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1 evation of C16-ceramide, and/or elevation of sphinganine.
2 lol, and the sphingoid bases sphingosine and sphinganine.
3  species is conserved up to the formation of sphinganine.
4 t was inhibited by preincubating clusters in sphinganine.
5  increase cellular levels of sphingosine and sphinganine.
6 the 2-amino-1,3-diol polar head of D-erythro-sphinganine.
7 ectively reduced to either erythro- or threo-sphinganines.
8            Exposure to either sphingosine or sphinganine (0.001 10 microM) for 6 h promoted apoptotic
9                              Similar to SPP, sphinganine 1-phosphate (dihydro-SPP), which also binds
10                                      SPP and sphinganine 1-phosphate bind to these receptors, whereas
11 by a decrease in sphingosine 1-phosphate and sphinganine 1-phosphate.
12                         One of the top hits, sphinganine-1-phosphate (SA1P), was found to induce calc
13 inds SPP with remarkable specificity as only sphinganine-1-phosphate displaced radiolabeled SPP, whil
14          Present findings suggest a role for sphinganine-1-phosphate in paclitaxel-induced biological
15 ntrations of key phosphosphingolipids (e.g., sphinganine-1-phosphate) were associated with increased
16 d-like metabolites such as 9S- and 13S-HODE, sphinganine-1-phosphate, the branched-chain amino acid 3
17                          In contrast to SPP, sphinganine-1-phosphate, which binds to and signals thro
18                                  Conversely, sphinganine-1-phosphate, which binds to and signals via
19  specific for SPP, as only unlabeled SPP and sphinganine-1-phosphate, which lacks the trans double bo
20 eled serine (substrate) into sphinganine and sphinganine-1-phosphate.
21                          Partially protected sphinganines 11 are also readily accessible in five step
22 c acid, caused sequential formation of [(3)H]sphinganine (220% over control) and [(3)H]ceramide (160%
23               A total synthesis of D-erythro-sphinganine [(2S,3R)-2-aminooctadecane-1,3-diol] startin
24 te hydrogen-bonding interactions between the sphinganine 3-OH with Asp-80.
25  (D-e-deh-Sph, IC50 0.25 mol %), (2S)-3-keto-sphinganine (3-keto-dh-Sph, IC50 0.34 mol %), (2S) 3-ket
26                                              Sphinganine, a positively charged sphingoid base, inhibi
27                      A fluorescent analog of sphinganine accumulated in mitochondria.
28                                          The sphinganine analog mycotoxin, AAL-toxin, induces a death
29 i (AAL) toxins are members of a new class of sphinganine analog mycotoxins that occur widely in the f
30 e used to modulate the relative synthesis of sphinganine and 1-deoxySa.
31 s system was used to elevate sphingosine and sphinganine and determine if PKC was affected.
32                         Whereas increases in sphinganine and dihydroceramide are responses to provisi
33 es (CerSs), which use two substrates, namely sphinganine and fatty acyl-CoAs.
34 vator of PKC, and this effect was blocked by sphinganine and PKC(19-36), inhibitors of PKC in bag cel
35                                 Decreases in sphinganine and SM concentrations were also observed in
36 able isotope-labeled serine (substrate) into sphinganine and sphinganine-1-phosphate.
37  of the protein kinase C inhibitor D-erythro-sphinganine and the antitumor agent (+)-spisulosine, whe
38  pentacosane, monogalactosyldiacylglycerols, sphinganine, and 12-hydroxyjasmonic acid), which are rec
39                   Particularly, sphingosine, sphinganine, and C24Cer appear as promising novel biomar
40                                 Sphingosine, sphinganine, and other long-chain (sphingoid) bases are
41 bin activation was inhibited by sphingosine, sphinganine, and stearylamine in the presence but not in
42                  This is significant because sphinganines are more easily accessed than phytosphingos
43 e, incorporation of 2-hydroxyoleic acid to a sphinganine base was also confirmed by MS/MS.
