is essential for sexual reproduction in meta

186 nclude that the ATP-induced current on mouse spermatozoa is mediated by the P2X2 purinergic receptor/

187 gesterone-dependent Ca(2+) influx into human spermatozoa is primarily mediated by cationic channel of

188 We suggest that AeAmt1 function in spermatozoa is to protect against ammonia toxicity based

189 ation of stem cells into millions of haploid spermatozoa--is elaborately organized in time and space.

190 schild of phase synchrony of nearby swimming spermatozoa, it has been a working hypothesis that synch

191 pecific CATSPERdelta are infertile and their spermatozoa lack both Ca(2+) current and hyperactivated

192 -out of the reproductive system and the tiny spermatozoa lacking a visible flagellum, suggest they be

193 the mouse ZP but did not inhibit adhesion of spermatozoa lacking zonadhesin.

194 dic chip to test the chemotactic response of spermatozoa made out of a hybrid hydrogel (8% gelatin/1%

195 were observed in the majority of the mutant spermatozoa, manifested by low, if any, sperm ATP produc

196 taxa and posit that OR-mediated responses in spermatozoa may represent a general characteristic of in

197 structural abnormalities particularly in the spermatozoa midpiece due to improper oxidation and polym

198 Normal epididymal sperm count, spermatozoa morphology, capacitation, and motility and r

199 e in Ncoa5(+/-) male mice partially improved spermatozoa motility and moderately rescued infertility

200 on channel, which was recently implicated in spermatozoa motility, was required for optimal superoxid

201 ll autonomously in male germ cells to ensure spermatozoa motility, whereas it functions non-cell-auto

202 e for NOX5-dependent ROS generation in human spermatozoa motility.

203 Mammalian spermatozoa must complete an acrosome reaction prior to

204 Spermatozoa must leave one organism, navigate long dista

205 ed, generation (n = 3 + 3) and also in adult spermatozoa (n = 2 + 2) in both generations.

206 crine system essential for testis-epididymis-spermatozoa (NELL2-ROS1-OVCH2-ADAM3) signaling and male

207 d seminiferous tubule area, testis size, and spermatozoa number and motility without affecting hormon

208 ects meiosis, spermiogenesis and reduces the spermatozoa number in the third generation (F3) male mic

209 tiation of pre-meiotic germ cells, decreased spermatozoa number, an increased proportion of abnormal

210 ype resulted from a combination of decreased spermatozoa number, reduced sperm motility and defective

211 Here, by recording ionic currents from spermatozoa of an infertile CatSper-deficient patient, w

212 land shore region of mmu-miR-15b in both the spermatozoa of F0 mice and the brains of F1 mice.

213 Spermatozoa of marine invertebrates are attracted to the

214 ear the ovum, it is unclear which cues guide spermatozoa on their long journey towards the egg.

215 progesterone is an innate property of human spermatozoa or is acquired as the result of exposure to

216 It is unknown which compounds in spermatozoa or seminal plasma may be involved in the reg

217 ine )) were higher in Prdx6 (-/-) than in WT spermatozoa (p </= 0.05).

218 he cleared female tract, we demonstrate that spermatozoa past the utero-tubal junction possess the in

219 tubules of the testes, producing millions of spermatozoa per day in an adult male in rodents and huma

220 male gametes and histone retention in mature spermatozoa, potentially priming certain regions of the

221 radients, alkalization depolarizes Slo3(-/-) spermatozoa, presumably from CatSper activation, in cont

222 uring late spermiogenesis in preparation for spermatozoa production.

223 sed germ cell apoptosis, effectively halting spermatozoa production.

224 However, we know very little about spermatozoa propagation in a complex fluidic, chemical a

225 ve been developed to determine properties of spermatozoa quality but few have been adopted into routi

226 Zan(-/-) males were fertile, and their spermatozoa readily fertilized mouse eggs in vitro.

227 These changes are maintained in spermatozoa, regulating tsRNA biogenesis, and together t

228 PII) binding and histone retention in mature spermatozoa relative to CTCF-only sites, but little else

229 ions: initiation of spermatid elongation and spermatozoa release.

230 f the single dense-core granule of mammalian spermatozoa relies on the same highly conserved molecule

231 f progesterone upon transcriptionally silent spermatozoa remains unexplained and is believed to be me

232 h haploid male germ cells differentiate into spermatozoa, represents an ideal model for studying post

233 forceful asymmetric motion of hyperactivated spermatozoa requires Ca2+ entry into the sperm tail by a

234 Sea urchin spermatozoa respond to sperm-activating peptides, which

235 ion of epididymal fluid from L68Q mice to WT spermatozoa resulted in a recapitulation of the L68Q phe

236 dymal fluid can be cytotoxic to the maturing spermatozoa resulting in male infertility.

237 imb overexpression, Asl levels are higher in spermatozoa, resulting in embryos with reduced viability

238 and Zan(-/-) males are fertile because their spermatozoa retain adhesion capability that is not speci

239 Studies using human and non-human mammalian spermatozoa revealed the role of the ubiquitin-proteasom

240 ype displays variable expressivity such that spermatozoa show a broad range of defects.

241 apitulation of the L68Q phenotype in that WT spermatozoa showed reduced cell viability and motility c

242 d the existence of morphologically different spermatozoa: slightly asymmetric cells with trajectories

243 In mature spermatozoa, SPE-38 is localized to the pseudopod and TR

244 differentiation of postmeiotic spermatids to spermatozoa (spermiogenesis) is thought to be indirectly

245 wn leads to significant reductions (~40%) of spermatozoa stored in seminal vesicles of males, resulti

246 mmalian reproductive tract are important for spermatozoa swimming behavior and play role in selection

247 e the influence of cell-cell interactions on spermatozoa swimming behavior in constrained environment

248 d blastocyst rates were lower in Prdx6 (-/-) spermatozoa than in C57BL/6J wild-type (WT) controls (p

249 centage points' fewer morphologically normal spermatozoa than men with a sleep score of 11-20.

250 olemma were lower in Prdx6 (-/-) capacitated spermatozoa than WT capacitated controls and lower in WT

251 tion-nonselective current in the midpiece of spermatozoa that is activated by external ATP, consisten

252 KSper, a pH-dependent K(+) current in mouse spermatozoa that is critical for fertility, is activated

253 The molecules on mammalian spermatozoa that mediate recognition and binding to the

254 mt1 expression in sperm flagella persists in spermatozoa that navigate the female reproductive tract

255 In human spermatozoa, the flagellar voltage-gated proton channel

256 Once spermatids become activated to spermatozoa, the reporter moves from the plasma membrane

257 cent protein (GFP) were incubated with mouse spermatozoa, these sperm were highly successful in produ

258 eggs also emit chemotactic agents that guide spermatozoa through the female reproductive tract to the

259 possibility that AgOrs mediate responses of spermatozoa to endogenous signaling molecules in A. gamb

260 in the efferent ducts that are required for spermatozoa to enter the epididymis.

261 m heterozygous breeding and an impairment of spermatozoa to fertilize oocytes in vitro.

262 iability, motility, and the ability of mouse spermatozoa to fertilize oocytes.

263 Exposure of human spermatozoa to NO donors caused mobilisation of stored C

264 ss of zonadhesin increased adhesion of mouse spermatozoa to pig, cow, and rabbit ZP but not mouse ZP.

265 posed domain inhibited adhesion of wild-type spermatozoa to the mouse ZP but did not inhibit adhesion

266 Specific binding of spermatozoa to the zona pellucida that surrounds mammali

267 rkable example is the steering of sea urchin spermatozoa towards the conspecific egg by a spatially a

268 It attracts spermatozoa towards the egg and helps them penetrate the

269 than WT capacitated controls and lower in WT spermatozoa treated with the PRDX6 inhibitor.

270 In spe-38 mutant spermatozoa, TRP-3/SPE-41 is trapped within the MOs and

271 ial treatments of ejaculated and capacitated spermatozoa under proteasome permissive/inhibiting condi

272 have IFT components and, like some metazoan spermatozoa, use IFT-independent mechanisms to build axo

273 te (19.2% pregnant with >15% SPTRX3-positive spermatozoa vs. 41.2% pregnant with <5% SPTRX3-positive

274 sialic acid residues bound to the surface of spermatozoa was documented in men with a recent history

275 d N-acetylneuraminic acid release from human spermatozoa was effectively counteracted by a sialidase

276 irmed, while persistence of both proteins in spermatozoa was revealed for the first time.

277 ng the patch-clamp technique to mature human spermatozoa, we found that nanomolar concentrations of p

278 urrents from human epididymal and testicular spermatozoa, we show that CatSper sensitivity to progest

279 Here, by successfully patch clamping human spermatozoa, we show that proton channel Hv1 is their do

280 Spermatozoa were assessed pre-freeze and 0, 30, 60 and 9

281 a2 mRNA and protein, and its localization in spermatozoa were determined.

282 zoa and percentage of morphologically normal spermatozoa were equal to or above the lower reference l

283 Spermatozoa were retrieved in 37% of patients and in 42.

284 Lentivirally transduced mouse spermatozoa were used in in vitro fertilization (IVF) st

285 High SPTRX3 levels (>15% SPTRX3-positive spermatozoa) were found in 51% of male infertility patie

286 , is localized to the flagella of A. gambiae spermatozoa where Orco-specific agonists, antagonists, a

287 ifically promotes their differentiation into spermatozoa, whereas recombinant follicle-stimulating ho

288 nvironment for the maturation and storage of spermatozoa, which is essential for male fertility.

289 onia, spermatocytes, haploid spermatids, and spermatozoa, which takes place in the epithelium of semi

290 n causative; however, extracts from nematode spermatozoa, which use Major Sperm Protein rather than a

291 r localization persisted in ejaculated human spermatozoa, while centriolar TSKS diminished in mouse s

292 ion showed a 1:1 ratio of sSMC(+) to sSMC(-) spermatozoa, while evaluation of sperm aneuploidy status

293 The swimming stability of spermatozoa with a specified planar beat pattern in the

294 generating transgenic animals by transducing spermatozoa with lentiviral vectors in vitro is a powerf

295 t the acrosomal region and that treatment of spermatozoa with NAADP resulted in a loss of the acrosom

296 merary marker chromosome (sSMC; sSMC(+)) and spermatozoa with normal chromosome complement (sSMC(-)),

297 matozoa (DDS), whose semen contains abnormal spermatozoa with tailless heads and headless tails due t

298 he human chromosomes 15, 18, X and Y between spermatozoa with the small supernumerary marker chromoso

299 ion of our data, obtained using mature human spermatozoa, with those obtained using bisulfite sequenc

300 lobule lumen (SLL), where they develop into spermatozoa without direct contact with the supporting S