44 ow direct study of cellular sphingosine- and sphinganine-based ceramide levels, we developed a mass s
45 ariations of serum SLs, with sphingosine and sphinganine being, both in univariate (P<0.05) as well a
46                              Sphingosine and sphinganine, but not ceramide or sphingosine-1-phosphate
47                      Elevation of endogenous sphinganine by a second method (addition of fumonisin B1
48 ng; therefore, elevations in sphingosine and sphinganine can both affect PKC.
49                                              Sphinganines can be synthesized in just three steps from
50                                              Sphinganine caused an increase in the cooperativity of c
51 ases (including C2 ceramide, sphingosine, or sphinganine) caused the accumulation of cyt c in the cyt
52                                          The sphinganine chain branching of BfaGCs is a critical dete
53 rt-chain alpha-GalCer ligand PBS-25, but its sphinganine chain is more deeply inserted into the F' po
54                  We have prepared the direct sphinganine-containing analogues of KRN7000 and OCH, 1 a
55  It was less potently inhibited by D-erythro-sphinganine (D-e-dh-Sph, IC50 0.20 mol %), D-erythro-deh
56                     Fumonisin B1, the N-acyl-sphinganine dehydrogenase (e.g., ceramide synthase) inhi
57 ion of sphingomyelin (SM) precursors such as sphinganine, dihydroceramide, and ceramide; (b) inhibite
58               C16-ceramide, sphingosine, and sphinganine directly inhibited complex IV activity in is
59                           On the other hand, sphinganine had little effect on the cooperativity of ph
60 or sphingomyelin are not substrates, whereas sphinganine has a limited capacity to accept the acetate
61                        Thus, sphingosine and sphinganine increased both the potency and efficacy of c
62          We suggest that C16-ceramide and/or sphinganine induce ROS formation through the modulation
63 eat-induced increase in incorporation of [3H]sphinganine into ceramide as well as the heat-induced in
64                                              Sphinganine is generated via the sequential activity of
65 amides (Cers) with consecutive elevations in sphinganine levels has been shown to cause a severe hepa
66 e liver, including elevated C16-ceramide and sphinganine levels in liver and in isolated mitochondria
67  and phosphatidylethanolamine) and cationic (sphinganine) lipids, nucleotides (ATP and CTP), N-ethylm
68  in Western diet for 12 weeks lowered SM and sphinganine plasma levels.
69 50) = 2.4 and 1.4 microm for sphingosine and sphinganine, respectively) as well as in whole plasma cl
70 es are N-acyl derivatives of sphingosine and sphinganine, respectively, which are the major sphingoid
71 and [(3)H]ceramide (160% over control), with sphinganine returning to baseline at 4 h, and ceramide c
72  its corresponding dihydro-saturated species sphinganine (Sa), are present in cell samples in low abu
73        Inhibition of CerS by FB(1) increases sphinganine (Sa), Sa 1-phosphate, and a previously unide
74 o significantly reduced urinary excretion of sphinganine (Sa), sphingosine (So), and Sa/So ratio, but
75 ted with improvements in plasma sphingosine, sphinganine sphingomyelin, and dihydrosphingomyelin lipi
76 of FB1, whereas the bioactive intermediates, sphinganine, sphingosine, and ceramide, were without eff
77 nd chain length of the N-acyl-spingosine or -sphinganine substrate.
78 st versatile templates described to date for sphinganine synthesis.
79 esemble the sphingoid bases, sphingosine and sphinganine, that are reported to play critical roles in
80 g1p) capable of catalyzing the conversion of sphinganine to ceramide, in contrast TgCerS2 was catalyt
81 ion in response to 4-HPR treatment, although sphinganine was still generated when 4-HPR and FB(1) wer
82 e versatility of the method, spisulosine and sphinganine were synthesized in two steps from the appro
83 ed with a decrease in plasma sphingosine and sphinganine, which was accompanied by a decrease in sphi